Risk factors for mortality during antiretroviral therapy in older populations in resource-limited settings

An increasing proportion of adult patients initiating antiretroviral therapy (ART) in resource‐limited settings are aged >50 years. Older populations on ART appear to have heightened risk of death, but little is known about factors influencing mortality in this population.

[1]  黄亚明,et al.  Journal of the International AIDS Society , 2017 .

[2]  L. Myer,et al.  Age in antiretroviral therapy programmes in South Africa: a retrospective, multicentre, observational cohort study. , 2015, The lancet. HIV.

[3]  W. El-Sadr,et al.  Characteristics and Outcomes among Older HIV-Positive Adults Enrolled in HIV Programs in Four Sub-Saharan African Countries , 2014, PloS one.

[4]  J. Elliott,et al.  Impact of Hiv-Associated Conditions on Mortality in People Commencing Anti-Retroviral Therapy in Resource Limited Settings , 2013, PloS one.

[5]  N. Ford,et al.  Male sex and the risk of mortality among individuals enrolled in antiretroviral therapy programs in Africa: a systematic review and meta-analysis , 2013, AIDS.

[6]  T. Spelman,et al.  Incidence of WHO Stage 3 and 4 Conditions following Initiation of Anti-Retroviral Therapy in Resource Limited Settings , 2012, PloS one.

[7]  N. Ford,et al.  Association between older age and adverse outcomes on antiretroviral therapy: a cohort analysis of programme data from nine countries , 2012, AIDS.

[8]  R. Baltussen,et al.  The impact of antiretroviral treatment on the age composition of the HIV epidemic in sub-Saharan Africa , 2012, AIDS.

[9]  M. Fox,et al.  Poorer ART Outcomes with Increasing Age at a Large Public Sector HIV Clinic in Johannesburg, South Africa , 2012, Journal of the International Association of Physicians in AIDS Care.

[10]  Thomas Lengauer,et al.  Risk Factors Associated with Older Age in Treatment-Naive HIV-Positive Patients , 2012, Intervirology.

[11]  E. Mills,et al.  Ageing faster with AIDS in Africa , 2011, The Lancet.

[12]  Richard D Moore,et al.  CD4 count at presentation for HIV care in the United States and Canada: Are those over 50 years more likely to have a delayed presentation? , 2010, AIDS research and therapy.

[13]  R. Cumming,et al.  HIV infection in older adults in sub-Saharan Africa: extrapolating prevalence from existing data. , 2010, Bulletin of the World Health Organization.

[14]  J. Sterne,et al.  Prognosis of patients with HIV-1 infection starting antiretroviral therapy in sub-Saharan Africa: a collaborative analysis of scale-up programmes , 2010, The Lancet.

[15]  P. Davies,et al.  Tuberculosis at extremes of age , 2010, Respirology.

[16]  N. Ford,et al.  Seven-year experience of a primary care antiretroviral treatment programme in Khayelitsha, South Africa , 2010, AIDS.

[17]  D. Schopper,et al.  Research Ethics Review in Humanitarian Contexts: The Experience of the Independent Ethics Review Board of Médecins Sans Frontières , 2009, PLoS medicine.

[18]  A. d’Arminio Monforte,et al.  Response to combination antiretroviral therapy: variation by age , 2008, AIDS.

[19]  L. Sandvik,et al.  Predictors of mortality in HIV-infected patients starting antiretroviral therapy in a rural hospital in Tanzania , 2008, BMC infectious diseases.

[20]  L. Palombi,et al.  Excessive early mortality in the first year of treatment in HIV type 1-infected patients initiating antiretroviral therapy in resource-limited settings. , 2008, AIDS research and human retroviruses.

[21]  Gemma Navarro,et al.  Bmc Infectious Diseases Epidemiological and Clinical Features, Response to Haart, and Survival in Hiv-infected Patients Diagnosed at the Age of 50 or More , 2022 .

[22]  E. Delaporte,et al.  Mortality and causes of death in adults receiving highly active antiretroviral therapy in Senegal: a 7-year cohort study , 2006, AIDS.

[23]  D. Costagliola,et al.  Immunologic and clinical responses to highly active antiretroviral therapy over 50 years of age. Results from the French Hospital Database on HIV , 2004, AIDS.

[24]  L. Lynen.  Clinical HIV/AIDS care guidelines for resource-poor settings. 2nd ed. , 2006 .