Reduced Tyk2 gene expression in β-cells due to natural mutation determines susceptibility to virus-induced diabetes

[1]  Zhijian J. Chen,et al.  Cyclic GMP-AMP Synthase Is a Cytosolic DNA Sensor That Activates the Type I Interferon Pathway , 2013, Science.

[2]  R. Mayeux,et al.  Epidemiology of Alzheimer disease. , 2012, Cold Spring Harbor perspectives in medicine.

[3]  T. Scully Diabetes in numbers , 2012, Nature.

[4]  E. Jonietz,et al.  Pathology: Cause and effect , 2012, Nature.

[5]  F. Tábrah Koch's postulates, carnivorous cows, and tuberculosis today. , 2011, Hawaii medical journal.

[6]  E. Unanue,et al.  RNA sensor-induced type I IFN prevents diabetes caused by a β cell-tropic virus in mice. , 2011, The Journal of clinical investigation.

[7]  S. Bonner-Weir,et al.  Single pancreatic beta cells co-express multiple islet hormone genes in mice , 2009, Diabetologia.

[8]  G. Barber,et al.  STING regulates intracellular DNA-mediated, type I interferon-dependent innate immunity , 2009, Nature.

[9]  R. Katoh,et al.  Enterovirus Infection, CXC Chemokine Ligand 10 (CXCL10), and CXCR3 Circuit , 2009, Diabetes.

[10]  J. Todd,et al.  Rare Variants of IFIH1, a Gene Implicated in Antiviral Responses, Protect Against Type 1 Diabetes , 2009, Science.

[11]  Osamu Takeuchi,et al.  Innate immunity to virus infection , 2009, Immunological reviews.

[12]  Shuichiro Ogawa,et al.  The significance of T cells, B cells, antibodies and macrophages against encephalomyocarditis (EMC)-D virus-induced diabetes in mice , 2008, Archives of Virology.

[13]  U. Boggi,et al.  Coxsackie B4 virus infection of β cells and natural killer cell insulitis in recent-onset type 1 diabetic patients , 2007, Proceedings of the National Academy of Sciences.

[14]  D. Clayton,et al.  A genome-wide association study of nonsynonymous SNPs identifies a type 1 diabetes locus in the interferon-induced helicase (IFIH1) region , 2006, Nature Genetics.

[15]  N. Sarvetnick,et al.  Target cell defense prevents the development of diabetes after viral infection , 2002, Nature Immunology.

[16]  H. Jun,et al.  The role of viruses in Type I diabetes: two distinct cellular and molecular pathogenic mechanisms of virus-induced diabetes in animals , 2001, Diabetologia.

[17]  M. Shibamori,et al.  Tyk2 plays a restricted role in IFN alpha signaling, although it is required for IL-12-mediated T cell function. , 2000, Immunity.

[18]  H. Pircher,et al.  Partial impairment of cytokine responses in Tyk2-deficient mice. , 2000, Immunity.

[19]  Amanda J. Wilson,et al.  A search for type 1 diabetes susceptibility genes in families from the United Kingdom , 1998, Nature Genetics.

[20]  H. Jun,et al.  Gain or loss of diabetogenicity resulting from a single point mutation in recombinant encephalomyocarditis virus , 1997, Journal of virology.

[21]  K. Taylor,et al.  Coxsackie B virus infection and onset of childhood diabetes , 1995, The Lancet.

[22]  G. Dahlquist,et al.  Maternal Enteroviral Infection During Pregnancy as a Risk Factor for ChildHood IDDM: A Population-Based Case-Control Study , 1995, Diabetes.

[23]  Yup Kang,et al.  A genetically determined host factor controlling susceptibility to encephalomyocarditis virus-induced diabetes in mice. , 1993, The Journal of general virology.

[24]  J. Bellanti,et al.  Poly I:C Accelerates Development of Diabetes Mellitus in Diabetes-Prone BB Rat , 1992, Diabetes.

[25]  Y. Bae,et al.  Molecular Identification of Diabetogenic Viral Gene , 1989, Diabetes.

[26]  J. Longstreth,et al.  Virus-induced Diabetes Mellitus: No Evidence for Immune Mechanisms in the Destruction of β-Cells by the D-Variant of Encephalomyocarditis Virus , 1985, Diabetes.

[27]  T. Onodera,et al.  Induction of diabetes by cumulative environmental insults from viruses and chemicals , 1980, Nature.

[28]  T. Onodera,et al.  Virus-induced diabetes mellitus. XVIII. Inhibition by a nondiabetogenic variant of encephalomyocarditis virus , 1980, The Journal of experimental medicine.

[29]  A. Notkins,et al.  PANCREATIC ISLET-CELL DAMAGE IN CHILDREN WITH FATAL VIRAL INFECTIONS , 1980, The Lancet.

[30]  D. Samolyk,et al.  DIABETES AND COXSACKIE VIRUS B5 INFECTION , 1980, The Lancet.

[31]  T. Onodera,et al.  Isolation of a virus from the pancreas of a child with diabetic ketoacidosis. , 1979, The New England journal of medicine.

[32]  T. Onodera,et al.  Evidence for a single locus controlling susceptibility to virus-induced diabetes mellitus , 1978, Nature.

[33]  T. Onodera,et al.  Virus-induced Diabetes Mellitus: IV. Genetic and Environmental Factors Influencing the Development of Diabetes After Infection with the M Variant of Encephalomyocarditis Virus , 1976, Diabetes.

[34]  T. Onodera,et al.  Virus-induced diabetes mellitus. XX. Polyendocrinopathy and autoimmunity , 1981, The Journal of experimental medicine.

[35]  J. Craighead,et al.  Diabetes Mellitus: Induction in Mice by Encephalomyocarditis Virus , 1968, Science.

[36]  A. Zuckerman,et al.  Diabetes and Viruses , 2013, Springer New York.

[37]  M. V. von Herrath,et al.  Virus infections in type 1 diabetes. , 2012, Cold Spring Harbor perspectives in medicine.

[38]  Андрей Соколов,et al.  Книги издательства Springer Science & Business Media , 2012 .

[39]  H. Hyöty,et al.  Enteroviruses in the pathogenesis of type 1 diabetes , 2010, Seminars in Immunopathology.

[40]  G. Porter Cause and effect , 2010, Nature Methods.

[41]  G. Bell,et al.  Transgenic mice with green fluorescent protein-labeled pancreatic beta -cells. , 2003, American journal of physiology. Endocrinology and metabolism.

[42]  G. Bell,et al.  Transgenic mice with green fluorescent protein-labeled pancreatic β-cells , 2003 .

[43]  N. J. Bigley,et al.  Exacerbation of the pathogenesis of the diabetogenic variant of encephalomyocarditis virus in mice by interferon. , 1985, Journal of interferon research.

[44]  A. Notkins,et al.  VIRUS-INDUCED DIABETES M ELLITUS I. HYPERGLYCEML~_ AND HYPOINSULINEMIA IN ~/IICE INFECTED WITH ENCEPHALOMYOCARDITIS VIRUS , 1973 .