The effects of 2,3,7,8-Tetrachlorodibenzo-p-dioxin on estrogen metabolism in MCF-7 breast cancer cells: Evidence for induction of a novel 17β-estradiol 4-hydroxylase

[1]  C. Jefcoate,et al.  Mouse cytochrome P-450EF, representative of a new 1B subfamily of cytochrome P-450s. Cloning, sequence determination, and tissue expression. , 1994, The Journal of biological chemistry.

[2]  E. Jabs,et al.  Complete cDNA sequence of a human dioxin-inducible mRNA identifies a new gene subfamily of cytochrome P450 that maps to chromosome 2. , 1994, The Journal of biological chemistry.

[3]  C. Jefcoate,et al.  Co-expression of human CYP1A1 and a human analog of cytochrome P450-EF in response to 2,3,7,8-tetrachloro-dibenzo-p-dioxin in the human mammary carcinoma-derived MCF-7 cells. , 1994, Carcinogenesis.

[4]  C. Jefcoate,et al.  Mouse endometrium stromal cells express a polycyclic aromatic hydrocarbon-inducible cytochrome P450 that closely resembles the novel P450 in mouse embryo fibroblasts (P450EF). , 1993, Carcinogenesis.

[5]  G. Chetrite,et al.  Transformation of estrone, estradiol, and estrone sulfate in uterine and vaginal isolated cells of fetal guinea pig. Effect of various antiestrogens in the conversion of estrone sulfate to estradiol , 1993, Steroids.

[6]  M. E. Schroeder,et al.  Reversal of cytochrome P-4501A1 and P-450-EF expression in MCA-C3H/10T1/2 cell-derived tumors as compared to cultured cells. , 1993, Cancer research.

[7]  M. J. Coon,et al.  The P450 superfamily: update on new sequences, gene mapping, accession numbers, early trivial names of enzymes, and nomenclature. , 1993, DNA and cell biology.

[8]  C. Jefcoate,et al.  Polycyclic aromatic hydrocarbon metabolism in rat adrenal, ovary, and testis microsomes is catalyzed by the same novel cytochrome P450 (P450RAP). , 1992, Endocrinology.

[9]  P. Beaune,et al.  Nature of cytochromes P450 involved in the 2-/4-hydroxylations of estradiol in human liver microsomes. , 1992, Biochemical pharmacology.

[10]  D. Roy,et al.  Elevated 4-hydroxylation of estradiol by hamster kidney microsomes: a potential pathway of metabolic activation of estrogens. , 1992, Endocrinology.

[11]  E. Schuetz,et al.  17 beta-estradiol hydroxylation catalyzed by human cytochrome P450 1A1: a comparison of the activities induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin in MCF-7 cells with those from heterologous expression of the cDNA. , 1992, Archives of biochemistry and biophysics.

[12]  K. Dold,et al.  Targets for dioxin: genes for plasminogen activator inhibitor-2 and interleukin-1 beta. , 1991, Science.

[13]  C. Jefcoate,et al.  A novel adrenocorticotropin-inducible cytochrome P450 from rat adrenal microsomes catalyzes polycyclic aromatic hydrocarbon metabolism. , 1991, Endocrinology.

[14]  C. Jefcoate,et al.  Purification and immunological characterization of a novel cytochrome P450 from C3H/10T1/2 cells. , 1991, Archives of biochemistry and biophysics.

[15]  L. Browne,et al.  Fadrozole hydrochloride: a potent, selective, nonsteroidal inhibitor of aromatase for the treatment of estrogen-dependent disease. , 1991, Journal of medicinal chemistry.

[16]  S. Bowser,et al.  Estrogen‐stimulation of postconfluent cell accumulation and foci formation of human MCF‐7 breast cancer cells , 1991, Journal of cellular biochemistry.

[17]  J. Gierthy,et al.  2,3,7,8-Tetrachlorodibenzo-p-dioxin causes an extensive alteration of 17 beta-estradiol metabolism in MCF-7 breast tumor cells. , 1990, Proceedings of the National Academy of Sciences of the United States of America.

[18]  K. Korzekwa,et al.  Estradiol metabolism by complementary deoxyribonucleic acid-expressed human cytochrome P450s. , 1990, Endocrinology.

[19]  R. Tukey,et al.  Metabolism of 2-acetylaminofluorene and benzo(a)pyrene and activation of food-derived heterocyclic amine mutagens by human cytochromes P-450. , 1990, Cancer research.

[20]  S. Dey,et al.  Catechol estrogen formation in the mouse uterus and its role in implantation , 1990, Molecular and Cellular Endocrinology.

[21]  C. Jefcoate,et al.  Characterization of a novel cytochrome P450 from the transformable cell line, C3H/10T1/2. , 1990, Carcinogenesis.

[22]  J. Hammond,et al.  Regulation of ovarian function by catecholestrogens: current concepts. , 1989, Journal of steroid biochemistry.

[23]  J. Weisz,et al.  Monooxygenase mediating catecholestrogen formation by rat anterior pituitary is an estrogen-4-hydroxylase. , 1989, Endocrinology.

[24]  D. Nebert,et al.  Regulation of the mammalian cytochrome P1-450 (CYP1A1) gene. , 1989, The International journal of biochemistry.

[25]  J. Pasqualini,et al.  Importance of estrogen sulfates in breast cancer. , 1989, Journal of steroid biochemistry.

[26]  F. Naftolin,et al.  Estrogen hydroxylase activity in the human placenta at term. , 1988, Journal of steroid biochemistry.

[27]  M. Blankenstein,et al.  Metabolism of estradiol by human breast cancer. , 1988, European journal of cancer & clinical oncology.

[28]  P. Chomczyński,et al.  Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. , 1987, Analytical biochemistry.

[29]  J. Hammond,et al.  Catecholestrogen production by porcine ovarian cells. , 1986, Endocrinology.

[30]  D. Waxman,et al.  17 beta-estradiol 2- and 4-hydroxylation catalyzed by rat hepatic cytochrome P-450: roles of individual forms, inductive effects, developmental patterns, and alterations by gonadectomy and hormone replacement. , 1986, Endocrinology.

[31]  R. Tukey,et al.  Cloning and isolation of human cytochrome P-450 cDNAs homologous to dioxin-inducible rabbit mRNAs encoding P-450 4 and P-450 6. , 1985, DNA.

[32]  R. Scholler,et al.  Estrogen 2-, 4-, 6- or 16-hydroxylation by human follicles shown by gas chromatography-mass spectrometry associated with stable isotope dilution. , 1984, Journal of steroid biochemistry.

[33]  R. Schwartz,et al.  Cloning and sequencing of a deoxyribonucleic acid copy of glyceraldehyde-3-phosphate dehydrogenase messenger ribonucleic acid isolated from chicken muscle. , 1983, Biochemistry.

[34]  J. Fishman Aromatic hydroxylation of estrogens. , 1983, Annual review of physiology.

[35]  R. Scholler,et al.  Simple methods for the synthesis of twenty different, highly enriched deuterium labelled steroids, suitable as internal standards for isotope dilution mass spectrometry , 1980 .

[36]  P. Thomas,et al.  Hybridization of denatured RNA and small DNA fragments transferred to nitrocellulose. , 1980, Proceedings of the National Academy of Sciences of the United States of America.

[37]  S. Paul,et al.  Catechol estrogen-forming enzyme of brain: demonstration of a cytochrome p450 monooxygenase. , 1977, Endocrinology.

[38]  D M Bissell,et al.  Drug metabolism in adult rat hepatocytes in primary monolayer culture. , 1977, Gastroenterology.

[39]  M. M. Bradford A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. , 1976, Analytical biochemistry.

[40]  U. K. Laemmli,et al.  Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4 , 1970, Nature.