Wnt signaling and cancer.
暂无分享,去创建一个
[1] D. Seldin,et al. Endogenous Protein Kinase CK2 Participates in Wnt Signaling in Mammary Epithelial Cells* , 2000, The Journal of Biological Chemistry.
[2] O. Hino,et al. beta-catenin mutations are absent in hepatocellular carcinomas of SV40 T-antigen transgenic mice. , 2000, International journal of oncology.
[3] Y. Jeng,et al. Somatic mutations of beta-catenin play a crucial role in the tumorigenesis of sporadic hepatoblastoma. , 2000, Cancer letters.
[4] Kris Vleminckx,et al. The p300/CBP acetyltransferases function as transcriptional coactivators of β‐catenin in vertebrates , 2000, The EMBO journal.
[5] Randall T. Moon,et al. The transcriptional coactivator CBP interacts with beta-catenin to activate gene expression. , 2000, The Journal of cell biology.
[6] T. Akiyama,et al. Down-regulation of β-Catenin by the Colorectal Tumor Suppressor APC Requires Association with Axin and β-Catenin* , 2000, The Journal of Biological Chemistry.
[7] K. Kinzler,et al. The beta-catenin binding domain of adenomatous polyposis coli is sufficient for tumor suppression. , 2000, Cancer research.
[8] M. Peifer,et al. Wnt signaling in oncogenesis and embryogenesis--a look outside the nucleus. , 2000, Science.
[9] A. Levine,et al. WISP-1 is a Wnt-1- and β-catenin-responsive oncogene , 2000, Genes & Development.
[10] M. Kirschner,et al. Control of beta-catenin stability: reconstitution of the cytoplasmic steps of the wnt pathway in Xenopus egg extracts. , 2000, Molecular cell.
[11] Yusuke Nakamura,et al. AXIN1 mutations in hepatocellular carcinomas, and growth suppression in cancer cells by virus-mediated transfer of AXIN1 , 2000, Nature Genetics.
[12] D. M. Ferkey,et al. Interaction among Gsk-3, Gbp, Axin, and APC in Xenopus Axis Specification , 2000, The Journal of cell biology.
[13] Naoto Ueno,et al. Interaction between Wnt and TGF-β signalling pathways during formation of Spemann's organizer , 2000, Nature.
[14] A. Üren,et al. Secreted Frizzled-related Protein-1 Binds Directly to Wingless and Is a Biphasic Modulator of Wnt Signaling* , 2000, The Journal of Biological Chemistry.
[15] M. Buendia,et al. Activation of β-catenin in epithelial and mesenchymal hepatoblastomas , 2000, Oncogene.
[16] R. Mariani-Costantini,et al. APC gene mutations and colorectal adenomatosis in familial adenomatous polyposis , 2000, British Journal of Cancer.
[17] T. Akiyama,et al. Down-regulation of beta-catenin by the colorectal tumor suppressor APC requires association with Axin and beta-catenin. , 2000, The Journal of biological chemistry.
[18] S. Olschwang,et al. Germline mutations of the APC gene in patients with familial adenomatous polyposis-associated thyroid carcinoma: results from a European cooperative study. , 2000, The Journal of clinical endocrinology and metabolism.
[19] A. Kispert,et al. SHH-N upregulates Sfrp2 to mediate its competitive interaction with WNT1 and WNT4 in the somitic mesoderm. , 2000, Development.
[20] M. Buendia,et al. Activation of beta-catenin in epithelial and mesenchymal hepatoblastomas. , 2000, Oncogene.
[21] S. Byers,et al. Cross-regulation of β-catenin–LEF/TCF and retinoid signaling pathways , 1999, Current Biology.
[22] M. Matsuda,et al. β-Catenin Mutations Are Frequent in Human Hepatocellular Carcinomas Associated with Hepatitis C Virus Infection , 1999 .
[23] B. Sanson,et al. A screen for identifying genes interacting with armadillo, the Drosophila homolog of beta-catenin. , 1999, Genetics.
[24] Sabine Tejpar,et al. Predominance of beta-catenin mutations and beta-catenin dysregulation in sporadic aggressive fibromatosis (desmoid tumor) , 1999, Oncogene.
[25] J. Papkoff,et al. A secreted frizzled related protein, FrzA, selectively associates with Wnt-1 protein and regulates wnt-1 signaling. , 1999, Journal of cell science.
[26] H Clevers,et al. TCF transcription factors: molecular switches in carcinogenesis. , 1999, Biochimica et biophysica acta.
[27] J. Jonkers,et al. Overexpression of Frat1 in transgenic mice leads to glomerulosclerosis and nephrotic syndrome, and provides direct evidence for the involvement of Frat1 in lymphoma progression , 1999, Oncogene.
[28] T. Pramila,et al. Human frizzled 1 interacts with transforming Wnts to transduce a TCF dependent transcriptional response , 1999, Oncogene.
[29] L. Williams,et al. Casein kinase iepsilon in the wnt pathway: regulation of beta-catenin function. , 1999, Proceedings of the National Academy of Sciences of the United States of America.
[30] R. Moll,et al. Analysis of β-Catenin Gene Mutations in Pancreatic Tumors , 1999, Digestion.
[31] K. Matsumoto,et al. Distinct Domains of Mouse Dishevelled Are Responsible for the c-Jun N-terminal Kinase/Stress-activated Protein Kinase Activation and the Axis Formation in Vertebrates* , 1999, The Journal of Biological Chemistry.
[32] Aaron M. Zorn,et al. Regulation of Wnt Signaling by Sox Proteins: XSox17α/β and XSox3 Physically Interact with β-catenin , 1999 .
[33] Kathleen E. Rankin,et al. Regulation of Glycogen Synthase Kinase 3β and Downstream Wnt Signaling by Axin , 1999, Molecular and Cellular Biology.
[34] J. Downing,et al. Oncogenic homeodomain transcription factor E2A-Pbx1 activates a novel WNT gene in pre-B acute lymphoblastoid leukemia. , 1999, Proceedings of the National Academy of Sciences of the United States of America.
[35] J. Graff,et al. Casein kinase I transduces Wnt signals , 1999, Nature.
[36] H. Clevers,et al. Synergy between tumor suppressor APC and the beta-catenin-Tcf4 target Tcf1. , 1999, Science.
[37] P. Cohen,et al. A GSK3‐binding peptide from FRAT1 selectively inhibits the GSK3‐catalysed phosphorylation of Axin and β‐catenin , 1999, FEBS letters.
[38] T. Iwama,et al. Frequent Mutation of β-Catenin and APC Genes in Primary Colorectal Tumors from Patients with Hereditary Nonpolyposis Colorectal Cancer , 1999 .
[39] R. Nusse,et al. A Drosophila Axin homolog, Daxin, inhibits Wnt signaling. , 1999, Development.
[40] M. Buendia,et al. Nuclear accumulation of mutated beta-catenin in hepatocellular carcinoma is associated with increased cell proliferation. , 1999, The American journal of pathology.
[41] S. H. Lee,et al. Frequent somatic mutations of the beta-catenin gene in intestinal-type gastric cancer. , 1999, Cancer research.
[42] Ian Tomlinson,et al. The type of somatic mutation at APC in familial adenomatous polyposis is determined by the site of the germline mutation: a new facet to Knudson's 'two-hit' hypothesis , 1999, Nature Medicine.
[43] M. Miyaki,et al. A novel case of a sporadic desmoid tumour with mutation of the beta catenin gene. , 1999, Journal of clinical pathology.
[44] G. Thomas,et al. Frequent frameshift mutations of the TCF-4 gene in colorectal cancers with microsatellite instability. , 1999, Cancer research.
[45] R. Moon,et al. Direct regulation of the Xenopus engrailed-2 promoter by the Wnt signaling pathway, and a molecular screen for Wnt-responsive genes, confirm a role for Wnt signaling during neural patterning in Xenopus , 1999, Mechanisms of Development.
[46] G. Chenevix-Trench,et al. β‐Catenin mutation and expression analysis in ovarian cancer: Exon 3 mutations and nuclear translocation in 16% of endometrioid tumours , 1999, International journal of cancer.
[47] M. von Knebel Doeberitz,et al. Mutational activation of the beta-catenin proto-oncogene is a common event in the development of Wilms' tumors. , 1999, Cancer research.
[48] J Mao,et al. Axin and Frat1 interact with Dvl and GSK, bridging Dvl to GSK in Wnt‐mediated regulation of LEF‐1 , 1999, The EMBO journal.
[49] J. Palacios,et al. β-Catenin Expression Pattern in Stage I and II Ovarian Carcinomas : Relationship with β-Catenin Gene Mutations, Clinicopathological Features, and Clinical Outcome , 1999 .
[50] C. Mello,et al. MOM-4, a MAP kinase kinase kinase-related protein, activates WRM-1/LIT-1 kinase to transduce anterior/posterior polarity signals in C. elegans. , 1999, Molecular cell.
[51] A. Ishimoto,et al. Characterization of Mouse Dishevelled (Dvl) Proteins in Wnt/Wingless Signaling Pathway* , 1999, The Journal of Biological Chemistry.
[52] A. Millar,et al. Beta-catenin mutations are specific for colorectal carcinomas with microsatellite instability but occur in endometrial carcinomas irrespective of mutator pathway. , 1999, Cancer research.
[53] R. Nusse,et al. Wnt-induced dephosphorylation of axin releases beta-catenin from the axin complex. , 1999, Genes & development.
[54] R. Moon,et al. XCtBP is a XTcf-3 co-repressor with roles throughout Xenopus development. , 1999, Development.
[55] Jan Bayer,et al. Beta-catenin mutations in hepatocellular carcinoma correlate with a low rate of loss of heterozygosity , 1999, Oncogene.
[56] M. Kraus,et al. Isolation and Biochemical Characterization of the Human Dkk-1 Homologue, a Novel Inhibitor of Mammalian Wnt Signaling* , 1999, The Journal of Biological Chemistry.
[57] R. Moon,et al. Protein kinase C is differentially stimulated by Wnt and Frizzled homologs in aG-protein-dependent manner , 1999, Current Biology.
[58] Christopher J. Thorpe,et al. MAP kinase and Wnt pathways converge to downregulate an HMG-domain repressor in Caenorhabditis elegans , 1999, Nature.
[59] Hans Clevers,et al. The TAK1–NLK–MAPK-related pathway antagonizes signalling between β-catenin and transcription factor TCF , 1999, Nature.
[60] T. Pramila,et al. Interaction of Frizzled Related Protein (FRP) with Wnt Ligands and the Frizzled Receptor Suggests Alternative Mechanisms for FRP Inhibition of Wnt Signaling* , 1999, The Journal of Biological Chemistry.
[61] M. Waterman,et al. Nuclear Localization and Formation of β-Catenin–Lymphoid Enhancer Factor 1 Complexes Are Not Sufficient for Activation of Gene Expression , 1999, Molecular and Cellular Biology.
[62] Akira Kikuchi,et al. DIX Domains of Dvl and Axin Are Necessary for Protein Interactions and Their Ability To Regulate β-Catenin Stability , 1999, Molecular and Cellular Biology.
[63] T. Dale,et al. Interaction of Axin and Dvl‐2 proteins regulates Dvl‐2‐stimulated TCF‐dependent transcription , 1999, The EMBO journal.
[64] C. Kaufmann,et al. Domains of Axin Involved in Protein–Protein Interactions, Wnt Pathway Inhibition, and Intracellular Localization , 1999, The Journal of cell biology.
[65] R Kucherlapati,et al. Apc1638T: a mouse model delineating critical domains of the adenomatous polyposis coli protein involved in tumorigenesis and development. , 1999, Genes & development.
[66] C. Albanese,et al. The cyclin D1 gene is a target of the beta-catenin/LEF-1 pathway. , 1999, Proceedings of the National Academy of Sciences of the United States of America.
[67] Hideki Yamamoto,et al. Phosphorylation of Axin, a Wnt Signal Negative Regulator, by Glycogen Synthase Kinase-3β Regulates Its Stability* , 1999, The Journal of Biological Chemistry.
[68] B. Charroux,et al. The C‐terminal domain of Armadillo binds to hypophosphorylated Teashirt to modulate Wingless signalling in Drosophila , 1999, The EMBO journal.
[69] D. Rimm,et al. Frequent mutation and nuclear localization of beta-catenin in anaplastic thyroid carcinoma. , 1999, Cancer research.
[70] M. von Knebel Doeberitz,et al. Dominant negative effect of the APC1309 mutation: a possible explanation for genotype-phenotype correlations in familial adenomatous polyposis. , 1999, Cancer research.
[71] R. Grosschedl,et al. Regulation of LEF-1/TCF transcription factors by Wnt and other signals. , 1999, Current opinion in cell biology.
[72] F. van Roy,et al. Beta-catenin mutations are more frequent in small colorectal adenomas than in larger adenomas and invasive carcinomas. , 1999, Cancer research.
[73] Frank McCormick,et al. β-Catenin regulates expression of cyclin D1 in colon carcinoma cells , 1999, Nature.
[74] J. Nathans,et al. A new secreted protein that binds to Wnt proteins and inhibits their activites , 1999, Nature.
[75] Elaine Fuchs,et al. A common human skin tumour is caused by activating mutations in β-catenin , 1999, Nature Genetics.
[76] Raymond L. White,et al. Regulation of β-Catenin Signaling by the B56 Subunit of Protein Phosphatase 2A , 1999 .
[77] J. Ninomiya-Tsuji,et al. The kinase TAK1 can activate the NIK-IκB as well as the MAP kinase cascade in the IL-1 signalling pathway , 1999, Nature.
[78] T. Akiyama,et al. Negative regulation of Wingless signaling by D-axin, a Drosophila homolog of axin. , 1999, Science.
[79] R. Benarous,et al. The F-box protein β-TrCP associates with phosphorylated β-catenin and regulates its activity in the cell , 1999, Current Biology.
[80] F. Costantini,et al. Identification of a Domain of Axin That Binds to the Serine/Threonine Protein Phosphatase 2A and a Self-binding Domain* , 1999, The Journal of Biological Chemistry.
[81] Paul Polakis,et al. The oncogenic activation of β-catenin , 1999 .
[82] S. Gallinger,et al. Inherited colorectal polyposis and cancer risk of the APC I1307K polymorphism. , 1999, American journal of human genetics.
[83] D. Rimm,et al. Frequent nuclear/cytoplasmic localization of beta-catenin without exon 3 mutations in malignant melanoma. , 1999, The American journal of pathology.
[84] M. Deardorff,et al. Xenopus axin interacts with glycogen synthase kinase-3 beta and is expressed in the anterior midbrain , 1999, Mechanisms of Development.
[85] S. Albrecht,et al. Childhood hepatoblastomas frequently carry a mutated degradation targeting box of the beta-catenin gene. , 1999, Cancer research.
[86] P. Vogt,et al. Nuclear endpoint of Wnt signaling: neoplastic transformation induced by transactivating lymphoid-enhancing factor 1. , 1999, Proceedings of the National Academy of Sciences of the United States of America.
[87] J Mao,et al. Dishevelled Proteins Lead to Two Signaling Pathways , 1999, The Journal of Biological Chemistry.
[88] R. Fodde,et al. Familial adenomatous polyposis associated with multiple adrenal adenomas in a patient with a rare 3′ APC mutation , 1999, Journal of medical genetics.
[89] S. Byers,et al. Cross-regulation of beta-catenin-LEF/TCF and retinoid signaling pathways. , 1999, Current biology : CB.
[90] J. Palacios,et al. beta-catenin expression pattern in stage I and II ovarian carcinomas : relationship with beta-catenin gene mutations, clinicopathological features, and clinical outcome. , 1999, The American journal of pathology.
[91] H. Varmus,et al. Regulation of Wnt signaling by Sox proteins: XSox17 alpha/beta and XSox3 physically interact with beta-catenin. , 1999, Molecular cell.
[92] R. Moll,et al. Analysis of beta-catenin gene mutations in pancreatic tumors. , 1999, Digestion.
[93] R. Moon,et al. Regulation of beta-catenin signaling by the B56 subunit of protein phosphatase 2A. , 1999, Science.
[94] R. Benarous,et al. The F-box protein beta-TrCP associates with phosphorylated beta-catenin and regulates its activity in the cell. , 1999, Current biology : CB.
[95] F. McCormick,et al. Beta-catenin regulates expression of cyclin D1 in colon carcinoma cells. , 1999, Nature.
[96] P. Polakis. The oncogenic activation of beta-catenin. , 1999, Current opinion in genetics & development.
[97] T. Iwama,et al. Frequent mutation of beta-catenin and APC genes in primary colorectal tumors from patients with hereditary nonpolyposis colorectal cancer. , 1999, Cancer research.
[98] A. Bauer,et al. Pontin52, an interaction partner of beta-catenin, binds to the TATA box binding protein. , 1998, Proceedings of the National Academy of Sciences of the United States of America.
[99] E. Fuchs,et al. De Novo Hair Follicle Morphogenesis and Hair Tumors in Mice Expressing a Truncated β-Catenin in Skin , 1998, Cell.
[100] J. Minna,et al. Alterations of the PPP2R1B gene in human lung and colon cancer. , 1998, Science.
[101] Hans Clevers,et al. Drosophila Tcf and Groucho interact to repress Wingless signalling activity , 1998, Nature.
[102] Hans Clevers,et al. The Xenopus Wnt effector XTcf-3 interacts with Groucho-related transcriptional repressors , 1998, Nature.
[103] Mariann Bienz,et al. Drosophila CBP represses the transcription factor TCF to antagonize Wingless signalling , 1998, Nature.
[104] Z. Paroush,et al. Transcriptional repression by AML1 and LEF-1 is mediated by the TLE/Groucho corepressors. , 1998, Proceedings of the National Academy of Sciences of the United States of America.
[105] A. Sparks,et al. Identification of c-MYC as a target of the APC pathway. , 1998, Science.
[106] W F Bodmer,et al. The APC variants I1307K and E1317Q are associated with colorectal tumors, but not always with a family history. , 1998, Proceedings of the National Academy of Sciences of the United States of America.
[107] K. Sugimachi,et al. A novel frizzled gene identified in human esophageal carcinoma mediates APC/beta-catenin signals. , 1998, Proceedings of the National Academy of Sciences of the United States of America.
[108] S. Hirohashi,et al. Beta-catenin mutation in carcinoma of the uterine endometrium. , 1998, Cancer research.
[109] Hans Clevers,et al. Depletion of epithelial stem-cell compartments in the small intestine of mice lacking Tcf-4 , 1998, Nature Genetics.
[110] M. Buendia,et al. Somatic mutations of the beta-catenin gene are frequent in mouse and human hepatocellular carcinomas. , 1998, Proceedings of the National Academy of Sciences of the United States of America.
[111] E. Wieschaus,et al. Regulation of Armadillo by a Drosophila APC Inhibits Neuronal Apoptosis during Retinal Development , 1998, Cell.
[112] E. Gelmann,et al. β-Catenin Mutations in Human Prostate Cancer , 1998 .
[113] Y. Nakamura,et al. Activation of the beta-catenin gene in primary hepatocellular carcinomas by somatic alterations involving exon 3. , 1998, Cancer research.
[114] D. M. Ferkey,et al. GBP, an Inhibitor of GSK-3, Is Implicated in Xenopus Development and Oncogenesis , 1998, Cell.
[115] T. Akiyama,et al. Axin, an inhibitor of the Wnt signalling pathway, interacts with β‐catenin, GSK‐3β and APC and reduces the β‐catenin level , 1998, Genes to cells : devoted to molecular & cellular mechanisms.
[116] Paul Polakis,et al. Downregulation of β-catenin by human Axin and its association with the APC tumor suppressor, β-catenin and GSK3β , 1998, Current Biology.
[117] S. Sokol,et al. Axis determination in Xenopus involves biochemical interactions of axin, glycogen synthase kinase 3 and β-catenin , 1998, Current Biology.
[118] W. Birchmeier,et al. Functional interaction of an axin homolog, conductin, with beta-catenin, APC, and GSK3beta. , 1998, Science.
[119] L. Williams,et al. Bridging of β-catenin and glycogen synthase kinase-3β by Axin and inhibition of β-catenin-mediated transcription , 1998 .
[120] Bert Vogelstein,et al. Mutational Analysis of the APC/β-Catenin/Tcf Pathway in Colorectal Cancer , 1998 .
[121] Akira Kikuchi,et al. Axin, a negative regulator of the Wnt signaling pathway, forms a complex with GSK‐3β and β‐catenin and promotes GSK‐3β‐dependent phosphorylation of β‐catenin , 1998 .
[122] C. Raffel,et al. Sporadic Medulloblastomas Contain Oncogenic β-Catenin Mutations , 1998 .
[123] Y. Nakamura,et al. Activation of the beta-catenin gene by interstitial deletions involving exon 3 in primary colorectal carcinomas without adenomatous polyposis coli mutations. , 1998, Cancer research.
[124] C. Niehrs,et al. Dickkopf-1 is a member of a new family of secreted proteins and functions in head induction , 1998, Nature.
[125] C. Raffel,et al. Sporadic medulloblastomas contain oncogenic beta-catenin mutations. , 1998, Cancer research.
[126] A. Sparks,et al. Mutational analysis of the APC/beta-catenin/Tcf pathway in colorectal cancer. , 1998, Cancer research.
[127] J. Palacios,et al. Mutations in the beta-catenin gene (CTNNB1) in endometrioid ovarian carcinomas. , 1998, Cancer research.
[128] J. Church,et al. APC genotype, polyp number, and surgical options in familial adenomatous polyposis. , 1998, Annals of surgery.
[129] E. Gelmann,et al. Beta-catenin mutations in human prostate cancer. , 1998, Cancer research.
[130] P. Polakis,et al. Downregulation of beta-catenin by human Axin and its association with the APC tumor suppressor, beta-catenin and GSK3 beta. , 1998, Current biology : CB.
[131] R. Nusse,et al. Mechanisms of Wnt signaling in development. , 1998, Annual review of cell and developmental biology.
[132] M. Mahadevappa,et al. SARPs: a family of secreted apoptosis-related proteins. , 1997, Proceedings of the National Academy of Sciences of the United States of America.
[133] A. Brown,et al. Transformation by Wnt family proteins correlates with regulation of beta-catenin. , 1997, Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research.
[134] P. Soballe,et al. Mutations in beta-catenin are uncommon in colorectal cancer occurring in occasional replication error-positive tumors. , 1997, Cancer research.
[135] F. Luyten,et al. The cysteine-rich frizzled domain of Frzb-1 is required and sufficient for modulation of Wnt signaling. , 1997, Proceedings of the National Academy of Sciences of the United States of America.
[136] H. Ostrer,et al. Familial colorectal cancer in Ashkenazim due to a hypermutable tract in APC , 1997, Nature Genetics.
[137] C. Verellen-Dumoulin,et al. Novel germline mutations in the APC gene and their phenotypic spectrum in familial adenomatous polyposis kindreds , 1997, Human Genetics.
[138] F. Cetta,et al. Hepatoblastoma and APC gene mutation in familial adenomatous polyposis , 1997, Gut.
[139] C. Mello,et al. Wnt Signaling and an APC-Related Gene Specify Endoderm in Early C. elegans Embryos , 1997, Cell.
[140] B. Alman,et al. Increased beta-catenin protein and somatic APC mutations in sporadic aggressive fibromatoses (desmoid tumors). , 1997, The American journal of pathology.
[141] Wei Hsu,et al. The Mouse Fused Locus Encodes Axin, an Inhibitor of the Wnt Signaling Pathway That Regulates Embryonic Axis Formation , 1997, Cell.
[142] H. Varmus,et al. Casein kinase 2 associates with and phosphorylates Dishevelled , 1997, The EMBO journal.
[143] Paul Polakis,et al. Stabilization of β-Catenin by Genetic Defects in Melanoma Cell Lines , 1997, Science.
[144] Hans Clevers,et al. Activation of β-Catenin-Tcf Signaling in Colon Cancer by Mutations in β-Catenin or APC , 1997, Science.
[145] F. Luyten,et al. Frzb, a Secreted Protein Expressed in the Spemann Organizer, Binds and Inhibits Wnt-8 , 1997, Cell.
[146] Mariann Bienz,et al. LEF-1, a Nuclear Factor Coordinating Signaling Inputs from wingless and decapentaplegic , 1997, Cell.
[147] T. Bouwmeester,et al. Frzb-1 Is a Secreted Antagonist of Wnt Signaling Expressed in the Spemann Organizer , 1997, Cell.
[148] Hans Clevers,et al. Armadillo Coactivates Transcription Driven by the Product of the Drosophila Segment Polarity Gene dTCF , 1997, Cell.
[149] J. Nathans,et al. A Member of the Frizzled Protein Family Mediating Axis Induction by Wnt-5A , 1997, Science.
[150] R Grosschedl,et al. ALY, a context-dependent coactivator of LEF-1 and AML-1, is required for TCRalpha enhancer function. , 1997, Genes & development.
[151] Konrad Basler,et al. pangolinencodes a Lef-1 homologue that acts downstream of Armadillo to transduce the Wingless signal in Drosophila , 1997, Nature.
[152] A. Berns,et al. Activation of a novel proto‐oncogene, Frat1, contributes to progression of mouse T‐cell lymphomas , 1997, The EMBO journal.
[153] B. Gumbiner,et al. Adenomatous Polyposis Coli Tumor Suppressor Protein Has Signaling Activity in Xenopus laevis Embryos Resulting in the Induction of an Ectopic Dorsoanterior Axis , 1997, The Journal of cell biology.
[154] P. Robbins,et al. Stabilization of beta-catenin by genetic defects in melanoma cell lines. , 1997, Science.
[155] R. Scott,et al. Familial infiltrative fibromatosis (desmoid tumours) (MIM135290) caused by a recurrent 3' APC gene mutation. , 1996, Human molecular genetics.
[156] G. Petersen,et al. Hepatoblastoma and APC gene mutation in familial adenomatous polyposis. , 1996, Gut.
[157] Rodney J. Scott,et al. Germline mutations in the 3′ part of APC exon 15 do not result in truncated proteins and are associated with attenuated adenomatous polyposis coli , 1996, Human Genetics.
[158] R. Moon,et al. A frizzled homolog functions in a vertebrate Wnt signaling pathway , 1996, Current Biology.
[159] B. Herrmann,et al. Nuclear localization of β-catenin by interaction with transcription factor LEF-1 , 1996, Mechanisms of Development.
[160] Michael Kühl,et al. Functional interaction of β-catenin with the transcription factor LEF-1 , 1996, Nature.
[161] Hans Clevers,et al. XTcf-3 Transcription Factor Mediates β-Catenin-Induced Axis Formation in Xenopus Embryos , 1996, Cell.
[162] Jeremy Nathans,et al. A new member of the frizzled family from Drosophila functions as a Wingless receptor , 1996, Nature.
[163] R. Moon,et al. The axis-inducing activity, stability, and subcellular distribution of beta-catenin is regulated in Xenopus embryos by glycogen synthase kinase 3. , 1996, Genes & development.
[164] Paul Polakis,et al. Binding of GSK3β to the APC-β-Catenin Complex and Regulation of Complex Assembly , 1996, Science.
[165] K. Irie,et al. Identification of a Member of the MAPKKK Family as a Potential Mediator of TGF-β Signal Transduction , 1995, Science.
[166] I. Dominguez,et al. Role of glycogen synthase kinase 3 beta as a negative regulator of dorsoventral axis formation in Xenopus embryos. , 1995, Proceedings of the National Academy of Sciences of the United States of America.
[167] M. Taketo,et al. Evidence against dominant negative mechanisms of intestinal polyp formation by Apc gene mutations. , 1995, Cancer research.
[168] M Oshima,et al. Loss of Apc heterozygosity and abnormal tissue building in nascent intestinal polyps in mice carrying a truncated Apc gene. , 1995, Proceedings of the National Academy of Sciences of the United States of America.
[169] Harold E. Varmus,et al. Glycogen synthase kinase-3 and dorsoventral patterning in Xenopus embryos , 1995, Nature.
[170] K. Kinzler,et al. The molecular basis of Turcot's syndrome. , 1995, The New England journal of medicine.
[171] P. Polakis,et al. Regulation of intracellular beta-catenin levels by the adenomatous polyposis coli (APC) tumor-suppressor protein. , 1995, Proceedings of the National Academy of Sciences of the United States of America.
[172] P. Leder,et al. Insertional mutagenesis identifies a member of the Wnt gene family as a candidate oncogene in the mammary epithelium of int-2/Fgf-3 transgenic mice. , 1995, Proceedings of the National Academy of Sciences of the United States of America.
[173] P. Leder,et al. Casein kinase II alpha transgene-induced murine lymphoma: relation to theileriosis in cattle , 1995, Science.
[174] I Fariñas,et al. Development of several organs that require inductive epithelial-mesenchymal interactions is impaired in LEF-1-deficient mice. , 1994, Genes & development.
[175] P. Edwards,et al. Alterations of the growth characteristics of the fibroblast cell line C3H 10T1/2 by members of the Wnt gene family. , 1994, Oncogene.
[176] A. McMahon,et al. Differential transformation of mammary epithelial cells by Wnt genes , 1994, Molecular and cellular biology.
[177] N. Nishida,et al. Amplification and overexpression of the cyclin D1 gene in aggressive human hepatocellular carcinoma. , 1994, Cancer research.
[178] J. Garvin,et al. Turcot's syndrome , 1994, Neurology.
[179] Norbert Perrimon,et al. dishevelled and armadillo act in the Wingless signalling pathway in Drosophila , 1994, Nature.
[180] K. Kinzler,et al. Association of the APC tumor suppressor protein with catenins. , 1993, Science.
[181] F. Masiarz,et al. Association of the APC gene product with beta-catenin. , 1993, Science.
[182] H. Hsu,et al. Amplification of the c-myc gene in human hepatocellular carcinoma: biologic significance. , 1993, Journal of the Formosan Medical Association = Taiwan yi zhi.
[183] V. Michels,et al. Risk of hepatoblastoma in familial adenomatous polyposis. , 1992, American journal of medical genetics.
[184] Y. Nakamura,et al. Correlation between the location of germ-line mutations in the APC gene and the number of colorectal polyps in familial adenomatous polyposis patients. , 1992, Cancer research.
[185] S Ichii,et al. Somatic mutations of the APC gene in colorectal tumors: mutation cluster region in the APC gene. , 1992, Human molecular genetics.
[186] K. Kinzler,et al. Erratum: Multiple Intestinal Neoplasia Caused By a Mutation in the Murine Homolog of the APC Gene , 1992, Science.
[187] Margaret Robertson,et al. Identification and characterization of the familial adenomatous polyposis coli gene , 1991, Cell.
[188] S. Altschul,et al. Identification of FAP locus genes from chromosome 5q21. , 1991, Science.
[189] R. Nusse,et al. Wnt-3, a gene activated by proviral insertion in mouse mammary tumors, is homologous to int-1/Wnt-1 and is normally expressed in mouse embryos and adult brain. , 1990, Proceedings of the National Academy of Sciences of the United States of America.
[190] P. Lawrence,et al. Phenocopies induced with antisense RNA identify the wingless gene , 1987, Cell.
[191] Detlef Weigel,et al. The Drosophila homology of the mouse mammary oncogene int-1 is identical to the segment polarity gene wingless , 1987, Cell.
[192] Harold E. Varmus,et al. Many tumors induced by the mouse mammary tumor virus contain a provirus integrated in the same region of the host genome , 1982, Cell.
[193] Ken Hsü. China: the legacy of the Cultural Revolution , 1979, Nature.