Genetic heterogeneity of gene defects responsible for familial Alzheimer disease

[1]  B. Hyman,et al.  Isolation and characterization of APLP2 encoding a homologue of the Alzheimer's associated amyloid β protein precursor , 1993, Nature Genetics.

[2]  B. Hyman,et al.  Cellular specificity and regional distribution of amyloid beta protein precursor alternative transcripts are unaltered in Alzheimer hippocampal formation. , 1993, Brain research. Molecular brain research.

[3]  B. Hyman,et al.  Nonisotopic in situ hybridization of amyloid beta protein precursor in Alzheimer's disease: expression in neurofibrillary tangle bearing neurons and in the microenvironment surrounding senile plaques. , 1993, Brain research. Molecular brain research.

[4]  R. Tanzi,et al.  The amyloid precursor-like protein (APLP) gene maps to the long arm of human chromosome 19. , 1993, Genomics.

[5]  D. Selkoe,et al.  Mutation of the β-amyloid precursor protein in familial Alzheimer's disease increases β-protein production , 1992, Nature.

[6]  C. Broeckhoven,et al.  Mapping of a gene predisposing to early–onset Alzheimer's disease to chromosome 14q24.3 , 1992, Nature Genetics.

[7]  D. Pollen,et al.  Genetic evidence for a novel familial Alzheimer's disease locus on chromosome 14 , 1992, Nature Genetics.

[8]  E. Murphy,et al.  Twin studies of Alzheimer disease: II. Some predictions under a genetic model. , 1992, American journal of medical genetics.

[9]  R. Tanzi,et al.  Identification of a mouse brain cDNA that encodes a protein related to the Alzheimer disease-associated amyloid beta protein precursor. , 1992, Proceedings of the National Academy of Sciences of the United States of America.

[10]  E. Wijsman,et al.  Linkage and mutational analysis of familial Alzheimer disease kindreds for the APP gene region. , 1992, American journal of human genetics.

[11]  J. Weber,et al.  Genetic linkage evidence for a familial Alzheimer's disease locus on chromosome 14. , 1992, Science.

[12]  S. Estus,et al.  Production of the Alzheimer amyloid beta protein by normal proteolytic processing. , 1992, Science.

[13]  T. Tully,et al.  Human amyloid precursor protein ameliorates behavioral deficit of flies deleted for appl gene , 1992, Neuron.

[14]  D. Selkoe,et al.  Isolation and quantification of soluble Alzheimer's β-peptide from biological fluids , 1992, Nature.

[15]  D. Selkoe,et al.  Amyloid β-peptide is produced by cultured cells during normal metabolism , 1992, Nature.

[16]  J. Haines,et al.  Assessment of amyloid beta-protein precursor gene mutations in a large set of familial and sporadic Alzheimer disease cases. , 1992, American journal of human genetics.

[17]  B. Winblad,et al.  A pathogenic mutation for probable Alzheimer's disease in the APP gene at the N–terminus of β–amyloid , 1992, Nature Genetics.

[18]  P. Greengard,et al.  Phosphorylation of alzheimer amyloid precursor protein by protein kinase C , 1992, Neuroscience.

[19]  B T Hyman,et al.  Kunitz Protease Inhibitor‐Containing Amyloid β Protein Precursor Immunoreactivity in Alzheimer's Disease , 1992, Journal of neuropathology and experimental neurology.

[20]  A. Hofman,et al.  Presenile dementia and cerebral haemorrhage linked to a mutation at codon 692 of the β–amyloid precursor protein gene , 1992, Nature Genetics.

[21]  B. Hyman,et al.  Studies of Amyloid β‐Protein Precursor Expression in Alzheimer's Disease , 1991, Annals of the New York Academy of Sciences.

[22]  J. Hardy,et al.  Sequencing of exons 16 and 17 of the β-amyloid precursor protein gene in 14 families with early onset Alzheimer's disease fails to reveal mutations in the β-amyloid sequence , 1991, Neuroscience Letters.

[23]  J. Hardy,et al.  Early-onset Alzheimer's disease caused by mutations at codon 717 of the β-amyloid precursor protein gene , 1991, Nature.

[24]  B. Ghetti,et al.  A mutation in the amyloid precursor protein associated with hereditary Alzheimer's disease. , 1991, Science.

[25]  M. Vitek,et al.  A novel species-specific RNA related to alternatively spliced amyloid precursor protein mRNAs , 1991, Neurobiology of Aging.

[26]  J. Hardy,et al.  Screening for the β-amyloid precursor protein mutation (APP717: Val → Ile) in extended pedigrees with early onset Alzheimer's disease , 1991, Neuroscience Letters.

[27]  J. Growdon,et al.  Segregation analysis reveals evidence of a major gene for Alzheimer disease. , 1991, American journal of human genetics.

[28]  J. Hardy,et al.  Amyloid precursor protein gene mutation in early-onset Alzheimer's disease , 1991, The Lancet.

[29]  S. Tsuji,et al.  Mis-sense mutation Val→Ile in exon 17 of amyloid precursor protein gene in Japanese familial Alzheimer's disease , 1991, The Lancet.

[30]  B. Hyman,et al.  Alzheimer's mutation , 1991, Nature.

[31]  M. Pericak-Vance,et al.  Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease , 1991, Nature.

[32]  I. Rainero,et al.  Genetic linkage studies suggest that Alzheimer's disease is not a single homogeneous disorder , 1990, Nature.

[33]  I. Lieberburg,et al.  Mutation of the Alzheimer's disease amyloid gene in hereditary cerebral hemorrhage, Dutch type. , 1990, Science.

[34]  David J. Anderson,et al.  Analysis of SCG10 gene expression in transgenic mice reveals that neural specificity is achieved through selective derepression , 1990, Neuron.

[35]  S. Koide,et al.  Characterization of cDNA encoding a human sperm membrane protein related to A4 amyloid protein. , 1990, Proceedings of the National Academy of Sciences of the United States of America.

[36]  J. Haines,et al.  Familial Alzheimer's disease: Progress and problems , 1989, Neurobiology of Aging.

[37]  F. D. de Sauvage,et al.  A novel mRNA of the A4 amyloid precursor gene coding for a possibly secreted protein. , 1989, Science.

[38]  K. White,et al.  A Drosophila gene encoding a protein resembling the human beta-amyloid protein precursor. , 1989, Proceedings of the National Academy of Sciences of the United States of America.

[39]  J. Weber,et al.  Abundant class of human DNA polymorphisms which can be typed using the polymerase chain reaction. , 1989, American journal of human genetics.

[40]  M. Pericak-Vance,et al.  Linkage studies in familial Alzheimer's disease. , 1989 .

[41]  R. Neve,et al.  Expression of the Alzheimer amyloid precursor gene transcripts in the human brain , 1988, Neuron.

[42]  S. M. Sumi,et al.  Absence of linkage of chromosome 21q21 markers to familial Alzheimer's disease. , 1988, Science.

[43]  R. Tanzi,et al.  Amyloid protein precursor messenger RNAs: differential expression in Alzheimer's disease. , 1988, Science.

[44]  P. Greengard,et al.  Phosphorylation of Alzheimer disease amyloid precursor peptide by protein kinase C and Ca2+/calmodulin-dependent protein kinase II. , 1988, Proceedings of the National Academy of Sciences of the United States of America.

[45]  J. Morrison,et al.  Distribution of precursor amyloid-beta-protein messenger RNA in human cerebral cortex: relationship to neurofibrillary tangles and neuritic plaques. , 1988, Proceedings of the National Academy of Sciences of the United States of America.

[46]  S. Shiojiri,et al.  Novel precursor of Alzheimer's disease amyloid protein shows protease inhibitory activity , 1988, Nature.

[47]  B. Greenberg,et al.  A new A4 amyloid mRNA contains a domain homologous to serine proteinase inhibitors , 1988, Nature.

[48]  J. Morrison,et al.  Differential regulation of amyloid-beta-protein mRNA expression within hippocampal neuronal subpopulations in Alzheimer disease. , 1988, Proceedings of the National Academy of Sciences of the United States of America.

[49]  J. Morrison,et al.  Localization of amyloid beta protein messenger RNA in brains from patients with Alzheimerʼs disease , 1988 .

[50]  L. Villa-komaroff,et al.  Protease inhibitor domain encoded by an amyloid protein precursor mRNA associated with Alzheimerʼs disease , 1988 .

[51]  M. Goedert Neuronal localization of amyloid beta protein precursor mRNA in normal human brain and in Alzheimer's disease. , 1987, The EMBO journal.

[52]  J. Haines,et al.  The genetic defect in familial Alzheimer's disease is not tightly linked to the amyloid β-protein gene , 1987, Nature.

[53]  J. Morrison,et al.  Localization of amyloid beta protein messenger RNA in brains from patients with Alzheimer's disease. , 1987, Science.

[54]  H. Wiśniewski,et al.  Molecular cloning and characterization of a cDNA encoding the cerebrovascular and the neuritic plaque amyloid peptides. , 1987, Proceedings of the National Academy of Sciences of the United States of America.

[55]  P. S. St George-Hyslop,et al.  Amyloid beta protein gene: cDNA, mRNA distribution, and genetic linkage near the Alzheimer locus. , 1987, Science.

[56]  D. Pollen,et al.  The genetic defect causing familial Alzheimer's disease maps on chromosome 21. , 1987, Science.

[57]  M. Lerman,et al.  Characterization and chromosomal localization of a cDNA encoding brain amyloid of Alzheimer's disease. , 1987, Science.

[58]  K. Grzeschik,et al.  The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor , 1987, Nature.

[59]  Jeffrey L. Cummings,et al.  Senile Dementia of the Alzheimer Type , 1987 .

[60]  G. Glenner,et al.  Alzheimer's disease: Initial report of the purification and characterization of a novel cerebrovascular amyloid protein , 1984 .