Effect of Cytoskeleton on the Mechanosensitivity of Genes in Osteoblasts

Mechanosensitivity is the ability of tissues and cells to detect and make response to mechanical stimuli. Osteoblast is a kind of important mechanosensitive cell in bone tissue, while cytoskeleton plays an important role in the mechanotransduction in osteoblasts. This article reviewed the roles of cytoskeleton on the mechanotransduction of genes in osteoblasts, summarized that cytoskeleton integrity is essential for the expression of bone formation–related genes in osteoblasts, and concluded that cytoskeleton reorganization inhibition can enhance the mechanosensitivity of some genes in osteoblasts. Further researches on the specific mechanisms of cytoskeleton will shed new light on the transmission mechanisms of mechanical stress in osteoblasts, and will lay the foundation for the further investigations on the biomechanical behaviors of bone cells and even bone tissues.

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