Introduction to Computational Immunology

Abstract Computational Immunology: Models and Tools is a reference book driven by immunologists to disseminate user-friendly immune modeling approaches to the immunology community. The models and tools are architected and deployed by computer scientists and modeling experts working closely with immunologists in transdisciplinary teams. The book is based on the notes and presentations stemming from the Center for Modeling Immunity to Enteric Pathogens (MIEP) at Virginia Tech. The MIEP program integrates computational modeling, big data analytics, portal science, and procedural knowledge to engineer synthetic information processing representations of the immune system. In the following chapters, we will discuss the value of computational modeling in the twenty-first century immunology research, types of models, modeling tools, informatics, and computational infrastructure needed for connecting computer modeling and wet-lab experimentation, as well as data analytics, aggregation, and visualization. Relevant immune modeling use cases are sprinkled throughout the chapters.

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