Signal-to-noise analysis for 3D luminescence imaging of hypoxia in deep tissues

We provide a detailed signal-to-noise analysis for 3D imaging of luminescence from a biomarker to detect hypoxic tumors in deep tissue. Preliminary studies on phantom tissues with inclusions and having homogeneous scattering and absorption coefficient of μs' ~ 15-20 cm-1 and μa ~ 2 cm-1 respectively, are reported as a function of oxygen tension, luminophore concentration, and tissue depth. The technique's sensitivity in terms of determination of spatial resolution is discussed.

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