Early stages of uptake and transport of horseradish‐peroxidase by cortical structures, and its use for the study of local neurons and their processes

It is well known that, when horseradish‐peroxidase (HRP) is injected into the central nervous system, it is taken up by nerve terminals and retrogradely transported to their cells of origin. We have now injected HRP into the visual cortex of cats in order to study light‐microscopically the pattern of its spread, the neural structures that take it up locally, and the initial steps of its retrograde descent towards the dorsal lateral geniculate nucleus (LGNd). Special attention was given to post‐injection times of ten minutes to eight hours, but animals with up tofive days' survival were also analyzed.

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