Two‐Dimensional Transition Metal Dichalcogenides in Biosystems

The intriguing properties of two-dimensional transition metal dichalcogenides (2D TMDCs) have led to a significant body of fundamental research and rapid uptake of these materials in many applications. Specifically, 2D TMDCs have shown great potential in biological systems due to their tunable electronic characteristics, unique optical properties, stability in aqueous environments, large surface area that can be manipulated and functionalized as well as an intercalatable layered structure, and low levels of toxicity. Here, the characteristics and use of 2D TMDCs for biological applications are reviewed and future possibilities for these materials in biological systems are outlined.

[1]  Chunming Wang,et al.  A novel way for detection of eugenol via poly (diallyldimethylammonium chloride) functionalized graphene-MoS2 nano-flower fabricated electrochemical sensor , 2014 .

[2]  Lu Wang,et al.  Functionalized MoS(2) nanosheet-based field-effect biosensor for label-free sensitive detection of cancer marker proteins in solution. , 2014, Small.

[3]  Lan Wang,et al.  Electrochemical sensing based on layered MoS2–graphene composites , 2013 .

[4]  Weibo Cai,et al.  Iron oxide decorated MoS2 nanosheets with double PEGylation for chelator-free radiolabeling and multimodal imaging guided photothermal therapy. , 2015, ACS nano.

[5]  Y. Shao,et al.  Direct detection of DNA below ppb level based on thionin-functionalized layered MoS2 electrochemical sensors. , 2014, Analytical chemistry.

[6]  Jun Jin,et al.  MoS2 nanosheet functionalized with Cu nanoparticles and its application for glucose detection , 2013 .

[7]  Zhong Lin Wang,et al.  Piezoelectricity of single-atomic-layer MoS2 for energy conversion and piezotronics , 2014, Nature.

[8]  Ruitao Lv,et al.  Transition metal dichalcogenides and beyond: synthesis, properties, and applications of single- and few-layer nanosheets. , 2015, Accounts of chemical research.

[9]  Shengli Chang,et al.  Adsorption of gas molecules on monolayer MoS2 and effect of applied electric field , 2013, Nanoscale Research Letters.

[10]  J. Schliemann,et al.  Plasmons and screening in a monolayer of MoS2 , 2013, 1306.1666.

[11]  L. Lauhon,et al.  Emerging device applications for semiconducting two-dimensional transition metal dichalcogenides. , 2014, ACS nano.

[12]  Qing Hua Wang,et al.  Electronics and optoelectronics of two-dimensional transition metal dichalcogenides. , 2012, Nature nanotechnology.

[13]  Edward I. Solomon,et al.  Structural and Functional Aspects of Metal Sites in Biology. , 1996, Chemical reviews.

[14]  P. Ajayan,et al.  Synthesis and defect investigation of two-dimensional molybdenum disulfide atomic layers. , 2015, Accounts of chemical research.

[15]  Zhuang Liu,et al.  Two-dimensional TiS₂ nanosheets for in vivo photoacoustic imaging and photothermal cancer therapy. , 2015, Nanoscale.

[16]  Jacob Bonde,et al.  Biomimetic hydrogen evolution: MoS2 nanoparticles as catalyst for hydrogen evolution. , 2005, Journal of the American Chemical Society.

[17]  Fred J Sigworth,et al.  Importance of the Debye screening length on nanowire field effect transistor sensors. , 2007, Nano letters.

[18]  Can Ataca,et al.  Stable, Single-Layer MX2 Transition-Metal Oxides and Dichalcogenides in a Honeycomb-Like Structure , 2012 .

[19]  J. Coleman,et al.  Preparation of High Concentration Dispersions of Exfoliated MoS2 with Increased Flake Size , 2012 .

[20]  Tao Liang,et al.  Antibacterial activity of two-dimensional MoS2 sheets. , 2014, Nanoscale.

[21]  R. Yu,et al.  A novel aptameric nanobiosensor based on the self-assembled DNA-MoS2 nanosheet architecture for biomolecule detection. , 2014, Journal of materials chemistry. B.

[22]  E. Benavente,et al.  Intercalation chemistry of molybdenum disulfide , 2002 .

[23]  M. Pumera,et al.  Toxicity of graphene related materials and transition metal dichalcogenides , 2015 .

[24]  E. Johnston-Halperin,et al.  Progress, challenges, and opportunities in two-dimensional materials beyond graphene. , 2013, ACS nano.

[25]  H. Lewerenz Enzyme–semiconductor interactions: Routes from fundamental aspects to photoactive devices , 2008 .

[26]  James M. Tour,et al.  Materials Science: Nanotube composites , 2007, Nature.

[27]  Dong Ju Han,et al.  Dual role of blue luminescent MoS2 quantum dots in fluorescence resonance energy transfer phenomenon. , 2014, Small.

[28]  T. Tang,et al.  Direct observation of a widely tunable bandgap in bilayer graphene , 2009, Nature.

[29]  K. Jacobsen,et al.  Plasmons on the edge of MoS 2 nanostructures , 2014, 1503.00538.

[30]  K. Banerjee,et al.  MoS₂ field-effect transistor for next-generation label-free biosensors. , 2014, ACS nano.

[31]  Single‐Layer MoS2 Mechanical Resonators , 2013, Advanced materials.

[32]  M. Kanatzidis,et al.  Nanoscale Composites Formed by Encapsulation of Polymers in MoS2. From Conjugated Polymers to Plastics. Detection of Metal to Insulator Transition , 1994 .

[33]  A. Splendiani,et al.  Emerging photoluminescence in monolayer MoS2. , 2010, Nano letters.

[34]  Brian C. Olsen,et al.  Lithium ion battery applications of molybdenum disulfide (MoS2) nanocomposites , 2014 .

[35]  N. Aluru,et al.  DNA base detection using a single-layer MoS2. , 2014, ACS nano.

[36]  Mrinmoy De,et al.  Ligand conjugation of chemically exfoliated MoS2. , 2013, Journal of the American Chemical Society.

[37]  Yu-Chuan Lin,et al.  Growth of large-area and highly crystalline MoS2 thin layers on insulating substrates. , 2012, Nano letters.

[38]  Andre K. Geim,et al.  Raman spectrum of graphene and graphene layers. , 2006, Physical review letters.

[39]  Dominique Baillargeat,et al.  From Bulk to Monolayer MoS2: Evolution of Raman Scattering , 2012 .

[40]  D. Fino,et al.  Hazard assessment of W and Mo sulphide nanomaterials for automotive use , 2014, Journal of Nanoparticle Research.

[41]  E. Benavente,et al.  High Electronic Conductivity Molybdenum Disulfide-Dialkylamine Nanocomposites , 1999 .

[42]  J. Coleman,et al.  Liquid Exfoliation of Layered Materials , 2013, Science.

[43]  Zhiwei Zhu,et al.  Biosensor based on ultrasmall MoS2 nanoparticles for electrochemical detection of H2O2 released by cells at the nanomolar level. , 2013, Analytical chemistry.

[44]  Liang Cheng,et al.  Drug Delivery with PEGylated MoS2 Nano‐sheets for Combined Photothermal and Chemotherapy of Cancer , 2014, Advanced materials.

[45]  Zhiyuan Zeng,et al.  Single-layer semiconducting nanosheets: high-yield preparation and device fabrication. , 2011, Angewandte Chemie.

[46]  Benjamin J. Carey,et al.  Investigation of Two-Solvent Grinding-Assisted Liquid Phase Exfoliation of Layered MoS2 , 2015 .

[47]  A. Mikos,et al.  Two-dimensional nanostructure-reinforced biodegradable polymeric nanocomposites for bone tissue engineering. , 2013, Biomacromolecules.

[48]  Ke-Jing Huang,et al.  Sub-femtomolar DNA detection based on layered molybdenum disulfide/multi-walled carbon nanotube composites, Au nanoparticle and enzyme multiple signal amplification. , 2014, Biosensors & bioelectronics.

[49]  Martin Pumera,et al.  MoS₂ exhibits stronger toxicity with increased exfoliation. , 2014, Nanoscale.

[50]  Peiyi Wu,et al.  One‐Pot, Facile, and Versatile Synthesis of Monolayer MoS2/WS2 Quantum Dots as Bioimaging Probes and Efficient Electrocatalysts for Hydrogen Evolution Reaction , 2015 .

[51]  Jian Zhen Ou,et al.  Two‐Dimensional Molybdenum Trioxide and Dichalcogenides , 2013 .

[52]  Martin Pumera,et al.  Cytotoxicity of exfoliated transition-metal dichalcogenides (MoS2 , WS2 , and WSe2 ) is lower than that of graphene and its analogues. , 2014, Chemistry.

[53]  Wold,et al.  Electronic structure of MoSe2, MoS2, and WSe2. I. Band-structure calculations and photoelectron spectroscopy. , 1987, Physical review. B, Condensed matter.

[54]  Liang Song,et al.  Protein-assisted fabrication of nano-reduced graphene oxide for combined in vivo photoacoustic imaging and photothermal therapy. , 2013, Biomaterials.

[55]  Andres Castellanos-Gomez,et al.  Elastic Properties of Freely Suspended MoS2 Nanosheets , 2012, Advanced materials.

[56]  Kristian Sommer Thygesen,et al.  Computational 2D Materials Database: Electronic Structure of Transition-Metal Dichalcogenides and Oxides , 2015, 1506.02841.

[57]  Liangzhu Feng,et al.  Photothermally enhanced photodynamic therapy delivered by nano-graphene oxide. , 2011, ACS nano.

[58]  Fei Meng,et al.  Highly active hydrogen evolution catalysis from metallic WS2 nanosheets , 2014 .

[59]  A. Geim,et al.  Two-dimensional gas of massless Dirac fermions in graphene , 2005, Nature.

[60]  Takeshi Fujita,et al.  Covalent functionalization of monolayered transition metal dichalcogenides by phase engineering. , 2015, Nature chemistry.

[61]  Bo Chen,et al.  Single‐Layer Transition Metal Dichalcogenide Nanosheet‐Based Nanosensors for Rapid, Sensitive, and Multiplexed Detection of DNA , 2015, Advanced materials.

[62]  Jing Kong,et al.  Antibacterial activity of graphite, graphite oxide, graphene oxide, and reduced graphene oxide: membrane and oxidative stress. , 2011, ACS nano.

[63]  P. Kim,et al.  Energy band-gap engineering of graphene nanoribbons. , 2007, Physical review letters.

[64]  A. Javey,et al.  High-performance single layered WSe₂ p-FETs with chemically doped contacts. , 2012, Nano letters.

[65]  Jian-Bai Xia,et al.  Photoresponsive and Gas Sensing Field-Effect Transistors based on Multilayer WS2 Nanoflakes , 2014, Scientific Reports.

[66]  J. Choy,et al.  Layered nanomaterials for green materials , 2009 .

[67]  J. Cheon,et al.  Tandem intercalation strategy for single-layer nanosheets as an effective alternative to conventional exfoliation processes , 2015, Nature Communications.

[68]  Yuming Cui,et al.  One-pot synthesis of α-Fe2O3 nanospheres by solvothermal method , 2013, Nanoscale Research Letters.

[69]  J. Coleman,et al.  Two-Dimensional Nanosheets Produced by Liquid Exfoliation of Layered Materials , 2011, Science.

[70]  Gang Liu,et al.  PEGylated WS2 Nanosheets as a Multifunctional Theranostic Agent for in vivo Dual‐Modal CT/Photoacoustic Imaging Guided Photothermal Therapy , 2014, Advanced materials.

[71]  J. Niemantsverdriet,et al.  Basic reaction steps in the sulfidation of crystalline MoO3 to MoS2, as studied by X-ray photoelectron and infrared emission spectroscopy , 1996 .

[72]  S. Dou,et al.  One-pot aqueous synthesis of cysteine-capped CdTe/CdS core–shell nanowires , 2014, Journal of Nanoparticle Research.

[73]  Yu Chen,et al.  Two-dimensional graphene analogues for biomedical applications. , 2015, Chemical Society reviews.

[74]  James R Friend,et al.  Electrochemical control of photoluminescence in two-dimensional MoS(2) nanoflakes. , 2013, ACS nano.

[75]  Fei Xu,et al.  Highly Sensitive and Selective Determination of Dopamine in the Presence of Ascorbic Acid Using Gold Nanoparticles‐Decorated MoS2 Nanosheets Modified Electrode , 2013 .

[76]  Zhiyuan Zeng,et al.  Electrochemically reduced single-layer MoS₂ nanosheets: characterization, properties, and sensing applications. , 2012, Small.

[77]  Hsieh-Chih Tsai,et al.  Highly concentrated MoS2 nanosheets in water achieved by thioglycolic acid as stabilizer and used as biomarkers , 2014 .

[78]  Benjamin J. Carey,et al.  Two solvent grinding sonication method for the synthesis of two-dimensional tungsten disulphide flakes. , 2015, Chemical communications.

[79]  J. Lemmon,et al.  Preparation of nanocomposites containing poly(ethylene oxide) and layered solids , 1995 .

[80]  R. Hennig,et al.  Computational Screening of 2D Materials for Photocatalysis. , 2015, The journal of physical chemistry letters.

[81]  D. Neff,et al.  DNA origami deposition on native and passivated molybdenum disulfide substrates , 2014, Beilstein journal of nanotechnology.

[82]  P M Campbell,et al.  Chemical vapor sensing with monolayer MoS2. , 2013, Nano letters.

[83]  Jie Yu,et al.  High-throughput synthesis of single-layer MoS2 nanosheets as a near-infrared photothermal-triggered drug delivery for effective cancer therapy. , 2014, ACS nano.

[84]  S. E. Moore,et al.  The role of hydrogen in the reaction of water with surface carbon to form methane , 1982 .

[85]  Michael S Strano,et al.  Ion-driven photoluminescence modulation of quasi-two-dimensional MoS2 nanoflakes for applications in biological systems. , 2014, Nano letters.

[86]  Bruce E. Logan,et al.  Electrochemical evaluation of molybdenum disulfide as a catalyst for hydrogen evolution in microbial , 2011 .

[87]  Alessandra Bonanni,et al.  Molybdenum disulfide (MoS2) nanoflakes as inherently electroactive labels for DNA hybridization detection. , 2014, Nanoscale.

[88]  James Hone,et al.  Measurement of mobility in dual-gated MoS₂ transistors. , 2013, Nature nanotechnology.

[89]  Ke Liu,et al.  Atomically thin molybdenum disulfide nanopores with high sensitivity for DNA translocation. , 2014, ACS nano.

[90]  Tianran Lin,et al.  Visual detection of blood glucose based on peroxidase-like activity of WS2 nanosheets. , 2014, Biosensors & bioelectronics.

[91]  J. Shan,et al.  Experimental demonstration of continuous electronic structure tuning via strain in atomically thin MoS2. , 2013, Nano letters.

[92]  E. Benavente,et al.  Microwave activated lithium intercalation in transition metal sulfides , 1997 .

[93]  Niall McEvoy,et al.  Edge and confinement effects allow in situ measurement of size and thickness of liquid-exfoliated nanosheets , 2014, Nature Communications.

[94]  Xiaopeng Zheng,et al.  WS2 nanosheet as a new photosensitizer carrier for combined photodynamic and photothermal therapy of cancer cells. , 2014, Nanoscale.

[95]  Qiyuan He,et al.  Fabrication of flexible MoS2 thin-film transistor arrays for practical gas-sensing applications. , 2012, Small.

[96]  Thomas Heine,et al.  Influence of quantum confinement on the electronic structure of the transition metal sulfide T S 2 , 2011, 1104.3670.

[97]  Hua Zhang,et al.  The chemistry of two-dimensional layered transition metal dichalcogenide nanosheets. , 2013, Nature chemistry.

[98]  P. Ajayan,et al.  Large Area Vapor Phase Growth and Characterization of MoS2 Atomic Layers on SiO2 Substrate , 2011, 1111.5072.

[99]  Andre K. Geim,et al.  Two-dimensional atomic crystals. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[100]  S. Bose,et al.  Recent advances in graphene-based biosensors. , 2011, Biosensors & bioelectronics.

[101]  Hongxiang Li,et al.  Synthesis of strongly fluorescent molybdenum disulfide nanosheets for cell-targeted labeling. , 2014, ACS applied materials & interfaces.

[102]  Zhihong Liu,et al.  Establishing water-soluble layered WS₂ nanosheet as a platform for biosensing. , 2014, Analytical chemistry.

[103]  Chunhai Fan,et al.  Single-layer MoS2-based nanoprobes for homogeneous detection of biomolecules. , 2013, Journal of the American Chemical Society.

[104]  Hisato Yamaguchi,et al.  Coherent atomic and electronic heterostructures of single-layer MoS2. , 2012, ACS nano.

[105]  Yong Wang,et al.  Molybdenum disulfide quantum dots as a photoluminescence sensing platform for 2,4,6-trinitrophenol detection. , 2014, Analytical chemistry.

[106]  Wang Yao,et al.  Coupled spin and valley physics in monolayers of MoS2 and other group-VI dichalcogenides. , 2011, Physical review letters.

[107]  Kourosh Kalantar-Zadeh,et al.  Atomically thin layers of MoS2 via a two step thermal evaporation-exfoliation method. , 2012, Nanoscale.

[108]  K. Sivula,et al.  Multiflake Thin Film Electronic Devices of Solution Processed 2D MoS2 Enabled by Sonopolymer Assisted Exfoliation and Surface Modification , 2014 .

[109]  Qingshan Lu,et al.  Immobilization and catalytic activity of horseradish peroxidase on molybdenum disulfide nanosheets modified electrode , 2013 .

[110]  L. David,et al.  Synthesis of Surface-Functionalized WS2 Nanosheets and Performance as Li-Ion Battery Anodes. , 2012, The journal of physical chemistry letters.

[111]  A. Radenović,et al.  Single-layer MoS2 transistors. , 2011, Nature nanotechnology.

[112]  S. Ciraci,et al.  Functionalization of Single-Layer MoS2 Honeycomb Structures , 2010, 1009.5527.

[113]  Kai Yang,et al.  Graphene in mice: ultrahigh in vivo tumor uptake and efficient photothermal therapy. , 2010, Nano letters.

[114]  Hee‐Tae Jung,et al.  Tunable volatile organic compounds sensor by using thiolated ligand conjugation on MoS2. , 2014, Nano letters.

[115]  Ke-Jing Huang,et al.  Fabrication of electrochemiluminescence aptasensor based on in situ growth of gold nanoparticles on layered molybdenum disulfide for sensitive detection of platelet-derived growth factor-BB , 2014 .

[116]  A. Du,et al.  Strain engineering of selective chemical adsorption on monolayer MoS2. , 2013, Nanoscale.

[117]  Hua Zhang,et al.  Fabrication of single- and multilayer MoS2 film-based field-effect transistors for sensing NO at room temperature. , 2012, Small.

[118]  Benjamin J. Carey,et al.  Plasmon resonances of highly doped two-dimensional MoS₂. , 2015, Nano letters.

[119]  Bin Liu,et al.  Sensing behavior of atomically thin-layered MoS2 transistors. , 2013, ACS nano.

[120]  G. Eda,et al.  Electronic structure and optical signatures of semiconducting transition metal dichalcogenide nanosheets. , 2015, Accounts of chemical research.

[121]  Hua Zhang,et al.  Two-dimensional transition metal dichalcogenide nanosheet-based composites. , 2015, Chemical Society reviews.

[122]  Mustafa Lotya,et al.  Large‐Scale Exfoliation of Inorganic Layered Compounds in Aqueous Surfactant Solutions , 2011, Advanced materials.