THE DISTRIBUTION OF ADRENERGIC NERVE FIBRES TO THE BLOOD VESSELS IN SKELETAL MUSCLE.

Fuxe K. and G. Sedvall. The distribution of adrenergic nerve fibres to the blood vessels in skeletal muscle. Acta physiol. scand. 1965. 64. 75–86. The distribution and morphological construction of the adrenergic innervation to the various sections of the vascular bed in skeletal muscle of the cat were studied using a specific histochemical fluorescence technique. A typical adrenergic ground plexus (Hillarp 1946, 1959) was seen directly superimposed on the smooth muscle layer of the vessels. The nerve terminals seldom penetrated into this layer. The arteries entering the muscles showed only a sparse amount of adrenergic fibres, whereas the intra-muscular arteries, arterioles and metarterioles exhibited a fairly rich supply. The innervation was uniform, no definite accumulation of adrenergic fibres being observed in any section of the vascular bed. The capillaries did not seem to receive any adrenergic fibres. The vessels on the venous side had a very sparse innervation. Single nerve bundles could be observed in relation to some small venules (20–40 μ) but only occasionally were adrenergic fibres seen around intramuscular veins with diameters above 50 μ. Possible mechanisms for the mediation of nervous vasoconstrictor stimuli to the various vessel sections are discussed.

[1]  B. Folkow,et al.  The chemical transmission of vasoconstrictor impulses to the hind limbs and the splanchnic region of the cat. , 1948, Acta physiologica Scandinavica.

[2]  A. Vendsalu.  Studies on adrenaline and noradrenaline in human plasma. , 1960, Acta physiologica Scandinavica. Supplementum.

[3]  C. Prosser,et al.  Conduction in smooth muscle: comparative structural properties. , 1960, The American journal of physiology.

[4]  I. Roddie.  The transmembrane potential changes associated with smooth muscle activity in turtle arteries and veins , 1962, The Journal of physiology.

[5]  B. Falck,et al.  Cellular localization of brain monoamines. , 1962, Acta physiologica Scandinavica. Supplementum.

[6]  J. Axelrod,et al.  FATE OF H3-NORADRENALINE IN SKELETAL MUSCLE BEFORE AND FOLLOWING SYMPATHETIC STIMULATION. , 1963, The American journal of physiology.

[7]  E. Bucherl,et al.  [Oxygen consumption of the relaxing skeletal muscle in reflectory vasoconstriction]. , 1952, Pflugers Archiv fur die gesamte Physiologie des Menschen und der Tiere.

[8]  C J CLEMEDSON,et al.  DYNAMIC RESPONSE OF CHEST WALL AND LUNG INJURIES IN RABBITS EXPOSED TO AIR SHOCK WAVES OF SHORT DURATION. , 1964, Acta physiologica Scandinavica. Supplementum.

[9]  G. Jonsson,et al.  FLUORESCENCE METHODS FOR THE HISTOCHEMICAL DEMONSTRATION OF MONOAMINES. 3. SODIUM BOROHYDRIDE REDUCTION OF THE FLUORESCENT COMPOUNDS AS A SPECIFICITY TEST , 1964 .

[10]  K. Fuxe,et al.  HISTOCHEMICAL AND BIOCHEMICAL OBSERVATIONS ON THE EFFECT OF RESERPINE ON NORADRENALINE STORAGE IN VASOCONSTRICTOR NERVES. , 1964, Acta physiologica Scandinavica.

[11]  O. Appenzeller.  ELECTRON MICROSCOPIC STUDY OF THE INNERVATION OF THE AURICULAR ARTERY IN THE RAT. , 1964, Journal of anatomy.

[12]  K. Fuxe,et al.  EVIDENCE FOR THE EXISTENCE OF MONOAMINE-CONTAINING NEURONS IN THE CENTRAL NERVOUS SYSTEM. I. DEMONSTRATION OF MONOAMINES IN THE CELL BODIES OF BRAIN STEM NEURONS. , 1964, Acta physiologica Scandinavica. Supplementum.

[13]  A. Esterhuizen,et al.  Fine Structure of the Arteriolar Nerves in the Guinea Pig Pancreas , 1961, Nature.

[14]  H. Corrodi,et al.  Fluoreszenzmethoden zur histochemischen Sichtbarmachung von Monoaminen. 1. Identifizierung der fluoreszierenden Produkte aus Modellversuchen mit 6,7‐Dimethoxyisochinolinderivaten und Formaldehyd , 1963 .

[15]  S. Mellander.  Comparative studies on the adrenergic neuro-hormonal control of resistance and capacitance blood vessels in the cat. , 1960, Acta physiologica Scandinavica. Supplementum.

[16]  T. Sundin,et al.  The urinary excretion of noradrenaline and adrenaline in healthy subjects during recumbency and standing. , 1955, Acta physiologica Scandinavica.

[17]  S. Rosell,et al.  Independent sympathetic vasoconstrictor innervation of arterioles and precapillary sphincters. , 1962, Acta physiologica Scandinavica.

[18]  D. Pease,et al.  Electron microscopy of muscular arteries; pial vessels of43 the cat and monkey. , 1960, Journal of ultrastructure research.

[19]  R. Eliasson.  Studies on prostaglandin; occurrence, formation and biological actions. , 1959, Acta physiologica Scandinavica. Supplementum.

[20]  J. V. Euw,et al.  Fluoreszenzenzmethoden zur histochemischen Sichtbarmachung von Monoaminen. 2.. Identifizierung des fluoreszierenden Produktes aus Dopamin und Formaldehyd , 1964 .

[21]  J. Haeggendal.  AN IMPROVED METHOD FOR FLUORIMETRIC DETERMINATION OF SMALL AMOUNTS OF ADRENALINE AND NORADRENALINE IN PLASMA AND TISSUES. , 1963, Acta physiologica Scandinavica.

[22]  C. Prosser,et al.  Conduction in smooth muscles: comparative electrical properties. , 1960, The American journal of physiology.

[23]  K. Fuxe,et al.  THE ADRENERGIC INNERVATION OF THE NASAL MUCOSA OF CERTAIN MAMMALS. , 1965, Acta oto-laryngologica.

[24]  G. Thieme,et al.  FLUORESCENCE OF CATECHOL AMINES AND RELATED COMPOUNDS CONDENSED WITH FORMALDEHYDE , 1962 .

[25]  Å. Bertler,et al.  STUDIES ON 5-HYDROXYTRYPTAMINE STORES IN PINEAL GLAND OF RAT. , 1964, Acta physiologica Scandinavica. Supplementum.