The relationship between sleep disturbance and depression

This paper focuses on several aspects of the relationship between sleep and depression, with particular attention to objective factors and subjective perceptions. It does not address the effect that antidepressants have on sleep, nor does it explore the wider implications of the types and course of depression, age, or other psychiatric conditions. “Normal sleep” is explored, examining typical sleep architecture in individuals without sleep disorders, psychiatric conditions or physical illness. Sleep disorders are reviewed and examined to present the nature of the disturbance and the role that they may play in depression, with particular attention paid to insomnia. Studies have identified a sub-group of insomnia patients (highly distressed poor sleepers), who appear to be less satisfied with their sleep quality than “low distressed poor sleepers”, even though they did not differ on sleep timing perceptions. Recent work has shown that depressed individuals to be less satisfied with sleep quality than healthy controls, even though they did not differ on sleep timing perceptions. The evidence presented here supports the view that subjective sleep perceptions play an important role in depression. Poor subjective perceptions of sleep in depression may be associated with faulty cognitions. This has been found extensively in insomnia, but is under-researched in depression.

[1]  C. Espie,et al.  The clinical effectiveness of cognitive behaviour therapy for chronic insomnia: implementation and evaluation of a sleep clinic in general medical practice. , 2001, Behaviour research and therapy.

[2]  C. Guilleminault,et al.  Medications for the treatment of narcolepsy , 2001, Expert opinion on emerging drugs.

[3]  J. Edinger,et al.  Psychological Status, Syndromatic Measures, and Compliance with Nasal CPAP Therapy for Sleep Apnea , 1994, Perceptual and motor skills.

[4]  M. Uchiyama,et al.  Sleep and mood disorders. , 1997, Sleep medicine reviews.

[5]  J. Gillin,et al.  Successful separation of depressed, normal, and insomniac subjects by EEG sleep data. , 1979, Archives of general psychiatry.

[6]  D. Baldwin,et al.  Assessing subjective sleep reports in the first‐degree relatives of antidepressant‐treated depressed outpatients , 2003, Human psychopharmacology.

[7]  I. Hindmarch,et al.  Factor analysis of a sleep evaluation questionnaire , 1978, Psychological Medicine.

[8]  D. Baldwin,et al.  Quantifying subjective assessment of sleep and life‐quality in antidepressant‐treated depressed patients , 2003, Human psychopharmacology.

[9]  W. Zung A SELF-RATING DEPRESSION SCALE. , 1965, Archives of general psychiatry.

[10]  W. Dement,et al.  The relation of eye movements during sleep to dream activity: an objective method for the study of dreaming. , 1957, Journal of experimental psychology.

[11]  A. Rush,et al.  Risk factors in families of unipolar depression. I. Psychiatric illness and reduced REM latency. , 1988, Journal of affective disorders.

[12]  A. Beck,et al.  An inventory for measuring clinical anxiety: psychometric properties. , 1988, Journal of consulting and clinical psychology.

[13]  A. Harvey,et al.  Catastrophic worry in primary insomnia. , 2003, Journal of behavior therapy and experimental psychiatry.

[14]  S. Hathaway,et al.  A Multiphasic Personality Schedule (Minnesota) : I. Construction of the Schedule , 1940 .

[15]  Haruo Nagayama,et al.  Discrepancy between subjective and objective sleep in patients with depression , 2003, Psychiatry and clinical neurosciences.

[16]  Charles F. Reynolds,et al.  Depression and insomnia: questions of cause and effect. , 2000, Sleep medicine reviews.

[17]  Daniel J Buysse,et al.  Which depressive symptoms are related to which sleep electroencephalographic variables? , 1997, Biological Psychiatry.

[18]  P. Lavie,et al.  Psychiatric symptoms in sleep apnea syndrome: effects of gender and respiratory disturbance index. , 1998, Chest.

[19]  W. Poewe,et al.  Restless legs syndrome , 2005, Neurology.

[20]  Maurice M Ohayon,et al.  The effects of breathing-related sleep disorders on mood disturbances in the general population. , 2003, The Journal of clinical psychiatry.

[21]  A. de Weerd,et al.  Sleep disorders and depressive feelings: a global survey with the Beck depression scale. , 2003, Sleep medicine.

[22]  C. Fichten,et al.  Poor sleepers who do not complain of insomnia: Myths and realities about psychological and lifestyle characteristics of older good and poor sleepers , 1995, Journal of Behavioral Medicine.

[23]  Gary Fireman,et al.  Nightmare prevalence, nightmare distress, and self-reported psychological disturbance. , 2002, Sleep.

[24]  S. Ancoli-Israel,et al.  Does obstructive sleep apnea confound sleep architecture findings in subjects with depressive symptoms? , 2000, Biological Psychiatry.

[25]  M. Thorpy,et al.  Current concepts in the etiology, diagnosis and treatment of narcolepsy. , 2001, Sleep medicine.

[26]  O. Ozer,et al.  Restless legs syndrome induced by mirtazapine. , 2002, The Journal of clinical psychiatry.

[27]  T. Monk,et al.  A Review of Its Clinical Aspects , 1995 .

[28]  Ruth O'Hara,et al.  Depression and Obstructive Sleep Apnea (OSA) , 2005, Annals of general psychiatry.

[29]  David J. Nutt,et al.  Correlation of subjective and objective sleep measurements at different stages of the treatment of depression , 2003, Psychiatry Research.

[30]  M. Thase,et al.  Depression, sleep, and antidepressants. , 1998, The Journal of clinical psychiatry.

[31]  D. Kupfer,et al.  Controlled comparison of electrophysiological sleep in families of probands with unipolar depression. , 1998, The American journal of psychiatry.

[32]  J. Amsterdam,et al.  Differences in nocturnal melatonin secretion between melancholic depressed patients and control subjects. , 1985, The American journal of psychiatry.

[33]  Ware J.E.Jr.,et al.  THE MOS 36- ITEM SHORT FORM HEALTH SURVEY (SF- 36) CONCEPTUAL FRAMEWORK AND ITEM SELECTION , 1992 .

[34]  A. Rush,et al.  Relationship between objective and subjective sleep measures in depressed patients and healthy controls , 1997, Depression and anxiety.

[35]  A. Beck,et al.  An inventory for measuring depression. , 1961, Archives of general psychiatry.

[36]  A. Muzet,et al.  Sleep microstructure around sleep onset differentiates major depressive insomnia from primary insomnia , 2003, Journal of sleep research.

[37]  U. Keil,et al.  Prevalence and risk factors of RLS in an elderly population , 2000, Neurology.

[38]  E. van Cauter,et al.  Effects of "jet lag" on hormonal patterns. I. Procedures, variations in total plasma proteins, and disruption of adrenocorticotropin-cortisol periodicity. , 1981, The Journal of clinical endocrinology and metabolism.

[39]  A. Williams,et al.  Rapid eye movement sleep behaviour disorder, depression and cognitive impairment. Case study. , 2000, The British journal of psychiatry : the journal of mental science.

[40]  T H Monk,et al.  The Pittsburgh Sleep Diary , 1994, Journal of sleep research.

[41]  Daniel J Buysse,et al.  The Pittsburgh sleep quality index: A new instrument for psychiatric practice and research , 1989, Psychiatry Research.

[42]  H. Lauerma,et al.  Mianserin and restless legs. , 1997, International clinical psychopharmacology.

[43]  T. Young,et al.  Epidemiology of restless legs symptoms in adults. , 2000, Archives of internal medicine.

[44]  I. Smith,et al.  Health‐related quality of life in narcolepsy , 2001, Journal of sleep research.

[45]  D. Ford,et al.  Insomnia in young men and subsequent depression. The Johns Hopkins Precursors Study. , 1997, American journal of epidemiology.

[46]  B. Phillips,et al.  Sleep-disordered breathing in healthy, aged persons. Fifth and final year follow-up. , 1996, Chest.

[47]  Daniel J. Taylor,et al.  Changes in Depressive Symptoms after Continuous Positive Airway Pressure Treatment for Obstructive Sleep Apnea , 2003, Sleep and Breathing.

[48]  W. Mendelson,et al.  MMPI correlates of sleep and respiratory disturbance in obstructive sleep apnea. , 1999, Sleep.

[49]  E. Mignot,et al.  Narcolepsy:Clinical Features, New Pathophysiologic Insights, and Future Perspectives , 2001, Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society.

[50]  D. Reboussin,et al.  Subjective estimates of sleep differ from polysomnographic measurements in obstructive sleep apnea patients. , 1995, Sleep.

[51]  M. Johns,et al.  A new method for measuring daytime sleepiness: the Epworth sleepiness scale. , 1991, Sleep.

[52]  E. van Cauter,et al.  Reciprocal interactions between the GH axis and sleep. , 2004, Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society.

[53]  D. Kupfer,et al.  Depressive psychopathology in male sleep apneics. , 1984, The Journal of clinical psychiatry.

[54]  Y. Dagan,et al.  Evaluating the role of melatonin in the long-term treatment of delayed sleep phase syndrome (DSPS). , 1998, Chronobiology international.

[55]  A. Rush,et al.  Polysomnographic findings in recently drug-free and clinically remitted depressed patients. , 1986, Archives of general psychiatry.

[56]  F. Watts,et al.  The contribution of worry to insomnia. , 1994, The British journal of clinical psychology.

[57]  S. Ancoli-Israel,et al.  Psychological correlates of sleep apnea. , 1999, Journal of psychosomatic research.

[58]  E J VAZ,et al.  Sleep and its disorders. , 1959, Indian journal of medical sciences.

[59]  S. Folkard,et al.  Can melatonin improve shift workers' tolerance of the night shift? Some preliminary findings. , 1993, Chronobiology international.

[60]  D. Kupfer Sleep research in depressive illness: Clinical implications —a tasting menu , 1995, Biological Psychiatry.

[61]  B. Harris,et al.  The impact of antidepressants on sleep and anxiety: a comparative study of fluoxetine and dothiepin using the Leeds Sleep Evaluation Questionnaire , 2000, Human psychopharmacology.

[62]  F. Holsboer,et al.  "Anxietas tibiarum". Depression and anxiety disorders in patients with restless legs syndrome. , 2005, Journal of neurology.

[63]  J. Manfreda,et al.  Diagnoses received by narcolepsy patients in the year prior to diagnosis by a sleep specialist. , 2002, Sleep.

[64]  A. Harvey,et al.  Pre-sleep cognitive activity: a comparison of sleep-onset insomniacs and good sleepers. , 2000, The British journal of clinical psychology.

[65]  T. Monk,et al.  Delayed sleep phase syndrome: a review of its clinical aspects. , 1995, The American journal of psychiatry.

[66]  C. Fichten,et al.  Role of Thoughts During Nocturnal Awake Times in the Insomnia Experience of Older Adults , 2001, Cognitive Therapy and Research.

[67]  J. Krieger,et al.  Why we sleep. The Functions of Sleep in Humans and other Mammals, Horne J.. Oxford University Press, New York (1988) , 1989 .

[68]  R. Stickgold,et al.  Nightcap: laboratory and home-based evaluation of a portable sleep monitor. , 1995, Psychophysiology.

[69]  O. Doğu,et al.  Correlation of anxiety and depression symptoms in patients with restless legs syndrome: a population based survey , 2004, Journal of Neurology, Neurosurgery & Psychiatry.

[70]  J. Fleetham,et al.  Treatment Outcome of Obstructive Sleep Apnea: Physiological and Neuropsychological Concomitants , 1987, The Journal of nervous and mental disease.

[71]  D. Kripke The Uses of Bright Light in an Office Practice , 1998 .

[72]  E. Cauter,et al.  Interactions Between Growth Hormone Secretion and Sleep , 2000 .

[73]  R. Daroff,et al.  The International Classification of Sleep Disorders , 1991, Neurology.

[74]  J. D. Johnson REM sleep and the development of context memory. , 2005, Medical hypotheses.

[75]  R. Kessler,et al.  The lifetime history of major depression in women. Reliability of diagnosis and heritability. , 1993, Archives of general psychiatry.

[76]  C. Reynolds,et al.  Sleep and affective disorders. A minireview. , 1987, The Psychiatric clinics of North America.

[77]  M. Young,et al.  Role of REM sleep and dream variables in the prediction of remission from depression , 1998, Psychiatry Research.

[78]  A. Vourdas,et al.  Narcolepsy and psychopathology: is there an association? , 2002, Sleep medicine.

[79]  A. Borbély A two process model of sleep regulation. , 1982, Human neurobiology.

[80]  N. Zisapel,et al.  Cross‐cultural validation of the Leeds sleep evaluation questionnaire (LSEQ) in insomnia patients , 2003, Human psychopharmacology.

[81]  J. Hobson,et al.  Nightcap: a home-based sleep monitoring system. , 1989, Sleep.

[82]  C. Sherbourne,et al.  The MOS 36-Item Short-Form Health Survey (SF-36) , 1992 .

[83]  M. Ohayon,et al.  Comorbidity of mental and insomnia disorders in the general population. , 1998, Comprehensive psychiatry.

[84]  C. Drake,et al.  Shift work sleep disorder: prevalence and consequences beyond that of symptomatic day workers. , 2004, Sleep.

[85]  Vincent Ibanez,et al.  Personality, anxiety and mood traits in patients with sleep-related breathing disorders: effect of reduced daytime alertness. , 2002, Sleep medicine.

[86]  T. Oei,et al.  The roles of depression and anxiety in the understanding and treatment of Obstructive Sleep Apnea Syndrome. , 2004, Clinical psychology review.

[87]  R. Dahl Common Sleep Problems in Children , 1998 .

[88]  R. Thisted,et al.  Sleep and Psychiatric Disorders: A Meta-analysis , 1992 .

[89]  Yaron Dagan,et al.  Circadian rhythm sleep disorders (CRSD). , 2002, Sleep medicine reviews.

[90]  T. Roth,et al.  Sleep disturbance and psychiatric disorders: A longitudinal epidemiological study of young Adults , 1996, Biological Psychiatry.

[91]  N. Zisapel,et al.  Subjective assessment of the effects of CNS‐active drugs on sleep by the Leeds sleep evaluation questionnaire: a review , 2003, Human psychopharmacology.

[92]  T. Akashiba,et al.  Relationship between quality of life and mood or depression in patients with severe obstructive sleep apnea syndrome. , 2002, Chest.

[93]  F. Baekeland,et al.  Exercise and Sleep Patterns in College Athletes , 1966, Perceptual and motor skills.

[94]  A C Heath,et al.  Evidence for genetic influences on sleep disturbance and sleep pattern in twins. , 1990, Sleep.

[95]  T. Pollmächer,et al.  REM Sleep Disinhibition at Sleep Onset: A Comparison between Narcolepsy and Depression , 1997, Biological Psychiatry.

[96]  E. Lugaresi,et al.  Restless legs syndrome and nocturnal myoclonus. , 1981, International journal of neurology.

[97]  Richard P Allen,et al.  Restless legs syndrome: diagnostic criteria, special considerations, and epidemiology. A report from the restless legs syndrome diagnosis and epidemiology workshop at the National Institutes of Health. , 2003, Sleep medicine.

[98]  D. Ford,et al.  Epidemiologic study of sleep disturbances and psychiatric disorders. An opportunity for prevention? , 1989, JAMA.

[99]  R G Priest,et al.  Night terrors, sleepwalking, and confusional arousals in the general population: their frequency and relationship to other sleep and mental disorders. , 1999, The Journal of clinical psychiatry.

[100]  C. Guilleminault Benzodiazepines, breathing, and sleep. , 1990, The American journal of medicine.

[101]  S. Himanen,et al.  Limitations of Rechtschaffen and Kales. , 2000, Sleep medicine reviews.

[102]  R. Stickgold,et al.  Nightcap measurement of sleep quality in self-described good and poor sleepers. , 1994, Sleep.

[103]  G. Jean-Louis,et al.  Actigraphic Assessment of Sleep in Insomnia Application of the Actigraph Data Analysis Software (ADAS) , 1998, Physiology & Behavior.

[104]  S. Kuna,et al.  Effect of nasal continuous positive airway pressure on neuropsychological function in sleep apnea-hypopnea syndrome. A randomized, placebo-controlled trial. , 2001, American journal of respiratory and critical care medicine.

[105]  T. Åkerstedt,et al.  The meaning of good sleep: a longitudinal study of polysomnography and subjective sleep quality , 1994, Journal of sleep research.

[106]  U. Keil,et al.  Prevalence and risk factors of RLS in an elderly population , 2000, Neurology.

[107]  L. Creti,et al.  A COGNITIVE MODEL OF INSOMNIA , 2022 .

[108]  J. Horne Human Sleep, Sleep Loss and Behaviour , 1993, British Journal of Psychiatry.

[109]  M. Hamilton A RATING SCALE FOR DEPRESSION , 1960, Journal of neurology, neurosurgery, and psychiatry.

[110]  R. Millman,et al.  Depression as a manifestation of obstructive sleep apnea: reversal with nasal continuous positive airway pressure. , 1989, The Journal of clinical psychiatry.

[111]  D J Kupfer,et al.  REM latency: a psychobiologic marker for primary depressive disease. , 1976, Biological psychiatry.

[112]  J. Edinger,et al.  The distribution and clinical significance of sleep time misperceptions among insomniacs. , 1995, Sleep.

[113]  D. Katz,et al.  Clinical correlates of insomnia in patients with chronic illness. , 1998, Archives of internal medicine.

[114]  A. Rush,et al.  A cross-sectional study of the effects of depression on REM latency , 1990, Biological Psychiatry.

[115]  J. Bussel,et al.  Use of intravenous gamma globulin for the treatment of autoimmune neutropenia of childhood and autoimmune hemolytic anemia. , 1987, The American journal of medicine.

[116]  E Libman,et al.  How is good and poor sleep in older adults and college students related to daytime sleepiness, fatigue, and ability to concentrate? , 2000, Journal of psychosomatic research.

[117]  N. Kleitman,et al.  Regularly occurring periods of eye motility, and concomitant phenomena, during sleep. , 1953, Science.

[118]  A. Beck Cognitive models of depression. , 1987 .

[119]  M. Uchiyama,et al.  Melatonin Rhythms in Delayed Sleep Phase Syndrome , 1999, Journal of biological rhythms.

[120]  V S Rotenberg,et al.  The relationship between subjective sleep estimation and objective sleep variables in depressed patients. , 2000, International journal of psychophysiology : official journal of the International Organization of Psychophysiology.

[121]  E Hartmann,et al.  Sleep need: how much sleep and what kind? , 1971, The American journal of psychiatry.

[122]  Daniel J Buysse,et al.  Electoencephalographic Sleep in Recently Remitted, Elderly Depressed Patients in Double-Blind Placebo-Maintenance Therapy , 1993, Neuropsychopharmacology.

[123]  E. van Cauter,et al.  Effects of "jet lag" on hormonal patterns. II. Adaptation of melatonin circadian periodicity. , 1981, Journal of Clinical Endocrinology and Metabolism.

[124]  D. Kupfer,et al.  Polysomnographic parameters in first-degree relatives of unipolar probands , 1989, Psychiatry Research.