Polymer conjugate of a microtubule destabilizer inhibits lung metastatic melanoma

[1]  R. Mahato,et al.  Combination therapy of paclitaxel and cyclopamine polymer-drug conjugates to treat advanced prostate cancer. , 2017, Nanomedicine : nanotechnology, biology, and medicine.

[2]  V. Bazan,et al.  Stabilizing versus Destabilizing the Microtubules: A Double-Edge Sword for an Effective Cancer Treatment Option? , 2015, Analytical cellular pathology.

[3]  Duane D. Miller,et al.  Structural Optimization of Indole Derivatives Acting at Colchicine Binding Site as Potential Anticancer Agents. , 2015, ACS medicinal chemistry letters.

[4]  F. Gergely,et al.  Hitting the brakes: targeting microtubule motors in cancer , 2015, British Journal of Cancer.

[5]  A. Ray,et al.  Biodegradable multiblock poly(N-2-hydroxypropyl)methacrylamide gemcitabine and paclitaxel conjugates for ovarian cancer cell combination treatment. , 2013, International journal of pharmaceutics.

[6]  Duane D. Miller,et al.  Discovery of 4-Aryl-2-benzoyl-imidazoles as tubulin polymerization inhibitor with potent antiproliferative properties. , 2013, Journal of medicinal chemistry.

[7]  Duane D. Miller,et al.  Discovery of novel 2-aryl-4-benzoyl-imidazole (ABI-III) analogues targeting tubulin polymerization as antiproliferative agents. , 2012, Journal of medicinal chemistry.

[8]  Tingyun Yang,et al.  Novel cathepsin B-sensitive paclitaxel conjugate: Higher water solubility, better efficacy and lower toxicity. , 2012, Journal of controlled release : official journal of the Controlled Release Society.

[9]  Richard A. Stanton,et al.  Drugs that target dynamic microtubules: A new molecular perspective , 2011, Medicinal research reviews.

[10]  A. Hauschild,et al.  The Oncologist® Academia–Pharma Intersect: Melanoma , 2022 .

[11]  C. Dumontet,et al.  Microtubule-binding agents: a dynamic field of cancer therapeutics , 2010, Nature Reviews Drug Discovery.

[12]  R. Mahato,et al.  Synthesis and characterization of amphiphilic lipopolymers for micellar drug delivery. , 2010, Biomacromolecules.

[13]  Duane D. Miller,et al.  Synthesis, formulation and in vitro evaluation of a novel microtubule destabilizer, SMART-100. , 2010, Journal of controlled release : official journal of the Controlled Release Society.

[14]  María J. Vicent,et al.  Combination therapy: opportunities and challenges for polymer-drug conjugates as anticancer nanomedicines. , 2009, Advanced drug delivery reviews.

[15]  X. Jing,et al.  Biodegradable amphiphilic polymer–drug conjugate micelles , 2009, Expert opinion on drug delivery.

[16]  A. Hauschild,et al.  Results of a phase III, randomized, placebo-controlled study of sorafenib in combination with carboplatin and paclitaxel as second-line treatment in patients with unresectable stage III or stage IV melanoma. , 2009, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[17]  F. Giles,et al.  Microtubule dynamics as a target in oncology. , 2009, Cancer treatment reviews.

[18]  Duane D. Miller,et al.  Discovery of 4-substituted methoxybenzoyl-aryl-thiazole as novel anticancer agents: synthesis, biological evaluation, and structure-activity relationships. , 2009, Journal of medicinal chemistry.

[19]  G. Kruh,et al.  The taccalonolides: microtubule stabilizers that circumvent clinically relevant taxane resistance mechanisms. , 2008, Cancer research.

[20]  Ruth Duncan,et al.  Polymer conjugates as anticancer nanomedicines , 2006, Nature Reviews Cancer.

[21]  J. Ingle,et al.  Combination of paclitaxel and carboplatin as second‐line therapy for patients with metastatic melanoma , 2006, Cancer.

[22]  I. Barasoain,et al.  Microtubule interactions with chemically diverse stabilizing agents: thermodynamics of binding to the paclitaxel site predicts cytotoxicity. , 2005, Chemistry & biology.

[23]  C. Garbe,et al.  Palliative therapy of disseminated malignant melanoma: a systematic review of 41 randomised clinical trials. , 2003, The Lancet. Oncology.

[24]  T. Fojo,et al.  The role of ABC transporters in clinical practice. , 2003, The oncologist.

[25]  Zhe-Sheng Chen,et al.  Characterization of the transport properties of human multidrug resistance protein 7 (MRP7, ABCC10). , 2003, Molecular pharmacology.

[26]  H. Ringsdorf Structure and properties of pharmacologically active polymers , 1975 .