Clinical safety and feasibility of a newly developed, simple algorithm for decision-making on neurovascular bundle preservation in radical prostatectomy.

OBJECTIVE We investigated the clinical safety and feasibility of an algorithm we developed for the decision-making on neurovascular bundle preservation in radical prostatectomy to decrease the incidence of positive surgical margins. METHODS We prospectively applied our algorithm to 82 patients (164 prostate sides) with clinically localized prostate cancer who underwent radical prostatectomy at our institution between October 2004 and September 2006. The algorithm was developed using the apical core characteristics, clinical T stage, preoperative prostate-specific antigen level and Gleason sum. All prostate sides were divided into two groups by the algorithm: 115 sides (70.1%) were qualified for neurovascular bundle preservation (favorable algorithm side group) and 49 sides (29.9%) for non-neurovascular bundle preservation (unfavorable algorithm side group). RESULTS Median patient age was 66 years (range: 52-77) and median prostate-specific antigen was 7.1 ng/ml (range: 1.4-29.6). Overall, a positive surgical margin was observed in 23 sides (14.0%). The incidence of positive surgical margins at the apex was significantly correlated with the maximal diameter of the tumor in the apex (P < 0.001). The incidence of positive surgical margins was 8.7% in the favorable algorithm group, whereas it was 26.5% in the unfavorable algorithm group (P = 0.003). When this algorithm was combined with surgeons' intraoperative assessments, the incidence of positive surgical margins was 2.1% in neurovascular bundle preservation sides, compared with 25.0% in non-neurovascular bundle preservation sides (P = 0.002). CONCLUSIONS This simple algorithm is safe and feasible for the decision-making on neurovascular bundle preservation from the aspect of cancer control in radical prostatectomy patients.

[1]  M. Kattan,et al.  Factors predicting recovery of erections after radical prostatectomy. , 2000, The Journal of urology.

[2]  J. Melamed,et al.  The New York University nerve sparing algorithm decreases the rate of positive surgical margins following radical retropubic prostatectomy. , 2003, The Journal of urology.

[3]  G. Andriole,et al.  Do Margins Matter? The Prognostic Significance of Positive Surgical Margins in Radical Prostatectomy Specimens , 2008 .

[4]  M. Kattan,et al.  Prognostic impact of positive surgical margins in surgically treated prostate cancer: multi-institutional assessment of 5831 patients. , 2005, Urology.

[5]  B. Laven,et al.  Early release of the neurovascular bundles and optical loupe magnification lead to improved and earlier return of potency following radical retropubic prostatectomy. , 2005, The Journal of urology.

[6]  N. Masumori,et al.  Recovery of sexual function after nerve‐sparing radical prostatectomy or cystectomy , 2001, International journal of urology : official journal of the Japanese Urological Association.

[7]  N. Oakley Anatomic radical prostatectomy: evolution of the surgical technique , 1999 .

[8]  E. Bergstralh,et al.  The impact of surgical approach (nerve bundle preservation versus wide local excision) on surgical margins and biochemical recurrence following radical prostatectomy. , 2004, The Journal of urology.

[9]  T. Tsuzuki,et al.  Radical retropubic prostatectomy. How often do experienced surgeons have positive surgical margins when there is extraprostatic extension in the region of the neurovascular bundle? , 2005, The Journal of urology.

[10]  T. Tsuzuki,et al.  Prediction of extraprostatic extension in the neurovascular bundle based on prostate needle biopsy pathology, serum prostate specific antigen and digital rectal examination. , 2005, The Journal of urology.

[11]  T. Tsukamoto,et al.  The correlation between penile tumescence measured by the erectometer and penile rigidity by the RigiScan , 2001, International journal of urology.

[12]  E. Crawford,et al.  Radical retropubic prostatectomy. , 1983, The Journal of urology.

[13]  N. Masumori,et al.  Prognostic value of surgical margin status for biochemical recurrence following radical prostatectomy. , 2008, Japanese journal of clinical oncology.

[14]  P. Troncoso,et al.  Validation of criteria used to predict extraprostatic cancer extension: a tool for use in selecting patients for nerve sparing radical prostatectomy. , 2005, The Journal of urology.

[15]  T. Tsukamoto,et al.  Erectile dysfunction following nerve‐sparing radical retropubic prostatectomy and its treatment with sildenafil , 2005, International journal of urology : official journal of the Japanese Urological Association.

[16]  A. Haese*,et al.  Influence of nerve-sparing (NS) procedure during radical prostatectomy (RP) on margin status and biochemical failure. , 2005, European urology.

[17]  Y. Kaiho,et al.  Intraoperative electrophysiological confirmation of urinary continence after radical prostatectomy. , 2005, The Journal of urology.

[18]  M. Soloway,et al.  Incidence, etiology, location, prevention and treatment of positive surgical margins after radical prostatectomy for prostate cancer. , 1998, The Journal of urology.

[19]  U Pichlmeier,et al.  A validated strategy for side specific prediction of organ confined prostate cancer: a tool to select for nerve sparing radical prostatectomy. , 2001, The Journal of urology.

[20]  P. Walsh Radical prostatectomy, preservation of sexual function, cancer control. The controversy. , 1987, The Urologic clinics of North America.