Raptor/mTORC1 loss in adipocytes causes progressive lipodystrophy and fatty liver disease
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[1] Kalyani V. P. Guntur,et al. Activation of mTORC1 is essential for β-adrenergic stimulation of adipose browning. , 2016, The Journal of clinical investigation.
[2] D. Guertin,et al. Emerging Complexities in Adipocyte Origins and Identity. , 2016, Trends in cell biology.
[3] Gregory A. Wyant,et al. The CASTOR Proteins Are Arginine Sensors for the mTORC1 Pathway , 2016, Cell.
[4] Dudley Lamming,et al. Rapamycin Blocks Induction of the Thermogenic Program in White Adipose Tissue , 2016, Diabetes.
[5] D. Sabatini,et al. Sestrin2 is a leucine sensor for the mTORC1 pathway , 2016, Science.
[6] J. Mintz,et al. Berardinelli-Seip congenital lipodystrophy 2 regulates adipocyte lipolysis, browning, and energy balance in adult animals[S] , 2015, Journal of Lipid Research.
[7] N. Patni,et al. Congenital generalized lipodystrophies—new insights into metabolic dysfunction , 2015, Nature Reviews Endocrinology.
[8] Y. Lian,et al. Distinct Regulatory Mechanisms Govern Embryonic versus Adult Adipocyte Maturation Hhs Public Access Introduction , 2022 .
[9] S. O’Rahilly,et al. Seipin oligomers can interact directly with AGPAT2 and lipin 1, physically scaffolding critical regulators of adipogenesis , 2015, Molecular metabolism.
[10] Jing Zhao,et al. Tuberous Sclerosis Complex 1–Mechanistic Target of Rapamycin Complex 1 Signaling Determines Brown-to-White Adipocyte Phenotypic Switch , 2014, Diabetes.
[11] E. Rosen,et al. Characterization of Cre recombinase models for the study of adipose tissue , 2014, Adipocyte.
[12] Peng Li,et al. Adipose-Specific Knockout of Seipin/Bscl2 Results in Progressive Lipodystrophy , 2014, Diabetes.
[13] K. Flegal,et al. Prevalence of childhood and adult obesity in the United States, 2011-2012. , 2014, JAMA.
[14] M. Lazar,et al. Lipoatrophy and severe metabolic disturbance in mice with fat-specific deletion of PPARγ , 2013, Proceedings of the National Academy of Sciences.
[15] D. Bernlohr,et al. Distinct functions of Ulk1 and Ulk2 in the regulation of lipid metabolism in adipocytes , 2013, Autophagy.
[16] C. Kahn,et al. Lessons on Conditional Gene Targeting in Mouse Adipose Tissue , 2013, Diabetes.
[17] M. Lazar,et al. A novel adipose-specific gene deletion model demonstrates potential pitfalls of existing methods. , 2013, Molecular endocrinology.
[18] D. Guertin,et al. PTEN loss in the Myf5 lineage redistributes body fat and reveals subsets of white adipocytes that arise from Myf5 precursors. , 2012, Cell metabolism.
[19] M. Blüher,et al. A novel ChREBP isoform in adipose tissue regulates systemic glucose metabolism , 2012, Nature.
[20] D. Sabatini,et al. mTOR Signaling in Growth Control and Disease , 2012, Cell.
[21] Anne E Carpenter,et al. mTOR Complex 1 Regulates Lipin 1 Localization to Control the SREBP Pathway , 2011, Cell.
[22] S. Gygi,et al. Phosphoproteomic Analysis Identifies Grb10 as an mTORC1 Substrate That Negatively Regulates Insulin Signaling , 2011, Science.
[23] D. Sabatini,et al. The mTOR-Regulated Phosphoproteome Reveals a Mechanism of mTORC1-Mediated Inhibition of Growth Factor Signaling , 2011, Science.
[24] U. Klein,et al. Transcriptional control of adipose lipid handling by IRF4. , 2011, Cell metabolism.
[25] D. Fingar,et al. mTORC1 Inhibition via Rapamycin Promotes Triacylglycerol Lipolysis and Release of Free Fatty Acids in 3T3-L1 Adipocytes , 2010, Lipids.
[26] K. Kandror,et al. Mammalian Target of Rapamycin Complex 1 Suppresses Lipolysis, Stimulates Lipogenesis, and Promotes Fat Storage , 2010, Diabetes.
[27] A. K. Agarwal,et al. Molecular mechanisms of hepatic steatosis and insulin resistance in the AGPAT2-deficient mouse model of congenital generalized lipodystrophy. , 2009, Cell metabolism.
[28] J. Auwerx,et al. Adipose-specific knockout of raptor results in lean mice with enhanced mitochondrial respiration. , 2008, Cell metabolism.
[29] B. Xue,et al. Genetic variability affects the development of brown adipocytes in white fat but not in interscapular brown fats⃞ Published, JLR Papers in Press, October 14, 2006. , 2007, Journal of Lipid Research.
[30] J. Schaack,et al. Suppression of adiponectin gene expression by histone deacetylase inhibitor valproic acid. , 2006, Endocrinology.
[31] C. Darimont,et al. C/EBPalpha regulates human adiponectin gene transcription through an intronic enhancer. , 2005, Diabetes.
[32] Sarah Yoon,et al. CCAAT/enhancer binding protein and nuclear factor-Y regulate adiponectin gene expression in adipose tissue. , 2004, Diabetes.
[33] J. Lawrence,et al. Insulin-stimulated phosphorylation of lipin mediated by the mammalian target of rapamycin , 2002, Proceedings of the National Academy of Sciences of the United States of America.
[34] Ping Xu,et al. Lipodystrophy in the fld mouse results from mutation of a new gene encoding a nuclear protein, lipin , 2001, Nature Genetics.