Corticotropin-releasing factor type II (CRF₂) receptors in the bed nucleus of the stria terminalis modulate conditioned defeat in Syrian hamsters (Mesocricetus auratus).

In Syrian hamsters (Mesocricetus auratus), social defeat produces a subsequent increase in submissive and defensive behavior and a loss of normal territorial aggression, which the authors have called conditioned defeat. In this study, the authors investigated the effect of blocking corticotropin-releasing factor (CRF) Type I and Type II receptors on conditioned defeat. Intracerebroventricular infusion of the CRF-sub-2 receptor antagonist antisauvagine-30 prior to testing significantly reduced conditioned defeat compared with vehicle controls, whereas the CRF-sub-1 receptor antagonist CP-154,526 had no effect. Also, infusion of antisauvagine-30 into the bed nucleus of the stria terminalis (BNST) 15 min, but not immediately, prior to testing reduced conditioned defeat in a dose-dependent manner. The authors' results provide evidence that CRF-sub-2 receptors in the BNST, but not CRF-sub-1 receptors, are an important component in the neural circuitry regulating conditioned defeat.

[1]  A. Jasnow,et al.  N-methyl-d-aspartate receptors in the amygdala are necessary for the acquisition and expression of conditioned defeat , 2004, Neuroscience.

[2]  Daan,et al.  Changes in Behaviour and Body Weight Following a Single or Double Social Defeat in Rats. , 1996, Stress.

[3]  F. Dautzenberg,et al.  125I-Antisauvagine-30: a novel and specific high-affinity radioligand for the characterization of corticotropin-releasing factor type 2 receptors , 2001, Neuropharmacology.

[4]  Paul E. Sawchenko,et al.  Mice deficient for corticotropin-releasing hormone receptor-2 display anxiety-like behaviour and are hypersensitive to stress , 2000, Nature Genetics.

[5]  A. Jasnow,et al.  Acute and Chronic Social Defeat Suppresses Humoral Immunity of Male Syrian Hamsters (Mesocricetus auratus) , 2001, Hormones and Behavior.

[6]  Robert L. Spencer,et al.  Visible burrow system as a model of chronic social stress: Behavioral and neuroendocrine correlates , 1995, Psychoneuroendocrinology.

[7]  A. Jasnow,et al.  Differential effects of two corticotropin-releasing factor antagonists on conditioned defeat in male Syrian hamsters (Mesocricetus auratus) , 1999, Brain Research.

[8]  S. Chaki,et al.  Receptor binding, behavioral, and electrophysiological profiles of nonpeptide corticotropin-releasing factor subtype 1 receptor antagonists CRA1000 and CRA1001. , 1999, The Journal of pharmacology and experimental therapeutics.

[9]  N. Kalin,et al.  Reduction of Stress-Induced Behavior by Antagonism of Corticotropin-Releasing Hormone 2 (CRH2) Receptors in Lateral Septum or CRH1 Receptors in Amygdala , 2002, The Journal of Neuroscience.

[10]  P. Sawchenko,et al.  Distribution of mRNAs encoding CRF receptors in brain and pituitary of rat and mouse , 2000, The Journal of comparative neurology.

[11]  M. Nijsen,et al.  The Role of the CRH Type 1 Receptor in Autonomic Responses to Corticotropin-Releasing Hormone in the Rat , 2000, Neuropsychopharmacology.

[12]  J. Radulovic,et al.  Modulation of Learning and Anxiety by Corticotropin-Releasing Factor (CRF) and Stress: Differential Roles of CRF Receptors 1 and 2 , 1999, The Journal of Neuroscience.

[13]  G. Koob,et al.  Reduced anxiety-like and cognitive performance in mice lacking the corticotropin-releasing factor receptor 1 1 Published on the World Wide Web on 27 November 1998. 1 , 1999, Brain Research.

[14]  S. Maier,et al.  Corticotropin Releasing Hormone Type 2 Receptors in the Dorsal Raphe Nucleus Mediate the Behavioral Consequences of Uncontrollable Stress , 2003, The Journal of Neuroscience.

[15]  H. Ohata,et al.  Both corticotropin-releasing factor receptor type 1 and type 2 are involved in stress-induced inhibition of food intake in rats , 2004, Psychopharmacology.

[16]  G. Koob,et al.  Corticotropin Releasing Factor Receptor 1–Deficient Mice Display Decreased Anxiety, Impaired Stress Response, and Aberrant Neuroendocrine Development , 1998, Neuron.

[17]  Anne W. Schmidt,et al.  The pharmacology of CP-154,526, a non-peptide antagonist of the CRH1 receptor: a review. , 2003, CNS drug reviews.

[18]  P. Sawchenko,et al.  Do Centrally Administered Neuropeptides Access Cognate Receptors?: An Analysis in the Central Corticotropin-Releasing Factor System , 2000, The Journal of Neuroscience.

[19]  Michael Davis,et al.  Involvement of central amygdalar and bed nucleus of the stria terminalis corticotropin-releasing factor in behavioral responses to social defeat. , 2004, Behavioral neuroscience.

[20]  A. Jasnow,et al.  Activation of GABAA receptors in the amygdala blocks the acquisition and expression of conditioned defeat in Syrian hamsters , 2001, Brain Research.

[21]  G. Koob,et al.  Corticotropin-releasing factor antagonist reduces emotionality in socially defeated rats via direct neurotropic action , 1992, Brain Research.

[22]  Anne W. Schmidt,et al.  CP-154,526: a potent and selective nonpeptide antagonist of corticotropin releasing factor receptors. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[23]  E. De Souza,et al.  Localization of novel corticotropin-releasing factor receptor (CRF2) mRNA expression to specific subcortical nuclei in rat brain: comparison with CRF1 receptor mRNA expression , 1995, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[24]  Susan E. Murray,et al.  Abnormal adaptations to stress and impaired cardiovascular function in mice lacking corticotropin-releasing hormone receptor-2 , 2000, Nature Genetics.

[25]  M. Rosenfeld,et al.  Structural requirements for peptidic antagonists of the corticotropin-releasing factor receptor (CRFR): development of CRFR2beta-selective antisauvagine-30. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[26]  O. Hermanson,et al.  Deletion of Crhr2 reveals an anxiolytic role for corticotropin-releasing hormone receptor-2 , 2000, Nature Genetics.

[27]  G. Perrault,et al.  Characterization of the behavioral profile of the non-peptide CRF receptor antagonist CP-154,526 in anxiety models in rodents Comparison with diazepam and buspirone , 1998, Psychopharmacology.

[28]  G. Koob,et al.  Characterization of a novel and potent corticotropin-releasing factor antagonist in rats. , 1994, The Journal of pharmacology and experimental therapeutics.

[29]  M. Smith,et al.  Attenuation of fear conditioning by antisense inhibition of brain corticotropin releasing factor-2 receptor. , 2001, Brain research. Molecular brain research.

[30]  T. Lovenberg,et al.  Corticotropin-releasing factor CRF1, but not CRF2, receptors mediate anxiogenic-like behavior , 1997, Regulatory Peptides.

[31]  R. Sapolsky,et al.  Hypercortisolism among socially subordinate wild baboons originates at the CNS level. , 1989, Archives of general psychiatry.

[32]  L. Takahashi,et al.  Antagonism of CRF2 receptors produces anxiolytic behavior in animal models of anxiety , 2001, Brain Research.

[33]  F. Holsboer,et al.  Chronic infusion of a CRH1 receptor antisense oligodeoxynucleotide into the central nucleus of the amygdala reduced anxiety-related behavior in socially defeated rats , 1995, Regulatory Peptides.

[34]  S. Maier,et al.  The Impact of the Nonpeptide Corticotropin-Releasing Hormone Antagonist Antalarmin on Behavioral and Endocrine Responses to Stress* *This research was supported by NIMH Grant MH-50479 and the Undergraduate Research Opportunities Program at the University of Colorado at Boulder. , 1999, Endocrinology.

[35]  M. Potegal,et al.  Conditioned defeat in the Syrian golden hamster (Mesocricetus auratus). , 1993, Behavioral and neural biology.

[36]  G. Koob,et al.  Human urocortin II: mild locomotor suppressive and delayed anxiolytic-like effects of a novel corticotropin-releasing factor related peptide , 2002, Brain Research.

[37]  M. Geyer,et al.  Role of corticotropin releasing factor (CRF) receptors 1 and 2 in CRF-potentiated acoustic startle in mice , 2003, Psychopharmacology.

[38]  M. Koch,et al.  Corticotropin‐releasing Factor in the Caudal Pontine Reticular Nucleus Mediates the Expression of Fear‐potentiated Startle in the Rat , 1997, The European journal of neuroscience.

[39]  J. Hagan,et al.  The behavioural effects of corticotropin-releasing factor-related peptides in rats , 1998, Psychopharmacology.

[40]  Craig W. Berridge,et al.  Physiological and behavioral responses to corticotropin-releasing factor administration: is CRF a mediator of anxiety or stress responses? , 1990, Brain Research Reviews.

[41]  C. Ferris,et al.  Acute and repeated exposure to social conflict in male golden hamsters: Increases in plasma POMC-peptides and cortisol and decreases in plasma testosterone , 1991, Hormones and Behavior.

[42]  G. Griebel,et al.  4-(2-Chloro-4-methoxy-5-methylphenyl)-N-[(1S)-2-cyclopropyl-1-(3-fluoro-4-methylphenyl)ethyl]5-methyl-N-(2-propynyl)-1, 3-thiazol-2-amine hydrochloride (SSR125543A), a potent and selective corticotrophin-releasing factor(1) receptor antagonist. II. Characterization in rodent models of stress-related , 2002, The Journal of pharmacology and experimental therapeutics.

[43]  F. Holsboer,et al.  Impaired stress response and reduced anxiety in mice lacking a functional corticotropin-releasing hormone receptor 1 , 1998, Nature Genetics.

[44]  A. Jasnow,et al.  Conditioned defeat in male and female syrian hamsters , 2003, Hormones and Behavior.

[45]  F. Holsboer,et al.  Differential behavioural effects of chronic infusion of CRH 1 and CRH 2 receptor antisense oligonucleotides into the rat brain. , 1999, Journal of psychiatric research.

[46]  L. P. Morin,et al.  stereotaxic atlas of the golden hamster brain , 2001 .

[47]  J. Falk.  Physiology and Behavior. , 1973 .

[48]  G. Koob,et al.  Effect of corticotropin-releasing factor antagonist on behavioral and neuroendocrine responses during exposure to defensive burying paradigm in rats , 1994, Physiology & Behavior.

[49]  N. Ling,et al.  Pharmacological evidence supporting a role for central corticotropin-releasing factor(2) receptors in behavioral, but not endocrine, response to environmental stress. , 2002, The Journal of pharmacology and experimental therapeutics.