Chemical and Technological Advances in Chitins and Chitosans Useful for the Formulation of Biopharmaceuticals

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[8]  M. Ishikawa,et al.  High/low temperature operation of electric double layer capacitor utilizing acidic cellulose–chitin hybrid gel electrolyte , 2010 .

[9]  P. Supaphol,et al.  Preparation and properties of α‐chitin‐whisker‐reinforced hyaluronan–gelatin nanocomposite scaffolds , 2010 .

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[11]  Changren Zhou,et al.  Hydrophobic modifications of cationic polymers for gene delivery , 2010 .

[12]  S. Nair,et al.  Novel carboxymethyl derivatives of chitin and chitosan materials and their biomedical applications , 2010 .

[13]  R. Muzzarelli.  Chitosan Scaffolds for Bone Regeneration , 2010 .

[14]  A. Potthast,et al.  Periodate oxidation of polysaccharides for modification of chemical and physical properties. , 2010, Carbohydrate research.

[15]  K. Opwis,et al.  Inhibition of microbial pathogens by fungal chitosan. , 2010, International journal of biological macromolecules.

[16]  Bo Li,et al.  Chitosan Modification and Pharmaceutical/Biomedical Applications , 2010, Marine drugs.

[17]  N. Sun,et al.  Dissolution or extraction of crustacean shells using ionic liquids to obtain high molecular weight purified chitin and direct production of chitin films and fibers , 2010 .

[18]  H. Yano,et al.  Fibrillation of dried chitin into 10–20 nm nanofibers by a simple grinding method under acidic conditions , 2010 .

[19]  Jorge F. J. Coelho,et al.  Temperature and pH responsive polymers based on chitosan: Applications and new graft copolymerization strategies based on living radical polymerization , 2010 .

[20]  Xiu-li Wang,et al.  Dissolution Behavior of Chitin in Ionic Liquids , 2010 .

[21]  J. Hamman.  Chitosan Based Polyelectrolyte Complexes as Potential Carrier Materials in Drug Delivery Systems , 2010, Marine drugs.

[22]  Y. Capan,et al.  LC-UV Determination of Melatonin from Chitosan Nanoparticles , 2010 .

[23]  P. Chang,et al.  Starch-based composites reinforced with novel chitin nanoparticles , 2010 .

[24]  P. Baldrick.  The safety of chitosan as a pharmaceutical excipient. , 2010, Regulatory toxicology and pharmacology : RTP.

[25]  S. Ifuku,et al.  Acetylation of chitin nanofibers and their transparent nanocomposite films. , 2010, Biomacromolecules.

[26]  Yimin Fan,et al.  Individual chitin nano-whiskers prepared from partially deacetylated α-chitin by fibril surface cationization , 2010 .

[27]  R. Muzzarelli.  Chitins and Chitosans as Immunoadjuvants and Non-Allergenic Drug Carriers , 2010, Marine drugs.

[28]  Sheng Yang,et al.  Chitosan kills Escherichia coli through damage to be of cell membrane mechanism , 2010 .

[29]  P. Supaphol,et al.  Wet-spun alginate/chitosan whiskers nanocomposite fibers: Preparation, characterization and release characteristic of the whiskers , 2010 .

[30]  M. Ishikawa,et al.  Performance of Electric Double-Layer Capacitor with Acidic Cellulose-Chitin Hybrid Gel Electrolyte , 2010 .

[31]  A. Casadevall,et al.  The use of chitosan to damage Cryptococcus neoformans biofilms. , 2010, Biomaterials.

[32]  Wim E Hennink,et al.  Chitosan-based delivery systems for protein therapeutics and antigens. , 2010, Advanced drug delivery reviews.

[33]  Miqin Zhang,et al.  Chitosan-based hydrogels for controlled, localized drug delivery. , 2010, Advanced drug delivery reviews.

[34]  Maria Jose Alonso,et al.  Chitosan-based nanostructures: a delivery platform for ocular therapeutics. , 2010, Advanced drug delivery reviews.

[35]  M. Thanou,et al.  Biodegradation, biodistribution and toxicity of chitosan. , 2010, Advanced drug delivery reviews.

[36]  C. Biliaderis,et al.  Metastability of nematic gels made of aqueous chitin nanocrystal dispersions. , 2010, Biomacromolecules.

[37]  K. Chennazhi,et al.  Chitosan conjugated DNA nanoparticles in gene therapy , 2010 .

[38]  Akihiko Takegawa,et al.  Preparation of chitin/cellulose composite gels and films with ionic liquids , 2010 .

[39]  Qian Wang,et al.  Efficient hydrolysis of chitosan in ionic liquids , 2009 .

[40]  D. Voinovich,et al.  Melatonin-loaded lecithin/chitosan nanoparticles: physicochemical characterisation and permeability through Caco-2 cell monolayers. , 2009, International journal of pharmaceutics.

[41]  H. Izawa,et al.  Acetylation of alpha-chitin in ionic liquids. , 2009, Carbohydrate research.

[42]  Yoshifumi Nakamura,et al.  Weak gel of chitin with ionic liquid, 1-allyl-3-methylimidazolium bromide. , 2009, International journal of biological macromolecules.

[43]  K. Marra,et al.  Synthesis and characterization of collagen/hyaluronan/chitosan composite sponges for potential biomedical applications. , 2009, Acta biomaterialia.

[44]  Carlo Rossi,et al.  FG90 chitosan as a new polymer for metronidazole mucoadhesive tablets for vaginal administration. , 2009, International journal of pharmaceutics.

[45]  Riccardo A.A. Muzzarelli,et al.  Genipin-crosslinked chitosan hydrogels as biomedical and pharmaceutical aids , 2009 .

[46]  H. Takeuchi,et al.  Modified chitosans for oral drug delivery. , 2009, Journal of pharmaceutical sciences.

[47]  H. Yano,et al.  Preparation of chitin nanofibers with a uniform width as alpha-chitin from crab shells. , 2009, Biomacromolecules.

[48]  R. Muzzarelli.  Chitins and chitosans for the repair of wounded skin, nerve, cartilage and bone , 2009 .

[49]  Laura Mercolini,et al.  Novel mucoadhesive nasal inserts based on chitosan/hyaluronate polyelectrolyte complexes for peptide and protein delivery , 2009 .

[50]  Cheng-Kang Lee,et al.  Preparation of biocompatible membranes by electrospinning , 2008 .

[51]  P. Supaphol,et al.  Fabrication, Structure, and Properties of Chitin Whisker-Reinforced Alginate Nanocomposite Fibers , 2008 .

[52]  V. Ambrogi,et al.  Chitosan and a modified chitosan as agents to improve performances of mucoadhesive vaginal gels. , 2008, Colloids and surfaces. B, Biointerfaces.

[53]  Peter Eaton,et al.  Atomic force microscopy study of the antibacterial effects of chitosans on Escherichia coli and Staphylococcus aureus. , 2008, Ultramicroscopy.

[54]  Y. Hu,et al.  Coagulation property of hyaluronic acid–collagen/chitosan complex film , 2008, Journal of materials science. Materials in medicine.

[55]  V. I. Gorbach,et al.  Comparative study of electrokinetic potentials and binding affinity of lipopolysaccharides-chitosan complexes. , 2008, Biophysical chemistry.

[56]  Y. Murata,et al.  Stabilization of α-lipoic acid by complex formation with chitosan. , 2008, Food chemistry.

[57]  Yimin Fan,et al.  Preparation of chitin nanofibers from squid pen beta-chitin by simple mechanical treatment under acid conditions. , 2008, Biomacromolecules.

[58]  A. P. Leonov,et al.  Biocompatible and biodegradable ultrafine fibrillar scaffold materials for tissue engineering by facile grafting of L-lactide onto chitosan. , 2008, Biomacromolecules.

[59]  V. Khutoryanskiy,et al.  Why is chitosan mucoadhesive? , 2008, Biomacromolecules.

[60]  S. Irie,et al.  A novel biomass-ionic liquid platform for the utilization of native chitin , 2008 .

[61]  P. Giunchedi,et al.  Spray-dried microspheres based on methylpyrrolidinone chitosan as new carrier for nasal administration of metoclopramide. , 2008, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

[62]  R. Muzzarelli,et al.  Chitin nanofibrils/chitosan glycolate composites as wound medicaments , 2007 .

[63]  T. Yui,et al.  Exhaustive crystal structure search and crystal modeling of β-chitin , 2007 .

[64]  W. Krause,et al.  Correlation of chitosan's rheological properties and its ability to electrospin. , 2007, Biomacromolecules.

[65]  Sei-ichi Aiba,et al.  Direct chitosan nanoscaffold formation via chitin whiskers , 2007 .

[66]  Xianfu Lin,et al.  N-methylimidazole significantly improves lipase-catalysed acylation of ribavirin. , 2007, Chemical communications.

[67]  P. Perugini,et al.  5-methyl-pyrrolidinone chitosan films as carriers for buccal administration of proteins , 2006, AAPS PharmSciTech.

[68]  F. Ahmad,et al.  Advances and potential applications of chitosan derivatives as mucoadhesive biomaterials in modern drug delivery , 2006, The Journal of pharmacy and pharmacology.

[69]  Suobo Zhang,et al.  Chitin and chitosan dissolved in ionic liquids as reversible sorbents of CO2 , 2006 .

[70]  K. Leong,et al.  Chitosan nanoparticles for oral drug and gene delivery , 2006, International journal of nanomedicine.

[71]  Jinghong Li,et al.  Composite system based on chitosan and room-temperature ionic liquid: direct electrochemistry and electrocatalysis of hemoglobin. , 2006, Biomacromolecules.

[72]  Y. Yamagata,et al.  Preparation of Polysaccharide Nanofiber Fabrics by Electrospray Deposition: Additive Effects of Poly(ethylene oxide) , 2005 .

[73]  Yao-xiong Huang,et al.  Study on biocompatibility of complexes of collagen-chitosan-sodium hyaluronate and cornea. , 2005, Artificial organs.

[74]  Liping Sun,et al.  Chitosan kills bacteria through cell membrane damage. , 2004, International journal of food microbiology.

[75]  G. Tosi,et al.  Spray-drying of solutions containing chitosan together with polyuronans and characterisation of the microspheres , 2004 .

[76]  K. Okuyama,et al.  Three D structures of chitosan. , 2004, International journal of biological macromolecules.

[77]  K. Hult,et al.  Vacuum-driven lipase-catalysed direct condensation of L-ascorbic acid and fatty acids in ionic liquids: synthesis of a natural surface active antioxidant , 2003 .

[78]  G. Tosi,et al.  Alkaline chitosan solutions. , 2003, Carbohydrate research.

[79]  P. Sun,et al.  A study on cytocompatible poly(chitosan-g-l-lactic acid) , 2003 .

[80]  T. Itoh,et al.  Efficient Lipase-Catalyzed Enantioselective Acylation in an Ionic Liquid Solvent System , 2003 .

[81]  J. Hamman,et al.  Evaluation of the Mucoadhesive Properties of N-Trimethyl Chitosan Chloride , 2003, Drug development and industrial pharmacy.

[82]  Robin D. Rogers,et al.  Dissolution of Cellose with Ionic Liquids , 2002 .

[83]  R. Ahvenainen,et al.  Chitosan disrupts the barrier properties of the outer membrane of gram-negative bacteria. , 2001, International journal of food microbiology.

[84]  Ann-Christine Albertsson,et al.  Synthesis and characterization of pH‐sensitive hydrogels based on chitosan and D,L‐lactic acid , 1999 .

[85]  Ann-Christine Albertsson,et al.  Structural change and swelling mechanism of pH-sensitive hydrogels based on chitosan and D,L-lactic acid , 1999 .

[86]  W. Glasser,et al.  Chitin derivatives. II. Time–temperature–transformation cure diagrams of the chitosan amidization process , 1999 .

[87]  R. Muzzarelli,et al.  Morphological study of bone regeneration in the presence of 6-oxychitin , 1999 .

[88]  Riccardo A.A. Muzzarelli,et al.  6-Oxychitins, novel hyaluronan-like regiospecifically carboxylated chitins , 1999 .

[89]  S. Davis,et al.  In vitro evaluation of the mucoadhesive properties of chitosan microspheres , 1998 .

[90]  W. Glasser,et al.  Chitin derivatives. I. Kinetics of the heat-induced conversion of chitosan to chitin , 1996 .

[91]  R. Muzzarelli,et al.  Antimicrobial properties of N-carboxybutyl chitosan , 1990, Antimicrobial Agents and Chemotherapy.

[92]  R. Muzzarelli.  Chitin Nanostructures in Living Organisms , 2011 .

[93]  Tara H McHugh,et al.  Nanocellulose reinforced chitosan composite films as affected by nanofiller loading and plasticizer content. , 2010, Journal of food science.

[94]  Sudesh Kumar Yadav,et al.  Biodegradable polymeric nanoparticles based drug delivery systems. , 2010, Colloids and surfaces. B, Biointerfaces.

[95]  S. Nair,et al.  Novel chitin and chitosan nanofibers in biomedical applications. , 2010, Biotechnology advances.

[96]  M. Garcia‐Fuentes,et al.  Chitosan-coated lipid nanocarriers for therapeutic applications , 2010 .

[97]  P. Supaphol,et al.  X‐ray diffraction and dynamic mechanical analyses of α‐chitin whisker‐reinforced poly(vinyl alcohol) nanocomposite nanofibers , 2010 .

[98]  R. Muzzarelli,et al.  Chitin and chitosan hydrogels , 2009 .

[99]  In-Yong Kim,et al.  Chitosan and its derivatives for tissue engineering applications. , 2008, Biotechnology advances.

[100]  T. Yui,et al.  Exhaustive crystal structure search and crystal modeling of beta-chitin. , 2007, International journal of biological macromolecules.

[101]  R. Bodmeier,et al.  In situ gelling, bioadhesive nasal inserts for extended drug delivery: in vitro characterization of a new nasal dosage form. , 2006, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

[102]  R. Muzzarelli,et al.  Chitosan chemistry : Relevance to the biomedical sciences , 2005 .

[103]  R. P. Swatloski,et al.  Room Temperature Ionic Liquids as Replacements for Traditional Organic Solvents and Their Applications Towards “Green Chemistry” in Separation Processes , 2003 .

[104]  R. Muzzarelli,et al.  Preparation and characterization of ampicillin loaded methylpyrrolidinone chitosan and chitosan microspheres. , 1998, Biomaterials.