No Association Between Glutathione Peroxidase Pro198Leu Polymorphism and Breast Cancer Risk

Selenium-dependent glutathione peroxidase (GPX1) is a cytosolic antioxidant enzyme that neutralizes H2O2 to water and oxygen ([1][1]). A GPX1 Pro→Leu polymorphism exists at codon 198, with the variant Leu allele being less responsive than the common Pro allele to the stimulation of enzyme activity

[1]  D. Hunter,et al.  No association between GPX1 Pro198Leu and breast cancer risk. , 2004, Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology.

[2]  A. Neugut,et al.  Myeloperoxidase Genotype, Fruit and Vegetable Consumption, and Breast Cancer Risk , 2004, Cancer Research.

[3]  A. Neugut,et al.  Environmental tobacco smoke and breast cancer incidence. , 2004, Environmental research.

[4]  A. Neugut,et al.  Fruits, vegetables, and micronutrients in relation to breast cancer modified by menopause and hormone receptor status. , 2004, Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology.

[5]  H. Nishiyama,et al.  Increased risk of bladder cancer associated with a glutathione peroxidase 1 codon 198 variant. , 2004, The Journal of urology.

[6]  I. Andrulis,et al.  Genetic Variants of GPX1 and SOD2 and Breast Cancer Risk at the Ontario Site of the Breast Cancer Family Registry , 2004, Cancer Epidemiology Biomarkers & Prevention.

[7]  A. Diamond,et al.  Role of glutathione peroxidase 1 in breast cancer: loss of heterozygosity and allelic differences in the response to selenium. , 2003, Cancer research.

[8]  Mary Beth Terry,et al.  The Long Island Breast Cancer Study Project: Description of a Multi-Institutional Collaboration to Identify Environmental Risk Factors for Breast Cancer , 2002, Breast Cancer Research and Treatment.

[9]  D. Albanes,et al.  Glutathione peroxidase codon 198 polymorphism variant increases lung cancer risk. , 2000, Cancer research.

[10]  P Griffiths,et al.  Mice with a Homozygous Null Mutation for the Most Abundant Glutathione Peroxidase, Gpx1, Show Increased Susceptibility to the Oxidative Stress-inducing Agents Paraquat and Hydrogen Peroxide* , 1998, The Journal of Biological Chemistry.

[11]  D. Hosmer,et al.  Applied Logistic Regression , 1991 .

[12]  C. Ambrosone.  Oxidants and antioxidants in breast cancer. , 2000, Antioxidants & redox signaling.