Mitochondrial dysfunction governs immunometabolism in leukocytes of patients with acute-on-chronic liver failure.

[1]  C. Junot,et al.  Assessing the role of amino acids in systemic inflammation and organ failure in patients with ACLF. , 2020, Journal of hepatology.

[2]  W. Guo,et al.  ATF4 activation promotes hepatic mitochondrial dysfunction by repressing NRF1–TFAM signalling in alcoholic steatohepatitis , 2020, Gut.

[3]  M. Manns,et al.  The PREDICT study uncovers three clinical courses in acutely decompensated cirrhosis with distinct pathophysiology (120/120). , 2020, Journal of hepatology.

[4]  A. Périanin,et al.  The innate immune cells in cirrhosis. , 2020, Journal of hepatology.

[5]  Y. Modis,et al.  FAMIN Is a Multifunctional Purine Enzyme Enabling the Purine Nucleotide Cycle , 2020, Cell.

[6]  B. Colsch,et al.  Blood metabolomics uncovers inflammation-associated mitochondrial dysfunction as a potential mechanism underlying ACLF. , 2019, Journal of hepatology.

[7]  David K. Finlay,et al.  Competition for nutrients and its role in controlling immune responses , 2019, Nature Communications.

[8]  M. Álvarez-Mon,et al.  Dysfunctional Immune Response in Acute-on-Chronic Liver Failure: It Takes Two to Tango , 2019, Front. Immunol..

[9]  C. Piantadosi,et al.  Peripheral Blood Mononuclear Cells Demonstrate Mitochondrial Damage Clearance During Sepsis , 2019, Critical care medicine.

[10]  Maxim N. Artyomov,et al.  Itaconate: the poster child of metabolic reprogramming in macrophage function , 2019, Nature Reviews Immunology.

[11]  T. Roskams,et al.  Inhibition of glutamine synthetase in monocytes from patients with acute-on-chronic liver failure resuscitates their antibacterial and inflammatory capacity , 2018, Gut.

[12]  T. Asselah,et al.  Mitochondrial Dysfunction and Signaling in Chronic Liver Diseases. , 2018, Gastroenterology.

[13]  C. Libert,et al.  Reprogramming of basic metabolic pathways in microbial sepsis: therapeutic targets at last? , 2018, EMBO molecular medicine.

[14]  J. Trebicka,et al.  Fibroblast growth factor 21 is an early predictor of acute‐on‐chronic liver failure in critically ill patients with cirrhosis , 2018, Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society.

[15]  Richard Moreau,et al.  Systemic inflammation in decompensated cirrhosis: Characterization and role in acute‐on‐chronic liver failure , 2016, Hepatology.

[16]  L. Joosten,et al.  Broad defects in the energy metabolism of leukocytes underlie immunoparalysis in sepsis , 2016, Nature Immunology.

[17]  F. Villarroya,et al.  GDF-15 Is Elevated in Children with Mitochondrial Diseases and Is Induced by Mitochondrial Dysfunction , 2016, PloS one.

[18]  E. Mills,et al.  Reprogramming mitochondrial metabolism in macrophages as an anti‐inflammatory signal , 2016, European journal of immunology.

[19]  Xianlin Han,et al.  Impaired mitochondrial fat oxidation induces adaptive remodeling of muscle metabolism , 2015, Proceedings of the National Academy of Sciences.

[20]  Qiang Li,et al.  Mitochondrial respiratory dysfunctions of blood mononuclear cells link with cardiac disturbance in patients with early-stage heart failure , 2015, Scientific Reports.

[21]  Abhishek K. Jha,et al.  Network integration of parallel metabolic and transcriptional data reveals metabolic modules that regulate macrophage polarization. , 2015, Immunity.

[22]  Philip A. Kramer,et al.  A review of the mitochondrial and glycolytic metabolism in human platelets and leukocytes: Implications for their use as bioenergetic biomarkers , 2014, Redox biology.

[23]  R. Moreau,et al.  Acute-on-chronic liver failure is a distinct syndrome that develops in patients with acute decompensation of cirrhosis. , 2013, Gastroenterology.

[24]  Nobuyuki Itoh,et al.  Autophagy deficiency leads to protection from obesity and insulin resistance by inducing Fgf21 as a mitokine , 2012, Nature Medicine.

[25]  Ò. Miró,et al.  The effects of sepsis on mitochondria. , 2012, The Journal of infectious diseases.

[26]  D. Mathis,et al.  Immunometabolism: an emerging frontier , 2011, Nature Reviews Immunology.

[27]  J. Tschopp,et al.  A role for mitochondria in NLRP3 inflammasome activation , 2011, Nature.

[28]  S. Black,et al.  CARNITINE HOMEOSTASIS, MITOCHONDRIAL FUNCTION, AND CARDIOVASCULAR DISEASE. , 2009, Drug discovery today. Disease mechanisms.

[29]  M. Koenig.  Presentation and diagnosis of mitochondrial disorders in children. , 2008, Pediatric Neurology.

[30]  R. Curi,et al.  Glutamine and glutamate—their central role in cell metabolism and function , 2003, Cell biochemistry and function.

[31]  Su-Min Lee,et al.  Control of Mitochondrial Redox Balance and Cellular Defense against Oxidative Damage by Mitochondrial NADP+-dependent Isocitrate Dehydrogenase* , 2001, The Journal of Biological Chemistry.

[32]  Jimmy D Bell,et al.  In vivo and in vitro hepatic phosphorus-31 magnetic resonance spectroscopy and electron microscopy in chronic ductopenic rejection of human liver allografts , 1998, Gut.

[33]  T. Herlin,et al.  Energy metabolism of human neutrophils during phagocytosis. , 1982, The Journal of clinical investigation.

[34]  H. Krebs,et al.  The redox state of free nicotinamide-adenine dinucleotide in the cytoplasm and mitochondria of rat liver. , 1967, The Biochemical journal.

[35]  M. J. Phillips.  Electron microscopy of the liver. , 1967, Postgraduate medicine.