Dissecting the puzzle of life: modularization of signal transduction networks

[1]  D. Koshland,et al.  An amplified sensitivity arising from covalent modification in biological systems. , 1981, Proceedings of the National Academy of Sciences of the United States of America.

[2]  P. Postma,et al.  Phosphoenolpyruvate:carbohydrate phosphotransferase system of bacteria. , 1985, Microbiological reviews.

[3]  L. Segel,et al.  On the validity of the steady state assumption of enzyme kinetics. , 1988, Bulletin of mathematical biology.

[4]  H. Westerhoff,et al.  Control theory of regulatory cascades. , 1991, Journal of theoretical biology.

[5]  J. S. Parkinson.  Signal transduction schemes of bacteria , 1993, Cell.

[6]  H. Westerhoff,et al.  Modular analysis of the control of complex metabolic pathways. , 1993, Biophysical chemistry.

[7]  J. Hoch,et al.  Two-component signal transduction , 1995 .

[8]  C. Marshall,et al.  Specificity of receptor tyrosine kinase signaling: Transient versus sustained extracellular signal-regulated kinase activation , 1995, Cell.

[9]  D. Bray.  Protein molecules as computational elements in living cells , 1995, Nature.

[10]  A. Levitzki.  Targeting signal transduction for disease therapy. , 1996, Current opinion in cell biology.

[11]  Chi-Ying F. Huang,et al.  Ultrasensitivity in the mitogen-activated protein kinase cascade. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[12]  J. Ferrell.  Tripping the switch fantastic: how a protein kinase cascade can convert graded inputs into switch-like outputs. , 1996, Trends in biochemical sciences.

[13]  B. Kholodenko,et al.  Quantification of information transfer via cellular signal transduction pathways , 1997, FEBS letters.

[14]  Ernst Dieter Gilles.  Network Theory for Chemical Processes , 1998 .

[15]  U. Bhalla,et al.  Emergent properties of networks of biological signaling pathways. , 1999, Science.

[16]  H. Schaeffer,et al.  Mitogen-Activated Protein Kinases: Specific Messages from Ubiquitous Messengers , 1999, Molecular and Cellular Biology.

[17]  B. Kholodenko,et al.  Quantification of Short Term Signaling by the Epidermal Growth Factor Receptor* , 1999, The Journal of Biological Chemistry.

[18]  J. Hopfield,et al.  From molecular to modular cell biology , 1999, Nature.

[19]  D. Fell,et al.  Differential feedback regulation of the MAPK cascade underlies the quantitative differences in EGF and NGF signalling in PC12 cells , 2000, FEBS letters.

[20]  J. Lengeler,et al.  Metabolic Networks: a Signal-Oriented Approach to Cellular Models , 2000, Biological chemistry.

[21]  Ann M Stock,et al.  Two-component signal transduction. , 2000, Annual review of biochemistry.

[22]  D. Lauffenburger,et al.  Bioengineering models of cell signaling. , 2000, Annual review of biomedical engineering.

[23]  B. Kholodenko,et al.  Negative feedback and ultrasensitivity can bring about oscillations in the mitogen-activated protein kinase cascades. , 2000, European journal of biochemistry.

[24]  E. Gilles,et al.  The organization of metabolic reaction networks: a signal-oriented approach to cellular models. , 2000, Metabolic engineering.

[25]  D. Lauffenburger,et al.  A Computational Study of Feedback Effects on Signal Dynamics in a Mitogen‐Activated Protein Kinase (MAPK) Pathway Model , 2001, Biotechnology progress.

[26]  E. Gilles,et al.  The organization of metabolic reaction networks. II. Signal processing in hierarchical structured functional units. , 2001, Metabolic engineering.

[27]  E. Gilles,et al.  The organization of metabolic reaction networks. III. Application for diauxic growth on glucose and lactose. , 2001, Metabolic engineering.

[28]  J. Ferrell,et al.  Bistability in the JNK cascade , 2001, Current Biology.

[29]  Y. Yarden.  The EGFR family and its ligands in human cancer. signalling mechanisms and therapeutic opportunities. , 2001, European journal of cancer.

[30]  J. Downward.  The ins and outs of signalling , 2001, Nature.

[31]  M. Karin,et al.  Mammalian MAP kinase signalling cascades , 2001, Nature.

[32]  B. Kholodenko,et al.  Modular response analysis of cellular regulatory networks. , 2002, Journal of theoretical biology.

[33]  J. Ferrell.  Self-perpetuating states in signal transduction: positive feedback, double-negative feedback and bistability. , 2002, Current opinion in cell biology.

[34]  G. Tortora,et al.  Anti-epidermal growth factor receptor drugs in cancer therapy , 2002, Expert opinion on investigational drugs.

[35]  Ernst Dieter Gilles,et al.  A network theory for the structured modelling of chemical processes , 2002 .

[36]  E. Gilles,et al.  Computational modeling of the dynamics of the MAP kinase cascade activated by surface and internalized EGF receptors , 2002, Nature Biotechnology.

[37]  H. Kitano.  Systems Biology: A Brief Overview , 2002, Science.

[38]  D. Lauffenburger,et al.  Computational modeling of the EGF-receptor system: a paradigm for systems biology. , 2003, Trends in cell biology.

[39]  Alexander Rives,et al.  Modular organization of cellular networks , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[40]  E. Gilles,et al.  Time hierarchies in the Escherichia coli carbohydrate uptake and metabolism. , 2004, Bio Systems.

[41]  E. Gilles,et al.  Analysis of two-component signal transduction by mathematical modeling using the KdpD/KdpE system of Escherichia coli. , 2004, Bio Systems.

[42]  A. Kremling,et al.  Modular analysis of signal transduction networks , 2004, IEEE Control Systems.