Targeting TRPV1-mediated autophagy attenuates nitrogen mustard-induced dermal toxicity

[1]  Siyue Lou,et al.  Autophagy Inhibition Potentiates the Anticancer Effects of a Bendamustine Derivative NL-101 in Acute T Lymphocytic Leukemia , 2020, BioMed research international.

[2]  P. Xu,et al.  Molecular regulation of autophagy machinery by mTOR‐dependent and ‐independent pathways , 2020, Annals of the New York Academy of Sciences.

[3]  P. Vandenabeele,et al.  The molecular machinery of regulated cell death , 2019, Cell Research.

[4]  B. Loos,et al.  The good, the bad and the autophagosome: exploring unanswered questions of autophagy-dependent cell death , 2019, Cell Death & Differentiation.

[5]  J. Quiles,et al.  Autophagy in Human Health and Disease: Novel Therapeutic Opportunities. , 2019, Antioxidants & redox signaling.

[6]  Dong Hun Lee,et al.  Ultraviolet light-induced gasdermin C expression is mediated via TRPV1/calcium/calcineurin/NFATc1 signaling. , 2018, International journal of molecular medicine.

[7]  Ben Loos,et al.  Measuring autophagosome flux , 2018, Autophagy.

[8]  R. Singh,et al.  Therapeutic journery of nitrogen mustard as alkylating anticancer agents: Historic to future perspectives. , 2018, European journal of medicinal chemistry.

[9]  C. Shea,et al.  Autophagy gene ATG7 regulates ultraviolet radiation-induced inflammation and skin tumorigenesis , 2017, Autophagy.

[10]  Pei-Shan Liu,et al.  Ultraviolet B irradiation increases keratin 1 and keratin 10 expressions in HaCaT keratinocytes via TRPV1 activation and ERK phosphorylation , 2017, Experimental dermatology.

[11]  Yu-Ying He,et al.  Adaptor protein p62 promotes skin tumor growth and metastasis and is induced by UVA radiation , 2017, The Journal of Biological Chemistry.

[12]  Ying-Jan Wang,et al.  Autophagy-inducing effect of pterostilbene: A prospective therapeutic/preventive option for skin diseases , 2016, Journal of food and drug analysis.

[13]  Ji-Eun Kim,et al.  Trifloxystrobin-induced mitophagy through mitochondrial damage in human skin keratinocytes. , 2016, The Journal of toxicological sciences.

[14]  J. Cheong,et al.  AMPK–ULK1-Mediated Autophagy Confers Resistance to BET Inhibitor JQ1 in Acute Myeloid Leukemia Stem Cells , 2016, Clinical Cancer Research.

[15]  N. Mizushima,et al.  An Autophagic Flux Probe that Releases an Internal Control. , 2016, Molecular cell.

[16]  Xiaoli Zhang,et al.  Lysosome calcium in ROS regulation of autophagy , 2016, Autophagy.

[17]  O. Volpert,et al.  Inhibition of mTOR by apigenin in UVB-irradiated keratinocytes: A new implication of skin cancer prevention. , 2016, Cellular signalling.

[18]  R. Agarwal,et al.  Nitrogen mustard exposure of murine skin induces DNA damage, oxidative stress and activation of MAPK/Akt-AP1 pathway leading to induction of inflammatory and proteolytic mediators. , 2015, Toxicology letters.

[19]  R. Agarwal,et al.  Flavanone silibinin treatment attenuates nitrogen mustard-induced toxic effects in mouse skin. , 2015, Toxicology and applied pharmacology.

[20]  M. Maiuri,et al.  Spermidine induces autophagy by inhibiting the acetyltransferase EP300 , 2014, Cell Death and Differentiation.

[21]  J. Yue,et al.  Vacuolin-1 potently and reversibly inhibits autophagosome-lysosome fusion by activating RAB5A , 2014, Autophagy.

[22]  J. Hofmeyr,et al.  Defining and measuring autophagosome flux—concept and reality , 2014, Autophagy.

[23]  M. Gollasch,et al.  Role of TRPV1 Channels in Ischemia/Reperfusion-Induced Acute Kidney Injury , 2014, PloS one.

[24]  Xiao-Yu Liu,et al.  Silencing of EEF2K (eukaryotic elongation factor-2 kinase) reveals AMPK-ULK1-dependent autophagy in colon cancer cells , 2014, Autophagy.

[25]  Y. Pi,et al.  TRPV1 activation impedes foam cell formation by inducing autophagy in oxLDL-treated vascular smooth muscle cells , 2014, Cell Death and Disease.

[26]  R. Agarwal,et al.  Histopathological and immunohistochemical evaluation of nitrogen mustard-induced cutaneous effects in SKH-1 hairless and C57BL/6 mice. , 2014, Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie.

[27]  R. Xavier,et al.  Autosis is a Na+,K+-ATPase–regulated form of cell death triggered by autophagy-inducing peptides, starvation, and hypoxia–ischemia , 2013, Proceedings of the National Academy of Sciences.

[28]  L. Eckhart,et al.  Autophagy in epithelial homeostasis and defense. , 2013, Frontiers in bioscience.

[29]  M. Mildner,et al.  Autophagy is induced by UVA and promotes removal of oxidized phospholipids and protein aggregates in epidermal keratinocytes. , 2013, The Journal of investigative dermatology.

[30]  A. Thorburn,et al.  Autophagy Inhibition for Chemosensitization and Radiosensitization in Cancer: Do the Preclinical Data Support This Therapeutic Strategy? , 2013, The Journal of Pharmacology and Experimental Therapeutics.

[31]  R. Rizzuto,et al.  Withdrawal of Essential Amino Acids Increases Autophagy by a Pathway Involving Ca2+/Calmodulin-dependent Kinase Kinase-β (CaMKK-β)* , 2012, The Journal of Biological Chemistry.

[32]  Xianglin Shi,et al.  GSK3β signaling is involved in ultraviolet B-induced activation of autophagy in epidermal cells , 2012, International journal of oncology.

[33]  G. Santoni,et al.  Transient receptor potential vanilloid 1 activation induces autophagy in thymocytes through ROS‐regulated AMPK and Atg4C pathways , 2012, Journal of leukocyte biology.

[34]  Sangeeta Khare,et al.  Guidelines for the use and interpretation of assays formonitoring autophagy (3rd edition) , 2016 .

[35]  Robert Clarke,et al.  Guidelines for the use and interpretation of assays for monitoring autophagy , 2012 .

[36]  D. Hardie,et al.  AMPK: a nutrient and energy sensor that maintains energy homeostasis , 2012, Nature Reviews Molecular Cell Biology.

[37]  Yi-Wei Chen,et al.  A Combined DNA-Affinic Molecule and N-Mustard Alkylating Agent Has an Anti-Cancer Effect and Induces Autophagy in Oral Cancer Cells , 2012, International journal of molecular sciences.

[38]  Li-Hsin Chen,et al.  Targeting autophagy enhances BO-1051-induced apoptosis in human malignant glioma cells , 2012, Cancer Chemotherapy and Pharmacology.

[39]  Xianglin Shi,et al.  Cadmium induces autophagy through ROS-dependent activation of the LKB1-AMPK signaling in skin epidermal cells. , 2011, Toxicology and applied pharmacology.

[40]  J. Chung,et al.  Inhibitory effects of TRPV1 blocker on UV-induced responses in the hairless mice , 2011, Archives of Dermatological Research.

[41]  Li-Hsin Chen,et al.  Autophagy inhibition enhances apoptosis triggered by BO-1051, an N-mustard derivative, and involves the ATM signaling pathway. , 2011, Biochemical pharmacology.

[42]  B. Viollet,et al.  AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1 , 2011, Nature Cell Biology.

[43]  Jeung-Hoon Lee,et al.  Autophagy Negatively Regulates Keratinocyte Inflammatory Responses via Scaffolding Protein p62/SQSTM1 , 2011, The Journal of Immunology.

[44]  M. Ghanei,et al.  Mustard gas toxicity: the acute and chronic pathological effects , 2010, Journal of applied toxicology : JAT.

[45]  Y. Kim,et al.  A novel role for the TRPV1 channel in UV‐induced matrix metalloproteinase (MMP)‐1 expression in HaCaT cells , 2009, Journal of cellular physiology.

[46]  R A Knight,et al.  Guidelines for the use and interpretation of assays for monitoring cell death in higher eukaryotes , 2009, Cell Death and Differentiation.

[47]  Guido Kroemer,et al.  Autophagy in the Pathogenesis of Disease , 2008, Cell.

[48]  R. Rizzuto,et al.  Control of macroautophagy by calcium, calmodulin-dependent kinase kinase-beta, and Bcl-2. , 2007, Molecular cell.

[49]  M. Steinhoff,et al.  Neurophysiological, neuroimmunological, and neuroendocrine basis of pruritus. , 2006, The Journal of investigative dermatology.

[50]  A. Patapoutian,et al.  Trp ion channels and temperature sensation. , 2006, Annual review of neuroscience.

[51]  S. Rodríguez-Enríquez,et al.  Tracker Dyes to Probe Mitochondrial Autophagy (Mitophagy) in Rat Hepatocytes , 2006, Autophagy.

[52]  C. Reilly,et al.  Calcium‐dependent and independent mechanisms of capsaicin receptor (TRPV1)‐mediated cytokine production and cell death in human bronchial epithelial cells , 2005, Journal of biochemical and molecular toxicology.

[53]  R. Heath,et al.  Ca2+/calmodulin-dependent protein kinase kinase-beta acts upstream of AMP-activated protein kinase in mammalian cells. , 2005, Cell metabolism.

[54]  A. Edelman,et al.  Calmodulin-dependent protein kinase kinase-beta is an alternative upstream kinase for AMP-activated protein kinase. , 2005, Cell metabolism.

[55]  R. DePinho,et al.  The LKB1 tumor suppressor negatively regulates mTOR signaling. , 2004, Cancer cell.

[56]  David Carling,et al.  Activation of yeast Snf1 and mammalian AMP-activated protein kinase by upstream kinases , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[57]  K. Matsunaga,et al.  Immunoreactivity of VR1 on epidermal keratinocyte of human skin. , 2001, Biochemical and biophysical research communications.

[58]  A. Basbaum,et al.  Bradykinin and nerve growth factor release the capsaicin receptor from PtdIns(4,5)P2-mediated inhibition , 2001, Nature.

[59]  P. Blumberg,et al.  Distribution of mRNA for vanilloid receptor subtype 1 (VR1), and VR1-like immunoreactivity, in the central nervous system of the rat and human. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[60]  A. Basbaum,et al.  The Cloned Capsaicin Receptor Integrates Multiple Pain-Producing Stimuli , 1998, Neuron.

[61]  R. Whitehead.  Colon cancer cells , 1990 .

[62]  Basappa,et al.  Modulating autophagy in cancer therapy: Advancements and challenges for cancer cell death sensitization , 2018, Biochemical pharmacology.

[63]  I. Díaz-Laviada,et al.  The potential antitumor effects of capsaicin. , 2014, Progress in drug research. Fortschritte der Arzneimittelforschung. Progres des recherches pharmaceutiques.

[64]  Teng Yu,et al.  Targeting autophagy in skin diseases , 2014, Journal of Molecular Medicine.

[65]  M. Demirci.  Comprehensive Clinical Nephrology 3rd Edition , 2011 .

[66]  L. Kenar,et al.  Morphological and immunohistochemical changes on rat skin exposed to nitrogen mustard. , 2004, Military medicine.