Polymeric delivery systems for nucleic acid therapeutics: approaching the clinic.

[1]  P. Dormitzer,et al.  Safety and Efficacy of the BNT162b2 mRNA Covid-19 Vaccine , 2020, The New England journal of medicine.

[2]  Fathema Uddin,et al.  CRISPR Gene Therapy: Applications, Limitations, and Implications for the Future , 2020, Frontiers in Oncology.

[3]  Drew M. Lowery,et al.  mRNA vaccines: intellectual property landscape , 2020, Nature Reviews Drug Discovery.

[4]  Haifa Shen,et al.  Nanoplatforms for mRNA Therapeutics , 2020 .

[5]  J. Mascola,et al.  An mRNA Vaccine against SARS-CoV-2 — Preliminary Report , 2020, The New England journal of medicine.

[6]  A. Walls,et al.  Structure, Function, and Antigenicity of the SARS-CoV-2 Spike Glycoprotein , 2020, Cell.

[7]  Wing-Cheung Law,et al.  Biodegradable Polymers for Gene-Delivery Applications , 2020, International journal of nanomedicine.

[8]  L. Scott.  Givosiran: First Approval , 2020, Drugs.

[9]  K. Park,et al.  The Importance of Poly(ethylene glycol) Alternatives for Overcoming PEG Immunogenicity in Drug Delivery and Bioconjugation , 2020, Polymers.

[10]  R. Titze-de-Almeida,et al.  Leading RNA Interference Therapeutics Part 2: Silencing Delta-Aminolevulinic Acid Synthase 1, with a Focus on Givosiran , 2019, Molecular Diagnosis & Therapy.

[11]  M. Manoharan,et al.  The Onpattro story and the clinical translation of nanomedicines containing nucleic acid-based drugs , 2019, Nature Nanotechnology.

[12]  Daniel G. Anderson,et al.  mRNA Delivery for Therapeutic Anti-HER2 Antibody Expression In Vivo. , 2019, Molecular therapy : the journal of the American Society of Gene Therapy.

[13]  Jinwoo Hong,et al.  Overcoming the limitations of locally administered oncolytic virotherapy , 2019, BMC biomedical engineering.

[14]  Z. Rehman,et al.  Carriers Break Barriers in Drug Delivery: Endocytosis and Endosomal Escape of Gene Delivery Vectors , 2019, Accounts of chemical research.

[15]  Enrico Mastrobattista,et al.  Delivery Aspects of CRISPR/Cas for in Vivo Genome Editing , 2019, Accounts of chemical research.

[16]  S. Fukushima,et al.  Precise tuning of disulphide crosslinking in mRNA polyplex micelles for optimising extracellular and intracellular nuclease tolerability , 2019, Journal of drug targeting.

[17]  Daniel G Anderson,et al.  Delivering the Messenger: Advances in Technologies for Therapeutic mRNA Delivery. , 2019, Molecular therapy : the journal of the American Society of Gene Therapy.

[18]  Hu Shan,et al.  Advances in mRNA Vaccines for Infectious Diseases , 2019, Front. Immunol..

[19]  Chin-Yu Lin,et al.  Preparation of Messenger RNA Nanomicelles via Non-Cytotoxic PEG-Polyamine Nanocomplex for Intracerebroventicular Delivery: A Proof-of-Concept Study in Mouse Models , 2019, Nanomaterials.

[20]  O. Madkhali,et al.  Modified gelatin nanoparticles for gene delivery , 2019, International journal of pharmaceutics.

[21]  U. Schubert,et al.  The great escape: how cationic polyplexes overcome the endosomal barrier. , 2018, Journal of materials chemistry. B.

[22]  N. Meader,et al.  Strimvelis® for Treating Severe Combined Immunodeficiency Caused by Adenosine Deaminase Deficiency: An Evidence Review Group Perspective of a NICE Highly Specialised Technology Evaluation , 2018, PharmacoEconomics - Open.

[23]  Jonathan R. Soucy,et al.  Advances in Receptor‐Mediated, Tumor‐Targeted Drug Delivery , 2018, Advanced therapeutics.

[24]  Wim E Hennink,et al.  mRNA Polyplexes with Post-Conjugated GALA Peptides Efficiently Target, Transfect, and Activate Antigen Presenting Cells , 2018, Bioconjugate chemistry.

[25]  Kevin Braeckmans,et al.  The proton sponge hypothesis: Fable or fact? , 2018, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

[26]  E. Wagner,et al.  Efficient Shielding of Polyplexes Using Heterotelechelic Polysarcosines , 2018, Polymers.

[27]  Heather H Gustafson,et al.  Serum Nuclease Susceptibility of mRNA Cargo in Condensed Polyplexes. , 2018, Molecular pharmaceutics.

[28]  A. Yoon,et al.  Hepatocellular carcinoma-targeting oncolytic adenovirus overcomes hypoxic tumor microenvironment and effectively disperses through both central and peripheral tumor regions , 2018, Scientific Reports.

[29]  Jinwoo Hong,et al.  A hypoxia- and telomerase-responsive oncolytic adenovirus expressing secretable trimeric TRAIL triggers tumour-specific apoptosis and promotes viral dispersion in TRAIL-resistant glioblastoma , 2018, Scientific Reports.

[30]  Wei Xu,et al.  The First Approved Gene Therapy Product for Cancer Ad-p53 (Gendicine): 12 Years in the Clinic. , 2018, Human gene therapy.

[31]  D. Weissman,et al.  mRNA vaccines — a new era in vaccinology , 2018, Nature Reviews Drug Discovery.

[32]  V. Chudasama,et al.  Advances in targeting the folate receptor in the treatment/imaging of cancers , 2017, Chemical science.

[33]  D. Corey,et al.  Chemistry, mechanism and clinical status of antisense oligonucleotides and duplex RNAs , 2017, Nucleic acids research.

[34]  Qixian Chen,et al.  Tumor-Targeted Accumulation of Ligand-Installed Polymeric Micelles Influenced by Surface PEGylation Crowdedness. , 2017, ACS applied materials & interfaces.

[35]  S. W. Kim,et al.  Synergistic antitumor effect mediated by a paclitaxel-conjugated polymeric micelle-coated oncolytic adenovirus. , 2017, Biomaterials.

[36]  Kai Shi,et al.  Cleavable PEGylation: a strategy for overcoming the “PEG dilemma” in efficient drug delivery , 2017, Drug delivery.

[37]  W. Strohl,et al.  Adeno-Associated Virus (AAV) as a Vector for Gene Therapy , 2017, BioDrugs.

[38]  Melanie Senior,et al.  After Glybera's withdrawal, what's next for gene therapy? , 2017, Nature Biotechnology.

[39]  E. Wagner,et al.  History of Polymeric Gene Delivery Systems , 2017, Topics in current chemistry.

[40]  G. Zuber,et al.  Self‐aggregating 1.8 kDa polyethylenimines with dissolution switch at endosomal acidic pH are delivery carriers for plasmid DNA, mRNA, siRNA and exon‐skipping oligonucleotides , 2017, Journal of controlled release : official journal of the Controlled Release Society.

[41]  K. Kataoka,et al.  Poly(ethylene glycol) Crowding as Critical Factor To Determine pDNA Packaging Scheme into Polyplex Micelles for Enhanced Gene Expression. , 2017, Biomacromolecules.

[42]  J. Engbersen,et al.  Disulfide-functional poly(amido amine)s with tunable degradability for gene delivery. , 2016, Journal of controlled release : official journal of the Controlled Release Society.

[43]  Rong Ni,et al.  Virus-inspired nucleic acid delivery system: Linking virus and viral mimicry. , 2016, Advanced drug delivery reviews.

[44]  K. Jensen,et al.  In vitro and ex vivo strategies for intracellular delivery , 2016, Nature.

[45]  Yuko Nakamura,et al.  Nanodrug Delivery: Is the Enhanced Permeability and Retention Effect Sufficient for Curing Cancer? , 2016, Bioconjugate chemistry.

[46]  T. Etrych,et al.  Acid-labile pHPMA modification of four-arm oligoaminoamide pDNA polyplexes balances shielding and gene transfer activity in vitro and in vivo. , 2016, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

[47]  Shibing Wang,et al.  Loss of coxsackie and adenovirus receptor expression in human colorectal cancer: A potential impact on the efficacy of adenovirus-mediated gene therapy in Chinese Han population , 2016, Molecular medicine reports.

[48]  J. Utikal,et al.  Abstract CT032: A first-in-human phase I/II clinical trial assessing novel mRNA-lipoplex nanoparticles for potent cancer immunotherapy in patients with malignant melanoma , 2016 .

[49]  S. W. Kim,et al.  Evolving lessons on nanomaterial-coated viral vectors for local and systemic gene therapy. , 2016, Nanomedicine.

[50]  Özlem Türeci,et al.  Systemic RNA delivery to dendritic cells exploits antiviral defence for cancer immunotherapy , 2016, Nature.

[51]  A. Gomes,et al.  Folate-targeted nanoparticles for rheumatoid arthritis therapy. , 2016, Nanomedicine : nanotechnology, biology, and medicine.

[52]  Tao Gong,et al.  Enhanced intranasal delivery of mRNA vaccine by overcoming the nasal epithelial barrier via intra- and paracellular pathways. , 2016, Journal of controlled release : official journal of the Controlled Release Society.

[53]  Laura M Ensign,et al.  PEGylation as a strategy for improving nanoparticle-based drug and gene delivery. , 2016, Advanced drug delivery reviews.

[54]  S. W. Kim,et al.  Redirecting adenovirus tropism by genetic, chemical, and mechanical modification of the adenovirus surface for cancer gene therapy , 2016, Expert opinion on drug delivery.

[55]  K. Kataoka,et al.  Systemic delivery of messenger RNA for the treatment of pancreatic cancer using polyplex nanomicelles with a cholesterol moiety. , 2016, Biomaterials.

[56]  K. Kataoka,et al.  Polyplex Micelles with Double-Protective Compartments of Hydrophilic Shell and Thermoswitchable Palisade of Poly(oxazoline)-Based Block Copolymers for Promoted Gene Transfection. , 2016, Biomacromolecules.

[57]  S. W. Kim,et al.  Potent antitumor effect of neurotensin receptor-targeted oncolytic adenovirus co-expressing decorin and Wnt antagonist in an orthotopic pancreatic tumor model. , 2015, Journal of controlled release : official journal of the Controlled Release Society.

[58]  Young Sook Lee,et al.  Polymeric oncolytic adenovirus for cancer gene therapy. , 2015, Journal of controlled release : official journal of the Controlled Release Society.

[59]  S. W. Kim,et al.  Tuning Surface Charge and PEGylation of Biocompatible Polymers for Efficient Delivery of Nucleic Acid or Adenoviral Vector. , 2015, Bioconjugate chemistry.

[60]  K. Kataoka,et al.  Screening of mRNA Chemical Modification to Maximize Protein Expression with Reduced Immunogenicity , 2015, Pharmaceutics.

[61]  Young Sook Lee,et al.  Oncolytic Adenovirus Coated with Multidegradable Bioreducible Core-Cross-Linked Polyethylenimine for Cancer Gene Therapy. , 2015, Biomacromolecules.

[62]  Y. Kwon,et al.  Mixing-sequence-dependent nucleic acid complexation and gene transfer efficiency by polyethylenimine. , 2015, Biomaterials science.

[63]  Andrew D. Wong,et al.  Quantitative Analysis of the Enhanced Permeation and Retention (EPR) Effect , 2015, PloS one.

[64]  Tomoko Fujiwara,et al.  Three-Layered Biodegradable Micelles Prepared by Two-Step Self-Assembly of PLA-PEI-PLA and PLA-PEG-PLA Triblock Copolymers as Efficient Gene Delivery System. , 2015, Macromolecular bioscience.

[65]  E. Wagner,et al.  Nucleic Acid Therapeutics Using Polyplexes: A Journey of 50 Years (and Beyond). , 2015, Chemical reviews.

[66]  C. van Nostrum,et al.  Decationized polyplexes for gene delivery , 2015, Expert opinion on drug delivery.

[67]  V. Patravale,et al.  Polymeric nanoparticles for targeted treatment in oncology: current insights , 2015, International journal of nanomedicine.

[68]  S. W. Kim,et al.  Dual tumor targeting with pH-sensitive and bioreducible polymer-complexed oncolytic adenovirus. , 2015, Biomaterials.

[69]  F. Kiessling,et al.  Decationized polyplexes as stable and safe carrier systems for improved biodistribution in systemic gene therapy. , 2014, Journal of controlled release : official journal of the Controlled Release Society.

[70]  Jean-Christophe Leroux,et al.  Disulfide-containing parenteral delivery systems and their redox-biological fate. , 2014, Journal of controlled release : official journal of the Controlled Release Society.

[71]  Amy Chan,et al.  Multivalent N-acetylgalactosamine-conjugated siRNA localizes in hepatocytes and elicits robust RNAi-mediated gene silencing. , 2014, Journal of the American Chemical Society.

[72]  C. D'Andrea,et al.  The study of polyplex formation and stability by time-resolved fluorescence spectroscopy of SYBR Green I-stained DNA , 2014, Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology.

[73]  H. Fausther-Bovendo,et al.  Pre-existing immunity against Ad vectors , 2014, Human vaccines & immunotherapeutics.

[74]  Long-Cheng Li,et al.  RNAa in action: From the exception to the norm , 2014, RNA biology.

[75]  Mark E. Davis,et al.  Correlating animal and human phase Ia/Ib clinical data with CALAA-01, a targeted, polymer-based nanoparticle containing siRNA , 2014, Proceedings of the National Academy of Sciences.

[76]  Cheol Joo Kim,et al.  Suppressive immune response of poly‐(sarcosine) chains in peptide‐nanosheets in contrast to polymeric micelles , 2014, Journal of peptide science : an official publication of the European Peptide Society.

[77]  S. W. Kim,et al.  Enhanced therapeutic efficacy of an adenovirus-PEI-bile-acid complex in tumors with low coxsackie and adenovirus receptor expression. , 2014, Biomaterials.

[78]  J. Xi,et al.  miR-19b promotes tumor growth and metastasis via targeting TP53 , 2014, RNA.

[79]  M. Vähä-Koskela,et al.  Tumor Restrictions to Oncolytic Virus , 2014, Biomedicines.

[80]  S. D. De Smedt,et al.  Cell division responsive peptides for optimized plasmid DNA delivery: the mitotic window of opportunity? , 2014, Journal of controlled release : official journal of the Controlled Release Society.

[81]  C. van Nostrum,et al.  Targeted decationized polyplexes for cell specific gene delivery. , 2014, Bioconjugate chemistry.

[82]  C. Yun,et al.  Efficient lung orthotopic tumor-growth suppression of oncolytic adenovirus complexed with RGD-targeted bioreducible polymer , 2014, Gene Therapy.

[83]  Yezi You,et al.  A new method to cross-link a polyplex for enhancing in vivo stability and transfection efficiency. , 2014, Biomaterials science.

[84]  K. Landfester,et al.  Polypeptoid-block-polypeptide copolymers: synthesis, characterization, and application of amphiphilic block Copolypept(o)ides in drug formulations and miniemulsion techniques. , 2014, Biomacromolecules.

[85]  T. Rana,et al.  Gene regulation by non-coding RNAs , 2014, Critical reviews in biochemistry and molecular biology.

[86]  T. Ishida,et al.  The accelerated blood clearance (ABC) phenomenon: clinical challenge and approaches to manage. , 2013, Journal of controlled release : official journal of the Controlled Release Society.

[87]  C. Pichon,et al.  An E3-14.7K peptide that promotes microtubules-mediated transport of plasmid DNA increases polyplexes transfection efficiency. , 2013, Small.

[88]  Christopher E. Nelson,et al.  Balancing cationic and hydrophobic content of PEGylated siRNA polyplexes enhances endosome escape, stability, blood circulation time, and bioactivity in vivo. , 2013, ACS nano.

[89]  E. Kang,et al.  Therapeutic targeting of chitosan-PEG-folate-complexed oncolytic adenovirus for active and systemic cancer gene therapy. , 2013, Journal of controlled release : official journal of the Controlled Release Society.

[90]  C. van Nostrum,et al.  Decationized crosslinked polyplexes for redox-triggered gene delivery. , 2013, Journal of controlled release : official journal of the Controlled Release Society.

[91]  Takahiro Nomoto,et al.  Tethered PEG Crowdedness Determining Shape and Blood Circulation Profile of Polyplex Micelle Gene Carriers , 2013 .

[92]  V. Šubr,et al.  In Vivo Nanotoxicity Testing using the Zebrafish Embryo Assay. , 2013, Journal of materials chemistry. B.

[93]  S. Pun,et al.  Investigation of Polyethylenimine/DNA Polyplex Transfection to Cultured Cells Using Radiolabeling and Subcellular Fractionation Methods. , 2013, Molecular pharmaceutics.

[94]  H. Harashima,et al.  The polyethyleneglycol dilemma: advantage and disadvantage of PEGylation of liposomes for systemic genes and nucleic acids delivery to tumors. , 2013, Biological & pharmaceutical bulletin.

[95]  S. W. Kim,et al.  Therapeutic efficacy of a systemically delivered oncolytic adenovirus - biodegradable polymer complex. , 2013, Biomaterials.

[96]  Josh Tycko,et al.  Lessons learned from the clinical development and market authorization of Glybera. , 2013, Human gene therapy. Clinical development.

[97]  E. Kang,et al.  Local sustained delivery of oncolytic adenovirus with injectable alginate gel for cancer virotherapy , 2013, Gene Therapy.

[98]  S. Fukushima,et al.  In Vivo Messenger RNA Introduction into the Central Nervous System Using Polyplex Nanomicelle , 2013, PloS one.

[99]  E. Wagner,et al.  Stabilizing effect of tyrosine trimers on pDNA and siRNA polyplexes. , 2013, Biomaterials.

[100]  Fabian Kiessling,et al.  Noninvasive optical imaging of nanomedicine biodistribution. , 2013, ACS nano.

[101]  Hamidreza Ghandehari,et al.  Cationic PAMAM dendrimers aggressively initiate blood clot formation. , 2012, ACS nano.

[102]  James D Bryers,et al.  Multifunctional triblock copolymers for intracellular messenger RNA delivery. , 2012, Biomaterials.

[103]  C. Yun,et al.  A review of RGD-functionalized nonviral gene delivery vectors for cancer therapy , 2012, Cancer Gene Therapy.

[104]  M. Sullivan,et al.  Requirements for the nuclear entry of polyplexes and nanoparticles during mitosis , 2012, The journal of gene medicine.

[105]  Y. Omidi,et al.  Cytotoxic impacts of linear and branched polyethylenimine nanostructures in a431 cells. , 2011, BioImpacts : BI.

[106]  Ruth Duncan,et al.  Endocytosis and intracellular trafficking as gateways for nanomedicine delivery: opportunities and challenges. , 2012, Molecular pharmaceutics.

[107]  F. Kiessling,et al.  Drug targeting to tumors: principles, pitfalls and (pre-) clinical progress. , 2012, Journal of controlled release : official journal of the Controlled Release Society.

[108]  K. Ulbrich,et al.  Polymer coatings for delivery of nucleic acid therapeutics. , 2012, Journal of controlled release : official journal of the Controlled Release Society.

[109]  P. Hadwiger,et al.  Nanosized multifunctional polyplexes for receptor-mediated siRNA delivery. , 2012, ACS nano.

[110]  F. Muntoni,et al.  Antisense oligonucleotide-mediated exon skipping for Duchenne muscular dystrophy: progress and challenges. , 2012, Current gene therapy.

[111]  M. Sullivan,et al.  Histone H3 tail peptides and poly(ethylenimine) have synergistic effects for gene delivery. , 2012, Molecular pharmaceutics.

[112]  Nobuhiro Nishiyama,et al.  Rational design of smart supramolecular assemblies for gene delivery: chemical challenges in the creation of artificial viruses. , 2012, Chemical Society reviews.

[113]  S. W. Kim,et al.  Bioreducible polymer-conjugated oncolytic adenovirus for hepatoma-specific therapy via systemic administration. , 2011, Biomaterials.

[114]  Rudolf Zentel,et al.  Overcoming the PEG-addiction: well-defined alternatives to PEG, from structure–property relationships to better defined therapeutics , 2011 .

[115]  S. W. Kim,et al.  Active targeting of RGD-conjugated bioreducible polymer for delivery of oncolytic adenovirus expressing shRNA against IL-8 mRNA. , 2011, Biomaterials.

[116]  Gert Storm,et al.  Endosomal escape pathways for delivery of biologicals. , 2011, Journal of controlled release : official journal of the Controlled Release Society.

[117]  Sarah E. Ewald,et al.  Nucleic acid recognition by the innate immune system. , 2011, Annual review of immunology.

[118]  Jun Fang,et al.  The EPR effect: Unique features of tumor blood vessels for drug delivery, factors involved, and limitations and augmentation of the effect. , 2011, Advanced drug delivery reviews.

[119]  S. W. Kim,et al.  Active targeting and safety profile of PEG-modified adenovirus conjugated with herceptin. , 2011, Biomaterials.

[120]  Yi Yan Yang,et al.  The role of PEG architecture and molecular weight in the gene transfection performance of PEGylated poly(dimethylaminoethyl methacrylate) based cationic polymers. , 2011, Biomaterials.

[121]  M. Gorospe,et al.  miR-182-mediated downregulation of BRCA1 impacts DNA repair and sensitivity to PARP inhibitors. , 2011, Molecular cell.

[122]  J. Engbersen,et al.  Disulfide-Based Poly(amido amine)s for siRNA Delivery: Effects of Structure on siRNA Complexation, Cellular Uptake, Gene Silencing and Toxicity , 2010, Pharmaceutical Research.

[123]  U. Schubert,et al.  Poly(ethylene glycol) in drug delivery: pros and cons as well as potential alternatives. , 2010, Angewandte Chemie.

[124]  K. Kataoka,et al.  Quantized folding of plasmid DNA condensed with block catiomer into characteristic rod structures promoting transgene efficacy. , 2010, Journal of the American Chemical Society.

[125]  S. Kawakami,et al.  Efficient gene transfection by histidine-modified chitosan through enhancement of endosomal escape. , 2010, Bioconjugate chemistry.

[126]  Mark E. Davis,et al.  Evidence of RNAi in humans from systemically administered siRNA via targeted nanoparticles , 2010, Nature.

[127]  S. W. Kim,et al.  The effect of surface modification of adenovirus with an arginine-grafted bioreducible polymer on transduction efficiency and immunogenicity in cancer gene therapy. , 2010, Biomaterials.

[128]  Wei Sun,et al.  Chitosan-based formulations for delivery of DNA and siRNA. , 2010, Advanced drug delivery reviews.

[129]  Wim E Hennink,et al.  Cyclodextrin-based polymeric materials: synthesis, properties, and pharmaceutical/biomedical applications. , 2009, Biomacromolecules.

[130]  T. Park,et al.  Functional polymers for targeted delivery of nucleic acid drugs. , 2009, Macromolecular bioscience.

[131]  Y. Matsumoto,et al.  Intranuclear fluorescence resonance energy transfer analysis of plasmid DNA decondensation from nonviral gene carriers , 2009, The journal of gene medicine.

[132]  Richard N Cohen,et al.  Quantification of plasmid DNA copies in the nucleus after lipoplex and polyplex transfection. , 2009, Journal of controlled release : official journal of the Controlled Release Society.

[133]  Mark E. Davis.  The first targeted delivery of siRNA in humans via a self-assembling, cyclodextrin polymer-based nanoparticle: from concept to clinic. , 2009, Molecular pharmaceutics.

[134]  W. Hennink,et al.  Reduction-sensitive polymers and bioconjugates for biomedical applications. , 2009, Biomaterials.

[135]  Meredith A Mintzer,et al.  Nonviral vectors for gene delivery. , 2009, Chemical reviews.

[136]  N. Wiradharma,et al.  Cationic micelles self-assembled from cholesterol-conjugated oligopeptides as an efficient gene delivery vector. , 2008, Biomaterials.

[137]  P. Choyke,et al.  Clearance properties of nano-sized particles and molecules as imaging agents: considerations and caveats. , 2008, Nanomedicine.

[138]  C. Bräuchle,et al.  Dynamics of photoinduced endosomal release of polyplexes. , 2008, Journal of controlled release : official journal of the Controlled Release Society.

[139]  M. Ogris,et al.  Amine-reactive pyridylhydrazone-based PEG reagents for pH-reversible PEI polyplex shielding. , 2008, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

[140]  S. Theocharis,et al.  Coxsackievirus and adenovirus receptor expression in human endometrial adenocarcinoma: possible clinical implications , 2008, World journal of surgical oncology.

[141]  Robert Langer,et al.  A combinatorial library of lipid-like materials for delivery of RNAi therapeutics , 2008, Nature Biotechnology.

[142]  Wim E Hennink,et al.  Biodegradable polymers as non-viral carriers for plasmid DNA delivery. , 2008, Journal of controlled release : official journal of the Controlled Release Society.

[143]  V. Préat,et al.  PEGylated quaternized copolymer/DNA complexes for gene delivery. , 2007, International journal of pharmaceutics.

[144]  G. Moseley,et al.  Targeted delivery to the nucleus. , 2007, Advanced drug delivery reviews.

[145]  J. Feijen,et al.  Reducible poly(amido ethylenimine) directed to enhance RNA interference. , 2007, Biomaterials.

[146]  W. Hennink,et al.  Effect of cationic carriers on the pharmacokinetics and tumor localization of nucleic acids after intravenous administration. , 2007, International journal of pharmaceutics.

[147]  George P Cobb,et al.  microRNAs as oncogenes and tumor suppressors. , 2007, Developmental biology.

[148]  J. Feijen,et al.  Linear poly(amido amine)s with secondary and tertiary amino groups and variable amounts of disulfide linkages: synthesis and in vitro gene transfer properties. , 2006, Journal of controlled release : official journal of the Controlled Release Society.

[149]  R. Lockey,et al.  Thiolated Chitosan/DNA Nanocomplexes Exhibit Enhanced and Sustained Gene Delivery , 2006, Pharmaceutical Research.

[150]  D. Oupický,et al.  Multiblock reducible copolypeptides containing histidine-rich and nuclear localization sequences for gene delivery. , 2006, Bioconjugate chemistry.

[151]  Rajan P Kulkarni,et al.  Structure-function correlation of chloroquine and analogues as transgene expression enhancers in nonviral gene delivery. , 2006, Journal of medicinal chemistry.

[152]  Jiyoung M Dang,et al.  Natural polymers for gene delivery and tissue engineering. , 2006, Advanced drug delivery reviews.

[153]  W. Hennink,et al.  The Nuclear Pore Complex: The Gateway to Successful Nonviral Gene Delivery , 2006, Pharmaceutical Research.

[154]  Nobuhiko Yui,et al.  Biocleavable Polyrotaxane−Plasmid DNA Polyplex for Enhanced Gene Delivery , 2006 .

[155]  Ken Garber,et al.  China approves world's first oncolytic virus therapy for cancer treatment. , 2006, Journal of the National Cancer Institute.

[156]  I. Khalil,et al.  Uptake Pathways and Subsequent Intracellular Trafficking in Nonviral Gene Delivery , 2006, Pharmacological Reviews.

[157]  Nicholas A Peppas,et al.  Opsonization, biodistribution, and pharmacokinetics of polymeric nanoparticles. , 2006, International journal of pharmaceutics.

[158]  J. Feijen,et al.  Low molecular weight linear polyethylenimine-b-poly(ethylene glycol)-b-polyethylenimine triblock copolymers: synthesis, characterization, and in vitro gene transfer properties. , 2005, Biomacromolecules.

[159]  Philip S Low,et al.  Folate receptor-mediated drug targeting: from therapeutics to diagnostics. , 2005, Journal of pharmaceutical sciences.

[160]  Y. Tabata,et al.  Targeting of plasmid DNA to renal interstitial fibroblasts by cationized gelatin. , 2005, Biological & pharmaceutical bulletin.

[161]  T. Ochiya,et al.  Efficient delivery of small interfering RNA to bone-metastatic tumors by using atelocollagen in vivo. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[162]  Houping Ni,et al.  Suppression of RNA recognition by Toll-like receptors: the impact of nucleoside modification and the evolutionary origin of RNA. , 2005, Immunity.

[163]  Y. Tabata,et al.  Delivery of plasmid DNA expressing small interference RNA for TGF-beta type II receptor by cationized gelatin to prevent interstitial renal fibrosis. , 2005, Journal of controlled release : official journal of the Controlled Release Society.

[164]  J. Kopeček,et al.  PEGylation of poly(ethylene imine) affects stability of complexes with plasmid DNA under in vivo conditions in a dose-dependent manner after intravenous injection into mice. , 2005, Bioconjugate chemistry.

[165]  A. Verkman,et al.  Actin Cytoskeleton as the Principal Determinant of Size-dependent DNA Mobility in Cytoplasm , 2005, Journal of Biological Chemistry.

[166]  Jaroslav Pelisek,et al.  Toward synthetic viruses: endosomal pH-triggered deshielding of targeted polyplexes greatly enhances gene transfer in vitro and in vivo. , 2005, Molecular therapy : the journal of the American Society of Gene Therapy.

[167]  C. van Nostrum,et al.  PEG shielded polymeric double-layered micelles for gene delivery. , 2005, Journal of controlled release : official journal of the Controlled Release Society.

[168]  D. Crommelin,et al.  An NLS peptide covalently linked to linear DNA does not enhance transfection efficiency of cationic polymer based gene delivery systems , 2005, The journal of gene medicine.

[169]  C. Culmsee,et al.  Purification of polyethylenimine polyplexes highlights the role of free polycations in gene transfer , 2004, The journal of gene medicine.

[170]  Mark E. Davis,et al.  Cyclodextrin-modified polyethylenimine polymers for gene delivery. , 2004, Bioconjugate chemistry.

[171]  F. Szoka,et al.  GALA: a designed synthetic pH-responsive amphipathic peptide with applications in drug and gene delivery. , 2004, Advanced drug delivery reviews.

[172]  Yuichi Yamasaki,et al.  In situ single cell observation by fluorescence resonance energy transfer reveals fast intra‐cytoplasmic delivery and easy release of plasmid DNA complexed with linear polyethylenimine , 2004, The journal of gene medicine.

[173]  D. Crommelin,et al.  Steric stabilization of poly(2‐(dimethylamino)ethyl methacrylate)‐based polyplexes mediates prolonged circulation and tumor targeting in mice , 2004, The journal of gene medicine.

[174]  Mark E. Davis,et al.  Transferrin-containing, cyclodextrin polymer-based particles for tumor-targeted gene delivery. , 2003, Bioconjugate chemistry.

[175]  Daniel G. Anderson,et al.  Semi-automated synthesis and screening of a large library of degradable cationic polymers for gene delivery. , 2003, Angewandte Chemie.

[176]  S. W. Kim,et al.  Modified linear polyethylenimine-cholesterol conjugates for DNA complexation. , 2003, Bioconjugate chemistry.

[177]  Jean Campbell,et al.  Design and synthesis of pH-responsive polymeric carriers that target uptake and enhance the intracellular delivery of oligonucleotides. , 2003, Journal of controlled release : official journal of the Controlled Release Society.

[178]  Thomas Kissel,et al.  In vitro cytotoxicity testing of polycations: influence of polymer structure on cell viability and hemolysis. , 2003, Biomaterials.

[179]  Mark E. Davis,et al.  Development of a nonviral gene delivery vehicle for systemic application. , 2002, Bioconjugate chemistry.

[180]  Kenneth A Howard,et al.  Importance of lateral and steric stabilization of polyelectrolyte gene delivery vectors for extended systemic circulation. , 2002, Molecular therapy : the journal of the American Society of Gene Therapy.

[181]  C. Cho,et al.  Galactosylated chitosan-graft-poly(ethylene glycol) as hepatocyte-targeting DNA carrier. , 2001, Journal of controlled release : official journal of the Controlled Release Society.

[182]  S. Carotta,et al.  Different behavior of branched and linear polyethylenimine for gene delivery in vitro and in vivo , 2001, The journal of gene medicine.

[183]  M. Hashida,et al.  The fate of poly(2-dimethyl amino ethyl)methacrylate-based polyplexes after intravenous administration. , 2001, International journal of pharmaceutics.

[184]  J. Hadgraft,et al.  Examination of the biophysical interaction between plasmid DNA and the polycations, polylysine and polyornithine, as a basis for their differential gene transfection in-vitro. , 2000, International journal of pharmaceutics.

[185]  S. W. Kim,et al.  pH-sensitive cationic polymer gene delivery vehicle: N-Ac-poly(L-histidine)-graft-poly(L-lysine) comb shaped polymer. , 2000, Bioconjugate chemistry.

[186]  S. W. Kim,et al.  Development of a safe gene delivery system using biodegradable polymer, poly[α-(4-aminobutyl)-L-glycolic acid] [19] , 2000 .

[187]  M. Bally,et al.  Use of poly(ethylene glycol)-lipid conjugates to regulate the surface attributes and transfection activity of lipid-DNA particles. , 2000, Journal of pharmaceutical sciences.

[188]  Stefaan C. De Smedt,et al.  Cationic Polymer Based Gene Delivery Systems , 2000, Pharmaceutical Research.

[189]  A S Verkman,et al.  Size-dependent DNA Mobility in Cytoplasm and Nucleus* , 2000, The Journal of Biological Chemistry.

[190]  E. Wagner,et al.  Development of transferrin-polycation/DNA based vectors for gene delivery to melanoma cells. , 1999, Journal of drug targeting.

[191]  W. Hennink,et al.  Association and Dissociation Characteristics of Polymer/DNA Complexes Used for Gene Delivery , 1999, Pharmaceutical Research.

[192]  D. Fischer,et al.  A Novel Non-Viral Vector for DNA Delivery Based on Low Molecular Weight, Branched Polyethylenimine: Effect of Molecular Weight on Transfection Efficiency and Cytotoxicity , 1999, Pharmaceutical Research.

[193]  H. Kittler,et al.  Immunotherapy of metastatic malignant melanoma by a vaccine consisting of autologous interleukin 2-transfected cancer cells: outcome of a phase I study. , 1999, Human gene therapy.

[194]  M. Ogris,et al.  PEGylated DNA/transferrin–PEI complexes: reduced interaction with blood components, extended circulation in blood and potential for systemic gene delivery , 1999, Gene Therapy.

[195]  A. Urtti,et al.  Interactions of polymeric and liposomal gene delivery systems with extracellular glycosaminoglycans: physicochemical and transfection studies. , 1999, Biochimica et biophysica acta.

[196]  J. Behr,et al.  Gene delivery: a single nuclear localization signal peptide is sufficient to carry DNA to the cell nucleus. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[197]  J. Behr,et al.  Template Oligomerization of DNA-Bound Cations Produces Calibrated Nanometric Particles , 1998 .

[198]  F. Liu,et al.  Polyethylene glycol-grafted poly-L-lysine as polymeric gene carrier. , 1998, Journal of controlled release : official journal of the Controlled Release Society.

[199]  K. Kataoka,et al.  Remarkable increase in nuclease resistance of plasmid DNA through supramolecular assembly with poly(ethylene glycol)-poly(L-lysine) block copolymer. , 1998, Journal of pharmaceutical sciences.

[200]  A. Haberland,et al.  H1 and HMG17 extracted from calf thymus nuclei are efficient DNA carriers in gene transfer , 1997, Gene Therapy.

[201]  F. Szoka,et al.  Design, synthesis, and characterization of a cationic peptide that binds to nucleic acids and permeabilizes bilayers. , 1997, Biochemistry.

[202]  Roland L. Dunbrack,et al.  The Proton Sponge: a Trick to Enter Cells the Viruses Did Not Exploit , 1997, CHIMIA.

[203]  K. Ulbrich,et al.  Characterization of vectors for gene therapy formed by self-assembly of DNA with synthetic block co-polymers. , 1996, Human gene therapy.

[204]  K. Mechtler,et al.  Activation of the complement system by synthetic DNA complexes: a potential barrier for intravenous gene delivery. , 1996, Human gene therapy.

[205]  M Monsigny,et al.  Putative role of chloroquine in gene transfer into a human hepatoma cell line by DNA/lactosylated polylysine complexes. , 1996, Experimental cell research.

[206]  Gert Storm,et al.  Surface modification of nanoparticles to oppose uptake by the mononuclear phagocyte system , 1995 .

[207]  M. Woodle,et al.  Sterically stabilized liposome therapeutics , 1995 .

[208]  D. Scherman,et al.  A versatile vector for gene and oligonucleotide transfer into cells in culture and in vivo: polyethylenimine. , 1995, Proceedings of the National Academy of Sciences of the United States of America.

[209]  M. Hashida,et al.  The Fate of Plasmid DNA After Intravenous Injection in Mice: Involvement of Scavenger Receptors in Its Hepatic Uptake , 1995, Pharmaceutical Research.

[210]  E. Wagner,et al.  Rhinovirus-mediated endosomal release of transfection complexes , 1995, Journal of virology.

[211]  A A Bogdanov,et al.  Poly(ethylene glycol) on the liposome surface: on the mechanism of polymer-coated liposome longevity. , 1994, Biochimica et biophysica acta.

[212]  K Mechtler,et al.  The influence of endosome-disruptive peptides on gene transfer using synthetic virus-like gene transfer systems. , 1994, The Journal of biological chemistry.

[213]  J. Chen,et al.  Galactosylated histone-mediated gene transfer and expression. , 1994, Human gene therapy.

[214]  V. Torchilin,et al.  Biodegradable long-circulating polymeric nanospheres. , 1994, Science.

[215]  K Zatloukal,et al.  Coupling of adenovirus to transferrin-polylysine/DNA complexes greatly enhances receptor-mediated gene delivery and expression of transfected genes. , 1992, Proceedings of the National Academy of Sciences of the United States of America.

[216]  M. Cotten,et al.  Adenovirus enhancement of transferrin-polylysine-mediated gene delivery. , 1991, Proceedings of the National Academy of Sciences of the United States of America.

[217]  T M Allen,et al.  Liposomes containing synthetic lipid derivatives of poly(ethylene glycol) show prolonged circulation half-lives in vivo. , 1991, Biochimica et biophysica acta.

[218]  G Gregoriadis,et al.  Influence of surface hydrophilicity of liposomes on their interaction with plasma protein and clearance from the circulation: studies with poly(ethylene glycol)-coated vesicles. , 1991, Biochimica et biophysica acta.

[219]  Kazuo Maruyama,et al.  Amphipathic polyethyleneglycols effectively prolong the circulation time of liposomes , 1990, FEBS letters.

[220]  K. Mechtler,et al.  Transferrin-polycation-mediated introduction of DNA into human leukemic cells: stimulation by agents that affect the survival of transfected DNA or modulate transferrin receptor levels. , 1990, Proceedings of the National Academy of Sciences of the United States of America.

[221]  F. Vogel,et al.  Condensation of vector DNA by the chromosomal protein HMG1 results in efficient transfection. , 1988, Biochimica et biophysica acta.

[222]  H. Luthman,et al.  High efficiency polyoma DNA transfection of chloroquine treated cells. , 1983, Nucleic acids research.

[223]  J. Butel,et al.  Optimal conditions for uptake of exogenous DNA by Chinese hamster lung cells deficient in hypoxanthine-guanine phosphoribosyltransferase. , 1975, Biochimica et biophysica acta.

[224]  Won Jong Kim,et al.  Phenylboronic acid-sugar grafted polymer architecture as a dual stimuli-responsive gene carrier for targeted anti-angiogenic tumor therapy. , 2016, Biomaterials.

[225]  T. Anchordoquy,et al.  Drug delivery trends in clinical trials and translational medicine: challenges and opportunities in the delivery of nucleic acid-based therapeutics. , 2011, Journal of pharmaceutical sciences.

[226]  S. Fukushima,et al.  Polyplex micelles prepared from ω-cholesteryl PEG-polycation block copolymers for systemic gene delivery. , 2011, Biomaterials.

[227]  J. Feijen,et al.  Novel bioreducible poly(amido amine)s for highly efficient gene delivery. , 2007, Bioconjugate chemistry.

[228]  R. Schiffelers,et al.  Cancer siRNA therapy by tumor selective delivery with ligand-targeted sterically stabilized nanoparticle. , 2004, Nucleic acids research.

[229]  Ernst Wagner,et al.  Novel shielded transferrin-polyethylene glycol-polyethylenimine/DNA complexes for systemic tumor-targeted gene transfer. , 2003, Bioconjugate chemistry.

[230]  J. Coll,et al.  Side‐effects of a systemic injection of linear polyethylenimine–DNA complexes , 2002, The journal of gene medicine.

[231]  D. Kirn.  Clinical research results with dl1520 (Onyx-015), a replication-selective adenovirus for the treatment of cancer: what have we learned? , 2001, Gene Therapy.

[232]  F. Farzaneh,et al.  Protein transduction: an alternative to genetic intervention? , 2001, Gene Therapy.