Interaction between an α-Helical Polypeptide Containing Side-Chain Pyridyl Groups and Poly(4-vinylpyridine) in the Ternary Cu2+ Ion Complex

Interaction between a Cu2+-α-helical polypeptide containing side-chain pyridyl groups, poly(Nω-2-pyridylmethyl-L-glutamine) (P2PG), and poly(4-vinylpyridine) (P4VP) as a macromolecular guest was investigated by absorption and circular dichroism spectroscopies in 2,2,2-trifluoroethanol solutions. P4VP was added to the Cu2+-one pyridyl side chain complex system prepared in advance. One or two P4VP nitrogens could bind to the remaining coordination sites of the Cu2+ ion in the host system, yielding ternary Cu2+ complexes. The circular dichroism spectra of Cu2+-P2PG with P4VP indicated that P4VP might bind to the α-helix of P2PG in such a manner as to form a left-handed superhelix around the α-helical core resulting from the formation of ternary Cu2+ complexes. The structure of the interpolymer complex system was also investigated by a monolayer method. The surface pressure–area isotherm of a Cu2+-P2PG-P4VP monolayer and its hysteresis supported the formation of the supramolecular structure suggested by the s...

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