Zebularine: a novel DNA methylation inhibitor that forms a covalent complex with DNA methyltransferases.
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D. Hornby | M. Dickman | L. Zhou | X. Cheng | B. Connolly | P. J. Hurd
[1] R J Roberts,et al. AdoMet-dependent methylation, DNA methyltransferases and base flipping. , 2001, Nucleic acids research.
[2] Peter A. Jones,et al. The Role of DNA Methylation in Mammalian Epigenetics , 2001, Science.
[3] J. Herman,et al. DNA methylation, chromatin inheritance, and cancer , 2001, Oncogene.
[4] T. Bestor,et al. Structure of human DNMT2, an enigmatic DNA methyltransferase homolog that displays denaturant-resistant binding to DNA. , 2001, Nucleic acids research.
[5] A. Bhagwat,et al. Reviving a dead enzyme: cytosine deaminations promoted by an inactive DNA methyltransferase and an S-adenosylmethionine analogue. , 2000, Biochemistry.
[6] T. Bestor,et al. The DNA methyltransferases of mammals. , 2000, Human molecular genetics.
[7] N. C. Price,et al. Mechanism-based inhibition of C5-cytosine DNA methyltransferases by 2-H pyrimidinone. , 1999, Journal of molecular biology.
[8] J. Christman,et al. Mechanism of inhibition of DNA (cytosine C5)-methyltransferases by oligodeoxyribonucleotides containing 5,6-dihydro-5-azacytosine. , 1999, Journal of molecular biology.
[9] L. Jeong,et al. Carbocyclic analogues of the potent cytidine deaminase inhibitor 1-(beta-D-ribofuranosyl)-1,2-dihydropyrimidin-2-one (zebularine). , 1998, Journal of medicinal chemistry.
[10] T. Bestor,et al. Gene silencing: Methylation meets acetylation , 1998, Nature.
[11] R T Walker,et al. DNA containing 4'-thio-2'-deoxycytidine inhibits methylation by HhaI methyltransferase. , 1997, Nucleic acids research.
[12] R. Jaenisch,et al. Mutagenicity of 5-aza-2'-deoxycytidine is mediated by the mammalian DNA methyltransferase. , 1997, Proceedings of the National Academy of Sciences of the United States of America.
[13] D. S. Joy,et al. Nucleoprotein-based nanoscale assembly. , 1997, Proceedings of the National Academy of Sciences of the United States of America.
[14] R. Roberts,et al. Enzymatic C5-cytosine methylation of DNA: mechanistic implications of new crystal structures for HhaL methyltransferase-DNA-AdoHcy complexes. , 1996, Journal of molecular biology.
[15] Hurd Pj. A study of the catalytic properties of M.MspI DNA methyltransferase. , 1996 .
[16] A. Bhagwat,et al. Cytosine methyltransferase from Escherichia coli in which active site cysteine is replaced with serine is partially active. , 1995, Biochemistry.
[17] A. Yang,et al. HhaI and HpaII DNA methyltransferases bind DNA mismatches, methylate uracil and block DNA repair. , 1995, Nucleic acids research.
[18] R. Roberts,et al. M.HhaI binds tightly to substrates containing mismatches at the target base. , 1995, Nucleic acids research.
[19] A. Bhagwat,et al. The mechanism of inhibition of DNA (cytosine-5-)-methyltransferases by 5-azacytosine is likely to involve methyl transfer to the inhibitor. , 1995, The Biochemical journal.
[20] Xiaodong Cheng,et al. Structure and function of DNA methyltransferases. , 1995, Annual review of biophysics and biomolecular structure.
[21] R. Roberts,et al. Hhal methyltransferase flips its target base out of the DNA helix , 1994, Cell.
[22] R. Wolfenden,et al. Cytidine deaminase. The 2.3 A crystal structure of an enzyme: transition-state analog complex. , 1994, Journal of molecular biology.
[23] N. C. Price,et al. Ligand-induced conformational states of the cytosine-specific DNA methyltransferase M.HgaI-2. , 1994, Journal of molecular biology.
[24] T. Bestor,et al. DNA methyltransferases. , 1994, Current opinion in cell biology.
[25] D. Hornby,et al. Determination of the order of substrate addition to MspI DNA methyltransferase using a novel mechanism-based inhibitor. , 1993, The Biochemical journal.
[26] Axel T. Brunger,et al. X-PLOR Version 3.1: A System for X-ray Crystallography and NMR , 1992 .
[27] William Arbuthnot Sir Lane,et al. Direct identification of the active-site nucleophile in a DNA (cytosine-5)-methyltransferase. , 1991, Biochemistry.
[28] S. S. Smith,et al. Recognition of unusual DNA structures by human DNA (cytosine-5)methyltransferase. , 1991, Journal of molecular biology.
[29] R. Wolfenden,et al. Binding of pyrimidin-2-one ribonucleoside by cytidine deaminase as the transition-state analogue 3,4-dihydrouridine and the contribution of the 4-hydroxyl group to its binding affinity. , 1989, Biochemistry.
[30] B. Connolly,et al. Synthesis and properties of oligonucleotides containing 4-thiothyniidine, 5-methyl-2-pyrunidinone-1-β-D(2'-dexoyriboside) and 2-thiothvmidine , 1989 .
[31] B. Connolly,et al. Synthesis and properties of oligonucleotides containing 4-thiothymidine, 5-methyl-2-pyrimidinone-1-beta-D(2'-deoxyriboside) and 2-thiothymidine. , 1989, Nucleic acids research.
[32] S. S. Smith,et al. Recognition of structural perturbations in DNA by human DNA(cytosine-5)methyltransferase. , 1988, Gene.
[33] S. S. Smith,et al. Human DNA (cytosine-5)methyltransferase selectively methylates duplex DNA containing mispairs. , 1987, Nucleic acids research.
[34] D. Santi,et al. Kinetic and catalytic mechanism of HhaI methyltransferase. , 1987, The Journal of biological chemistry.
[35] D. Santi,et al. Covalent bond formation between a DNA-cytosine methyltransferase and DNA containing 5-azacytosine. , 1984, Proceedings of the National Academy of Sciences of the United States of America.
[36] P. Barr,et al. On the mechanism of inhibition of DNA-cytosine methyltransferases by cytosine analogs , 1983, Cell.
[37] Peter A. Jones,et al. Cellular differentiation, cytidine analogs and DNA methylation , 1980, Cell.