Effects of in utero and environmental tobacco smoke exposure on lung function in boys and girls with and without asthma.

To investigate whether the effects of in utero exposure to maternal smoking and environmental tobacco smoke (ETS) exposure on lung function vary by sex or asthma status, we examined medical history and tobacco smoke exposure data for 5,263 participants in the Children's Health Study. At study enrollment, parents or guardians of each subject completed a questionnaire, and lung function was measured spirometrically with maximum forced expiratory flow-volume maneuvers. To assess the in utero effects of maternal smoking and ETS exposure on lung function, we used regression splines that accounted for the nonlinear relationship between pulmonary function, height, and age. In utero exposure to maternal smoking was independently associated with deficits in lung function that were larger for children with asthma. Boys and girls with a history of in utero exposure to maternal smoking showed deficits in maximum midexpiratory flow (MMEF) and a decrease in the FEV(1)/FVC ratio. As compared with children without asthma, boys with asthma had significantly larger deficits from in utero exposure in FVC, MMEF, and FEV(1)/FVC, and girls with asthma had larger decreases in FEV(1)/FVC. The effect of ETS exposure varied by children's gender and asthma status. Deficits in flows associated with current ETS exposure were present in children with and without asthma but were significant only among children without asthma. Past ETS exposure was associated with reduced FEV(1), MMEF, and FEV(1)/FVC among boys with asthma. In contrast, past ETS exposure was associated with decreased flow rates in girls without asthma. In summary, both in utero exposure to maternal smoking and ETS exposure were associated with persistent deficits in lung function. The effects of in utero exposure were greatest among children with asthma.

[1]  Yasutaka Osada.  Maternal smoking during pregnancy, environmental tobacco smoke exposure and childhood lung function. Gilliland, F. G., Berhane, K., McConnell, R., Gauderman, W. J., Vora, H., Rappaport, E. B., Avol, E., and Peters, J.M.: Throrax, 55(4): 271-276, 2000.(Abstracts of foreign literature) , 2001 .

[2]  Edward B Rappaport,et al.  environmental tobacco smoke exposure and childhood lung function , 2022 .

[3]  J. Malo,et al.  Maternal smoking and childhood asthma. , 1999, American journal of epidemiology.

[4]  C. Ulrik.  Outcome of asthma: longitudinal changes in lung function. , 1999, The European respiratory journal.

[5]  K. Pinkerton,et al.  Perinatal exposure to aged and diluted sidestream cigarette smoke produces airway hyperresponsiveness in older rats. , 1999, Toxicology and applied pharmacology.

[6]  S J London,et al.  A study of twelve Southern California communities with differing levels and types of air pollution. I. Prevalence of respiratory morbidity. , 1999, American journal of respiratory and critical care medicine.

[7]  W S Linn,et al.  A study of twelve Southern California communities with differing levels and types of air pollution. II. Effects on pulmonary function. , 1999, American journal of respiratory and critical care medicine.

[8]  D. Strachan,et al.  Parental smoking and spirometric indices in children , 1998 .

[9]  J. Hanrahan,et al.  Antenatal interventions in childhood asthma. , 1998, The European respiratory journal. Supplement.

[10]  K. Carlsen,et al.  In utero exposure to cigarette smoking influences lung function at birth. , 1997, The European respiratory journal.

[11]  J. Stocks,et al.  Lung development and early origins of childhood respiratory illness. , 1997, British medical bulletin.

[12]  P. Lee.  Health effects of exposure to environmental tobacco smoke. California Environmental Protection Agency. , 1997, Tobacco control.

[13]  P. Sly,et al.  Effects of maternal smoking during pregnancy and a family history of asthma on respiratory function in newborn infants , 1996, The Lancet.

[14]  W. Jędrychowski,et al.  [Cigarette smoking of mothers in pregnancy and environmental tobacco smoke as factors of increasing susceptibility of older children to acute respiratory infections]. , 1996, Przeglad epidemiologiczny.

[15]  D. Dockery,et al.  Environmental tobacco smoke, wheezing, and asthma in children in 24 communities. , 1996, American journal of respiratory and critical care medicine.

[16]  I. Tager,et al.  Maternal smoking during pregnancy. Effects on lung function during the first 18 months of life. , 1995, American journal of respiratory and critical care medicine.

[17]  D. Dockery,et al.  Racial differences in the association between maternal smoking during pregnancy and lung function in children. , 1995, American journal of respiratory and critical care medicine.

[18]  A. Woolcock,et al.  Effect of passive smoking, asthma, and respiratory infection on lung function in Australian children , 1994, Pediatric pulmonology.

[19]  D. Dockery,et al.  Maternal smoking during pregnancy as a predictor of lung function in children. , 1994, American journal of epidemiology.

[20]  D. Dockery,et al.  A longitudinal study of the effects of parental smoking on pulmonary function in children 6-18 years. , 1994, American journal of respiratory and critical care medicine.

[21]  M. Villa,et al.  Relationship between cotinine levels, household and personal smoking habit and season in 9-14 year old children. , 1994, The European respiratory journal.

[22]  D. Dockery,et al.  Race and gender differences in respiratory illness prevalence and their relationship to environmental exposures in children 7 to 14 years of age. , 1993, The American review of respiratory disease.

[23]  F. Speizer,et al.  Lung function, pre- and post-natal smoke exposure, and wheezing in the first year of life. , 1993, The American review of respiratory disease.

[24]  F. Speizer,et al.  The effect of maternal smoking during pregnancy on early infant lung function. , 1992, The American review of respiratory disease.

[25]  Phil A. Silva,et al.  Longitudinal effects of passive smoking on pulmonary function in New Zealand children. , 1992, The American review of respiratory disease.

[26]  M. Lebowitz,et al.  Smoking and symptom effects on the curves of lung function growth and decline. , 1991, The American review of respiratory disease.

[27]  F. Kauffmann,et al.  In utero exposure to parental smoking, cotinine measurements, and cord blood IgE. , 1991, The Journal of allergy and clinical immunology.

[28]  J S Boleij,et al.  Respiratory health effects of the indoor environment in a population of Dutch children. , 1990, The American review of respiratory disease.

[29]  J. Samet,et al.  Variability of measures of exposure to environmental tobacco smoke in the home. , 1990, The American review of respiratory disease.

[30]  David W. Scott.  The New S Language , 1990 .

[31]  J. Samet,et al.  Questionnaire assessment of lifetime and recent exposure to environmental tobacco smoke. , 1989, American journal of epidemiology.

[32]  F. Speizer,et al.  The natural history of forced expiratory volumes. Effect of cigarette smoking and respiratory symptoms. , 1988, The American review of respiratory disease.

[33]  A. Murray,et al.  Passive smoking and the seasonal difference of severity of asthma in children. , 1988, Chest.

[34]  F. Speizer,et al.  The effect of maternal cigarette smoking on the pulmonary function of children and adolescents. Analyses of data from two populations. , 1987, The American review of respiratory disease.

[35]  A. Breslin,et al.  Passive cigarette smoking and patients with asthma. , 1985, The Medical journal of Australia.

[36]  F. Speizer,et al.  Longitudinal study of the effects of maternal smoking on pulmonary function in children. , 1983, The New England journal of medicine.

[37]  L. Taussig,et al.  "As the twig is bent, the tree inclines" (perhaps) , 2015, The American review of respiratory disease.

[38]  M. Lebowitz,et al.  Epidemiologic observations on eosinophilia and its relation to respiratory disorders. , 2015, The American review of respiratory disease.

[39]  B. Burrows,et al.  The prevalence and incidence of asthma and asthma-like symptoms in a general population sample. , 1980, The American review of respiratory disease.

[40]  M. Burr,et al.  A community survey of asthmatic characteristics. , 1975, Thorax.