The four main scientific objectives of PRIMA – the Phase-Referenced Imaging and Micro-arc second Astrometry facility for the VLTI – will be described:– extra-solar system characterization with astrometry, to detect planets and evaluate their mass, and imaging of the dust accretion disk,– galactic center study with astrometry(dynamics of the bulge stars) and imaging at 10μm (piercing the gas and dust clouds surrounding the galactic center),– observations of AGNs and other extra-galactic objects, too faint to be observed without PRIMA, for which partial imaging is needed to constrain their structuremodels,– micro-gravitational lensing event resolution (imaging and astrometry of their photo-center) in the Galactic Bulge and Magellanic Clouds, helping to determine directly the lens mass and distance.