Cochlear implantation trauma and noise-induced hearing loss: Apoptosis and therapeutic strategies.

Cochlear implantation trauma and noise-induced hearing loss both involve a physical disruption of the organ of Corti and may involve several mechanisms of cell death at the molecular level, i.e., necrosis, necrosis-like programmed cell death (PCD; type 2 PCD), and apoptosis (type 1 PCD). This article reviews several promising therapeutic strategies that are currently being developed. One of these promising new strategies involves the use of a highly effective peptide inhibitor of the c-Jun N-terminal kinase cell death signal cascade (i.e., D-JNKI-1) to prevent apoptosis of injured auditory hair cells. Our recent studies showed prevention of cochlear implantation-induced hearing loss by infusing this peptide into the cochlea of guinea pigs. Another otoprotective therapy under investigation is the application of mild hypothermia to protect the cochlea from the development of a hearing loss that follows exposure to a physical trauma, e.g., electrode array insertional trauma. These forward-looking strategies have the potential of improving hearing outcomes after cochlear implantation and providing novel means of otoprotection from noise-induced trauma.

[1]  A. Eshraghi,et al.  Arrest of Apoptosis in Auditory Neurons: Implications for Sensorineural Preservation in Cochlear Implantation , 2003, Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology.

[2]  A. Eshraghi,et al.  Comparative Study of Cochlear Damage With Three Perimodiolar Electrode Designs , 2003, The Laryngoscope.

[3]  K. Henry,et al.  Hypothermia protects the cochlea from noise damage , 1984, Hearing Research.

[4]  N. Hakuba,et al.  Hypothermia reduces glutamate efflux in perilymph following transient cochlear ischemia , 2001, Neuroreport.

[5]  A. Eshraghi,et al.  Small-fenestra cochleostomy for MED-EL electrode. , 2004 .

[6]  T. Nicotera,et al.  Extremely rapid induction of outer hair cell apoptosis in the chinchilla cochlea following exposure to impulse noise , 2006, Hearing Research.

[7]  Adrien A Eshraghi,et al.  Modiolar Proximity of Three Perimodiolar Cochlear Implant Electrodes , 2002, Acta oto-laryngologica.

[8]  F. de Ribaupierre,et al.  A Peptide Inhibitor of C-jun N-terminal Kinase Protects against Both Aminoglycoside and Acoustic Trauma-induced Auditory Hair Cell Death and Hearing Loss , 2022 .

[9]  D. Henderson,et al.  Intense noise-induced apoptosis in hair cells of guinea pig cochleae. , 2000, Acta oto-laryngologica.

[10]  J. Virkkala,et al.  Rescue of Hearing, Auditory Hair Cells, and Neurons by CEP-1347/KT7515, an Inhibitor of c-Jun N-Terminal Kinase Activation , 2000, The Journal of Neuroscience.

[11]  T. R. Van De Water,et al.  The MAPK/JNK signalling pathway offers potential therapeutic targets for the prevention of acquired deafness. , 2004, Current drug targets. CNS and neurological disorders.

[12]  Adrien A Eshraghi,et al.  Cochlear temperature correlates with both temporalis muscle and rectal temperatures. Application for testing the otoprotective effect of hypothermia , 2005, Acta oto-laryngologica.

[13]  N. Greig,et al.  Comparative brain and plasma pharmacokinetics and anticancer activities of chlorambucil and melphalan in the rat , 2004, Cancer Chemotherapy and Pharmacology.

[14]  William F. House,et al.  Cochlear Implants: Histopathologic Findings Related to Performance in 16 Human Temporal Bones , 1991, The Annals of otology, rhinology, and laryngology.

[15]  Wei Ping Yang,et al.  Quantitative analysis of apoptotic and necrotic outer hair cells after exposure to different levels of continuous noise , 2004, Hearing Research.

[16]  F-actin cleavage in apoptotic outer hair cells in chinchilla cochleas exposed to intense noise , 2002, Hearing Research.

[17]  A. Eshraghi,et al.  Mild Hypothermia Protects Auditory Function During Cochlear Implant Surgery , 2005, The Laryngoscope.

[18]  C. Piantadosi,et al.  Brain Temperature Alters Hydroxyl Radical Production during Cerebral Ischemia/Reperfusion in Rats , 1996, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[19]  K. Tanabe,et al.  Role of mitochondria as the gardens of cell death , 2006, Cancer Chemotherapy and Pharmacology.

[20]  T. Nicotera,et al.  The Caspase Pathway in Noise-Induced Apoptosis of the Chinchilla Cochlea , 2003, Journal of the Association for Research in Otolaryngology.

[21]  W. Dalton Dietrich,et al.  Small Differences in Intraischemic Brain Temperature Critically Determine the Extent of Ischemic Neuronal Injury , 1987, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[22]  M. Praetorius,et al.  A mouse model of implantation trauma , 2004 .

[23]  K. Henry.  Hyperthermia exacerbates and hypothermia protects from noise-induced threshold elevation of the cochlear nerve envelope response in the C57BL/6J mouse , 2003, Hearing Research.

[24]  R. Busto,et al.  Post-traumatic brain hypothermia reduces histopathological damage following concussive brain injury in the rat , 1994, Acta Neuropathologica.

[25]  Donald K. Eddington,et al.  Histopathology of Cochlear Implants in Humans , 2001, The Annals of otology, rhinology, and laryngology.

[26]  J. A. Weil,et al.  Neuroprotective effects of hypothermia and U‐78517F in cerebral ischemia are due to reducing oxygen‐based free radicals: An electron paramagnetic resonance study with gerbils , 1996, Journal of neuroscience research.

[27]  C. Hetz,et al.  Beyond apoptosis: nonapoptotic cell death in physiology and disease. , 2005, Biochemistry and cell biology = Biochimie et biologie cellulaire.

[28]  B Malgrange,et al.  Caspases, the enemy within, and their role in oxidative stress-induced apoptosis of inner ear sensory cells. , 2004, Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology.

[29]  T. Nicotera,et al.  Involvement of apoptosis in progression of cochlear lesion following exposure to intense noise 1 1 Presented in part at the Midwinter Meeting of the Association for Research in Otolaryngology, 2001, St. Petersburg Beach, FL, USA. , 2002, Hearing Research.

[30]  R. Busto,et al.  Brain damage and temperature: cellular and molecular mechanisms. , 1996, Advances in neurology.

[31]  Je-Jung Lee,et al.  CHOP plus etoposide and gemcitabine (CHOP-EG) as front-line chemotherapy for patients with peripheral T cell lymphomas , 2006, Cancer Chemotherapy and Pharmacology.

[32]  D. Schorderet,et al.  Cell-Permeable Peptide Inhibitors of JNK: Novel Blockers of β-Cell Death , 2001 .

[33]  M. Charles Liberman,et al.  Sound conditioning reduces noise-induced permanent threshold shift in mice , 2000, Hearing Research.

[34]  B J Gantz,et al.  Insertional trauma of multichannel cochlear implants , 1993, The Laryngoscope.

[35]  F. Telischi,et al.  Pattern Of Hearing Loss In A Rat Model Of Cochlear Implantation Trauma , 2005, Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology.