Primary care guidelines for the management of persons infected with HIV: 2013 update by the HIV Medicine Association of the Infectious Diseases Society of America.

Evidence-based guidelines for the management of persons infected with human immunodeficiency virus (HIV) were prepared by an expert panel of the HIV Medicine Association of the Infectious Diseases Society of America. These updated guidelines replace those published in 2009. The guidelines are intended for use by healthcare providers who care for HIV-infected patients. Since 2009, new antiretroviral drugs and classes have become available, and the prognosis of persons with HIV infection continues to improve. However, with fewer complications and increased survival, HIV-infected persons are increasingly developing common health problems that also affect the general population. Some of these conditions may be related to HIV infection itself or its treatment. HIV-infected persons should be managed and monitored for all relevant age- and sex-specific health problems. New information based on publications from the period 2009-2013 has been incorporated into this document.

[1]  S. Kalra,et al.  Diagnosis of diabetes. , 2015, JPMA. The Journal of the Pakistan Medical Association.

[2]  David K. Henderson,et al.  Updated US Public Health Service Guidelines for the Management of Occupational Exposures to Human Immunodeficiency Virus and Recommendations for Postexposure Prophylaxis , 2013, Infection Control & Hospital Epidemiology.

[3]  F. Hughes,et al.  Quality of evidence , 2013, BDJ.

[4]  B. Branson,et al.  Detection of Acute HIV Infection in Two Evaluations of a New HIV Diagnostic Testing Algorithm — United States, 2011–2013 , 2013, MMWR. Morbidity and mortality weekly report.

[5]  A. Labriola,et al.  Is frequent CD4+ T-lymphocyte count monitoring necessary for persons with counts >=300 cells/μL and HIV-1 suppression? , 2013, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[6]  L. Mofenson,et al.  Disclosure of Illness Status to Children and Adolescents with HIV Infection , 2013, Pediatric Clinical Practice Guidelines & Policies.

[7]  K. Mayer Assessment, diagnosis, and treatment of HIV-associated neurocognitive disorder: a consensus report of the mind exchange program. , 2013, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[8]  B. Branson,et al.  Performance of a fourth-generation HIV screening assay and an alternative HIV diagnostic testing algorithm , 2013, AIDS.

[9]  C. Bridges,et al.  Recommended Adult Immunization Schedule: United States, 2013* , 2013, Annals of Internal Medicine.

[10]  S. Kahn Quantifying β-Cells in Health and Disease: The Past, the Present, and the Need , 2012, Diabetes Care.

[11]  Executive Summary: Standards of Medical Care in Diabetes—2013 , 2012, Diabetes Care.

[12]  K. Hoffman,et al.  Influence of SLCO1B1 Polymorphisms on the Drug‐Drug Interaction Between Darunavir/Ritonavir and Pravastatin , 2012, Journal of clinical pharmacology.

[13]  VariZIG Cangene FDA Approval of an Extended Period for Administering VariZIG for Postexposure Prophylaxis of Varicella , 2012, MMWR. Morbidity and mortality weekly report.

[14]  J. Aberg,et al.  Risk factors for tuberculin skin test conversion among HIV-infected patients in New York City. , 2012, International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases.

[15]  V. Moyer,et al.  Screening for Cervical Cancer: U.S. Preventive Services Task Force Recommendation Statement , 2012, Annals of Internal Medicine.

[16]  Christine Y. Yu,et al.  Effects of Steady-State Lopinavir/Ritonavir on the Pharmacokinetics of Pitavastatin in Healthy Adult Volunteers , 2012, Journal of acquired immune deficiency syndromes.

[17]  C. K. Kwan,et al.  Glycated Hemoglobin A(1c) as screening for diabetes mellitus in HIV-infected individuals. , 2012, AIDS patient care and STDs.

[18]  Executive Summary: Standards of Medical Care in Diabetes—2012 , 2011, Diabetes Care.

[19]  Joel E Gallant,et al.  Essential components of effective HIV care: a policy paper of the HIV Medicine Association of the Infectious Diseases Society of America and the Ryan White Medical Providers Coalition. , 2011, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[20]  P. Emmanuel,et al.  Adolescents and HIV Infection: The Pediatrician's Role in Promoting Routine Testing , 2011, Pediatrics.

[21]  S. Swindells,et al.  Prevention of HIV-1 infection with early antiretroviral therapy , 2011, Journal of Family Planning and Reproductive Health Care.

[22]  D. Kolson,et al.  Current understanding of HIV-associated neurocognitive disorders pathogenesis. , 2011, Current opinion in neurology.

[23]  L. Mofenson,et al.  Antiretroviral Treatment of US Children With Perinatally Acquired HIV Infection: Temporal Changes in Therapy Between 1991 and 2009 and Predictors of Immunologic and Virologic Outcomes , 2011, Journal of acquired immune deficiency syndromes.

[24]  S. El-Kamary,et al.  Hepatitis C virus infection during pregnancy and the newborn period – are they opportunities for treatment? , 2011, Journal of viral hepatitis.

[25]  M. Poljak,et al.  European recommendations for the clinical use of HIV drug resistance testing: 2011 update. , 2011, AIDS reviews.

[26]  Stuart Berman,et al.  Sexually transmitted diseases treatment guidelines, 2010. , 2010, MMWR. Recommendations and reports : Morbidity and mortality weekly report. Recommendations and reports.

[27]  S. Chandwani,et al.  Sexual Transmission Risk Behavior of Adolescents With HIV Acquired Perinatally or Through Risky Behaviors , 2010, Journal of acquired immune deficiency syndromes.

[28]  Jeannie S. Huang,et al.  Bone disease in HIV infection: a practical review and recommendations for HIV care providers. , 2010, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[29]  J. Palefsky,et al.  Safety and immunogenicity of the quadrivalent human papillomavirus vaccine in HIV-1-infected men. , 2010, The Journal of infectious diseases.

[30]  A. Moscicki,et al.  Safety and Immunogenicity of a Quadrivalent Human Papillomavirus (Types 6, 11, 16, and 18) Vaccine in HIV-Infected Children 7 to 12 Years Old , 2010, Journal of acquired immune deficiency syndromes.

[31]  S. Asch,et al.  Development of national and multiagency HIV care quality measures. , 2010, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[32]  Jeffrey N. Martin,et al.  Initiation of antiretroviral therapy at higher nadir CD4+ T-cell counts is associated with reduced arterial stiffness in HIV-infected individuals , 2010, AIDS.

[33]  D. Costagliola,et al.  Rosuvastatin versus pravastatin in dyslipidemic HIV-1-infected patients receiving protease inhibitors: a randomized trial , 2010, AIDS.

[34]  S. Walmsley,et al.  Etravirine for HIV-I: Addressing the Limitations of the Nonnucleoside Reverse Transcriptase Inhibitor Class , 2009, Journal of the International Association of Physicians in AIDS Care.

[35]  A. Horvath,et al.  Grading quality of evidence and strength of recommendations for diagnostic tests and strategies. , 2009, Clinical chemistry.

[36]  K. Samaras Prevalence and pathogenesis of diabetes mellitus in HIV-1 infection treated with combined antiretroviral therapy. , 2009, Journal of acquired immune deficiency syndromes.

[37]  A. Westfall,et al.  Missed visits and mortality among patients establishing initial outpatient HIV treatment. , 2009, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[38]  L. Mofenson,et al.  Evaluation and Management of the Infant Exposed to HIV-1 in the United States , 2009, Pediatrics.

[39]  V. Calvez,et al.  Optimal use of maraviroc in clinical practice. , 2008, AIDS.

[40]  L. Mofenson,et al.  HIV Testing and Prophylaxis to Prevent Mother-to-Child Transmission in the United States , 2008, Pediatrics.

[41]  S. Hammer,et al.  Antiretroviral treatment of adult HIV infection: 2010 recommendations of the International AIDS Society-USA panel. , 2008, JAMA.

[42]  Peter Reiss,et al.  Antiretroviral treatment of adult HIV infection: 2008 recommendations of the International AIDS Society-USA panel. , 2008, JAMA.

[43]  G. Guyatt,et al.  Use of GRADE grid to reach decisions on clinical practice guidelines when consensus is elusive , 2008, BMJ : British Medical Journal.

[44]  G. Guyatt,et al.  Incorporating considerations of resources use into grading recommendations , 2008, BMJ : British Medical Journal.

[45]  G. Guyatt,et al.  Going from evidence to recommendations , 2008, BMJ : British Medical Journal.

[46]  G. Guyatt,et al.  What is “quality of evidence” and why is it important to clinicians? , 2008, BMJ : British Medical Journal.

[47]  J. Gerber,et al.  Drug/Drug Interaction Between Lopinavir/Ritonavir and Rosuvastatin in Healthy Volunteers , 2008, Journal of acquired immune deficiency syndromes.

[48]  J. Aberg,et al.  Prevalence and Significance of G6PD Deficiency in Patients of an Urban HIV Clinic , 2008, Journal of the International Association of Physicians in AIDS Care.

[49]  L. Hurley,et al.  Effects of Depression and Selective Serotonin Reuptake Inhibitor Use on Adherence to Highly Active Antiretroviral Therapy and on Clinical Outcomes in HIV-Infected Patients , 2008, Journal of acquired immune deficiency syndromes.

[50]  A. Angelino,et al.  The Need for Sociocultural Awareness to Maximize Treatment Acceptance and Adherence in Individuals Initiating HIV Therapy , 2008 .

[51]  J. Peto,et al.  Current CD4 cell count and the short-term risk of AIDS and death before the availability of effective antiretroviral therapy in HIV-infected children and adults. , 2008, The Journal of infectious diseases.

[52]  S. Swindells,et al.  Alendronate with calcium and vitamin D supplementation is safe and effective for the treatment of decreased bone mineral density in HIV , 2007, AIDS.

[53]  Christopher H. Johnson,et al.  Trends in Hospitalizations of HIV-Infected Children and Adolescents in the United States: Analysis of Data From the 1994–2003 Nationwide Inpatient Sample , 2007, Pediatrics.

[54]  J. Seward,et al.  Prevention of varicella: recommendations of the Advisory Committee on Immunization Practices (ACIP). , 2007, MMWR. Recommendations and reports : Morbidity and mortality weekly report. Recommendations and reports.

[55]  M. Suarez‐Almazor,et al.  Retention in care: a challenge to survival with HIV infection. , 2007, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[56]  M. Rieder,et al.  Interventions for the treatment of decreased bone mineral density associated with HIV infection. , 2007, The Cochrane database of systematic reviews.

[57]  Douglas K Owens,et al.  Screening Mammography for Women 40 to 49 Years of Age: A Clinical Practice Guideline from the American College of Physicians , 2007, Annals of Internal Medicine.

[58]  S. Marhefka,et al.  Disclosure of an HIV Diagnosis to Children: History, Current Research, and Future Directions , 2007, Journal of developmental and behavioral pediatrics : JDBP.

[59]  J Darbyshire,et al.  CD4+ count-guided interruption of antiretroviral treatment. , 2006, The New England journal of medicine.

[60]  O. Ramilo,et al.  Initiating Highly Active Antiretroviral Therapy in Human Immunodeficiency Virus Type 1-Infected Children in Europe and the United States: Comparing Clinical Practice to Guidelines and Literature Evidence , 2006, The Pediatric infectious disease journal.

[61]  Atlanta,et al.  Revised recommendations for HIV testing of adults, adolescents, and pregnant women in health-care settings. , 2006, MMWR. Recommendations and reports : Morbidity and mortality weekly report. Recommendations and reports.

[62]  M. Levin,et al.  Administration of live varicella vaccine to HIV-infected children with current or past significant depression of CD4(+) T cells. , 2006, The Journal of infectious diseases.

[63]  T. Flanigan,et al.  The good, the bad, and the ugly: providing highly active antiretroviral therapy when it is most difficult. , 2006, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[64]  L. Mofenson,et al.  A Behavioral and Cognitive Profile of Clinically Stable HIV-Infected Children , 2006, Pediatrics.

[65]  C. Fichtenbaum,et al.  Effect of Efavirenz on the Pharmacokinetics of Simvastatin, Atorvastatin, and Pravastatin: Results of AIDS Clinical Trials Group 5108 Study , 2005, Journal of acquired immune deficiency syndromes.

[66]  K. Tashima,et al.  Guidelines for the management of chronic kidney disease in HIV-infected patients: recommendations of the HIV Medicine Association of the Infectious Diseases Society of America. , 2005, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[67]  P. Sax,et al.  Response to hepatitis B vaccine in HIV-1-positive subjects who test positive for isolated antibody to hepatitis B core antigen: implications for hepatitis B vaccine strategies. , 2005, The Journal of infectious diseases.

[68]  S. Holmberg,et al.  Efficacy of a brief case management intervention to link recently diagnosed HIV-infected persons to care , 2005, AIDS.

[69]  John Schneider,et al.  Better physician-patient relationships are associated with higher reported adherence to antiretroviral therapy in patients with HIV infection , 2004, Journal of General Internal Medicine.

[70]  V. Stone,et al.  Primary care guidelines for the management of persons infected with human immunodeficiency virus: 2009 update by the HIV medicine Association of the Infectious Diseases Society of America. , 2004, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[71]  C. Heilig,et al.  Abnormal Vaginal Cytology in HIV-Infected and At-Risk Women After Hysterectomy , 2004, Journal of acquired immune deficiency syndromes.

[72]  V. Stone Optimizing the care of minority patients with HIV/AIDS. , 2004, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[73]  W. K. Henry,et al.  Guidelines for the evaluation and management of dyslipidemia in human immunodeficiency virus (HIV)-infected adults receiving antiretroviral therapy: recommendations of the HIV Medical Association of the Infectious Disease Society of America and the Adult AIDS Clinical Trials Group. , 2003, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[74]  Gale R. Burstein,et al.  Sexually transmitted diseases treatment guidelines , 2003, Current opinion in pediatrics.

[75]  V. Stone,et al.  An examination of HIV/AIDS patients who have excellent adherence to HAART , 2003, AIDS care.

[76]  M. Chesney,et al.  Adherence to HAART regimens. , 2003, AIDS patient care and STDs.

[77]  J. V. D. van der Meer,et al.  Post-exposure prophylaxis , 2002, International journal of STD & AIDS.

[78]  L. Pantanowitz,et al.  Pathology of the Breast Associated With HIV/AIDS , 2002, The breast journal.

[79]  Mark Sherman,et al.  The 2001 Bethesda System: terminology for reporting results of cervical cytology. , 2002, JAMA.

[80]  H. Hutton,et al.  Psychiatric issues in the management of patients with HIV infection. , 2001, JAMA.

[81]  G. Gray,et al.  Human Immunodefi ciency Virus Infection , 2001 .

[82]  Susan Swindells,et al.  Adherence to Protease Inhibitor Therapy and Outcomes in Patients with HIV Infection , 2000, Annals of Internal Medicine.

[83]  M. Chesney,et al.  Factors affecting adherence to antiretroviral therapy. , 2000, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[84]  W L Holzemer,et al.  Relationships between perception of engagement with health care provider and demographic characteristics, health status, and adherence to therapeutic regimen in persons with HIV/AIDS. , 2000, AIDS patient care and STDs.

[85]  M. Hirsch,et al.  Drug susceptibility in HIV infection after viral rebound in patients receiving indinavir-containing regimens. , 2000, JAMA.

[86]  R. Chaisson,et al.  Highly Active Antiretroviral Therapy in a Large Urban Clinic: Risk Factors for Virologic Failure and Adverse Drug Reactions , 1999, Annals of Internal Medicine.

[87]  Richard A. Loftus,et al.  HIV RNA and CD4 cell count response to protease inhibitor therapy in an urban AIDS clinic: response to both initial and salvage therapy. , 1999, AIDS.

[88]  J. Feldman,et al.  Prevalence and incidence of gynecologic disorders among women infected with human immunodeficiency virus. , 1999, American journal of obstetrics and gynecology.

[89]  J. J. Henning,et al.  Guidelines for the Use of Antiretroviral Agents in HIV-Infected Adults and Adolescents, January 28, 2000 , 1998, HIV clinical trials.

[90]  J. Oleske,et al.  Guidelines for the use of antiretroviral agents in pediatric HIV infection , 1998 .

[91]  Henry Nider,et al.  Report of the Committee on Infectious Diseases , 1989 .

[92]  Thomas R. Frieden Advisory Committee on Immunization Practices (ACIP) recommended immunization schedules for persons aged 0 through 18 years and adults aged 19 years and older--United States, 2013. , 2013, MMWR supplements.

[93]  Huldrych F. Günthard,et al.  Antiretroviral treatment of adult HIV infection: 2012 recommendations of the International Antiviral Society-USA panel. , 2012, JAMA.

[94]  J. D. De Santis,et al.  Development of a protocol for transitioning adolescents with HIV infection to adult care. , 2011, Journal of pediatric health care : official publication of National Association of Pediatric Nurse Associates & Practitioners.

[95]  S. Zeuzem,et al.  EASL Clinical Practice Guidelines: management of hepatitis C virus infection. , 2011, Journal of hepatology.

[96]  C. Fichtenbaum Metabolic abnormalities associated with HIV infection and antiretroviral therapy , 2009, Current infectious disease reports.

[97]  W. Fawzi,et al.  Human Immunodeficiency Virus Infection , 2008 .

[98]  G. Seage,et al.  Reproductive health of adolescent girls perinatally infected with HIV. , 2007, American journal of public health.

[99]  S. Erlinger,et al.  European Association for the Study of the Liver , 2006 .

[100]  Diagnosis and classification of diabetes mellitus. , 2005, Diabetes care.

[101]  V. Stone,et al.  Primary care guidelines for the management of persons infected with human immunodeficiency virus: recommendations of the HIV Medicine Association of the Infectious Diseases Society of America. , 2004, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[102]  J. Bartlett,et al.  Recommendations for Use of Antiretroviral Drugs in Pregnant HIV-1-Infected Women for Maternal Health and Interventions to reduce Perinatal HIV-1Transmission in the United States , 2003 .

[103]  L. Pantanowitz,et al.  Breast cancer in HIV positive women: a report of four cases and review of the literature. , 2003, Cancer investigation.

[104]  Thomas C Wright,et al.  Consensus Guidelines for the Management of Women With Cervical Cytological Abnormalities , 2002 .

[105]  Disclosure of illness status to children and adolescents with HIV infection. American Academy of Pediatrics Committee on Pediatrics AIDS. , 1999, Pediatrics.

[106]  Anergy skin testing and tuberculosis [corrected] preventive therapy for HIV-infected persons: revised recommendations. Centers for Disease Control and Prevention. , 1997, MMWR. Recommendations and reports : Morbidity and mortality weekly report. Recommendations and reports.

[107]  L. Soto-Ramírez,et al.  [Treatment of tuberculosis]. , 1997, Gaceta medica de Mexico.

[108]  From the Centers for Disease Control and prevention. 1993 revised classification system for HIV infection and expanded surveillance case definition for AIDS among adolescents and adults. , 1993, JAMA.

[109]  M. Field,et al.  Clinical practice guidelines : directions for a new program , 1990 .

[110]  GrADE: an emerging consensus on rating quality of evidence and strength of recommendations , 2022 .