Sensorless control for a sophisticated artificial myocardial contraction by using shape memory alloy fibre

The authors have been developing an artificial myocardium, which is capable of supporting natural contractile function from the outside of the ventricle. The system was originally designed by using sophisticated covalent shape memory alloy fibres, and the surface did not implicate blood compatibility. The purpose of our study on the development of artificial myocardium was to achieve the assistance of myocardial functional reproduction by the integrative small mechanical elements without sensors, so that the effective circulatory support could be accomplished. In this study, the authors fabricated the prototype artificial myocardial assist unit composed of the sophisticated shape memory alloy fibre (Biometal), the diameter of which was 100 microns, and examined the mechanical response by using pulse width modulation (PWM) control method in each unit. Prior to the evaluation of dynamic characteristics, the relationship between strain and electric resistance and also the inditial response of each unit were obtained. The component for the PWM control was designed in order to regulate the myocardial contractile function, which consisted of an originally-designed RISC microcomputer with the input of displacement, and its output signal was controlled by pulse wave modulation method. As a result, the optimal PWM parameters were confirmed and the fibrous displacement was successfully regulated under the different heat transfer conditions simulating internal body temperature as well as bias tensile loading. Then it was indicated that this control theory might be applied for more sophisticated ventricular passive or active restraint by the artificial myocardium on physiological demand.

[1]  James W Long,et al.  Long-term destination therapy with the HeartMate XVE left ventricular assist device: improved outcomes since the REMATCH study. , 2005, Congestive heart failure.

[2]  Masayoshi Esashi,et al.  Addition of rhythm to non-pulsatile circulation. , 2004, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

[3]  Mitsuo Umezu,et al.  An artificial myocardium assist system: electrohydraulic ventricular actuation improves myocardial tissue perfusion in goats. , 2004, Artificial organs.

[4]  B. Horne,et al.  Effect of mechanical circulatory support on outcomes after heart transplantation in the modern era , 2004 .

[5]  Masayoshi Esashi,et al.  Artificial myocardium with an artificial baroreflex system using nano technology. , 2003, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

[6]  Mitsuo Umezu,et al.  Fabrication of Pulsatile Cardiac Tissue Grafts Using a Novel 3-Dimensional Cell Sheet Manipulation Technique and Temperature-Responsive Cell Culture Surfaces , 2002, Circulation research.

[7]  M C Oz,et al.  Long-term use of a left ventricular assist device for end-stage heart failure. , 2001, The New England journal of medicine.

[8]  H Suga,et al.  Dynamic cardiac compression improves contractile efficiency of the heart. , 1997, The Journal of thoracic and cardiovascular surgery.

[9]  J. Lowe,et al.  Direct mechanical ventricular actuation: a review. , 1991, Resuscitation.

[10]  J Ross,et al.  Contractile State of the Left Ventricle in Man: Instantaneous Tension‐Velocity‐Length Relations in Patients With And Without Disease of the Left Ventricular Myocardium , 1968, Circulation research.

[11]  J. V. Gilfrich,et al.  Effect of Low‐Temperature Phase Changes on the Mechanical Properties of Alloys near Composition TiNi , 1963 .

[12]  B. Horne,et al.  Effect of mechanical circulatory support on outcomes after heart transplantation. , 2006, The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation.

[13]  Y. Saijo,et al.  An Innovative Approach to Evaluate a Cardiac Function Based on Surface Measurement , 2005, 2005 IEEE Engineering in Medicine and Biology 27th Annual Conference.

[14]  R. Novick,et al.  The Registry of the International Society for Heart and Lung Transplantation: fifteenth official report--1998. , 1998, The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation.

[15]  D. Honma,et al.  SHAPE MEMORY EFFECT IN Ti-Ni ALLOY DURING RAPID HEATING. , 1982 .

[16]  N Ramasamy,et al.  FURTHER STUDY OF NITINOL WIRE AS CONTRACTILE ARTIFICIAL MUSCLE FOR AN ARTIFICIAL HEART. , 1976, Cardiovascular diseases.