The place of 57Co-bleomycin scanning in the evaluation of tumors.

The clinical records and imaging studies of 140 patients who had 57Co-bleomycin scans were reviewed. In 53% of the patients with known tumor at the time of examination, all clinically demonstrable lesions picked up cobalt. The success rate was particularly high in carcinoma of the lung (15 of 17) and gastrointestinal tract (12 of 17). The major role of cobalt bleomycin seems to be as an early screening test for metastases in patients with carcinoma of the lung, gastrointestinal tract, and uterus. The scan is most useful in demonstrating spread to the brain, liver, and adrenals.

[1]  H. S. Winchell Mechanisms for localization of radiopharmaceuticals in neoplasms. , 1976, Seminars in nuclear medicine.

[2]  R. Reba,et al.  Iodinated bleomycin: an unsatisfactory radiopharmaceutical for tumor localization. , 1976, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[3]  J. Rasker,et al.  Some experience with 57Co-labeled bleomycin as a tumor-seeking agent. , 1975, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[4]  R. Reba,et al.  Cobalt-labeled bleomycin--a new radiopharmaceutical for tumor localization. A comparative clinical evaluation with gallium citrate. , 1975, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[5]  G. Denardo,et al.  Preparation and chemical characterization of radioiodinated bleomycin. , 1975, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[6]  M. Thakur,et al.  111-In-labelled bleomycin; clinical experience as a diagnostic agent in tumours of the thorax and abdomen. , 1975, The British journal of radiology.

[7]  W. Beierwaltes,et al.  Relative tissue distribution of radioactivity in rats with endocrine "autonomous" breast carcinomas after 3H-,99mTc-, and 64Cu-bleomycin. , 1975, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[8]  T. Higashi,et al.  Comparison of uptake of 67Ga-citrate and 57Co-bleomycin in tumor using a semiconductor detector. , 1974, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[9]  J. Fujimoto Radioautographic studies on the intracellular distribution of bleomycin-14C in mouse tumor cells. , 1974, Cancer research.

[10]  R. Reba,et al.  Clinical evaluation of radiolabeled bleomycin (BLEO) for tumor detection. , 1974, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[11]  D. Goodwin,et al.  Bleomycin as a 99mTc carrier in tumor visualization. , 1974, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[12]  E. Silberstein,et al.  111-In-bleomycin kinetics in mice bearing transplantable tumors of lung, skin, and bone. , 1974, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[13]  K. Hisada,et al.  [Clinical evaluation of tumor scanning with 57Co bleomycin]. , 1974, Kaku igaku. The Japanese journal of nuclear medicine.

[14]  L. Mamo,et al.  Use of radioactive bleomycin to detect malignant intracranial tumors. Comparative study with technetium-99m in 104 cases. , 1973, Journal of neurosurgery.

[15]  R. Reba,et al.  Distribution of labeled bleomycin in normal and tumor-bearing mice. , 1973, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[16]  S. Salmon,et al.  Failure of indium 111-labeled bleomycin tumor scanning to predict response to bleomycin (NSC-125066) treatment. , 1974, Cancer chemotherapy reports.