Critical thermal maximum in mice.

The critical thermal maximum (the colonic temperature of heat-induced convulsion and righting reflex loss) and thermoregulatory response of male mice were examined following I, exposure to colonic temperature (Tco) 42 degrees C; II, a single exposure to the critical thermal maximum (Tco 44 degrees C); AND III, acclimation at ambient temperatures of 15 or 30 degrees C for 14 days. The critical thermal maximum (CTM) was greater in 30 degrees C acclimated mice than 15 degrees C acclimated mice but was unchanged in mice surviving exposure to Tco 42 degrees C or the CTM. The heating time to apparent breakdown of thermoregulation coincident with an explosive rise in the Tco during exposure to ambient temperature 40.8 degrees C was increased (100%) during the 48-h period following exposure to Tco 42 degrees. It appeared that mice exposed to severe, short-term heat stress (Tco 42 degrees) undergo a compensatory increase in their thermoregulatory cooling capacity with little or no change in the upper temperature tolerated. The animals did, however, exhibit the capability for adaptive adjustments of the upper thermal limit during extended exposure to the more prolonged and less severe environmental heat stress of acclimation at 30 degrees C.

[1]  R. B. Cowles,et al.  A preliminary study of the thermal requirements of desert reptiles. Bulletin of the AMNH ; v. 83, article 5 , 1944 .

[2]  E. Adolph,et al.  Tolerance to heat and dehydration in several species of mammals. , 1947, The American journal of physiology.

[3]  R. Zweifel Studies on the Critical Thermal Maxima of Salamanders , 1957 .

[4]  V. H. Hutchison Critical Thermal Maxima in Salamanders , 1961, Physiological Zoology.

[5]  R. Goldsmith,et al.  Acclimatization to heat in man by controlled elevation of body temperature , 1963, The Journal of physiology.

[6]  Effects of cold stress on cellular structure and function. AMRL-TR-66-30. , 1966, AMRL-TR. Aerospace Medical Research Laboratories.

[7]  D. G. Dunlap Critical Thermal Maximum as a Function of Temperature of Acclimation in Two Species of Hylid Frogs , 1968, Physiological Zoology.

[8]  Otto G Edholm The Effect of Heat on Acclimatized and Unacclimatized Groups of Very Fit Men , 1969, Proceedings of the Royal Society of Medicine.

[9]  V. H. Hutchison,et al.  Critical Thermal Tolerances and Heating and Cooling Rates of Lizards from Diverse Habitats , 1970 .

[10]  F. White,et al.  Physiological thermoregulation in turtles. , 1971, The American journal of physiology.

[11]  C. Johnson Thermoregulation in pythons. I. Effect of shelter, substrate type and posture on body temperature of the Australian carpet python, Morelia spilotes variegata. , 1972, Comparative biochemistry and physiology. A, Comparative physiology.

[12]  E. C. Crawford,et al.  Effects of core, skin, and brain temperature on panting in the lizard Sauromalus obesus. , 1974, The American journal of physiology.

[13]  Y. Isobe,et al.  Prediction of survival time of rats in severe heat. , 1975, Journal of applied physiology.