A Mangifera indica L. Extract Could Be Used to Treat Neuropathic Pain and Implication of Mangiferin

It has been accepted that neuroinflammation, oxidative stress and glial activation are involved in the central sensitization underlying neuropathic pain. Vimang is an aqueous extract of Mangifera indica L. traditionally used in Cuba for its analgesic, anti-inflammatory, antioxidant and immunomodulatory properties. Several formulations are available, and also for mangiferin, its major component. Preclinical studies demonstrated that these products prevented tumor necrosis factor α -induced IκB degradation and the binding of nuclear factor κB to DNA, which induces the transcription of genes implicated in the expression of some mediators and enzymes involved in inflammation, pain, oxidative stress and synaptic plasticity. In this paper we propose its potential utility in the neuropathic pain treatment. This hypothesis is supported in the cumulus of preclinical and clinical evidence around the extract and mangiferin, its major component, and speculates about the possible mechanism of action according to recent advances in the physiopathology of neuropathic pain.

[1]  Yan Ping Zhang,et al.  Transgenic inhibition of glial NF-kappa B reduces pain behavior and inflammation after peripheral nerve injury , 2010, PAIN®.

[2]  C. Matute,et al.  Mangifera Indica L. Extract Attenuates Glutamate-induced Neurotoxicity on Rat Cortical Neurons , 2022 .

[3]  S. J. Kim,et al.  Transient receptor potential vanilloid type 1 receptor regulates glutamatergic synaptic inputs to the spinothalamic tract neurons of the spinal cord deep dorsal horn , 2009, Neuroscience.

[4]  C. Matute,et al.  Molecular mechanisms of neuroprotection by two natural antioxidant polyphenols. , 2009, Cell calcium.

[5]  Bárbara B. Garrido-Suárez,et al.  Introducción de la suplementación con formulaciones Vimang ® en el síndrome doloroso regional complejo: experiencia en 15 pacientes , 2009 .

[6]  M. Wallace,et al.  NGX-4010, a high-concentration capsaicin patch, for the treatment of postherpetic neuralgia: a randomised, double-blind study , 2008, The Lancet Neurology.

[7]  B. Fiebich,et al.  Mangiferin inhibits cyclooxygenase-2 expression and prostaglandin E2 production in activated rat microglial cells. , 2008, Archives of biochemistry and biophysics.

[8]  K. Chung,et al.  Reactive oxygen species (ROS) are involved in enhancement of NMDA-receptor phosphorylation in animal models of pain , 2007, PAIN.

[9]  K. Sakimura,et al.  Nitric oxide (NO) serves as a retrograde messenger to activate neuronal NO synthase in the spinal cord via NMDA receptors. , 2007, Nitric oxide : biology and chemistry.

[10]  Ji-Tian Xu,et al.  Peri-sciatic administration of recombinant rat TNF-α induces mechanical allodynia via upregulation of TNF-α in dorsal root ganglia and in spinal dorsal horn: The role of NF-kappa B pathway , 2007, Experimental Neurology.

[11]  Mariela Guevara-García,et al.  The paradox of natural products as pharmaceuticals. Experimental evidences of a mango stem bark extract. , 2007, Pharmacological research.

[12]  Ji-Tian Xu,et al.  Tumor necrosis factor-α induces long-term potentiation of C-fiber evoked field potentials in spinal dorsal horn in rats with nerve injury: The role of NF-kappa B, JNK and p38 MAPK , 2007, Neuropharmacology.

[13]  G. Czéh,et al.  Relative roles of protein kinase A and protein kinase C in modulation of transient receptor potential vanilloid type 1 receptor responsiveness in rat sensory neurons in vitro and peripheral nociceptors in vivo , 2006, Neuroscience.

[14]  S. Dane,et al.  Antioxidants attenuate multiple phases of formalin-induced nociceptive response in mice , 2006, Behavioural Brain Research.

[15]  V. R. Prakash,et al.  Role of oxidative stress in pathophysiology of peripheral neuropathy and modulation by N‐acetyl‐l‐cysteine in rats , 2006, European journal of pain.

[16]  A. Routtenberg,et al.  Evolutionarily‐conserved role of the NF‐κB transcription factor in neural plasticity and memory , 2006, The European journal of neuroscience.

[17]  Amaia M. Arranz,et al.  Neuroprotection by two polyphenols following excitotoxicity and experimental ischemia , 2006, Neurobiology of Disease.

[18]  Ji-Tian Xu,et al.  The role of tumor necrosis factor-alpha in the neuropathic pain induced by Lumbar 5 ventral root transection in rat , 2006, PAIN.

[19]  G. Garrido,et al.  Protective effects of a standard extract of Mangifera indica L. (VIMANG) against mouse ear edemas and its inhibition of eicosanoid production in J774 murine macrophages. , 2006, Phytomedicine : international journal of phytotherapy and phytopharmacology.

[20]  Jun-Li Zhou,et al.  Analgesic effect of vitamin E is mediated by reducing central sensitization in neuropathic pain , 2006, PAIN.

[21]  V. Tawfik,et al.  The tetrapartite synapse: Path to CNS sensitization and chronic pain , 2006, PAIN.

[22]  J. Calixto,et al.  Long-lasting neuropathic pain induced by brachial plexus injury in mice: Role triggered by the pro-inflammatory cytokine, tumour necrosis factor α , 2006, Neuropharmacology.

[23]  A. Pickering,et al.  Tactile allodynia in patients with postherpetic neuralgia: Lack of change in skin blood flow upon dynamic stimulation , 2005, Pain.

[24]  C. Sommer,et al.  Intraneural injection of interleukin-1β and tumor necrosis factor-alpha into rat sciatic nerve at physiological doses induces signs of neuropathic pain , 2005, Pain.

[25]  M. Blanco-Molina,et al.  An aqueous stem bark extract of Mangifera indica (Vimang®) inhibits T cell proliferation and TNF‐induced activation of nuclear transcription factor NF‐κB , 2005, Phytotherapy research : PTR.

[26]  P. Lui,et al.  Preemptive effects of intrathecal cyclooxygenase inhibitor or nitric oxide synthase inhibitor on thermal hypersensitivity following peripheral nerve injury. , 2004, Life sciences.

[27]  L. Urbán,et al.  The role of the vanilloid (capsaicin) receptor (TRPV1) in physiology and pathology. , 2004, European journal of pharmacology.

[28]  R. Coggeshall,et al.  Reactive oxygen species (ROS) play an important role in a rat model of neuropathic pain , 2004, Pain.

[29]  G. Garrido,et al.  In vivo and in vitro anti-inflammatory activity of , 2022 .

[30]  G. Garrido,et al.  Protection against septic shock and suppression of tumor necrosis factor alpha and nitric oxide production on macrophages and microglia by a standard aqueous extract of Mangifera indica L. (VIMANG). Role of mangiferin isolated from the extract. , 2004, Pharmacological research.

[31]  J. Leiro,et al.  An Anacardiaceae preparation reduces the expression of inflammation-related genes in murine macrophages. , 2004, International immunopharmacology.

[32]  S. Maier,et al.  Peri-sciatic proinflammatory cytokines, reactive oxygen species, and complement induce mirror-image neuropathic pain in rats , 2004, Pain.

[33]  Florencio M Ubeira,et al.  Expression profiles of genes involved in the mouse nuclear factor-kappa B signal transduction pathway are modulated by mangiferin. , 2004, International immunopharmacology.

[34]  F. Ubeira,et al.  Mangifera indica L. extract (Vimang) and mangiferin modulate mouse humoral immune responses , 2003, Phytotherapy research : PTR.

[35]  R. Schwartzman,et al.  Thalidomide has activity in treating complex regional pain syndrome. , 2003, Archives of internal medicine.

[36]  I. A. Ross,et al.  Mangifera indica L. , 2003 .

[37]  J. Sawynok,et al.  Modulation of formalin-induced behaviors and edema by local and systemic administration of dextromethorphan, memantine and ketamine. , 2002, European journal of pharmacology.

[38]  F. Ubeira,et al.  Modulation of rat macrophage function by the Mangifera indica L. extracts Vimang and mangiferin. , 2002, International immunopharmacology.

[39]  S. Rajkumar,et al.  Complete resolution of reflex sympathetic dystrophy with thalidomide treatment. , 2001, Archives of internal medicine.

[40]  G. Martínez,et al.  Effect of Mangifera indica L. extract (QF808) on protein and hepatic microsome peroxidation , 2001, Phytotherapy research : PTR.

[41]  G. Geisslinger,et al.  Release of glutamate, nitric oxide and prostaglandin E2 and metabolic activity in the spinal cord of rats following peripheral nociceptive stimulation , 2001, Pain.

[42]  K. Okuda,et al.  Characterization of nociceptive responses and spinal releases of nitric oxide metabolites and glutamate evoked by different concentrations of formalin in rats , 2001, Pain.

[43]  G. Garrido,et al.  Analgesic and anti‐inflammatory effects of Mangifera indica L. extract (Vimang) , 2001, Phytotherapy research : PTR.

[44]  E. Candelario-Jalil,et al.  Mangifera indica L. extract (QF808) reduces ischaemia-induced neuronal loss and oxidative damage in the gerbil brain , 2001, Free radical research.

[45]  O. S. León-Fernández,et al.  Protective effects of Mangifera indica L. extract, mangiferin and selected antioxidants against TPA-induced biomolecules oxidation and peritoneal macrophage activation in mice. , 2000, Pharmacological research.

[46]  A I Basbaum,et al.  Impaired nociception and pain sensation in mice lacking the capsaicin receptor. , 2000, Science.

[47]  R. Yezierski,et al.  Cytokine involvement in dynorphin-induced allodynia , 2000, PAIN®.

[48]  K. Tyler,et al.  A randomized vehicle-controlled trial of topical capsaicin in the treatment of postherpetic neuralgia. , 1993, Clinical therapeutics.

[49]  R. Melzack,et al.  Central nervous system plasticity in the tonic pain response to subcutaneous formalin injection , 1990, Brain Research.

[50]  R. Delgado,et al.  Protective effects of Mangifera indica L extract (Vimang), and its major component mangiferin, on iron-induced oxidative damage to rat serum and liver. , 2008, Pharmacological research.

[51]  G. Gutiérrez,et al.  Siameses: presentación de un caso , 2007 .

[52]  B. Pearce.  Models and Mechanisms , 2003 .

[53]  R. Wallace,et al.  A RANDOMISED DOUBLE-BLIND STUDY , 1993 .