Acyl glucuronides: biological activity, chemical reactivity, and chemical synthesis.
暂无分享,去创建一个
John C Lindon | Ian D Wilson | I. Wilson | J. Lindon | B. K. Park | J. Maggs | B Kevin Park | Andrew V Stachulski | John R Harding | James L Maggs | A. Stachulski | J. Harding | B. Park | and B. Kevin Park
[1] A. Siraki,et al. Application of quantitative structure-toxicity relationships for acute NSAID cytotoxicity in rat hepatocytes. , 2005, Chemico-biological interactions.
[2] F. Kauffman. Conjugation—Deconjugation Reactions in Drug Metabolism and Toxicity , 1994, Handbook of Experimental Pharmacology.
[3] C. King,et al. Glucuronidation of carboxylic acid containing compounds by UDP-glucuronosyltransferase isoforms. , 2004, Archives of biochemistry and biophysics.
[4] I. Wilson,et al. Kinetic studies on the intramolecular acyl migration of β-1-O-acyl glucuronides: Application to the glucuronides of (R)- and (S)-ketoprofen, (R)- and (S)-hydroxy-ketoprofen metabolites, and tolmetin by 1H-NMR spectroscopy , 2005, Xenobiotica; the fate of foreign compounds in biological systems.
[5] D. Keglević,et al. Glucuronic Esters—III , 1965 .
[6] W. Tang,et al. Bioactivation of a toxic metabolite of valproic acid, (E)-2-propyl-2,4-pentadienoic acid, via glucuronidation. LC/MS/MS characterization of the GSH-glucuronide diconjugates. , 1996, Chemical research in toxicology.
[7] G. R. Cannell,et al. Inhibition of tubulin assembly and covalent binding to microtubular protein by valproic acid glucuronide in vitro. , 2002, Life sciences.
[8] R. Kostiainen,et al. Mass spectrometric and tandem mass spectrometric behavior of nitrocatechol glucuronides: A comparison of atmospheric pressure chemical ionization and electrospray ionization , 1999, Journal of the American Society for Mass Spectrometry.
[9] B. Hamrén,et al. Pharmacokinetics and metabolism of tesaglitazar, a novel dual-acting peroxisome proliferator-activated receptor alpha/gamma agonist, after a single oral and intravenous dose in humans. , 2004, Drug metabolism and disposition: the biological fate of chemicals.
[10] P. Haycock,et al. A comparison of quantitative NMR and radiolabelling studies of the metabolism and excretion of Statil (3-(4-bromo-2-fluorobenzyl)-4-oxo-3H-phthalazin-1-ylacetic acid) in the rat. , 2002, Journal of pharmaceutical and biomedical analysis.
[11] S. Wrighton,et al. Characterization by liquid chromatography-nuclear magnetic resonance spectroscopy and liquid chromatography-mass spectrometry of two coupled oxidative-conjugative metabolic pathways for 7-ethoxycoumarin in human liver microsomes treated with alamethicin. , 2002, Drug metabolism and disposition: the biological fate of chemicals.
[12] I. Wilson,et al. NMR and QSAR studies on the transacylation reactivity of model 1β-O-acyl glucuronides. I: design, synthesis and degradation rate measurement , 2004, Xenobiotica; the fate of foreign compounds in biological systems.
[13] I. Wilson,et al. The application of high performance liquid chromatography, coupled to nuclear magnetic resonance spectroscopy and mass spectrometry (HPLC-NMR-MS), to the characterisation of ibuprofen metabolites from human urine , 1998 .
[14] R. Dickinson,et al. Studies on the reactivity of acyl glucuronides--I. Phenolic glucuronidation of isomers of diflunisal acyl glucuronide in the rat. , 1991, Biochemical pharmacology.
[15] C. Fenselau,et al. Reaction of 1-O-acyl glucuronides with 4-(p-nitrobenzyl)pyridine. , 1986, Drug metabolism and disposition: the biological fate of chemicals.
[16] T. Ebner,et al. Disposition and chemical stability of telmisartan 1-O-acylglucuronide. , 1999, Drug metabolism and disposition: the biological fate of chemicals.
[17] Kumiko Mushiake,et al. Chemical synthesis of 24-beta-D-galactopyranosides of bile acids: a new type of bile acid conjugates in human urine. , 2005, Chemistry and physics of lipids.
[18] R. Barnaby,et al. Human hepatic metabolism of a novel 2-carboxyindole glycine antagonist for stroke: in vitro-in vivo correlations , 2000, Xenobiotica; the fate of foreign compounds in biological systems.
[19] David M. Shackleford,et al. Stereoselective Hepatic Disposition of Model Diastereomeric Acyl Glucuronides , 2004, Journal of Pharmacokinetics and Pharmacodynamics.
[20] B. Ma,et al. GLYCOSIDATION OF AN ENDOTHELIN ETA RECEPTOR ANTAGONIST AND DICLOFENAC IN HUMAN LIVER MICROSOMES: AGLYCONE-DEPENDENT UDP-SUGAR SELECTIVITY , 2005, Drug Metabolism and Disposition.
[21] R. Aster,et al. Immune thrombocytopenia resulting from sensitivity to metabolites of naproxen and acetaminophen. , 2001, Blood.
[22] In vitro and in vivo studies on acyl-coenzyme A-dependent bioactivation of zomepirac in rats. , 2005, Chemical research in toxicology.
[23] D. Holt,et al. Effective synthesis of 1beta-acyl glucuronides by selective acylation. , 2005, Organic letters.
[24] B. K. Park,et al. Syntheses and characterization of the acyl glucuronide and hydroxy metabolites of diclofenac. , 2004, Journal of medicinal chemistry.
[25] H. Nau,et al. Synthesis, high-performance liquid chromatography-nuclear magnetic resonance characterization and pharmacokinetics in mice of CD271 glucuronide. , 2001, Journal of chromatography. B, Biomedical sciences and applications.
[26] K. Bock. Vertebrate UDP-glucuronosyltransferases: functional and evolutionary aspects. , 2003, Biochemical pharmacology.
[27] N. Mano,et al. Rapid and simple quantitative assay method for diastereomeric flurbiprofen glucuronides in the incubation mixture. , 2002, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
[28] R. Kostiainen,et al. Electrospray and atmospheric pressure chemical ionization tandem mass spectrometric behavior of eight anabolic steroid glucuronides , 2000, Journal of the American Society for Mass Spectrometry.
[29] K. Kakehi,et al. In vitro regioselective stability of beta-1-O- and 2-O-acyl glucuronides of naproxen and their covalent binding to human serum albumin. , 1999, Journal of pharmaceutical sciences.
[30] M. Nakajima,et al. Glucuronidation of etoposide in human liver microsomes is specifically catalyzed by UDP-glucuronosyltransferase 1A1. , 2003, Drug metabolism and disposition: the biological fate of chemicals.
[31] C. Rice-Evans,et al. Modulation of Pro-survival Akt/Protein Kinase B and ERK1/2 Signaling Cascades by Quercetin and Its in Vivo Metabolites Underlie Their Action on Neuronal Viability* , 2003, Journal of Biological Chemistry.
[32] D. Lightner,et al. Synthesis and metabolism of the first thia-bilirubin. , 2001, The Journal of organic chemistry.
[33] Y. Shinohara,et al. Studies on the stereoselective internal acyl migration of ketoprofen glucuronides using 13C labeling and nuclear magnetic resonance spectroscopy. , 1998, Drug metabolism and disposition: the biological fate of chemicals.
[34] T. Hashimoto,et al. Rapid internal acyl migration and protein binding of synthetic probenecid glucuronides. , 2002, Chemical Research in Toxicology.
[35] W. Krol,et al. Pharmacokinetics of dibutylphthalate in pregnant rats. , 2004, Toxicological sciences : an official journal of the Society of Toxicology.
[36] S. Hansen,et al. Stereospecific pH-dependent degradation kinetics of R- and S-naproxen-beta-l-O-acyl-glucuronide. , 2002, Chirality.
[37] D. Marguet,et al. Hepatic covalent adduct formation with zomepirac in the CD26‐deficient mouse , 2002, Journal of gastroenterology and hepatology.
[38] H. Leis,et al. Quantitative gas chromatographic/mass spectrometric analysis of morphine glucuronides in human plasma by negative ion chemical ionization mass spectrometry. , 2002, Journal of mass spectrometry : JMS.
[39] J. Weekley,et al. Bioactivation of carboxylic acid compounds by UDP-Glucuronosyltransferases to DNA-damaging intermediates: role of glycoxidation and oxidative stress in genotoxicity. , 2006, Chemical research in toxicology.
[40] J. Magdalou,et al. Glycation of human serum albumin by acylglucuronides of nonsteroidal anti-inflammatory drugs of the series of phenylpropionates. , 1999, Life Science.
[41] Hiromi Ito,et al. Enantioselective immunorecognition of protein modification with optically active ibuprofen using polyclonal antibody. , 2004, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
[42] B. Baguley,et al. Identification and reactivity of the major metabolite (ß-1-glucuronide) of the anti-tumour agent 5,6-dimethylxanthenone-4-acetic acid (DMXAA) in humans , 2001, Xenobiotica; the fate of foreign compounds in biological systems.
[43] V. Armstrong,et al. Acyl Glucuronide Drug Metabolites: Toxicological and Analytical Implications , 2003, Therapeutic drug monitoring.
[44] I. Wilson,et al. Development of a simple liquid chromatographic method for the separation of mixtures of positional isomers and anomers of synthetic 2-, 3- and 4-fluorobenzoic acid glucuronides formed via acyl migration reactions. , 1996, Journal of chromatography. B, Biomedical applications.
[45] J. Ware,et al. Immunochemical detection and identification of protein adducts of diclofenac in the small intestine of rats: possible role in allergic reactions. , 1998, Chemical research in toxicology.
[46] Liang-Shang Gan,et al. Disposition of 1-[3-(aminomethyl)phenyl]-N-[3-fluoro-2'- (methylsulfonyl)-[1,1'-biphenyl]-4-yl]-3-(trifluoromethyl)- 1H-pyrazole-5-carboxamide (DPC 423) by novel metabolic pathways. Characterization of unusual metabolites by liquid chromatography/mass spectrometry and NMR. , 2002, Chemical research in toxicology.
[47] R. Schmidt,et al. Stereoselective glycosidations of uronic acids , 1980 .
[48] C. Fenselau,et al. Characterization and formation of the glutathione conjugate of clofibric acid. , 1995, Drug metabolism and disposition: the biological fate of chemicals.
[49] A. D. Rodrigues,et al. GLUCURONIDATION CONVERTS GEMFIBROZIL TO A POTENT, METABOLISM-DEPENDENT INHIBITOR OF CYP2C8: IMPLICATIONS FOR DRUG-DRUG INTERACTIONS , 2006, Drug Metabolism and Disposition.
[50] M. Lhermitte,et al. Identification and quantitation of xenobiotics by 1H NMR spectroscopy in poisoning cases. , 2003, Forensic science international.
[51] D. Lightner,et al. Synthesis, Conformation, and Metabolism of a Selenium Bilirubin , 2004 .
[52] K. Tomer,et al. Effect of nonenzymatic glycation of albumin and superoxide dismutase by glucuronic acid and suprofen acyl glucuronide on their functions in vitro. , 1999, Chemico-biological interactions.
[53] K. Cassidy,et al. Preclinical characterization of 2-[3-[3-[(5-ethyl-4'-fluoro-2-hydroxy[1,1'-biphenyl]-4-yl)oxy]propoxy]-2-propylphenoxy]benzoic acid metabolism: in vitro species comparison and in vivo disposition in rats. , 2003, Drug metabolism and disposition: the biological fate of chemicals.
[54] A. Barua,et al. All-trans-retinoyl beta-glucuronide: new procedure for chemical synthesis and its metabolism in vitamin A-deficient rats. , 1996, The Biochemical journal.
[55] A L Burlingame,et al. Mechanisms for covalent binding of benoxaprofen glucuronide to human serum albumin. Studies By tandem mass spectrometry. , 1998, Drug metabolism and disposition: the biological fate of chemicals.
[56] R. R. Schmidt,et al. Einfache Synthese von ß-D-Glucopyranosyluronaten , 1981 .
[57] J. Goto,et al. Synthesis of Bile Acid 24-acyl Glucuronides , 1998, Steroids.
[58] I. Wilson,et al. NMR spectroscopic studies of the transacylation reactivity of ibuprofen 1-beta-O-acyl glucuronide. , 2006, Journal of pharmaceutical and biomedical analysis.
[59] Yuan-qing Xia,et al. SPECIES DIFFERENCES IN THE ELIMINATION OF A PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR AGONIST HIGHLIGHTED BY OXIDATIVE METABOLISM OF ITS ACYL GLUCURONIDE , 2005, Drug Metabolism and Disposition.
[60] Shufeng Zhou,et al. Preclinical factors influencing the relative contributions of Phase I and II enzymes to the metabolism of the experimental anti-cancer drug 5,6-dimethylxanthenone-4-acetic acid. , 2003, Biochemical pharmacology.
[61] I. Wilson,et al. Assignment of the 750 MHz 1H NMR resonances from a mixture of transacylated ester glucuronic acid conjugates with the aid of oversampling and digital filtering during acquisition. , 1995, Journal of pharmaceutical and biomedical analysis.
[62] A. Stachulski,et al. The synthesis of O-glucuronides. , 1998, Natural product reports.
[63] David M. Shackleford,et al. A small-scale synthesis and enantiomeric resolution of (RS)-[1-14C]-2-Phenylpropionic acid and biosynthesis of its diastereomeric acyl glucuronides , 2001 .
[64] I. Yamatsu,et al. Synthesis of glucuronides of α,β-unsaturated carboxylic acids , 1993 .
[65] I. Wilson,et al. Identification of the Positional Isomers of 2-Fluorobenzoic acid 1-O-Acyl Glucuronide by Directly Coupled HPLC-NMR , 1995 .
[66] R. Dickinson,et al. Studies on the reactivity of acyl glucuronides--II. Interaction of diflunisal acyl glucuronide and its isomers with human serum albumin in vitro. , 1991, Biochemical pharmacology.
[67] Ernesto Callegari,et al. A comprehensive listing of bioactivation pathways of organic functional groups. , 2005, Current drug metabolism.
[68] M. Bailey,et al. Acyl glucuronide reactivity in perspective: biological consequences. , 2003, Chemico-biological interactions.
[69] T. Yoshioka,et al. Synthesis of 1-beta-O-acyl glucuronides of diclofenac, mefenamic acid and (S)-naproxen by the chemo-selective enzymatic removal of protecting groups from the corresponding methyl acetyl derivatives. , 2006, Organic & biomolecular chemistry.
[70] B. Ransil,et al. Hepatic microsomal bilirubin UDP-glucuronosyltransferase. The kinetics of bilirubin mono- and diglucuronide synthesis. , 1992, Journal of Biological Chemistry.
[71] T. Baillie,et al. Extrapolation of Diclofenac Clearance from in Vitro Microsomal Metabolism Data: Role of Acyl Glucuronidation and Sequential Oxidative Metabolism of the Acyl Glucuronide , 2002, Journal of Pharmacology and Experimental Therapeutics.
[72] L. Benet,et al. Acyl glucuronides revisited: is the glucuronidation process a toxification as well as a detoxification mechanism? , 1992, Drug metabolism reviews.
[73] W. Humphreys,et al. BIOTRANSFORMATION OF CARBON-14-LABELED MURAGLITAZAR IN MALE MICE: INTERSPECIES DIFFERENCE IN METABOLIC PATHWAYS LEADING TO UNIQUE METABOLITES , 2006, Drug Metabolism and Disposition.
[74] A. Vickers,et al. In vitro metabolism of tegaserod in human liver and intestine: assessment of drug interactions. , 2001, Drug metabolism and disposition: the biological fate of chemicals.
[75] Y. Kato,et al. Species differences in absorption, metabolism and excretion of pranoprofen, a 2-arylpropionic acid derivative, in experimental animals. , 1990, Journal of pharmacobio-dynamics.
[76] A. Robichaud,et al. The metabolic disposition of aprepitant, a substance P receptor antagonist, in rats and dogs. , 2004, Drug metabolism and disposition: the biological fate of chemicals.
[77] R. O. Oude Elferink,et al. Selective protein adduct formation of diclofenac glucuronide is critically dependent on the rat canalicular conjugate export pump (Mrp2). , 1998, Chemical research in toxicology.
[78] E M Faed,et al. Properties of acyl glucuronides: implications for studies of the pharmacokinetics and metabolism of acidic drugs. , 1984, Drug metabolism reviews.
[79] B. Sallustio,et al. Reactivity of gemfibrozil 1-o-beta-acyl glucuronide. Pharmacokinetics of covalently bound gemfibrozil-protein adducts in rats. , 1995, Drug Metabolism And Disposition.
[80] J. Goto,et al. Separatory determination of diastereomeric ibuprofen glucuronides in human urine by liquid chromatography/electrospray ionization-mass spectrometry. , 1998, Biomedical chromatography : BMC.
[81] S. Harigaya,et al. Metabolism of ethyl 2-(4-chlorophenyl)-5-(2-furyl)-oxazole-4-acetate, a new hypolipidemic agent, in the rat, rabbit, and dog. Glucuronidation of carboxyl group and cleavage of furan ring. , 1987, Drug Metabolism And Disposition.
[82] V. Armstrong,et al. Induction of cytokine release by the acyl glucuronide of mycophenolic acid: a link to side effects? , 2000, Clinical biochemistry.
[83] P. Hoffmann,et al. A new protected form of glucuronic acid for the synthesis of labile 1-O-acyl-β-D-glucuronides , 1989 .
[84] N. Mano,et al. Inhibition of the rat hepatic microsomal flurbiprofen acyl glucuronidation by bile acids. , 2003, Journal of pharmaceutical sciences.
[85] E. Francotte,et al. Preparative Enzymatic Synthesis of the Acylglucuronide of Mycophenolic Acid , 2003 .
[86] GLUCURONIDATION AS A MAJOR METABOLIC CLEARANCE PATHWAY OF 14C-LABELED MURAGLITAZAR IN HUMANS: METABOLIC PROFILES IN SUBJECTS WITH OR WITHOUT BILE COLLECTION , 2006, Drug Metabolism and Disposition.
[87] S. Hansen,et al. S-naproxen-beta-1-O-acyl glucuronide degradation kinetic studies by stopped-flow high-performance liquid chromatography-1H NMR and high-performance liquid chromatography-UV. , 2001, Drug metabolism and disposition: the biological fate of chemicals.
[88] R. Schmidt. New Methods for the Synthesis of Glycosides and Oligosaccharides ‐ Are there Alternatives to the Koenigs‐Knorr‐Method? , 1986 .
[89] L. Benet,et al. Enantioselective covalent binding of 2-phenylpropionic Acid to protein in vitro in rat hepatocytes. , 2002, Chemical research in toxicology.
[90] N. Mano,et al. Potential bile acid metabolites. 24. An efficient synthesis of carboxyl-linked glucosides and their chemical properties , 2002, Lipids.
[91] Martin Hofmann,et al. Directly Coupled 800 MHz HPLC−NMR Spectroscopy of Urine and Its Application to the Identification of the Major Phase II Metabolites of Tolfenamic Acid , 1997 .
[92] C. Huselton,et al. Synthesis of Novel Glucuronide Conjugates of Retinoid Carboxylic Acids , 1996 .
[93] M. Bailey,et al. Zomepirac acyl glucuronide covalently modifies tubulin in vitro and in vivo and inhibits its assembly in an in vitro system. , 1998, Chemico-biological interactions.
[94] M. Jemal,et al. METABOLISM OF [14C]GEMOPATRILAT AFTER ORAL ADMINISTRATION TO RATS, DOGS, AND HUMANS , 2006, Drug Metabolism and Disposition.
[95] B. K. Park,et al. FORMATION AND PROTEIN BINDING OF THE ACYL GLUCURONIDE OF A LEUKOTRIENE B4 ANTAGONIST (SB-209247): RELATION TO SPECIES DIFFERENCES IN HEPATOTOXICITY , 2005, Drug Metabolism and Disposition.
[96] G. Valaskovic,et al. Ultra-low flow nanospray for the normalization of conventional liquid chromatography/mass spectrometry through equimolar response: standard-free quantitative estimation of metabolite levels in drug discovery. , 2006, Rapid communications in mass spectrometry : RCM.
[97] S. Harper,et al. Preclinical pharmacokinetics and metabolism of a potent non-nucleoside inhibitor of the hepatitis C virus NS5B polymerase , 2005, Xenobiotica; the fate of foreign compounds in biological systems.
[98] I. Wilson,et al. NMR spectroscopic and theoretical chemistry studies on the internal acyl migration reactions of the 1-O-acyl-beta-D-glucopyranuronate conjugates of 2-, 3-, and 4-(trifluoromethyl) benzoic acids. , 1996, Chemical research in toxicology.
[99] R. Barnaby,et al. Pharmacokinetics, metabolism and excretion of the glycine antagonist GV150526A in rat and dog , 2003, Xenobiotica; the fate of foreign compounds in biological systems.
[100] F. Kaspersen,et al. A review of the methods of chemical synthesis of sulphate and glucuronide conjugates. , 1987, Xenobiotica; the fate of foreign compounds in biological systems.
[101] T Hashimoto,et al. Kinetics of intramolecular acyl migration of 1beta-O-acyl glucuronides of (R)- and (S)-2-phenylpropionic acids. , 2001, Biological & pharmaceutical bulletin.
[102] F. Fontaine,et al. UDP-glucuronosyltransferase-dependent bioactivation of clofibric acid to a DNA-damaging intermediate in mouse hepatocytes. , 2003, Chemico-biological interactions.
[103] I. Wilson,et al. pH dependent formation of beta-glucuronidase resistant conjugates from the biosynthetic ester glucuronide of isoxepac. , 1981, Biochemical pharmacology.
[104] J C Lindon,et al. Nuclear magnetic resonance (NMR) and quantitative structure–activity relationship (QSAR) studies on the transacylation reactivity of model 1β-O-acyl glucuronides. II: QSAR modelling of the reaction using both computational and experimental NMR parameters , 2004, Xenobiotica; the fate of foreign compounds in biological systems.
[105] B. Ma,et al. Acyl glucuronidation and glucosidation of a new and selective endothelin ET(A) receptor antagonist in human liver microsomes. , 2003, Drug metabolism and disposition: the biological fate of chemicals.
[106] G. Blaschke,et al. Capillary electrophoresis-mass spectrometry, liquid chromatography-mass spectrometry and nanoelectrospray-mass spectrometry of praziquantel metabolites. , 2000, Journal of chromatography. B, Biomedical sciences and applications.
[107] V. Armstrong,et al. Identification of glucoside and carboxyl‐linked glucuronide conjugates of mycophenolic acid in plasma of transplant recipients treated with mycophenolate mofetil , 1999, British journal of pharmacology.
[108] J. Magdalou,et al. Stereoselective irreversible binding of ketoprofen glucuronides to albumin. Characterization of the site and the mechanism. , 1996, Drug metabolism and disposition: the biological fate of chemicals.
[109] I. Wilson,et al. 750 MHz HPLC-NMR spectroscopic studies on the separation and characterization of the positional isomers of the glucuronides of 6,11-dihydro-11-oxodibenz[b,e]oxepin-2-acetic acid. , 1996, Analytical chemistry.
[110] S. Hansen,et al. LC-1H NMR used for determination of the elution order of S-naproxen glucuronide isomers in two isocratic reversed-phase LC-systems. , 2001, Journal of pharmaceutical and biomedical analysis.
[111] D. Dalvie,et al. Metabolism of CP-195,543, a leukotriene B4 receptor antagonist, in the Long-Evans rat and Cynomolgus monkey. , 1999, Xenobiotica; the fate of foreign compounds in biological systems.
[112] K. Shimada,et al. Analysis of acetaminophen glucuronide conjugate accompanied by adduct ion production by liquid chromatography-atmospheric pressure chemical ionization-mass spectrometry. , 2003, Journal of pharmaceutical and biomedical analysis.
[113] N. Mano,et al. Synthesis and characterization of deoxycholyl 2-deoxyglucuronide: A water-soluble affinity labeling reagent , 2003, Lipids.
[114] I. Wilson,et al. Measurement of Internal Acyl Migration Reaction Kinetics Using Directly Coupled HPLC-NMR: Application for the Positional Isomers of Synthetic (2-Fluorobenzoyl)-d-glucopyranuronic Acid. , 1996, Analytical chemistry.
[115] L. Benet,et al. Studies on the chemical reactivity of 2-phenylpropionic acid 1-O-acyl glucuronide and S-acyl-CoA thioester metabolites. , 2002, Chemical research in toxicology.
[116] U. Boelsterli. REACTIVE ACYL GLUCURONIDES: POSSIBLE ROLE IN SMALL INTESTINAL TOXICITY INDUCED BY NONSTEROIDAL ANTI-INFLAMMATORY DRUGS , 1999 .
[117] C. Bedford,et al. Glucuronic acid conjugates. , 1998, Journal of chromatography. B, Biomedical sciences and applications.
[118] J. Yuan,et al. Characterization of metabolites of Celecoxib in rabbits by liquid chromatography/tandem mass spectrometry. , 2000, Journal of mass spectrometry : JMS.
[119] U. Boelsterli. Xenobiotic acyl glucuronides and acyl CoA thioesters as protein-reactive metabolites with the potential to cause idiosyncratic drug reactions. , 2002, Current drug metabolism.
[120] Shufeng Zhou,et al. Determination of two major metabolites of the novel anti-tumour agent 5,6-dimethylxanthenone-4-acetic acid in hepatic microsomal incubations by high-performance liquid chromatography with fluorescence detection , 1999 .
[121] M. Davis,et al. Metabolic activation of diclofenac by human cytochrome P450 3A4: role of 5-hydroxydiclofenac. , 1999, Chemical research in toxicology.
[122] R. Nation,et al. Hepatic disposition of the acyl glucuronide1-O-gemfibrozil-beta-D-glucuronide: effects of dibromosulfophthalein on membrane transport and aglycone formation. , 1999, The Journal of pharmacology and experimental therapeutics.
[123] V. Armstrong,et al. Identification of protein targets for mycophenolic acid acyl glucuronide in rat liver and colon tissue , 2004, Proteomics.
[124] T. Ohkawa,et al. Rapid LC-TOFMS method for identification of binding sites of covalent acylglucuronide-albumin complexes. , 2003, Journal of pharmaceutical and biomedical analysis.
[125] F. Azam,et al. A novel approach for predicting acyl glucuronide reactivity via Schiff base formation: development of rapidly formed peptide adducts for LC/MS/MS measurements. , 2004, Chemical research in toxicology.
[126] T. Hsia,et al. INHIBITION OF LUNG CANCER CELL GROWTH BY QUERCETIN GLUCURONIDES VIA G2/M ARREST AND INDUCTION OF APOPTOSIS , 2006, Drug Metabolism and Disposition.
[127] P. Inskeep,et al. Tissue distribution and biotransformation of zopolrestat, an aldose reductase inhibitor, in rats. , 1998, Drug metabolism and disposition: the biological fate of chemicals.
[128] H. Kunz,et al. Solid Phase Synthesis of Peptides and Glycopeptides on Polymeric Supports with Allylic Anchor Groups , 1988 .
[129] M. Ohashi,et al. Hopantenic acid beta-glucoside as a new urinary metabolite of calcium hopantenate in dogs. , 1986, Drug Metabolism And Disposition.
[130] A. Akin,et al. Preparation of CI‐1027 Glucuronide: Metabolite of a Remarkable Lipid‐Modulating Agent , 2005 .
[131] W. Thormann,et al. Analysis of codeine, dihydrocodeine and their glucuronides in human urine by electrokinetic capillary immunoassays and capillary electrophoresis-ion trap mass spectrometry. , 2000, Journal of chromatography. A.
[132] C. Larsen,et al. Metabolism and excretion of citalopram in man: identification of O-acyl- and N-glucuronides. , 1999, Xenobiotica; the fate of foreign compounds in biological systems.
[133] Y. Shinohara,et al. Stereoselective internal acyl migration of 1beta-O-acyl glucuronides of enantiomeric 2-phenylpropionic acids. , 2000, Biological & pharmaceutical bulletin.