Analysis of the packaging enclosing a counterfeit pharmaceutical tablet using Raman microscopy and two-dimensional correlation spectroscopy

Abstract Counterfeit medicine is a serious global problem. Vibrational spectroscopy combined with chemometric methods can be used to combat the pharmaceutical counterfeit problem. In this study, packages containing counterfeit tablets were analyzed using Raman microscopy and two-dimensional correlation spectroscopy. Two color regions were analyzed and different chemical origins from the color region could be resolved by two-dimensional correlation spectroscopy. Univariate Raman images were used to show the spatial distribution of the chemical components and confirm the findings of two-dimensional correlation analysis.

[1]  Yukihiro Ozaki,et al.  Two-Dimensional Correlation Spectroscopy: Applications in Vibrational and Optical Spectroscopy , 2002 .

[2]  R. J. Clark,et al.  Pigment study by Raman microscopy of 23 paintings by the Portuguese artist Henrique Pousão (1859–1884) , 2007 .

[3]  K. Gordon,et al.  Quantitative analysis of polymorphic mixtures of ranitidine hydrochloride by Raman spectroscopy and principal components analysis. , 2002, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

[4]  I. Noda.  Generalized Two-Dimensional Correlation Method Applicable to Infrared, Raman, and other Types of Spectroscopy , 1993 .

[5]  H. Edwards,et al.  Spanish mediaeval frescoes at Basconcillos del Tozo: a Fourier transform Raman spectroscopic study , 1999 .

[6]  A. Mahadevan-Jansen,et al.  Automated Method for Subtraction of Fluorescence from Biological Raman Spectra , 2003, Applied spectroscopy.

[7]  D. Bousfield,et al.  Raman Spectroscopic Analysis of Paper Coatings , 2002 .

[8]  J. Rantanen,et al.  Determination of amorphous content in the pharmaceutical process environment , 2007, The Journal of pharmacy and pharmacology.

[9]  Ute B. Cappel,et al.  Removing Cosmic Ray Features from Raman Map Data by a Refined Nearest Neighbor Comparison Method as a Precursor for Chemometric Analysis , 2010, Applied spectroscopy.

[10]  A. Savitzky,et al.  Smoothing and Differentiation of Data by Simplified Least Squares Procedures. , 1964 .

[11]  S. Onoue,et al.  Crystalline Form Information from Multiwell Plate Salt Screening by Use of Raman Microscopy , 2006, Pharmaceutical Research.

[12]  Håkan Wikström,et al.  Manipulating Theophylline Monohydrate Formation During High-Shear Wet Granulation Through Improved Understanding of the Role of Pharmaceutical Excipients , 2008, Pharmaceutical Research.

[13]  I. Noda,et al.  Determination of Two-Dimensional Correlation Spectra Using the Hilbert Transform , 2000 .

[14]  R. J. Clark,et al.  Comparison of genuine (1851-1852AD) and forged or reproduction Hawaiian Missionary stamps using Raman microscopy , 2002 .

[15]  L Peltonen,et al.  Better understanding of dissolution behaviour of amorphous drugs by in situ solid-state analysis using Raman spectroscopy. , 2009, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

[16]  Paul N. Newton,et al.  Prevalence and Detection of Counterfeit Pharmaceuticals: A Mini Review , 2008 .

[17]  R. Vehring.  Red-Excitation Dispersive Raman Spectroscopy is a Suitable Technique for Solid-State Analysis of Respirable Pharmaceutical Powders , 2005, Applied spectroscopy.

[18]  Y. Ozaki,et al.  Raman imaging analysis of pharmaceutical tablets by two-dimensional (2D) correlation spectroscopy , 2009 .

[19]  R. Clark,et al.  Analysis of pigmentary materials on the vinland map and tartar relation by Raman microprobe spectroscopy. , 2002, Analytical chemistry.

[20]  J. Rantanen,et al.  Improved Understanding of Factors Contributing to Quantification of Anhydrate/Hydrate Powder Mixtures , 2005, Applied spectroscopy.

[21]  A. E. Dowrey,et al.  Generalized Two-Dimensional Correlation Spectroscopy , 2000 .

[22]  F. Clarke,et al.  Chemical image fusion. The synergy of FT-NIR and Raman mapping microscopy to enable a more complete visualization of pharmaceutical formulations. , 2001, Analytical chemistry.

[23]  P. Ropret,et al.  Raman identification of yellow synthetic organic pigments in modern and contemporary paintings: reference spectra and case studies. , 2008, Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy.