Screening for cell migration inhibitors via automated microscopy reveals a Rho-kinase inhibitor.

[1]  T. Mitchison,et al.  A high-throughput cell migration assay using scratch wound healing, a comparison of image-based readout methods , 2004, BMC biotechnology.

[2]  M. Kirschner,et al.  Chemical inhibition of N-WASP by stabilization of a native autoinhibited conformation , 2004, Nature Structural &Molecular Biology.

[3]  Tudor I. Oprea,et al.  Pursuing the leadlikeness concept in pharmaceutical research. , 2004, Current opinion in chemical biology.

[4]  A. Takeshita,et al.  Long-Term Inhibition of Rho-Kinase Suppresses Left Ventricular Remodeling After Myocardial Infarction in Mice , 2004, Circulation.

[5]  T. Mitchison,et al.  Fascin-mediated propulsion of Listeria monocytogenes independent of frequent nucleation by the Arp2/3 complex , 2004, The Journal of cell biology.

[6]  D. L. Taylor,et al.  High content screening applied to large-scale cell biology. , 2004, Trends in biotechnology.

[7]  Pamela A. Silver,et al.  A chemical genetic screen identifies inhibitors of regulated nuclear export of a Forkhead transcription factor in PTEN-deficient tumor cells. , 2003, Cancer cell.

[8]  Dennis Lee,et al.  Rho kinase inhibitors as potential therapeutic agents for cardiovascular diseases. , 2003, Current opinion in investigational drugs.

[9]  T. Mitchison,et al.  Phenotypic screening of small molecule libraries by high throughput cell imaging. , 2003, Combinatorial chemistry & high throughput screening.

[10]  T. Kapoor,et al.  HR22C16: a potent small-molecule probe for the dynamics of cell division. , 2003, Angewandte Chemie.

[11]  Ashutosh P Jadhav,et al.  Exo1: A new chemical inhibitor of the exocytic pathway , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[12]  Timothy J Mitchison,et al.  Dissecting Temporal and Spatial Control of Cytokinesis with a Myosin II Inhibitor , 2003, Science.

[13]  D. Chang,et al.  ROCK-II-induced membrane blebbing and chromatin condensation require actin cytoskeleton. , 2002, Experimental cell research.

[14]  Tudor I. Oprea.  Current trends in lead discovery: Are we looking for the appropriate properties? , 2002, J. Comput. Aided Mol. Des..

[15]  C. Kanthou,et al.  The tumor vascular targeting agent combretastatin A-4-phosphate induces reorganization of the actin cytoskeleton and early membrane blebbing in human endothelial cells. , 2002, Blood.

[16]  M. Kirschner,et al.  A chemical inhibitor of N-WASP reveals a new mechanism for targeting protein interactions , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[17]  J. Bertoglio,et al.  Caspase-3-mediated cleavage of ROCK I induces MLC phosphorylation and apoptotic membrane blebbing , 2001, Nature Cell Biology.

[18]  E. Sahai,et al.  Membrane blebbing during apoptosis results from caspase-mediated activation of ROCK I , 2001, Nature Cell Biology.

[19]  R. May,et al.  Phagocytosis and the actin cytoskeleton. , 2001, Journal of cell science.

[20]  D L Taylor,et al.  Real-time molecular and cellular analysis: the new frontier of drug discovery. , 2001, Current opinion in biotechnology.

[21]  P. Cohen,et al.  Specificity and mechanism of action of some commonly used protein kinase inhibitors , 2000 .

[22]  S. Narumiya,et al.  Pharmacological properties of Y-27632, a specific inhibitor of rho-associated kinases. , 2000, Molecular pharmacology.

[23]  S. Narumiya,et al.  Use and properties of ROCK-specific inhibitor Y-27632. , 2000, Methods in enzymology.

[24]  S. Haggarty,et al.  Small molecule inhibitor of mitotic spindle bipolarity identified in a phenotype-based screen. , 1999, Science.

[25]  S. Narumiya,et al.  Signaling from Rho to the actin cytoskeleton through protein kinases ROCK and LIM-kinase. , 1999, Science.

[26]  R. Treisman,et al.  Transformation mediated by RhoA requires activity of ROCK kinases , 1999, Current Biology.

[27]  W. Kiosses,et al.  Regulation of the small GTP‐binding protein Rho by cell adhesion and the cytoskeleton , 1999, The EMBO journal.

[28]  S. Narumiya,et al.  Molecular Dissection of the Rho-associated Protein Kinase (p160ROCK)-regulated Neurite Remodeling in Neuroblastoma N1E-115 Cells , 1998, The Journal of cell biology.

[29]  Jason C. Mills,et al.  Apoptotic Membrane Blebbing Is Regulated by Myosin Light Chain Phosphorylation , 1998, The Journal of cell biology.

[30]  Shuh Narumiya,et al.  Calcium sensitization of smooth muscle mediated by a Rho-associated protein kinase in hypertension , 1997, Nature.

[31]  Rong Li,et al.  In Vitro Reconstitution of Cortical Actin Assembly Sites in Budding Yeast , 1997, The Journal of cell biology.

[32]  F. Lombardo,et al.  Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings , 1997 .

[33]  Yoshiharu Matsuura,et al.  Phosphorylation and Activation of Myosin by Rho-associated Kinase (Rho-kinase)* , 1996, The Journal of Biological Chemistry.

[34]  Kozo Kaibuchi,et al.  Regulation of Myosin Phosphatase by Rho and Rho-Associated Kinase (Rho-Kinase) , 1996, Science.

[35]  T. Yamamoto,et al.  Rho‐associated kinase, a novel serine/threonine kinase, as a putative target for small GTP binding protein Rho. , 1996, The EMBO journal.

[36]  D. Drubin,et al.  Regulation of cortical actin cytoskeleton assembly during polarized cell growth in budding yeast , 1995, The Journal of cell biology.

[37]  T. Mitchison,et al.  Towards a pharmacological genetics. , 1994, Chemistry & biology.

[38]  A. Pockley,et al.  A rapid microplate-based fluorometric assay for phagocytosis. , 1993, Immunological investigations.

[39]  P. Janmey,et al.  Actin-binding protein requirement for cortical stability and efficient locomotion. , 1992, Science.

[40]  Thomas A. Mustoe, MD, FACS,et al.  Platelet-derived growth factor and transforming growth factor-beta enhance tissue repair activities by unique mechanisms , 1989, The Journal of cell biology.

[41]  Gary R. Grotendorst,et al.  Platelet-derived growth factor in chemotactic for fibroblasts , 1982, The Journal of cell biology.

[42]  U. Shmueli,et al.  Latrunculin, a new 2-thiazolidinone macrolide from the marine sponge latrunculia magnifica , 1980 .

[43]  A. McPhail,et al.  Plant antitumor agents. VI. The isolation and structure of taxol, a novel antileukemic and antitumor agent from Taxus brevifolia. , 1971, Journal of the American Chemical Society.