Cholangiocyte pathobiology

[1]  S. Glaser,et al.  Ductular Reaction in Liver Diseases: Pathological Mechanisms and Translational Significances , 2018, Hepatology.

[2]  A. Franchitto,et al.  Contribution of Resident Stem Cells to Liver and Biliary Tree Regeneration in Human Diseases , 2018, International journal of molecular sciences.

[3]  S. Bicciato,et al.  Transcriptional addiction in cancer cells is mediated by YAP/TAZ through BRD4 , 2018, Nature Medicine.

[4]  D. Thorburn,et al.  MAIT cells are chronically activated in patients with autoimmune liver disease and promote profibrogenic hepatic stellate cell activation , 2018, Hepatology.

[5]  R. Coppel,et al.  The immunobiology of mucosal-associated invariant T cell (MAIT) function in primary biliary cholangitis: Regulation by cholic acid-induced Interleukin-7. , 2018, Journal of autoimmunity.

[6]  Kari A. Huppert,et al.  De novo formation of the biliary system by TGFβ-mediated hepatocyte transdifferentiation , 2018, Nature.

[7]  F. Lemaigre,et al.  Development of the liver: Insights into organ and tissue morphogenesis. , 2018, Journal of hepatology.

[8]  R. Fiorotto,et al.  β‐Catenin and interleukin‐1β–dependent chemokine (C‐X‐C motif) ligand 10 production drives progression of disease in a mouse model of congenital hepatic fibrosis , 2018, Hepatology.

[9]  N. LaRusso,et al.  MicroRNA‐506 promotes primary biliary cholangitis–like features in cholangiocytes and immune activation , 2018, Hepatology.

[10]  R. Sandberg,et al.  Mouse Model of Alagille Syndrome and Mechanisms of Jagged1 Missense Mutations , 2017, Gastroenterology.

[11]  R. Fiorotto,et al.  Pathophysiologic implications of innate immunity and autoinflammation in the biliary epithelium. , 2017, Biochimica et biophysica acta. Molecular basis of disease.

[12]  M. Marzioni,et al.  Role of inflammation and proinflammatory cytokines in cholangiocyte pathophysiology. , 2017, Biochimica et biophysica acta. Molecular basis of disease.

[13]  N. LaRusso,et al.  Physiology of Cholngiocytes , 2018 .

[14]  Anthony Atala,et al.  Self‐assembled liver organoids recapitulate hepatobiliary organogenesis in vitro , 2018, Hepatology.

[15]  T. Karlsen,et al.  Primary sclerosing cholangitis - a comprehensive review. , 2017, Journal of hepatology.

[16]  R. Fiorotto,et al.  Notch signaling and progenitor/ductular reaction in steatohepatitis , 2017, PloS one.

[17]  T. Karlsen,et al.  The Microbiome in Primary Sclerosing Cholangitis: Current Evidence and Potential Concepts , 2017, Seminars in Liver Disease.

[18]  S. Piccolo,et al.  Mechanobiology of YAP and TAZ in physiology and disease , 2017, Nature Reviews Molecular Cell Biology.

[19]  M. Bartolini,et al.  Structural and functional integrity of human serum albumin: Analytical approaches and clinical relevance in patients with liver cirrhosis. , 2017, Journal of pharmaceutical and biomedical analysis.

[20]  M. Manns,et al.  Genetic association analysis identifies variants associated with disease progression in primary sclerosing cholangitis , 2017, Gut.

[21]  C. Spirlí,et al.  Emerging concepts in biliary repair and fibrosis. , 2017, American journal of physiology. Gastrointestinal and liver physiology.

[22]  T. Karlsen,et al.  Cholangiocytes and the environment in primary sclerosing cholangitis: where is the link? , 2017, Gut.

[23]  M. Grompe,et al.  Adult Mouse Liver Contains Two Distinct Populations of Cholangiocytes , 2017, Stem cell reports.

[24]  T. Karlsen,et al.  Reconstruction of the mouse extrahepatic biliary tree using primary human extrahepatic cholangiocyte organoids , 2017, Nature Medicine.

[25]  G. Gores,et al.  Development and Characterization of Cholangioids from Normal and Diseased Human Cholangiocytes as an In Vitro Model to Study Primary Sclerosing Cholangitis , 2017, Laboratory Investigation.

[26]  F. Lund-Johansen,et al.  Novel serum and bile protein markers predict primary sclerosing cholangitis disease severity and prognosis. , 2017, Journal of hepatology.

[27]  Shenghui He,et al.  Senescence in Health and Disease , 2017, Cell.

[28]  Wei-Yu Lu,et al.  Cholangiocytes act as Facultative Liver Stem Cells during Impaired Hepatocyte Regeneration , 2017, Nature.

[29]  S. Monga,et al.  Update on the Mechanisms of Liver Regeneration , 2017, Seminars in Liver Disease.

[30]  G. Michalopoulos.  Hepatostat: Liver regeneration and normal liver tissue maintenance , 2017, Hepatology.

[31]  L. Vallier,et al.  Directed differentiation of human induced pluripotent stem cells into functional cholangiocyte-like cells , 2017, Nature Protocols.

[32]  T. Karlsen,et al.  Nlrp3 Activation Induces Il-18 Synthesis and Affects the Epithelial Barrier Function in Reactive Cholangiocytes. , 2017, The American journal of pathology.

[33]  T. Karlsen,et al.  The role of natural killer T cells in a mouse model with spontaneous bile duct inflammation , 2017, Physiological reports.

[34]  T. D. de Assunção,et al.  Regenerative Medicine and the Biliary Tree , 2017, Seminars in Liver Disease.

[35]  K. Takeishi,et al.  Current strategies to generate mature human induced pluripotent stem cells derived cholangiocytes and future applications , 2017, Organogenesis.

[36]  G. Gores,et al.  Targeting senescent cholangiocytes and activated fibroblasts with Bcl-xL inhibitors ameliorates fibrosis in Mdr 2-/-mice , 2017 .

[37]  G. Gores,et al.  SOX17 regulates cholangiocyte differentiation and acts as a tumor suppressor in cholangiocarcinoma. , 2017, Journal of hepatology.

[38]  G. Cortopassi,et al.  Galectin‐3 regulates inflammasome activation in cholestatic liver injury , 2016, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[39]  T. Karlsen,et al.  Elevated interleukin‐8 in bile of patients with primary sclerosing cholangitis , 2016, Liver international : official journal of the International Association for the Study of the Liver.

[40]  T. Itoh.  Stem/progenitor cells in liver regeneration , 2016, Hepatology.

[41]  A. Miyajima,et al.  Heterogeneity and stochastic growth regulation of biliary epithelial cells dictate dynamic epithelial tissue remodeling , 2016, eLife.

[42]  G. Carpino,et al.  The hepatic, biliary, and pancreatic network of stem/progenitor cell niches in humans: A new reference frame for disease and regeneration , 2016, Hepatology.

[43]  K. Sekiguchi,et al.  Laminin 411 and 511 promote the cholangiocyte differentiation of human induced pluripotent stem cells. , 2016, Biochemical and biophysical research communications.

[44]  P. Klenerman,et al.  Biliary epithelium and liver B cells exposed to bacteria activate intrahepatic MAIT cells through MR1 , 2016, Journal of hepatology.

[45]  D. Schuppan,et al.  Macrophage recruitment by fibrocystin‐defective biliary epithelial cells promotes portal fibrosis in congenital hepatic fibrosis , 2016, Hepatology.

[46]  M. Grompe,et al.  Stem cells versus plasticity in liver and pancreas regeneration , 2016, Nature Cell Biology.

[47]  L. Fabris,et al.  Revisiting Epithelial-to-Mesenchymal Transition in Liver Fibrosis: Clues for a Better Understanding of the “Reactive” Biliary Epithelial Phenotype , 2016, Stem cells international.

[48]  Z. Yu,et al.  [Advances in pathogenesis, diagnosis and treatment of complement dysregulation-associated atypical hemolytic uremic syndrome]. , 2016, Zhonghua er ke za zhi = Chinese journal of pediatrics.

[49]  M. Trauner,et al.  Bile acids in regulation of inflammation and immunity: friend or foe? , 2016, Clinical and experimental rheumatology.

[50]  L. Fabris,et al.  Epithelial-to-Mesenchymal Transition and Cancer Invasiveness: What Can We Learn from Cholangiocarcinoma? , 2015, Journal of clinical medicine.

[51]  J. McCluskey,et al.  The burgeoning family of unconventional T cells , 2015, Nature Immunology.

[52]  G. Michalopoulos,et al.  Liver Stem Cells: Experimental Findings and Implications for Human Liver Disease. , 2015, Gastroenterology.

[53]  T. Karlsen,et al.  The biliary epithelium presents antigens to and activates natural killer T cells , 2015, Hepatology.

[54]  J. Prieto,et al.  CD8+ T cells undergo activation and programmed death-1 repression in the liver of aged Ae2a,b−/− mice favoring autoimmune cholangitis , 2015, Oncotarget.

[55]  A. Cole,et al.  Hepatic progenitor cells of biliary origin with liver repopulation capacity , 2015, Nature Cell Biology.

[56]  Shinichiro Ogawa,et al.  Directed differentiation of cholangiocytes from human pluripotent stem cells , 2015, Nature Biotechnology.

[57]  T. Evans,et al.  Orchestrating liver development , 2015, Development.

[58]  Rui Dong,et al.  Interleukin‐8: A critical chemokine in biliary atresia , 2015, Journal of gastroenterology and hepatology.

[59]  F. Lemaigre.  Determining the fate of hepatic cells by lineage tracing: Facts and pitfalls , 2015, Hepatology.

[60]  H. Shiraha,et al.  TLR4, TLR9, and NLRP3 in biliary epithelial cells of primary sclerosing cholangitis: Relationship with clinical characteristics , 2015, Journal of gastroenterology and hepatology.

[61]  Ruslan Medzhitov,et al.  Homeostasis, Inflammation, and Disease Susceptibility , 2015, Cell.

[62]  Y. Li,et al.  Development and Characterization of Human Induced Pluripotent Stem Cell-Derived Cholangiocytes , 2015, Laboratory Investigation.

[63]  B. Stanger.  Cellular homeostasis and repair in the mammalian liver. , 2015, Annual review of physiology.

[64]  M. Strazzabosco,et al.  Emerging roles of Notch signaling in liver disease , 2015, Hepatology.

[65]  R. Bataller,et al.  The biliary epithelium gives rise to liver progenitor cells , 2014, Hepatology.

[66]  E. Pikarsky,et al.  Adult hepatocytes are generated by self-duplication rather than stem cell differentiation. , 2014, Cell stem cell.

[67]  H. Willenbring,et al.  Evidence against a Stem Cell Origin of New Hepatocytes in a Common Mouse Model of Chronic Liver Injury , 2014, Cell reports.

[68]  N. LaRusso,et al.  Characterization of cultured cholangiocytes isolated from livers of patients with primary sclerosing cholangitis , 2014, Laboratory Investigation.

[69]  M. Grompe,et al.  Clonal tracing of Sox9+ liver progenitors in mouse oval cell injury , 2014, Hepatology.

[70]  L. Combettes,et al.  Generation of functional cholangiocyte-like cells from human pluripotent stem cells and HepaRG cells , 2014, Hepatology.

[71]  D. Adams,et al.  Vascular cell adhesion molecule 1 expression by biliary epithelium promotes persistence of inflammation by inhibiting effector T‐cell apoptosis , 2014, Hepatology.

[72]  J. Prieto,et al.  Anion exchanger 2 is critical for CD8+ T cells to maintain pHi homeostasis and modulate immune responses , 2014, European journal of immunology.

[73]  R. Medzhitov,et al.  Stress, inflammation, and defense of homeostasis. , 2014, Molecular cell.

[74]  A. Miyajima,et al.  Liver regeneration by stem/progenitor cells , 2014, Hepatology.

[75]  D. Stainier,et al.  Extensive conversion of hepatic biliary epithelial cells to hepatocytes after near total loss of hepatocytes in zebrafish. , 2014, Gastroenterology.

[76]  Huiqiang Lu,et al.  Regeneration of liver after extreme hepatocyte loss occurs mainly via biliary transdifferentiation in zebrafish. , 2014, Gastroenterology.

[77]  M. Nagino,et al.  Inhibition of Toll-like receptor 4 suppresses liver injury induced by biliary obstruction and subsequent intraportal lipopolysaccharide injection. , 2014, American journal of physiology. Gastrointestinal and liver physiology.

[78]  A. Ardura-Fabregat,et al.  Role of AE2 for pHi regulation in biliary epithelial cells , 2013, Front. Physiol..

[79]  R. Schwabe,et al.  Fate-tracing reveals hepatic stellate cells as dominant contributors to liver fibrosis independent of its etiology , 2013, Nature Communications.

[80]  L. Fabris,et al.  Vascular biology of the biliary epithelium , 2013, Journal of gastroenterology and hepatology.

[81]  J. Boyer,et al.  Bile formation and secretion. , 2013, Comprehensive Physiology.

[82]  R. Fiorotto,et al.  Notch signaling regulates tubular morphogenesis during repair from biliary damage in mice. , 2013, Journal of Hepatology.

[83]  N. LaRusso,et al.  Ciliary subcellular localization of TGR5 determines the cholangiocyte functional response to bile acid signaling. , 2013, American journal of physiology. Gastrointestinal and liver physiology.

[84]  A. Franchitto,et al.  Recent advances in the morphological and functional heterogeneity of the biliary epithelium , 2013, Experimental biology and medicine.

[85]  S. Monga,et al.  Cellular and molecular basis of liver development. , 2013, Comprehensive Physiology.

[86]  N. LaRusso,et al.  The dynamic biliary epithelia: molecules, pathways, and disease. , 2013, Journal of hepatology.

[87]  Hans Clevers,et al.  In vitro expansion of single Lgr5+ liver stem cells induced by Wnt-driven regeneration , 2013, Nature.

[88]  R. Mancinelli,et al.  Recent advances on the mechanisms regulating cholangiocyte proliferation and the significance of the neuroendocrine regulation of cholangiocyte pathophysiology. , 2012, Annals of translational medicine.

[89]  N. LaRusso,et al.  Physiology of cholangiocytes. , 2013, Comprehensive Physiology.

[90]  I. Leclercq,et al.  Liver progenitor cells yield functional hepatocytes in response to chronic liver injury in mice. , 2012, Gastroenterology.

[91]  D. Kavanagh,et al.  CXCR3-dependent recruitment and CCR6-mediated positioning of Th-17 cells in the inflamed liver , 2012, Journal of hepatology.

[92]  B. Stanger,et al.  Molecular mechanisms of liver and bile duct development , 2012, Wiley interdisciplinary reviews. Developmental biology.

[93]  Jean S. Campbell,et al.  Liver regeneration. , 2012, Journal of hepatology.

[94]  N. LaRusso,et al.  Up‐regulation of microRNA 506 leads to decreased Cl−/HCO3− anion exchanger 2 expression in biliary epithelium of patients with primary biliary cirrhosis , 2012, Hepatology.

[95]  L. Fabris,et al.  Development of the bile ducts: essentials for the clinical hepatologist. , 2012, Journal of hepatology.

[96]  Fanyin Meng,et al.  Interleukin-6 and its receptor, key players in hepatobiliary inflammation and cancer. , 2012, Translational gastrointestinal cancer.

[97]  T. Roskams,et al.  Macrophage-derived Wnt opposes Notch signaling to specify hepatic progenitor cell fate in chronic liver disease , 2012, Nature Medicine.

[98]  P. Schirmacher,et al.  S100A9 is a Biliary Protein Marker of Disease Activity in Primary Sclerosing Cholangitis , 2012, PloS one.

[99]  C. Paulusma,et al.  A biliary HCO3− umbrella constitutes a protective mechanism against bile acid‐induced injury in human cholangiocytes , 2012, Hepatology.

[100]  M. Kay,et al.  Fate tracing of mature hepatocytes in mouse liver homeostasis and regeneration. , 2011, The Journal of clinical investigation.

[101]  A. Franchitto,et al.  Castration inhibits biliary proliferation induced by bile duct obstruction: novel role for the autocrine trophic effect of testosterone. , 2011, American journal of physiology. Gastrointestinal and liver physiology.

[102]  T. Berg,et al.  Enhanced innate immune responsiveness and intolerance to intestinal endotoxins in human biliary epithelial cells contributes to chronic cholangitis , 2011, Liver international : official journal of the International Association for the Study of the Liver.

[103]  M. Trauner,et al.  Loss of CFTR affects biliary epithelium innate immunity and causes TLR4-NF-κB-mediated inflammatory response in mice. , 2011, Gastroenterology.

[104]  P. Lescuyer,et al.  A step further in the analysis of human bile proteome. , 2011, Journal of proteome research.

[105]  L. Fabris,et al.  Epithelial-mesenchymal interactions in biliary diseases. , 2011, Seminars in liver disease.

[106]  A. Antoniou,et al.  Biliary differentiation and bile duct morphogenesis in development and disease. , 2011, The international journal of biochemistry & cell biology.

[107]  J. Deng,et al.  Continuous cell supply from a Sox9-expressing progenitor zone in adult liver, exocrine pancreas and intestine , 2011, Nature Genetics.

[108]  N. LaRusso,et al.  Opisthorchis viverrini excretory/secretory products induce toll-like receptor 4 upregulation and production of interleukin 6 and 8 in cholangiocyte. , 2010, Parasitology international.

[109]  D. Rockey,et al.  Identification and Functional Characterization of TMEM16A, a Ca2+-activated Cl− Channel Activated by Extracellular Nucleotides, in Biliary Epithelium* , 2010, The Journal of Biological Chemistry.

[110]  N. LaRusso,et al.  Biliary exosomes influence cholangiocyte regulatory mechanisms and proliferation through interaction with primary cilia. , 2010, American journal of physiology. Gastrointestinal and liver physiology.

[111]  Yasunori Sato,et al.  Bile ductular cells undergoing cellular senescence increase in chronic liver diseases along with fibrous progression. , 2010, American journal of clinical pathology.

[112]  F. Lemaigre.  Molecular mechanisms of biliary development. , 2010, Progress in molecular biology and translational science.

[113]  J. Tchorz,et al.  Notch2 signaling promotes biliary epithelial cell fate specification and tubulogenesis during bile duct development in mice , 2009, Hepatology.

[114]  M. Grompe,et al.  Stem cells and liver regeneration. , 2009, Gastroenterology.

[115]  F. Lemaigre.  Mechanisms of liver development: concepts for understanding liver disorders and design of novel therapies. , 2009, Gastroenterology.

[116]  M. Gershwin,et al.  Lymphocyte recruitment and homing to the liver in primary biliary cirrhosis and primary sclerosing cholangitis , 2009, Seminars in Immunopathology.

[117]  D. Wendum,et al.  Bile salts control the antimicrobial peptide cathelicidin through nuclear receptors in the human biliary epithelium. , 2009, Gastroenterology.

[118]  K. Kaestner,et al.  Foxl1 is a marker of bipotential hepatic progenitor cells in mice , 2009, Hepatology.

[119]  A. Hofmann.  The enterohepatic circulation of bile acids in mammals: form and functions. , 2009, Frontiers in bioscience.

[120]  J. Boyer,et al.  OST alpha-OST beta: a key membrane transporter of bile acids and conjugated steroids. , 2009, Frontiers in bioscience.

[121]  N. LaRusso,et al.  Cholangiocyte primary cilia are chemosensory organelles that detect biliary nucleotides via P2Y12 purinergic receptors. , 2008, American journal of physiology. Gastrointestinal and liver physiology.

[122]  Nicholas F LaRusso,et al.  Cholangiocyte primary cilia in liver health and disease , 2008, Developmental dynamics : an official publication of the American Association of Anatomists.

[123]  G. Gores,et al.  Cholangiocarcinoma: Advances in pathogenesis, diagnosis, and treatment , 2008, Hepatology.

[124]  R. Mancinelli,et al.  Progesterone stimulates the proliferation of female and male cholangiocytes via autocrine/paracrine mechanisms. , 2008, American journal of physiology. Gastrointestinal and liver physiology.

[125]  R. Medzhitov.  Origin and physiological roles of inflammation , 2008, Nature.

[126]  L. Fabris,et al.  Functional Anatomy of Normal Bile Ducts , 2008, Anatomical record.

[127]  J. Prieto,et al.  Ae2a,b-deficient mice develop antimitochondrial antibodies and other features resembling primary biliary cirrhosis. , 2008, Gastroenterology.

[128]  F. Endo,et al.  FGF signaling segregates biliary cell‐lineage from chick hepatoblasts cooperatively with BMP4 and ECM components in vitro , 2008, Developmental dynamics : an official publication of the American Association of Anatomists.

[129]  D. Rickman,et al.  Stabilization of β‐catenin affects mouse embryonic liver growth and hepatoblast fate , 2007, Hepatology.

[130]  L. Boon,et al.  Coculture of human liver macrophages and cholangiocytes leads to CD40‐dependent apoptosis and cytokine secretion , 2007, Hepatology.

[131]  N. LaRusso,et al.  Cholangiocyte cilia express TRPV4 and detect changes in luminal tonicity inducing bicarbonate secretion , 2007, Proceedings of the National Academy of Sciences.

[132]  K. Isse,et al.  Innate immune response to double‐stranded RNA in biliary epithelial cells is associated with the pathogenesis of biliary atresia , 2007, Hepatology.

[133]  S. Glaser,et al.  The α2-adrenergic receptor agonist UK 14,304 inhibits secretin-stimulated ductal secretion by downregulation of the cAMP system in bile duct-ligated rats , 2007 .

[134]  R. Fiorotto,et al.  Analysis of liver repair mechanisms in Alagille syndrome and biliary atresia reveals a role for notch signaling. , 2007, The American journal of pathology.

[135]  K. Isse,et al.  IL‐8 expression by biliary epithelial cells is associated with neutrophilic infiltration and reactive bile ductules , 2007, Liver international : official journal of the International Association for the Study of the Liver.

[136]  Yasunori Sato,et al.  Interaction of Toll-like receptors with bacterial components induces expression of CDX2 and MUC2 in rat biliary epithelium in vivo and in culture , 2007, Laboratory Investigation.

[137]  A. Bergquist,et al.  Biliary epithelial cell antibodies link adaptive and innate immune responses in primary sclerosing cholangitis. , 2007, Gastroenterology.

[138]  I. Mackay,et al.  AMA production in primary biliary cirrhosis is promoted by the TLR9 ligand CpG and suppressed by potassium channel blockers , 2007, Hepatology.

[139]  G. Michalopoulos,et al.  Liver Regeneration , 1997, Journal of cellular physiology.

[140]  S. Glaser,et al.  Proliferating cholangiocytes: a neuroendocrine compartment in the diseased liver. , 2007, Gastroenterology.

[141]  S. Glaser,et al.  The alpha2-adrenergic receptor agonist UK 14,304 inhibits secretin-stimulated ductal secretion by downregulation of the cAMP system in bile duct-ligated rats. , 2007, American journal of physiology. Cell physiology.

[142]  Nicholas F LaRusso,et al.  Cholangiocyte cilia detect changes in luminal fluid flow and transmit them into intracellular Ca2+ and cAMP signaling. , 2006, Gastroenterology.

[143]  N. LaRusso,et al.  Isolation and characterization of cholangiocyte primary cilia. , 2006, American journal of physiology. Gastrointestinal and liver physiology.

[144]  A. Franchitto,et al.  Cholangiocytes and blood supply. , 2006, World journal of gastroenterology.

[145]  A. Franchitto,et al.  Estrogens and the pathophysiology of the biliary tree. , 2006, World journal of gastroenterology.

[146]  J. Prieto,et al.  Cholangiocyte anion exchange and biliary bicarbonate excretion. , 2006, World journal of gastroenterology.

[147]  G. Svegliati-Baroni,et al.  Estrogens maintain bile duct mass and reduce apoptosis after biliodigestive anastomosis in bile duct ligated rats. , 2006, Journal of hepatology.

[148]  J. Prieto,et al.  Bicarbonate-rich choleresis induced by secretin in normal rat is taurocholate-dependent and involves AE2 anion exchanger. , 2006, Hepatology.

[149]  J. Dranoff,et al.  Secretion of MCP-1/CCL2 by bile duct epithelia induces myofibroblastic transdifferentiation of portal fibroblasts. , 2006, American journal of physiology. Gastrointestinal and liver physiology.

[150]  J. Prieto,et al.  Bicarbonate‐rich choleresis induced by secretin in normal rat is taurocholate‐dependent and involves AE2 anion exchanger , 2006 .

[151]  P. Dawson,et al.  OSTα‐OSTβ: A major basolateral bile acid and steroid transporter in human intestinal, renal, and biliary epithelia , 2005 .

[152]  Hajime Isomoto,et al.  Interleukin 6 upregulates myeloid cell leukemia‐1 expression through a STAT3 pathway in cholangiocarcinoma cells , 2005, Hepatology.

[153]  N. LaRusso,et al.  Multiple TLRs Are Expressed in Human Cholangiocytes and Mediate Host Epithelial Defense Responses to Cryptosporidium parvum via Activation of NF-κB1 , 2005, The Journal of Immunology.

[154]  P. Courtoy,et al.  Control of liver cell fate decision by a gradient of TGF beta signaling modulated by Onecut transcription factors. , 2005, Genes & development.

[155]  Masahiro Ito,et al.  Hepatic expression of toll-like receptor 4 in primary biliary cirrhosis. , 2005, Journal of autoimmunity.

[156]  G. Gores,et al.  Interleukin-6 contributes to Mcl-1 up-regulation and TRAIL resistance via an Akt-signaling pathway in cholangiocarcinoma cells. , 2005, Gastroenterology.

[157]  D. Adams,et al.  CXC Chemokine Ligand 16 Promotes Integrin-Mediated Adhesion of Liver-Infiltrating Lymphocytes to Cholangiocytes and Hepatocytes within the Inflamed Human Liver1 , 2005, The Journal of Immunology.

[158]  M. Harada,et al.  Biliary epithelial cells regulate autoreactive T cells: Implications for biliary‐specific diseases , 2005, Hepatology.

[159]  P. Dawson,et al.  OSTalpha-OSTbeta: a major basolateral bile acid and steroid transporter in human intestinal, renal, and biliary epithelia. , 2005, Hepatology.

[160]  E. Porta,et al.  Ciliated biliary epithelial cells in the livers of non-human primates , 2005, Experientia.

[161]  T. Roskams,et al.  α‐1 adrenergic receptor agonists modulate ductal secretion of BDL rats via Ca2+‐ and PKC‐dependent stimulation of cAMP , 2004, Hepatology.

[162]  N. LaRusso,et al.  The cholangiopathies: disorders of biliary epithelia. , 2004, Gastroenterology.

[163]  S. Glaser,et al.  cAMP stimulates the secretory and proliferative capacity of the rat intrahepatic biliary epithelium through changes in the PKA/Src/MEK/ERK1/2 pathway. , 2004, Journal of hepatology.

[164]  T. Hirayama,et al.  Peptide antibiotic human beta‐defensin‐1 and ‐2 contribute to antimicrobial defense of the intrahepatic biliary tree , 2004, Hepatology.

[165]  A. Kamiya,et al.  TNF‐α regulates mouse fetal hepatic maturation induced by oncostatin M and extracellular matrices , 2004, Hepatology.

[166]  A. West,et al.  Nomenclature of the finer branches of the biliary tree: Canals, ductules, and ductular reactions in human livers , 2004, Hepatology.

[167]  C. Benz,et al.  [Primary sclerosing cholangitis]. , 2000, Der Internist.

[168]  T. Roskams,et al.  Progenitor cells in diseased human liver. , 2003, Seminars in liver disease.

[169]  K. Isse,et al.  Lipopolysaccharide Activates Nuclear Factor-KappaB through Toll-Like Receptors and Related Molecules in Cultured Biliary Epithelial Cells , 2003, Laboratory Investigation.

[170]  N. LaRusso,et al.  Agonist-induced Coordinated Trafficking of Functionally Related Transport Proteins for Water and Ions in Cholangiocytes* , 2003, Journal of Biological Chemistry.

[171]  G. Stoica,et al.  Dopaminergic inhibition of secretin-stimulated choleresis by increased PKC-gamma expression and decrease of PKA activity. , 2003, American journal of physiology. Gastrointestinal and liver physiology.

[172]  R. Hultcrantz,et al.  The Myofibroblastic Conversion of Peribiliary Fibrogenic Cells Distinct from Hepatic Stellate Cells Is Stimulated by Platelet-Derived Growth Factor During Liver Fibrogenesis , 2003, Laboratory Investigation.

[173]  M. Kaplan,et al.  Quantitation and phenotypic analysis of natural killer T cells in primary biliary cirrhosis using a human CD1d tetramer. , 2002, Gastroenterology.

[174]  D. Adams,et al.  The role of cholangiocytes in the development of chronic inflammatory liver disease. , 2002, Frontiers in bioscience : a journal and virtual library.

[175]  J. Neuberger,et al.  Defective regulation of cholangiocyte Cl−/HCO−3 and Na+/H+ exchanger activities in primary biliary cirrhosis , 2002, Hepatology.

[176]  S. Glaser,et al.  Stimulation of α2‐adrenergic receptor inhibits cholangiocarcinoma growth through modulation of Raf‐1 and B‐Raf activities , 2002 .

[177]  D. Adams,et al.  Homing of mucosal lymphocytes to the liver in the pathogenesis of hepatic complications of inflammatory bowel disease , 2002, The Lancet.

[178]  M. Nathanson,et al.  Bile duct epithelia regulate biliary bicarbonate excretion in normal rat liver. , 2001, Gastroenterology.

[179]  R. Cameron,et al.  Accumulation of macrophages in primary sclerosing cholangitis. , 2001, Clinical biochemistry.

[180]  J. Boyer,et al.  Cellular localization and up‐regulation of multidrug resistance–associated protein 3 in hepatocytes and cholangiocytes during obstructive cholestasis in rat liver , 2001, Hepatology.

[181]  N F LaRusso,et al.  Alternative splicing of the rat sodium/bile acid transporter changes its cellular localization and transport properties. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[182]  D. Alvaro,et al.  Regulation and deregulation of cholangiocyte proliferation. , 2000, Journal of hepatology.

[183]  J. Neuberger,et al.  Characterization and isolation of ductular cells coexpressing neural cell adhesion molecule and Bcl-2 from primary cholangiopathies and ductal plate malformations. , 2000, The American journal of pathology.

[184]  S. Glaser,et al.  Functional heterogeneity of the intrahepatic biliary epithelium , 2000, Hepatology.

[185]  H. Takikawa,et al.  ATP-dependent Transport of Bile Salts by Rat Multidrug Resistance-associated Protein 3 (Mrp3)* , 2000, The Journal of Biological Chemistry.

[186]  J. Martí-Climent,et al.  Assessment of biliary bicarbonate secretion in humans by positron emission tomography. , 1999, Gastroenterology.

[187]  G. Peters,et al.  MRP3, an organic anion transporter able to transport anti-cancer drugs. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[188]  R. Roman,et al.  Endogenous ATP release regulates Cl- secretion in cultured human and rat biliary epithelial cells. , 1999, American journal of physiology. Gastrointestinal and liver physiology.

[189]  B. Sobel,et al.  TNF- a and insulin, alone and synergistically, induce plasminogen activator inhibitor-1 expression in adipocytes , 1999 .

[190]  S. Glaser,et al.  Endothelin-1 inhibits secretin-stimulated ductal secretion by interacting with ETA receptors on large cholangiocytes. , 1998, American journal of physiology. Gastrointestinal and liver physiology.

[191]  E. Ritman,et al.  Anatomy of the human biliary system studied by quantitative computer‐aided three‐dimensional imaging techniques , 1998, Hepatology.

[192]  S. Milani,et al.  Increased expression of monocyte chemotactic protein-1 during active hepatic fibrogenesis: correlation with monocyte infiltration. , 1998, The American journal of pathology.

[193]  M. Strazzabosco,et al.  Liver and biliary problems in cystic fibrosis. , 1998, Seminars in liver disease.

[194]  P. Dawson,et al.  Rat cholangiocytes absorb bile acids at their apical domain via the ileal sodium-dependent bile acid transporter. , 1997, The Journal of clinical investigation.

[195]  S. Glaser,et al.  Gastrin inhibits secretin-induced ductal secretion by interaction with specific receptors on rat cholangiocytes. , 1997, American journal of physiology. Gastrointestinal and liver physiology.

[196]  J. Boyer,et al.  Role of kinases and phosphatases in the regulation of fluid secretion and Cl-/HCO3- exchange in cholangiocytes. , 1997, The American journal of physiology.

[197]  Colin C. Collins,et al.  Alagille syndrome is caused by mutations in human Jagged1, which encodes a ligand for Notch1 , 1997, Nature Genetics.

[198]  G. Svegliati-Baroni,et al.  Carrier-mediated transport of conjugated bile acids across the basolateral membrane of biliary epithelial cells. , 1997, The American journal of physiology.

[199]  S. Glaser,et al.  Large but not small intrahepatic bile ducts are involved in secretin-regulated ductal bile secretion. , 1997, The American journal of physiology.

[200]  N. LaRusso,et al.  Kinetic and molecular identification of sodium-dependent glucose transporter in normal rat cholangiocytes. , 1997, The American journal of physiology.

[201]  D. Adams,et al.  Inflammatory cytokines stimulate human biliary epithelial cells to express interleukin-8 and monocyte chemotactic protein-1. , 1997, Biochemical Society transactions.

[202]  J. Prieto,et al.  Decreased anion exchanger 2 immunoreactivity in the liver of patients with primary biliary cirrhosis , 1997, Hepatology.

[203]  D. Adams.  Biliary epithelial cells: innocent victims or active participants in immune-mediated liver disease? , 1996, The Journal of laboratory and clinical medicine.

[204]  G. Michalopoulos,et al.  Ductular reaction after submassive necrosis in humans. Special emphasis on analysis of ductular hepatocytes. , 1996, The American journal of pathology.

[205]  A. Jones,et al.  Intestinal immunisation with Escherichia coli protects rats against Escherichia coli induced cholangitis. , 1996, Gut.

[206]  N. LaRusso,et al.  Morphological, molecular, and functional heterogeneity of cholangiocytes from normal rat liver. , 1996, Gastroenterology.

[207]  N. LaRusso,et al.  Development and characterization of polarized primary cultures of rat intrahepatic bile duct epithelial cells. , 1996, Laboratory investigation; a journal of technical methods and pathology.

[208]  A. Malik,et al.  Arg-Gly-Asp peptide increases endothelial hydraulic conductivity: comparison with thrombin response. , 1995, The American journal of physiology.

[209]  N. LaRusso,et al.  Somatostatin inhibits secretin-induced ductal hypercholeresis and exocytosis by cholangiocytes. , 1995, The American journal of physiology.

[210]  M. Sharpe,et al.  Scatter factor/hepatocyte growth factor is essential for liver development , 1995, Nature.

[211]  V. Desmet.  Histopathology of cholestasis. , 1995, Verhandlungen der Deutschen Gesellschaft fur Pathologie.

[212]  D. Adams,et al.  Intercellular adhesion molecule-1 and MHC antigens on human intrahepatic bile duct cells: effect of pro-inflammatory cytokines. , 1993, Gut.

[213]  B. Markus,et al.  Establishment and immunological characterization of cultured human gallbladder epithelial cells , 1993, Hepatology.

[214]  A. Scheynius,et al.  Induced expression of heat‐shock protein on biliary epithelium in patients with primary sclerosing cholangitis and primary biliary cirrhosis , 1993, Hepatology.

[215]  G. Feldmann,et al.  Immunoperoxidase localization of ursodeoxycholic acid in rat biliary epithelial cells. Evidence for a cholehepatic circulation. , 2008, Liver.

[216]  G. Alpini,et al.  Secretin stimulates bile ductular secretory activity through the cAMP system. , 1992, The American journal of physiology.

[217]  K. Saito,et al.  Lactoferrin and lysozyme in the intrahepatic bile duct of normal livers and hepatolithiasis. An immunohistochemical study. , 1992, Journal of hepatology.

[218]  S. Williams,et al.  Liver and biliary problems in cystic fibrosis. , 1992, British medical bulletin.

[219]  H. Stein,et al.  Transforming growth factors beta 1 and beta 2 are differentially expressed in fibrotic liver disease. , 1991, The American journal of pathology.

[220]  N. LaRusso,et al.  Isolation and morphologic characterization of bile duct epithelial cells from normal rat liver. , 1989, Gastroenterology.

[221]  W. Brown,et al.  The liver and IgA: Immunological, cell biological and clinical implications , 1989, Hepatology.

[222]  K. Einarsson,et al.  Evidence that vasoactive intestinal peptide induces ductular secretion of bile in humans. , 1989, Gastroenterology.

[223]  J. Boyer,et al.  Biliary catabolism of glutathione and differential reabsorption of its amino acid constituents. , 1988, The American journal of physiology.

[224]  C. Johanson.  Benzodiazepine self-administration in rhesus monkeys: Estazolam, flurazepam and lorazepam , 1987, Pharmacology Biochemistry and Behavior.

[225]  A. van de Wiel,et al.  Characteristics of serum IgA and liver IgA deposits in alcoholic liver disease , 1987, Hepatology.

[226]  L. Sollid,et al.  Production and secretion of immunoglobulins in the gastrointestinal tract. , 1987, Annals of allergy.

[227]  J. Boyer,et al.  Intrabiliary glutathione hydrolysis. A source of glutamate in bile. , 1986, The Journal of biological chemistry.

[228]  E. Dickson,et al.  Primary Sclerosing Cholangitis , 1984, New England Journal of Medicine.

[229]  D. Kaminski,et al.  Effect of somatostatin and bombesin on secretin-stimulated ductular bile flow in dogs. , 1983, Gastroenterology.

[230]  W. Walker,et al.  Hepatobiliary Clearance of IgA Immune Complexes Formed in the Circulation , 2007, Hepatology.

[231]  P. D. Smith,et al.  IGA in human bile and liver. , 1981, Journal of immunology.

[232]  E. Robin.  Physiology of Membrane Disorders , 1979, Springer US.

[233]  I. Sternlieb,et al.  Special article: functional implications of human portal and bile ductular ultrastructure. , 1972, Gastroenterology.