Research development of kinetic mechanism of gallstone formation

Some studies indicate that the decreased gallbladder contractility may be the key factor responsible for gallstone formation.This article discusses the kinetic mechanism of gallstone formation from the following aspects: ①Nervous and humoral regulation of gallbladder emptying function;②Classification and diagnosis of gallbladder function;③Changes of plasma cholecystokinin(CCK) levels in patients with gallstone;④Correlation between gallstone and gallbladder dysmotility;⑤The molecular mechanism of gallbladder dysmotility;⑥Correlation between gene expression of cholecystokinin receptor(CCK-R) and cholesterol in bile.