Roles of Nitric Oxide in Treatment of Alzheimer ’ s Disease

Alzheimer’s disease (AD) is a primary neurodegenerative disorder with cognitive impairment and autonomic nervous system dysfunction. Nitric oxide (NO) is a major signaling molecule in neurons which influences the formation of Aβ. In addition, NO reduces neurogenic inflammation, oxidation and nitridation and NF-κB passway to restrain inducible nitric oxide synthetase (iNOS). This paper reviewed NO effects on the development and therapy of AD.

[1]  S. Huo,et al.  The Mechanism of Memory Enhancement of Acteoside (Verbascoside) in the Senescent Mouse Model Induced by a Combination of d‐gal and AlCl3 , 2015, Phytotherapy research : PTR.

[2]  X. Bao,et al.  FLZ attenuates learning and memory deficits via suppressing neuroinflammation induced by LPS in mice , 2015, Journal of Asian natural products research.

[3]  F. Islam,et al.  Effect of hesperidin on neurobehavioral, neuroinflammation, oxidative stress and lipid alteration in intracerebroventricular streptozotocin induced cognitive impairment in mice , 2015, Journal of the Neurological Sciences.

[4]  N. Seeram,et al.  Anti-Inflammatory Effects of Novel Standardized Solid Lipid Curcumin Formulations. , 2014, Journal of medicinal food.

[5]  W. Yeh,et al.  Naringenin Suppresses Neuroinflammatory Responses Through Inducing Suppressor of Cytokine Signaling 3 Expression , 2016, Molecular Neurobiology.

[6]  S. Hashioka,et al.  Gold drug auranofin could reduce neuroinflammation by inhibiting microglia cytotoxic secretions and primed respiratory burst , 2014, Journal of Neuroimmunology.

[7]  Bing Liu,et al.  Jujuboside A, a neuroprotective agent from semen Ziziphi Spinosae ameliorates behavioral disorders of the dementia mouse model induced by Aβ 1-42. , 2014, European journal of pharmacology.

[8]  Ting Wu,et al.  SCM-198 inhibits microglial overactivation and attenuates Aβ1-40-induced cognitive impairments in rats via JNK and NF-кB pathways , 2014, Journal of Neuroinflammation.

[9]  Chunbo Li,et al.  Tanshinone IIA reduces the risk of Alzheimer's disease by inhibiting iNOS, MMP‑2 and NF‑κBp65 transcription and translation in the temporal lobes of rat models of Alzheimer's disease. , 2014, Molecular medicine reports.

[10]  J. Hong,et al.  Inhibitory effect of ent-Sauchinone on amyloidogenesis via inhibition of STAT3-mediated NF-κB activation in cultured astrocytes and microglial BV-2 cells , 2014, Journal of Neuroinflammation.

[11]  Ming Yan,et al.  Effects of polyprenols from pine needles of Pinus massoniana on ameliorating cognitive impairment in a d-galactose-induced mouse model , 2014, AGE.

[12]  M. Oh,et al.  Bombycis excrementum reduces amyloid-β oligomer-induced memory impairments, neurodegeneration, and neuroinflammation in mice. , 2014, Journal of Alzheimer's disease : JAD.

[13]  He Zhang,et al.  Rutin improves spatial memory in Alzheimer's disease transgenic mice by reducing Aβ oligomer level and attenuating oxidative stress and neuroinflammation , 2014, Behavioural Brain Research.

[14]  M. Oh,et al.  Neuroprotective effect of Chunghyuldan from amyloid beta oligomer induced neuroinflammation in vitro and in vivo. , 2014, Canadian journal of physiology and pharmacology.

[15]  C. Mancuso,et al.  Ferulic acid: pharmacological and toxicological aspects. , 2014, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

[16]  Y. Tsai,et al.  The aqueous extract from Toona sinensis leaves inhibits microglia‐mediated neuroinflammation , 2013, The Kaohsiung Journal of Medical Sciences.

[17]  M. Oh,et al.  Donepezil inhibits the amyloid-beta oligomer-induced microglial activation in vitro and in vivo. , 2014, Neurotoxicology.

[18]  A. Zabłocka,et al.  Colostrinin: a proline-rich polypeptide complex of potential therapeutic interest. , 2013, Cellular and molecular biology.

[19]  X. M. Zhang,et al.  Acetylpuerarin reduces inflammation and improves memory function in a rat model of Alzheimer's disease induced by Abeta1-42. , 2013, Die Pharmazie.

[20]  Yu Young Lee,et al.  www.mdpi.com/journal/ijms Anti-Inflammatory Effect of Ginsenoside Rg5 in , 2013 .

[21]  Tie-mei Shao,et al.  Salidroside attenuates beta amyloid-induced cognitive deficits via modulating oxidative stress and inflammatory mediators in rat hippocampus , 2013, Behavioural Brain Research.

[22]  Xinmin Liu,et al.  Neuroprotective effects of forsythiaside on learning and memory deficits in senescence-accelerated mouse prone (SAMP8) mice , 2013, Pharmacology Biochemistry and Behavior.

[23]  Dong Hyun Kim,et al.  Neuroprotective effects of salvianolic acid B on an Aβ25-35 peptide-induced mouse model of Alzheimer's disease. , 2013, European journal of pharmacology.

[24]  J. Lee,et al.  Tartary buckwheat improves cognition and memory function in an in vivo amyloid-β-induced Alzheimer model. , 2013, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

[25]  C. Hölscher,et al.  The type 2 diabetes drug liraglutide reduces chronic inflammation induced by irradiation in the mouse brain. , 2013, European journal of pharmacology.

[26]  Kewu Zeng,et al.  Protosappanin A inhibits oxidative and nitrative stress via interfering the interaction of transmembrane protein CD14 with Toll-like receptor-4 in lipopolysaccharide-induced BV-2 microglia. , 2012, International immunopharmacology.

[27]  J. Chavis,et al.  Resveratrol effects on astrocyte function: relevance to neurodegenerative diseases. , 2012, Biochemical and biophysical research communications.

[28]  A. Zabłocka,et al.  Effect of the Proline-Rich Polypeptide Complex/Colostrinin™ on the Enzymatic Antioxidant System , 2012, Archivum Immunologiae et Therapiae Experimentalis.

[29]  S. Abbasi,et al.  Recognition of betaine as an inhibitor of lipopolysaccharide-induced nitric oxide production in activated microglial cells. , 2012, Iranian biomedical journal.

[30]  Yu-jiong Wang,et al.  Rutin inhibits β-amyloid aggregation and cytotoxicity, attenuates oxidative stress, and decreases the production of nitric oxide and proinflammatory cytokines. , 2012, Neurotoxicology.

[31]  M. Oh,et al.  Acacetin Attenuates Neuroinflammation via Regulation the Response to LPS Stimuli In Vitro and In Vivo , 2012, Neurochemical Research.

[32]  K. Vafeiadou,et al.  Neuroinflammation: modulation by flavonoids and mechanisms of action. , 2012, Molecular aspects of medicine.

[33]  I. I. Malyshev,et al.  [Prevention of the brain neurodegeneration in rats with experimental Alzheimer's disease by adaptation to hypoxia]. , 2009, Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova.