RNA interference therapy via functionalized scaffolds.

[1]  S. W. Kim,et al.  Primary cardiomyocyte-targeted bioreducible polymer for efficient gene delivery to the myocardium. , 2010, Biomaterials.

[2]  David W Grainger,et al.  Device-based local delivery of siRNA against mammalian target of rapamycin (mTOR) in a murine subcutaneous implant model to inhibit fibrous encapsulation. , 2010, Journal of controlled release : official journal of the Controlled Release Society.

[3]  J. Kjems,et al.  siRNA nanoparticle functionalization of nanostructured scaffolds enables controlled multilineage differentiation of stem cells. , 2010, Molecular therapy : the journal of the American Society of Gene Therapy.

[4]  D. Leake,et al.  Silencing of reporter gene expression in skin using siRNAs and expression of plasmid DNA delivered by a soluble protrusion array device (PAD). , 2010, Molecular therapy : the journal of the American Society of Gene Therapy.

[5]  M. Oulad-Abdelghani,et al.  SiRNA-loaded multi-shell nanoparticles incorporated into a multilayered film as a reservoir for gene silencing. , 2010, Biomaterials.

[6]  P. Kaiser,et al.  RNAi-based treatment for neovascular age-related macular degeneration by Sirna-027. , 2010, American journal of ophthalmology.

[7]  Sing Yian Chew,et al.  RNA interference by nanofiber-based siRNA delivery system. , 2010, Journal of Controlled Release.

[8]  Rob Lambkin-Williams,et al.  A randomized, double-blind, placebo-controlled study of an RNAi-based therapy directed against respiratory syncytial virus , 2010, Proceedings of the National Academy of Sciences.

[9]  D. Dean,et al.  Progress and prospects: nuclear import of nonviral vectors , 2010, Gene Therapy.

[10]  Abhay Pandit,et al.  Non-viral polyplexes: Scaffold mediated delivery for gene therapy , 2010 .

[11]  Mark E. Davis,et al.  Evidence of RNAi in humans from systemically administered siRNA via targeted nanoparticles , 2010, Nature.

[12]  Yuquan Wei,et al.  Efficient inhibition of non-small-cell lung cancer xenograft by systemic delivery of plasmid-encoding short-hairpin RNA targeting VEGF. , 2010, Cancer biotherapy & radiopharmaceuticals.

[13]  R. Hickerson,et al.  First-in-human mutation-targeted siRNA phase Ib trial of an inherited skin disorder. , 2010, Molecular therapy : the journal of the American Society of Gene Therapy.

[14]  M. Ghosh,et al.  Solution structure of the Drosha double-stranded RNA-binding domain , 2010, Silence.

[15]  R. Langer,et al.  Lipid‐based nanotherapeutics for siRNA delivery , 2010, Journal of internal medicine.

[16]  H. Möhwald,et al.  Surface-supported multilayers decorated with bio-active material aimed at light-triggered drug delivery. , 2009, Langmuir : the ACS journal of surfaces and colloids.

[17]  Abhay Pandit,et al.  Snail1 down-regulation using small interfering RNA complexes delivered through collagen scaffolds. , 2009, Bioconjugate chemistry.

[18]  L. Feldman,et al.  Development of a functionalized polymer for stent coating in the arterial delivery of small interfering RNA. , 2009, Biomacromolecules.

[19]  H. Garg,et al.  Strategies for targeted nonviral delivery of siRNAs in vivo. , 2009, Trends in molecular medicine.

[20]  Jeffrey Perkel.  RNAI Therapeutics: A Two-Year Update , 2009 .

[21]  Ashutosh Kumar Singh,et al.  In-situ crosslinking hydrogels for combinatorial delivery of chemokines and siRNA-DNA carrying microparticles to dendritic cells. , 2009, Biomaterials.

[22]  A. Lendlein,et al.  Polymer Networks Combining Controlled Drug Release, Biodegradation, and Shape Memory Capability , 2009, Advanced materials.

[23]  P. Shankar,et al.  Lentiviral delivery of short hairpin RNAs. , 2009, Advanced drug delivery reviews.

[24]  Timothy O'Brien,et al.  A matrix reservoir for improved control of non-viral gene delivery. , 2009, Journal of controlled release : official journal of the Controlled Release Society.

[25]  Eben Alsberg,et al.  Localized and sustained delivery of silencing RNA from macroscopic biopolymer hydrogels. , 2009, Journal of the American Chemical Society.

[26]  S. Nakae,et al.  Therapeutic silencing of an endogenous gene by siRNA cream in an arthritis model mouse , 2009, Gene Therapy.

[27]  M. Czech,et al.  Orally delivered siRNA targeting macrophage Map4k4 suppresses systemic inflammation , 2009, Nature.

[28]  A. George,et al.  Targeting gene delivery to activated vascular endothelium using anti E/P-Selectin antibody linked to PAMAM dendrimers. , 2009, Journal of immunological methods.

[29]  Silvestro Micera,et al.  Magnetic alginate microspheres: system for the position controlled delivery of nerve growth factor , 2009, Biomedical microdevices.

[30]  Michael S. Goldberg,et al.  Claudin-3 gene silencing with siRNA suppresses ovarian tumor growth and metastasis , 2009, Proceedings of the National Academy of Sciences.

[31]  Sung Wan Kim,et al.  Efficient siRNA Delivery with Non-viral Polymeric Vehicles , 2009, Pharmaceutical Research.

[32]  Daniel G. Anderson,et al.  Knocking down barriers: advances in siRNA delivery , 2009, Nature Reviews Drug Discovery.

[33]  Olivier Voinnet,et al.  Revisiting the principles of microRNA target recognition and mode of action , 2009, Nature Reviews Molecular Cell Biology.

[34]  Seeram Ramakrishna,et al.  Electrospun biomimetic nanocomposite nanofibers of hydroxyapatite/chitosan for bone tissue engineering. , 2008, Biomaterials.

[35]  V. Patzel,et al.  siRNA stabilization prolongs gene knockdown in primary T lymphocytes , 2008, European journal of immunology.

[36]  Dale L. Greiner,et al.  T Cell-Specific siRNA Delivery Suppresses HIV-1 Infection in Humanized Mice , 2008, Cell.

[37]  T. Park,et al.  Local and systemic delivery of VEGF siRNA using polyelectrolyte complex micelles for effective treatment of cancer. , 2008, Journal of controlled release : official journal of the Controlled Release Society.

[38]  Justine R. Smith,et al.  Sequence- and target-independent angiogenesis suppression by siRNA via TLR3 , 2008, Nature.

[39]  Junji Kato,et al.  Resolution of liver cirrhosis using vitamin A–coupled liposomes to deliver siRNA against a collagen-specific chaperone , 2008, Nature Biotechnology.

[40]  J. Kjems,et al.  Delivery of siRNA from lyophilized polymeric surfaces. , 2008, Biomaterials.

[41]  W. Filipowicz,et al.  Mechanisms of post-transcriptional regulation by microRNAs: are the answers in sight? , 2008, Nature Reviews Genetics.

[42]  J. Stenvang,et al.  MicroRNAs as targets for antisense-based therapeutics , 2008, Expert opinion on biological therapy.

[43]  W. Theurkauf,et al.  Biogenesis and germline functions of piRNAs , 2007, Development.

[44]  G. Rettig,et al.  Potency of siRNA versus shRNA mediated knockdown in vivo. , 2007, Journal of pharmaceutical sciences.

[45]  Shubiao Zhang,et al.  Cationic lipids and polymers mediated vectors for delivery of siRNA. , 2007, Journal of controlled release : official journal of the Controlled Release Society.

[46]  Y. Iwasaki,et al.  Efficient regulation of viral replication by siRNA in a non-human primate surrogate model for hepatitis C. , 2007, Biochemical and biophysical research communications.

[47]  Yunje Cho,et al.  Crystal structure of human DGCR8 core , 2007, Nature Structural &Molecular Biology.

[48]  D. Jans,et al.  Nucleocytoplasmic transport of DNA: enhancing non-viral gene transfer. , 2007, The Biochemical journal.

[49]  A. Miyajima,et al.  TRB2, a Mouse Tribbles Ortholog, Suppresses Adipocyte Differentiation by Inhibiting AKT and C/EBPβ* , 2007, Journal of Biological Chemistry.

[50]  Y. Won,et al.  Polymer-based siRNA delivery: perspectives on the fundamental and phenomenological distinctions from polymer-based DNA delivery. , 2007, Journal of controlled release : official journal of the Controlled Release Society.

[51]  Yanjie Lu,et al.  Retracted: Novel approaches for gene‐specific interference via manipulating actions of microRNAs: Examination on the pacemaker channel genes HCN2 and HCN4 , 2007, Journal of cellular physiology.

[52]  J. Hubbell,et al.  RNA interference targeting hypoxia inducible factor 1alpha reduces post-operative adhesions in rats. , 2007, The Journal of surgical research.

[53]  Lonnie D Shea,et al.  Non-viral vector delivery from PEG-hyaluronic acid hydrogels. , 2007, Journal of controlled release : official journal of the Controlled Release Society.

[54]  D. Leake,et al.  shRNAs targeting hepatitis C: effects of sequence and structural features, and comparision with siRNA. , 2007, Oligonucleotides.

[55]  S. Warren,et al.  Topical matrix-based siRNA silences local gene expression in a murine wound model , 2007, Gene Therapy.

[56]  N. Lau,et al.  The coming of age for Piwi proteins. , 2007, Molecular cell.

[57]  A. Pandit,et al.  Assessment of cell viability in a three-dimensional enzymatically cross-linked collagen scaffold , 2007, Journal of materials science. Materials in medicine.

[58]  Sheng Ding,et al.  A high-throughput siRNA library screen identifies osteogenic suppressors in human mesenchymal stem cells , 2007, Proceedings of the National Academy of Sciences.

[59]  Lonnie D Shea,et al.  Matrices and scaffolds for DNA delivery in tissue engineering. , 2007, Advanced drug delivery reviews.

[60]  James P Cox,et al.  Drug release from pH-responsive thermogelling pentablock copolymers. , 2007, Journal of biomedical materials research. Part A.

[61]  M. Stoffel,et al.  Specificity, duplex degradation and subcellular localization of antagomirs , 2007, Nucleic acids research.

[62]  E. Fattal,et al.  Ocular delivery of nucleic acids: antisense oligonucleotides, aptamers and siRNA. , 2006, Advanced drug delivery reviews.

[63]  Y. Takakura,et al.  Suppression of tumor growth by intratumoral injection of short hairpin RNA-expressing plasmid DNA targeting beta-catenin or hypoxia-inducible factor 1alpha. , 2006, Journal of controlled release : official journal of the Controlled Release Society.

[64]  R. Vemuganti,et al.  JAK2 and STAT3 activation contributes to neuronal damage following transient focal cerebral ischemia , 2006, Journal of neurochemistry.

[65]  Amy C Richards Grayson,et al.  Biophysical and Structural Characterization of Polyethylenimine-Mediated siRNA Delivery in Vitro , 2006, Pharmaceutical Research.

[66]  Yong Wang,et al.  Cell type–specific delivery of siRNAs with aptamer-siRNA chimeras , 2006, Nature Biotechnology.

[67]  Paul A. Serbinowski,et al.  A structural basis for discriminating between self and nonself double-stranded RNAs in mammalian cells , 2006, Nature Biotechnology.

[68]  I. Khalil,et al.  Uptake Pathways and Subsequent Intracellular Trafficking in Nonviral Gene Delivery , 2006, Pharmacological Reviews.

[69]  Priti Kumar,et al.  A Single siRNA Suppresses Fatal Encephalitis Induced by Two Different Flaviviruses , 2006, PLoS medicine.

[70]  Mark Graham,et al.  miR-122 regulation of lipid metabolism revealed by in vivo antisense targeting. , 2006, Cell metabolism.

[71]  Angela N. Brooks,et al.  Structural Basis for Double-Stranded RNA Processing by Dicer , 2006, Science.

[72]  Mark E. Davis,et al.  Insights into the kinetics of siRNA-mediated gene silencing from live-cell and live-animal bioluminescent imaging , 2006, Nucleic acids research.

[73]  Jian-xing Ma,et al.  Inhibition of Ocular Angiogenesis by Diced Small Interfering RNAs (siRNAs) Specific to Vascular Endothelial Growth Factor (VEGF) , 2006, Current eye research.

[74]  N. Rajewsky,et al.  Silencing of microRNAs in vivo with ‘antagomirs’ , 2005, Nature.

[75]  Jonathan Preall,et al.  RNAi: RISC Gets Loaded , 2005, Cell.

[76]  R. Shiekhattar,et al.  TRBP recruits the Dicer complex to Ago2 for microRNA processing and gene silencing , 2005, Nature.

[77]  B. Rouse,et al.  Blocking mouse MMP-9 production in tumor cells and mouse cornea by short hairpin (sh) RNA encoding plasmids. , 2005, Oligonucleotides.

[78]  M. Maiuri,et al.  Enhanced intracellular uptake and inhibition of NF‐κB activation by decoy oligonucleotide released from PLGA microspheres , 2005, The journal of gene medicine.

[79]  G. Lukács,et al.  Intracellular routing of plasmid DNA during non-viral gene transfer. , 2005, Advanced drug delivery reviews.

[80]  A. Judge,et al.  Sequence-dependent stimulation of the mammalian innate immune response by synthetic siRNA , 2005, Nature Biotechnology.

[81]  Wei Ge,et al.  Synthetic shRNAs as potent RNAi triggers , 2005, Nature Biotechnology.

[82]  Sangdun Choi,et al.  Synthetic dsRNA Dicer substrates enhance RNAi potency and efficacy , 2005, Nature Biotechnology.

[83]  C. Burge,et al.  Conserved Seed Pairing, Often Flanked by Adenosines, Indicates that Thousands of Human Genes are MicroRNA Targets , 2005, Cell.

[84]  Lei Shen,et al.  Silencing of SOCS1 enhances antigen presentation by dendritic cells and antigen-specific anti-tumor immunity , 2004, Nature Biotechnology.

[85]  T. O’Brien,et al.  Current status of catheter- and stent-based gene therapy. , 2004, Cardiovascular research.

[86]  Sanghyuk Lee,et al.  MicroRNA genes are transcribed by RNA polymerase II , 2004, The EMBO journal.

[87]  Stephen P. Fox,et al.  Sustained Polymeric Delivery of Gene Silencing Antisense ODNs, siRNA, DNAzymes and Ribozymes: In Vitro and In Vivo Studies , 2004, Journal of drug targeting.

[88]  Lin He,et al.  MicroRNAs: small RNAs with a big role in gene regulation , 2004, Nature Reviews Genetics.

[89]  D. Weissman,et al.  Small Interfering RNAs Mediate Sequence-Independent Gene Suppression and Induce Immune Activation by Signaling through Toll-Like Receptor 31 , 2004, The Journal of Immunology.

[90]  D. Bartel,et al.  MicroRNA-Directed Cleavage of HOXB8 mRNA , 2004, Science.

[91]  Jennifer H Elisseeff,et al.  Synthesis and characterization of a novel degradable phosphate-containing hydrogel. , 2003, Biomaterials.

[92]  Jeffrey A Hubbell,et al.  Materials as morphogenetic guides in tissue engineering. , 2003, Current opinion in biotechnology.

[93]  D F P Larkin,et al.  Antibody targeted gene transfer to endothelium , 2003, The journal of gene medicine.

[94]  B. Samuelsson,et al.  Ribonuclease activity and RNA binding of recombinant human Dicer , 2002, The EMBO journal.

[95]  Lichun Lu,et al.  Controlled release of NFkappaB decoy oligonucleotides from biodegradable polymer microparticles. , 2002, Biomaterials.

[96]  T. Tuschl,et al.  Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells , 2001, Nature.

[97]  M. Manoharan.  2'-carbohydrate modifications in antisense oligonucleotide therapy: importance of conformation, configuration and conjugation. , 1999, Biochimica et biophysica acta.

[98]  A. Brunger,et al.  The 1.8 A crystal structure of a statically disordered 17 base-pair RNA duplex: principles of RNA crystal packing and its effect on nucleic acid structure. , 1999, Journal of molecular biology.

[99]  G. Stark,et al.  How cells respond to interferons. , 1998, Annual review of biochemistry.

[100]  A. Fire,et al.  Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans , 1998, Nature.

[101]  N. Bishop.  An Update on Non‐clathrin‐coated Endocytosis , 1997, Reviews in medical virology.

[102]  S. Akhtar,et al.  Antisense oligonucleotide delivery to cultured macrophages is improved by incorporation into sustained-release biodegradable polymer microspheres , 1997 .

[103]  J. Leiden,et al.  Immune responses to transgene–encoded proteins limit the stability of gene expression after injection of replication–defective adenovirus vectors , 1996, Nature Medicine.

[104]  A. Rolland,et al.  Controllable gene therapy pharmaceutics of non-viral gene delivery systems , 1996 .

[105]  P. Hagerman,et al.  Investigation of the flexibility of DNA using transient electric birefringence , 1981, Biopolymers.

[106]  A. Pandit,et al.  Liposomal gene delivery mediated by tissue-engineered scaffolds. , 2010, Trends in biotechnology.

[107]  C. Esau,et al.  Inhibition of microRNA with antisense oligonucleotides. , 2008, Methods.

[108]  P. Tan,et al.  Gene knockdown with intrathecal siRNA of NMDA receptor NR2B subunit reduces formalin-induced nociception in the rat , 2005, Gene Therapy.

[109]  W. J. Irwin,et al.  Development of a sustained-release biodegradable polymer delivery system for site-specific delivery of oligonucleotides: characterization of P(LA-GA) copolymer microspheres in vitro. , 1998, Journal of drug targeting.