Multicomponent Lyme vaccine: three is not a crowd.

[1]  E. Fikrig,et al.  OspC facilitates Borrelia burgdorferi invasion of Ixodes scapularis salivary glands. , 2004, The Journal of clinical investigation.

[2]  M. Breitenbach,et al.  A DNA vaccine encoding the outer surface protein C from Borrelia burgdorferi is able to induce protective immune responses. , 2003, Microbes and infection.

[3]  E. Brown,et al.  Decorin-binding Sites in the Adhesin DbpA from Borrelia burgdorferi , 2003, Journal of Biological Chemistry.

[4]  M. Mbow,et al.  Inability of outer-surface protein C (OspC)-primed mice to elicit a protective anamnestic immune response to a tick-transmitted challenge of Borrelia burgdorferi. , 2003, Journal of medical microbiology.

[5]  A. Casadevall,et al.  More Is Not Necessarily Better: Prozone-Like Effects in Passive Immunization with IgG1 , 2003, The Journal of Immunology.

[6]  E. Fikrig,et al.  Molecular Adaptation of Borrelia burgdorferi in the Murine Host , 2002, The Journal of experimental medicine.

[7]  F. Liang,et al.  An Immune Evasion Mechanism for Spirochetal Persistence in Lyme Borreliosis , 2002, The Journal of experimental medicine.

[8]  Andrew T. Revel,et al.  DNA microarray analysis of differential gene expression in Borrelia burgdorferi, the Lyme disease spirochete , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[9]  W. Erhardt,et al.  Parental Knowledge of and Attitudes Toward LYMErix (Recombinant Osp A Lyme Vaccine) , 2002, Clinical pediatrics.

[10]  Jean C. Lee.  Development of antistaphylococcal vaccines , 2001, Current infectious disease reports.

[11]  S. Hoffman,et al.  Multistage Multiantigen Heterologous Prime Boost Vaccine forPlasmodium knowlesi Malaria Provides Partial Protection in Rhesus Macaques , 2001, Infection and Immunity.

[12]  Jie Yu,et al.  A plant-based multicomponent vaccine protects mice from enteric diseases , 2001, Nature Biotechnology.

[13]  Barbara J. B. Johnson,et al.  Mapping the Ligand-Binding Region of Borrelia burgdorferi Fibronectin-Binding Protein BBK32 , 2001, Infection and Immunity.

[14]  M. Kripke,et al.  The Effect of UV Irradiation on Infection of Mice with Borrelia burgdorferi¶ , 2001, Photochemistry and photobiology.

[15]  A. Siebers,et al.  DNA Vaccines Expressing a Fusion Product of Outer Surface Proteins A and C from Borrelia burgdorferi Induce Protective Antibodies Suitable for Prophylaxis but Not for Resolution of Lyme Disease , 2001, Infection and Immunity.

[16]  B. P. Guo,et al.  Resistance to Lyme disease in decorin-deficient mice. , 2001, The Journal of clinical investigation.

[17]  A. Casadevall,et al.  Immunoglobulin M Efficacy Against Cryptococcus neoformans: Mechanism, Dose Dependence, and Prozone-Like Effects in Passive Protection Experiments1 , 2001, The Journal of Immunology.

[18]  J. Sambrook,et al.  Molecular Cloning: A Laboratory Manual , 2001 .

[19]  M. Hanson,et al.  Evidence for Vaccine Synergy between Borrelia burgdorferi Decorin Binding Protein A and Outer Surface Protein A in the Mouse Model of Lyme Borreliosis , 2000, Infection and Immunity.

[20]  K. Matsui,et al.  Specific immune response to a synthetic peptide derived from outer surface protein C of Borrelia burgdorferi predicts protective borreliacidal antibodies. , 2000, FEMS immunology and medical microbiology.

[21]  J. Radolf,et al.  Decorin-Binding Protein A (DbpA) of Borrelia burgdorferi Is Not Protective When Immunized Mice Are Challenged via Tick Infestation and Correlates with the Lack of DbpA Expression by B. burgdorferi in Ticks , 2000, Infection and Immunity.

[22]  E. Fikrig,et al.  Arthropod- and Host-Specific Borrelia burgdorferi bbk32 Expression and the Inhibition of Spirochete Transmission1 , 2000, The Journal of Immunology.

[23]  R. Schoen,et al.  The Lyme Disease Vaccine: Conception, Development, and Implementation , 2000, Annals of Internal Medicine.

[24]  D. Parenti,et al.  Lyme disease vaccine. , 2000, Journal of the American Medical Association (JAMA).

[25]  J. Piesman,et al.  Inhibition of Borrelia burgdorferi Migration from the Midgut to the Salivary Glands following Feeding by Ticks on OspC-Immunized Mice , 2000, Infection and Immunity.

[26]  M. Mbow,et al.  Conformational Nature of the Borrelia burgdorferi B31 Outer Surface Protein C Protective Epitope , 1999, Infection and Immunity.

[27]  M. Mbow,et al.  An OspC-Specific Monoclonal Antibody Passively Protects Mice from Tick-Transmitted Infection by Borrelia burgdorferi B31 , 1999, Infection and Immunity.

[28]  B. P. Guo,et al.  Adherence of Borrelia burgdorferi , 1999, The Journal of Biological Chemistry.

[29]  D. Parenti.  Lyme disease vaccine--LYMErix. , 1999, Connecticut medicine.

[30]  M. Kramer,et al.  Resolution of experimental and tick‐borne Borrelia burgdorferiinfection in mice by passive, but not active immunization using recombinant OspC , 1999, European journal of immunology.

[31]  T. Foster,et al.  Surface protein adhesins of Staphylococcus aureus. , 1998, Trends in microbiology.

[32]  Barbara J. B. Johnson,et al.  Identification of a 47 kDa fibronectin‐binding protein expressed by Borrelia burgdorferi isolate B31 , 1998, Molecular microbiology.

[33]  B. P. Guo,et al.  Decorin‐binding adhesins from Borrelia burgdorferi , 1998, Molecular microbiology.

[34]  C. Schmid,et al.  Vaccination against Lyme disease with recombinant Borrelia burgdorferi outer-surface lipoprotein A with adjuvant. Lyme Disease Vaccine Study Group. , 1998, The New England journal of medicine.

[35]  J. Radolf,et al.  Decorin-Binding Protein of Borrelia burgdorferi Is Encoded within a Two-Gene Operon and Is Protective in the Murine Model of Lyme Borreliosis , 1998, Infection and Immunity.

[36]  B. P. Guo,et al.  Active and Passive Immunity against Borrelia burgdorferi Decorin Binding Protein A (DbpA) Protects against Infection , 1998, Infection and Immunity.

[37]  M. Kramer,et al.  Therapeutic passive vaccination against chronic Lyme disease in mice. , 1997, Proceedings of the National Academy of Sciences of the United States of America.

[38]  E. Fikrig,et al.  Borrelia burgdorferi P35 and P37 proteins, expressed in vivo, elicit protective immunity. , 1997, Immunity.

[39]  Ruth R. Montgomery,et al.  Temporal pattern of Borrelia burgdorferi p21 expression in ticks and the mammalian host. , 1997, The Journal of clinical investigation.

[40]  T. Burkot,et al.  Outer surface protein C (OspC), but not P39, is a protective immunogen against a tick-transmitted Borrelia burgdorferi challenge: evidence for a conformational protective epitope in OspC , 1996, Infection and immunity.

[41]  E. Fikrig,et al.  P55, an immunogenic but nonprotective 55-kilodalton Borrelia burgdorferi protein in murine Lyme disease , 1996, Infection and Immunity.

[42]  E. Fikrig,et al.  Borrelia burgdorferi OspA is an arthropod-specific transmission- blocking Lyme disease vaccine , 1996, The Journal of experimental medicine.

[43]  S. Norris,et al.  Modulation of immunity to Borrelia burgdorferi by ultraviolet irradiation: Differential effect on Th1 and Th2 immune responses , 1995, European journal of immunology.

[44]  B. P. Guo,et al.  Adherence of Borrelia burgdorferi to the proteoglycan decorin , 1995, Infection and immunity.

[45]  M. Kramer,et al.  Molecular cloning and immunological characterization of a novel linear-plasmid-encoded gene, pG, of Borrelia burgdorferi expressed only in vivo , 1995, Infection and immunity.

[46]  S. Szu,et al.  Perspective: hypothesis: serum IgG antibody is sufficient to confer protection against infectious diseases by inactivating the inoculum. , 1995, The Journal of infectious diseases.

[47]  C. Schmid,et al.  Treatment of Lyme arthritis. , 1994, Arthritis and rheumatism.

[48]  R. Lefebvre,et al.  Protection of C3H/HeN mice from challenge with Borrelia burgdorferi through active immunization with OspA, OspB, or OspC, but not with OspD or the 83-kilodalton antigen , 1994, Infection and immunity.

[49]  U. Schaible,et al.  Protection against Borrelia burgdorferi infection in SCID mice is conferred by presensitized spleen cells and partially by B but not T cells alone. , 1994, International immunology.

[50]  A. Sampieri,et al.  Molecular characterization and expression of p23 (OspC) from a North American strain of Borrelia burgdorferi , 1993, Infection and immunity.

[51]  U. Schaible,et al.  Molecular and immunological characterization of a novel polymorphic lipoprotein of Borrelia burgdorferi , 1993, Infection and immunity.

[52]  E. Fikrig,et al.  Protective immunity in lyme borreliosis. , 1993, Parasitology today.

[53]  S. Norris,et al.  Low-passage-associated proteins of Borrelia burgdorferi B31: characterization and molecular cloning of OspD, a surface-exposed, plasmid-encoded lipoprotein , 1992, Infection and immunity.

[54]  E. Fikrig,et al.  Long-term protection of mice from Lyme disease by vaccination with OspA , 1992, Infection and immunity.

[55]  E. Fikrig,et al.  Roles of OspA, OspB, and flagellin in protective immunity to Lyme borreliosis in laboratory mice , 1992, Infection and immunity.

[56]  E. Fikrig,et al.  Protection of mice against the Lyme disease agent by immunizing with recombinant OspA , 1990, Science.

[57]  U. Schaible,et al.  Monoclonal antibodies specific for the outer surface protein A (OspA) of Borrelia burgdorferi prevent Lyme borreliosis in severe combined immunodeficiency (scid) mice. , 1990, Proceedings of the National Academy of Sciences of the United States of America.

[58]  J. Benach,et al.  Interaction between Borrelia burgdorferi and endothelium in vitro. , 1990, The Journal of clinical investigation.

[59]  P. Glynn,et al.  Competition between foreign and self proteins in antigen presentation. Ovalbumin can inhibit activation of myelin basic protein-specific T cells. , 1990, Journal of immunology.

[60]  C. Janeway,et al.  Immunoregulatory role of Ig isotypes. II. Activation of cells that block induction of contact sensitivity responses by antibodies of IgG2a and IgG2b isotypes. , 1988, Journal of immunology.

[61]  D. Green,et al.  Immunoregulatory role of Ig isotypes. I. Induction of contrasuppressor T cells for contact sensitivity responses by antibodies of the IgM, IgG1, and IgG3 isotypes. , 1988, Journal of immunology.

[62]  W. Frank,et al.  Protective mechanism of the immune response to a ribosomal vaccine from Pseudomonas aeruginosa. II. In vitro bactericidal and opsonophagocytic studies with specific antiserum. , 1988, The Journal of surgical research.

[63]  C. Bona,et al.  Immunologic response to influenza virus neuraminidase is influenced by prior experience with the associated viral hemagglutinin. III. Reduced generation of neuraminidase-specific helper T cells in hemagglutinin-primed mice. , 1987, Journal of immunology.

[64]  J. Halperin,et al.  Failure of tetracycline therapy in early Lyme disease. , 1987, Arthritis and rheumatism.

[65]  R. C. Johnson,et al.  Passive immunization of hamsters against experimental infection with the Lyme disease spirochete , 1986, Infection and immunity.

[66]  R. Coffman,et al.  Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins. , 1986, Journal of immunology.

[67]  A. Stere.  SUCCESSFUL PARENTERAL PENICILLIN THERAPY OF ESTABLISHED LYME ARTHRITIS , 1985 .

[68]  A. Barbour.  Isolation and cultivation of Lyme disease spirochetes. , 1984, The Yale journal of biology and medicine.

[69]  S. Stagno,et al.  Potentiation of neutralization of Varicella-Zoster virus to antibody to immunoglobulin. , 1982, The Journal of infectious diseases.

[70]  W. Hall,et al.  Infection and serological responses in cattle given 45/20 vaccine and later challenged with Brucella abortus. , 1976, Australian veterinary journal.

[71]  F. Horsfall,et al.  THE PROTECTIVE ACTION OF TYPE I ANTIPNEUMOCOCCUS SERUM IN MICE , 1935, The Journal of experimental medicine.

[72]  L. D. Felton.  The Units of Protective Antibody in Anti-Pneumococcus Serum and Antibody Solution , 1928 .

[73]  E. Fikrig,et al.  Characterization of a 30-kDa Borrelia burgdorferi substrate-binding protein homologue. , 1996, Research in microbiology.

[74]  R. Glück,et al.  Virosomes as carriers for combined vaccines. , 1995, Vaccine.

[75]  L. Brown,et al.  Antigenic competition in a multivalent foot rot vaccine. , 1994, Vaccine.

[76]  M. Höök,et al.  MSCRAMM-mediated adherence of microorganisms to host tissues. , 1994, Annual review of microbiology.

[77]  E. Fikrig,et al.  Serologic response to the Borrelia burgdorferi flagellin demonstrates an epitope common to a neuroblastoma cell line. , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[78]  A. Steere.  Lyme disease. , 1989, The New England journal of medicine.

[79]  R. Coffman,et al.  TH1 and TH2 cells: different patterns of lymphokine secretion lead to different functional properties. , 1989, Annual review of immunology.

[80]  A. Steere.  Medical progress. Lyme disease , 1989 .

[81]  A. Cross,et al.  Evaluation of immunotherapeutic approaches for the potential treatment of infections caused by K1-positive Escherichia coli. , 1983, The Journal of infectious diseases.