The effect of the Asp175Asn and Glu180Gly TPM1 mutations on actin-myosin interaction during the ATPase cycle.

[1]  P. Robinson,et al.  The effect of the dilated cardiomyopathy-causing Glu40Lys TPM1 mutation on actin-myosin interactions during the ATPase cycle. , 2011, Biochemical and biophysical research communications.

[2]  C. Redwood,et al.  Hypertrophic cardiomyopathy-causing Asp175asn and Glu180gly Tpm1 mutations shift tropomyosin strands further towards the open position during the ATPase cycle. , 2011, Biochemical and biophysical research communications.

[3]  P. Chase,et al.  Several cardiomyopathy causing mutations on tropomyosin either destabilize the active state of actomyosin or alter the binding properties of tropomyosin. , 2011, Biochemical and biophysical research communications.

[4]  Katherine A. Sheehan,et al.  Functional effects of a tropomyosin mutation linked to FHC contribute to maladaptation during acidosis. , 2011, Journal of molecular and cellular cardiology.

[5]  Stefan Fischer,et al.  Tropomyosin position on F-actin revealed by EM reconstruction and computational chemistry. , 2011, Biophysical journal.

[6]  D. Heeley,et al.  Mechanism of Regulation of Native Cardiac Muscle Thin Filaments by Rigor Cardiac Myosin-S1 and Calcium* , 2010, The Journal of Biological Chemistry.

[7]  G. Jagatheesan,et al.  Investigations into tropomyosin function using mouse models. , 2010, Journal of molecular and cellular cardiology.

[8]  Birgit Funke,et al.  Familial dilated cardiomyopathy caused by an alpha-tropomyosin mutation: the distinctive natural history of sarcomeric dilated cardiomyopathy. , 2010, Journal of the American College of Cardiology.

[9]  M. Kawai,et al.  The Effect of Hypertrophic Cardiomyopathy (HCM) Mutations of Tropomyosin on Force Generation and Cross-Bridge Kinetics in Thin-Filament Reconstituted Bovine Cardiac Muscle Fibers , 2010 .

[10]  P. Robinson,et al.  The effect of the dilated cardiomyopathy-causing mutation Glu54Lys of alpha-tropomyosin on actin-myosin interactions during the ATPase cycle. , 2009, Archives of biochemistry and biophysics.

[11]  C. Redwood,et al.  Modulation of the effects of tropomyosin on actin and myosin conformational changes by troponin and Ca2+. , 2009, Biochimica et biophysica acta.

[12]  P. Robinson,et al.  Dilated cardiomyopathy mutations in alpha-tropomyosin inhibit its movement during the ATPase cycle. , 2009, Biochemical and biophysical research communications.

[13]  William Lehman,et al.  Structural basis for the activation of muscle contraction by troponin and tropomyosin. , 2008, Journal of molecular biology.

[14]  David D. Thomas,et al.  Structure and dynamics of the force-generating domain of myosin probed by multifrequency electron paramagnetic resonance. , 2008, Biophysical journal.

[15]  G. Jagatheesan,et al.  The role of tropomyosin in heart disease. , 2008, Advances in experimental medicine and biology.

[16]  S. Morimoto.  Sarcomeric proteins and inherited cardiomyopathies. , 2008, Cardiovascular research.

[17]  P. J. Griffiths,et al.  Dilated and Hypertrophic Cardiomyopathy Mutations in Troponin and &agr;-Tropomyosin Have Opposing Effects on the Calcium Affinity of Cardiac Thin Filaments , 2007, Circulation research.

[18]  G. Boivin,et al.  Rescue of tropomyosin-induced familial hypertrophic cardiomyopathy mice by transgenesis. , 2007, American journal of physiology. Heart and circulatory physiology.

[19]  M. Geeves,et al.  Role of tropomyosin isoforms in the calcium sensitivity of striated muscle thin filaments , 2007, Journal of Muscle Research and Cell Motility.

[20]  T. Burghardt,et al.  Rotation of actin monomers during isometric contraction of skeletal muscle. , 2007, Journal of biomedical optics.

[21]  S. Ishiwata,et al.  Use of thin filament reconstituted muscle fibres to probe the mechanism of force generation , 2006, Journal of Muscle Research & Cell Motility.

[22]  Chen Xu,et al.  An atomic model of the thin filament in the relaxed and Ca2+-activated states. , 2006, Journal of molecular biology.

[23]  J. Borejdo,et al.  Measuring Rotations of a Few Cross-Bridges in Skeletal Muscle , 2006, Experimental biology and medicine.

[24]  J. Potter,et al.  Functional Consequences of Hypertrophic and Dilated Cardiomyopathy-causing Mutations in α-Tropomyosin* , 2005, Journal of Biological Chemistry.

[25]  H. Watkins,et al.  Dilated Cardiomyopathy Mutations in Three Thin Filament Regulatory Proteins Result in a Common Functional Phenotype* , 2005, Journal of Biological Chemistry.

[26]  Chen Xu,et al.  Single particle analysis of relaxed and activated muscle thin filaments. , 2005, Journal of molecular biology.

[27]  Kenneth C Holmes,et al.  The molecular mechanism of muscle contraction. , 2005, Advances in protein chemistry.

[28]  K C Holmes,et al.  The structure of the rigor complex and its implications for the power stroke. , 2004, Philosophical transactions of the Royal Society of London. Series B, Biological sciences.

[29]  M. Geeves,et al.  Effects of two familial hypertrophic cardiomyopathy mutations in alpha-tropomyosin, Asp175Asn and Glu180Gly, on the thermal unfolding of actin-bound tropomyosin. , 2004, Biophysical journal.

[30]  C. Ramos,et al.  Effects of cardiomyopathic mutations on the biochemical and biophysical properties of the human alpha-tropomyosin. , 2004, European journal of biochemistry.

[31]  David D. Thomas,et al.  Structural dynamics of actin during active interaction with myosin: different effects of weakly and strongly bound myosin heads. , 2004, Biochemistry.

[32]  A. Wrzosek,et al.  Behavior of caldesmon upon interaction of thin filaments with myosin subfragment 1 in ghost fibers. , 2004, Biochimica et biophysica acta.

[33]  C G dos Remedios,et al.  Fluorescence depolarization of actin filaments in reconstructed myofibers: the effect of S1 or pPDM-S1 on movements of distinct areas of actin. , 2004, Biophysical journal.

[34]  C. Farah,et al.  Ca2+-induced Rolling of Tropomyosin in Muscle Thin Filaments , 2004, Journal of Biological Chemistry.

[35]  S. Ishiwata,et al.  The effect of tropomyosin on force and elementary steps of the cross‐bridge cycle in reconstituted bovine myocardium , 2004, The Journal of physiology.

[36]  T. Burghardt,et al.  Changes in orientation of actin during contraction of muscle. , 2004, Biophysical journal.

[37]  O. Andreev,et al.  Fluorescence polarization study of the rigor complexes formed at different degrees of saturation of actin filaments with myosin subfragment-1 , 1995, Journal of Muscle Research & Cell Motility.

[38]  R. Goody,et al.  Stereochemical aspects of the interaction of myosin and actomyosin with nucleotides , 1980, Journal of Muscle Research & Cell Motility.

[39]  R. Prabhakar,et al.  Altered signaling surrounding the C-lobe of cardiac troponin C in myofilaments containing an α-tropomyosin mutation linked to familial hypertrophic cardiomyopathy , 2003 .

[40]  J. Metzger,et al.  Cardiac Dysfunction in Hypertrophic Cardiomyopathy Mutant Tropomyosin Mice Is Transgene-Dependent, Hypertrophy-Independent, and Improved by &bgr;-Blockade , 2002, Circulation research.

[41]  G. Boivin,et al.  A familial hypertrophic cardiomyopathy alpha-tropomyosin mutation causes severe cardiac hypertrophy and death in mice. , 2001, Journal of molecular and cellular cardiology.

[42]  T. Burghardt,et al.  Conformation of myosin interdomain interactions during contraction: deductions from muscle fibers using polarized fluorescence. , 2001, Biochemistry.

[43]  B. Wolska,et al.  Altered hemodynamics in transgenic mice harboring mutant tropomyosin linked to hypertrophic cardiomyopathy. , 2000, American journal of physiology. Heart and circulatory physiology.

[44]  Steven B Marston,et al.  A simple method for measuring the relative force exerted by myosin on actin filaments in the in vitro motility assay: evidence that tropomyosin and troponin increase force in single thin filaments. , 2000, The Biochemical journal.

[45]  J. Moraczewska,et al.  Proteolytic cleavage of actin within the DNase-I-binding loop changes the conformation of F-actin and its sensitivity to myosin binding. , 2000, Biochimica et biophysica acta.

[46]  M. Khoroshev,et al.  [Cleavage of DNA-binding loops of actin by subtilisin prevent formation of a strong type of myosin binding with actin]. , 2000, Tsitologiia.

[47]  B. Brenner,et al.  Kinetics of thin filament activation probed by fluorescence of N-((2-(iodoacetoxy)ethyl)-N-methyl)amino-7-nitrobenz-2-oxa-1,3-diazole-labeled troponin I incorporated into skinned fibers of rabbit psoas muscle: implications for regulation of muscle contraction. , 1999, Biophysical journal.

[48]  H. Watkins,et al.  Properties of mutant contractile proteins that cause hypertrophic cardiomyopathy. , 1999, Cardiovascular Research.

[49]  M. Irving,et al.  Dynamic measurement of myosin light-chain-domain tilt and twist in muscle contraction , 1999, Nature.

[50]  M. Geeves,et al.  Cooperativity and switching within the three-state model of muscle regulation. , 1999, Biochemistry.

[51]  Y. Borovikov.  Conformational changes of contractile proteins and their role in muscle contraction. , 1999, International review of cytology.

[52]  M. Geeves,et al.  Actin-tropomyosin activation of myosin subfragment 1 ATPase and thin filament cooperativity. The role of tropomyosin flexibility and end-to-end interactions. , 1997, Biochemistry.

[53]  J. Seidman,et al.  Effects of two familial hypertrophic cardiomyopathy-causing mutations on alpha-tropomyosin structure and function. , 1997, Biochemistry.

[54]  K. Holmes.  The swinging lever-arm hypothesis of muscle contraction , 1997, Current Biology.

[55]  J. Corrie,et al.  Fluorescence polarization of skeletal muscle fibers labeled with rhodamine isomers on the myosin heavy chain. , 1996, Biophysical journal.

[56]  S. Ishiwata,et al.  Structural and functional reconstitution of thin filaments in the contractile apparatus of cardiac muscle. , 1996, Biophysical journal.

[57]  R. Moss,et al.  Calcium alone does not fully activate the thin filament for S1 binding to rigor myofibrils. , 1996, Biophysical journal.

[58]  D. D. Thomas,et al.  Orientation of intermediate nucleotide states of indane dione spin-labeled myosin heads in muscle fibers. , 1996, Biophysical journal.

[59]  R A Milligan,et al.  Protein-protein interactions in the rigor actomyosin complex. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[60]  W. Lehman,et al.  Steric-blocking by tropomyosin visualized in relaxed vertebrate muscle thin filaments. , 1995, Journal of molecular biology.

[61]  Malcolm Irving,et al.  Tilting of the light-chain region of myosin during step length changes and active force generation in skeletal muscle , 1995, Nature.

[62]  D. D. Thomas,et al.  A spin label that binds to myosin heads in muscle fibers with its principal axis parallel to the fiber axis. , 1994, Biophysical journal.

[63]  F. Reinach,et al.  Functional alpha-tropomyosin produced in Escherichia coli. A dipeptide extension can substitute the amino-terminal acetyl group. , 1994, The Journal of biological chemistry.

[64]  M. Geeves,et al.  Regulation of the interaction between actin and myosin subfragment 1: evidence for three states of the thin filament. , 1993, Biophysical journal.

[65]  R A Milligan,et al.  Structure of the actin-myosin complex and its implications for muscle contraction. , 1993, Science.

[66]  B. Yus,et al.  Polarization microfluorimetry study of interaction between myosin head and F-actin in muscle fibers. , 1991 .

[67]  Khoroshev Mi,et al.  [The ghost muscle fiber with thin filaments reconstructed from nonmuscle actin--a model for studying the cytoskeleton using polarization microfluorimetry]. , 1991 .

[68]  Toshio Yanagida,et al.  Force measurements by micromanipulation of a single actin filament by glass needles , 1988, Nature.

[69]  Y. Ishii,et al.  Fluorescence probe studies of the state of tropomyosin in reconstituted muscle thin filaments. , 1987, Biochemistry.

[70]  D. Szczesna,et al.  Conformational changes of F-actin in myosin-free ghost single fibre induced by either phosphorylated or dephosphorylated heavy meromyosin. , 1987, Biochimica et biophysica acta.

[71]  N. Thompson,et al.  Motion of myosin cross-bridges in skeletal muscle fibers studied by time-resolved fluorescence anisotropy decay. , 1985, Biochemistry.

[72]  F. Oosawa,et al.  Studies on conformation of F-actin in muscle fibers in the relaxed state, rigor, and during contraction using fluorescent phalloidin , 1983, The Journal of cell biology.

[73]  N. Gusev,et al.  Effect of troponin-tropomyosin complex and Ca2+ on conformational changes in F-actin induced by myosin subfragment-1. , 1983, European journal of biochemistry.

[74]  T. Ando,et al.  Cross-bridge orientation in skeletal muscle measured by linear dichroism of an extrinsic chromophore. , 1982, Journal of molecular biology.

[75]  L. Smillie,et al.  Structural interpretation of the two-site binding of troponin on the muscle thin filament. , 1981, Journal of molecular biology.

[76]  P. Wahl,et al.  Study of actin and its interactions with heavy meromyosin and the regulatory proteins by the pulse fluorimetry in polarized light of a fluorescent probe attached to an actin cysteine. , 1978, European journal of biochemistry.

[77]  A. Weeds,et al.  Studies on the chymotryptic digestion of myosin. Effects of divalent cations on proteolytic susceptibility. , 1977, Journal of molecular biology.

[78]  J Borejdo,et al.  Polarization of fluorescence from single skinned glycerinated rabbit psoas fibers in rigor and relaxation. , 1977, Biochimica et biophysica acta.

[79]  A. Mclachlan,et al.  The 14-fold periodicity in α-tropomyosin and the interaction with actin , 1976 .

[80]  R. Mendelson,et al.  Polarization from a helix of fluorophores and its relation to that obtained from muscle. , 1975, Biophysical journal.

[81]  F. Oosawa,et al.  Conformational changes of F-actin in the thin filaments of muscle induced in vivo and in vitro by calcium ions. , 1974, Journal of molecular biology.

[82]  Rozanov IuM,et al.  Estimation of the magnitude of depolarization induced by microobjectives during polarization fluorescence measurements , 1974 .

[83]  R. Mendelson,et al.  Use of fluorescence polarization to observe changes in attitude of S-1 moieties in muscle fibers. , 1974, Biophysical journal.

[84]  John M. Murray,et al.  Manifestations of Cooperative Behavior in the Regulated Actin Filament during Actin-Activated ATP Hydrolysis in the Presence of Calcium , 1973 .

[85]  J. Spudich,et al.  The regulation of rabbit skeletal muscle contraction. I. Biochemical studies of the interaction of the tropomyosin-troponin complex with actin and the proteolytic fragments of myosin. , 1971, The Journal of biological chemistry.

[86]  A. Szent-Györgyi.  Meromyosins, the subunits of myosin , 1953 .