A deleted B chromosome in a mosaic mother and her cri du chat progeny.

Familial occurrence of chromosomal anomalies may be caused by: (1) numerical chromosomal abnormalities present in all or some of the cells of one of the parents (secondary non-disjunction), or (2) by a genetically determined tendency to meiotic or mitotic non-disjunction. Structural chromosomal abnormalities such as translocations have also been described as frequent causes of familial chromosomal errors. It is the purpose of this paper to report the results of chromosome studies in a family in which two sibs carried a deletion of a short arm of a chromosome No. 5. One was a child with the typical cri du chat syndrome, the other was a fetus weighing 14 g. The mother was found to be a mosaic of normal cells and cells with a deleted B chromosome. A fertile mosaic of this type has not been reported before.

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