Synthesis of 11C, 18F, 15O, and 13N radiolabels for positron emission tomography.

Positron emission tomography (PET) is a powerful and rapidly developing area of molecular imaging that is used to study and visualize human physiology by the detection of positron-emitting radiopharmaceuticals. Information about metabolism, receptor/enzyme function, and biochemical mechanisms in living tissue can be obtained directly from PET experiments. Unlike magnetic resonance imaging (MRI) or computerized tomography (CT), which mainly provide detailed anatomical images, PET can measure chemical changes that occur before macroscopic anatomical signs of a disease are observed. PET is emerging as a revolutionary method for measuring body function and tailoring disease treatment in living subjects. The development of synthetic strategies for the synthesis of new positron-emitting molecules is, however, not trivial. This Review highlights key aspects of the synthesis of PET radiotracers with the short-lived positron-emitting radionuclides (11)C, (18)F, (15)O, and (13)N, with emphasis on the most recent strategies.

[1]  Antony D. Gee,et al.  Ab initio computational study of positron emission tomography ligands interacting with lipid molecule for the prediction of nonspecific binding , 2008, J. Comput. Chem..

[2]  R. Templer,et al.  Formulation Affects the Rate of Membrane Degradation Catalyzed by Cationic Amphiphilic Drugs , 2008 .

[3]  E. Mishani,et al.  [11C]-dimethylamine as a labeling agent for PET biomarkers. , 2008, Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine.

[4]  M. A. Filannino,et al.  Fully automated [18F]fluorocholine synthesis in the TracerLab MX FDG Coincidence synthesizer. , 2008, Nuclear medicine and biology.

[5]  S. Oh,et al.  Comparison of synthesis yields of 3'-deoxy-3'-[18F]fluorothymidine by nucleophilic fluorination in various alcohol solvents , 2008 .

[6]  J. Gispert,et al.  New method for routine production of L‐[methyl‐11C]methionine: in loop synthesis , 2008 .

[7]  J. Katzenellenbogen,et al.  Facile nucleophilic fluorination reactions using tert-alcohols as a reaction medium: significantly enhanced reactivity of alkali metal fluorides and improved selectivity. , 2008, The Journal of organic chemistry.

[8]  M. Kilbourn,et al.  Determination of residual Kryptofix 2.2.2 levels in [18F]-labeled radiopharmaceuticals for human use. , 2007, Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine.

[9]  Xiaoyuan Chen,et al.  Click Chemistry for 18F-Labeling of RGD Peptides and microPET Imaging of Tumor Integrin αvβ3 Expression , 2007 .

[10]  Hatem Alkadhi,et al.  Absolute Quantification of Myocardial Blood Flow with 13N-Ammonia and 3-Dimensional PET , 2007, Journal of Nuclear Medicine.

[11]  Senshang Lin,et al.  Hydromorphone in the management of cancer-related pain: an update on routes of administration and dosage forms. , 2007, Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques.

[12]  W. Klunk,et al.  Impact of amyloid imaging on drug development in Alzheimer's disease. , 2007, Nuclear medicine and biology.

[13]  Robert A Koeppe,et al.  Time‐course of change in [11C]carfentanil and [11C]raclopride binding potential after a nonpharmacological challenge , 2007, Synapse.

[14]  Obaidur Rahman,et al.  [11C]Carbon monoxide, a versatile and useful precursor in labelling chemistry for PET‐ligand development , 2007 .

[15]  B. Långström,et al.  Radical carbonylation with [11C]carbon monoxide promoted by oxygen-centered radicals: experimental and DFT studies of the mechanism. , 2007, Journal of the American Chemical Society.

[16]  F. Wuest,et al.  Radiolabeling of multimeric neurotensin(8-13) analogs with the short-lived positron emitter fluorine-18. , 2007, Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine.

[17]  E. Årstad,et al.  Synthesis and reactivity of [18F]-N-fluorobenzenesulfonimide. , 2007, Chemical communications.

[18]  S. Oh,et al.  An efficient F-18 labeling method for PET study: Huisgen 1,3-dipolar cycloaddition of bioactive substances and F-18-labeled compounds , 2007 .

[19]  H. E. Wang,et al.  A robotic synthesis of [18F]fluoromisonidazole ([18F]FMISO). , 2007, Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine.

[20]  S. Fanti,et al.  A simple Tracerlab module modification for automated on-column [11C]methylation and [11C]carboxylation. , 2007, Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine.

[21]  H. Coenen,et al.  Nucleophilic 18F-fluorination of heteroaromatic iodonium salts with no-carrier-added [18F]fluoride. , 2007, Journal of the American Chemical Society.

[22]  R. Langlois,et al.  Automated synthesis of 11β-methoxy-4,16α-[16α-18F]difluoroestradiol (4F-M[18F]FES) for estrogen receptor imaging by positron emission tomography , 2007 .

[23]  J. Aerts,et al.  PET/CT of Skull Base Meningiomas Using 2-18F-Fluoro-l-Tyrosine: Initial Report , 2007, Journal of Nuclear Medicine.

[24]  Jae Seung Kim,et al.  One-step high-radiochemical-yield synthesis of [18F]FP-CIT using a protic solvent system. , 2007, Nuclear medicine and biology.

[25]  P. Hoskin,et al.  Positron emission tomography in oncology: a review. , 2007, Clinical oncology (Royal College of Radiologists (Great Britain)).

[26]  R. deKemp,et al.  Will 3-dimensional PET-CT enable the routine quantification of myocardial blood flow? , 2007, Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology.

[27]  S. Moore,et al.  Clinical Myocardial Perfusion PET/CT* , 2007, Journal of Nuclear Medicine.

[28]  M. Glaser,et al.  "Click labeling" with 2-[18f]fluoroethylazide for positron emission tomography. , 2007, Bioconjugate chemistry.

[29]  Jan Passchier,et al.  Rapid multiphase carbonylation reactions by using a microtube reactor: applications in positron emission tomography 11C-radiolabeling. , 2007, Angewandte Chemie.

[30]  R. Cohen.  The Application of Positron-Emitting Molecular Imaging Tracers in Alzheimer’s Disease , 2007, Molecular Imaging and Biology.

[31]  Hélène Audrain.  Positronenemissionstomographie (PET) und Mikrofluidiksysteme: ein methodischer Durchbruch auf der Mikroskala† , 2007 .

[32]  H. Audrain.  Positron emission tomography (PET) and microfluidic devices: a breakthrough on the microscale? , 2007, Angewandte Chemie.

[33]  Nobuyuki Oyama,et al.  18F-fluoroacetate: a potential acetate analog for prostate tumor imaging--in vivo evaluation of 18F-fluoroacetate versus 11C-acetate. , 2007, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[34]  C. Meltzer,et al.  PET/CT: form and function. , 2007, Radiology.

[35]  H. Wadsworth,et al.  A solid-phase route to 18F-labeled tracers, exemplified by the synthesis of [18F]2-Fluoro-2-deoxy-D-glucose. , 2007, Angewandte Chemie.

[36]  Haoran Sun,et al.  Fluoride relay: a new concept for the rapid preparation of anhydrous nucleophilic fluoride salts from KF. , 2007, Chemical communications.

[37]  B. Långström,et al.  Synthesis of [11C]/[13C]acrylamides by palladium-mediated carbonylation , 2007 .

[38]  J. Baron,et al.  Rapid preparation of [11C]flumazenil: captive solvent synthesis combined with purification by analytical sized columns , 2007 .

[39]  V. Pike,et al.  Radioligand Development for PET Imaging of β-Amyloid (Aβ)-Current Status , 2007 .

[40]  P. Gmeiner,et al.  3,4,6-Tri-O-acetyl-2-deoxy-2-[18F]fluoroglucopyranosyl phenylthiosulfonate: a thiol-reactive agent for the chemoselective 18F-glycosylation of peptides. , 2007, Bioconjugate chemistry.

[41]  J. Lever.  PET and SPECT imaging of the opioid system: receptors, radioligands and avenues for drug discovery and development. , 2007, Current pharmaceutical design.

[42]  F. Wuest,et al.  Labeling of low-density lipoproteins using the 18F-labeled thiol-reactive reagent N-[6-(4-[18F]fluorobenzylidene)aminooxyhexyl]maleimide. , 2007, Nuclear medicine and biology.

[43]  L. Barré,et al.  Methyl transfer reaction from monomethyltin reagent under palladium(0) catalysis: a versatile method for labelling with carbon-11. , 2006, Chemical communications.

[44]  Keigo Endo,et al.  Present role and future prospects of positron emission tomography in clinical oncology , 2006, Cancer science.

[45]  Dong Wook Kim,et al.  A new class of SN2 reactions catalyzed by protic solvents: Facile fluorination for isotopic labeling of diagnostic molecules. , 2006, Journal of the American Chemical Society.

[46]  D. Bars.  Fluorine-18 and medical imaging: Radiopharmaceuticals for positron emission tomography , 2006 .

[47]  C. Niemeyer,et al.  18F-Markierung von Peptiden mithilfe eines Organosilicium-Fluoridacceptors† , 2006 .

[48]  K. Jurkschat,et al.  18F-labeling of peptides by means of an organosilicon-based fluoride acceptor. , 2006, Angewandte Chemie.

[49]  M. Pomper,et al.  Synthesis of [11C]gefitinib for imaging epidermal growth factor receptor tyrosine kinase with positron emission tomography , 2006 .

[50]  D. Soloviev,et al.  Captive solvent [11C]acetate synthesis in GMP conditions. , 2006, Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine.

[51]  D. Bonnet-Delpon,et al.  Recent advances (1995–2005) in fluorinated pharmaceuticals based on natural products ☆ , 2006 .

[52]  K. Kirk,et al.  Fluorine in medicinal chemistry: Recent therapeutic applications of fluorinated small molecules , 2006 .

[53]  F. Wuest,et al.  Synthesis of 18F‐labelled biphenyls via SUZUKI cross‐coupling with 4‐[18F]fluoroiodobenzene , 2006 .

[54]  J. Barletta,et al.  Synthesis of diethyl [carbonyl‐11C]malonate from [11C]carbon monoxide by rhodium‐promoted carbonylation and its application as a reaction intermediate , 2006 .

[55]  D. Holt,et al.  Synthesis of a mGluR5 antagonist using [11C]copper(I) cyanide , 2006 .

[56]  W. Weber.  Positron emission tomography as an imaging biomarker. , 2006, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[57]  Sven H. Hausner,et al.  Solid-phase synthesis of 2-[18F]fluoropropionyl peptides. , 2006, Bioconjugate chemistry.

[58]  C. Halldin,et al.  Radiosynthesis of [18F]LBT-999, a selective radioligand for the visualization of the dopamine transporter with PET , 2006 .

[59]  Weibo Cai,et al.  A Thiol-Reactive 18F-Labeling Agent, N-[2-(4-18F-Fluorobenzamido)Ethyl]Maleimide, and Synthesis of RGD Peptide-Based Tracer for PET Imaging of αvβ3 Integrin Expression , 2006 .

[60]  Young Joo Kim,et al.  An improved method of 18F peptide labeling: hydrazone formation with HYNIC-conjugated c(RGDyK). , 2006, Nuclear medicine and biology.

[61]  M. Grégoire,et al.  Improved synthesis of the peripheral benzodiazepine receptor ligand [11C]DPA-713 using [11C]methyl triflate. , 2006, Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine.

[62]  J. Barletta,et al.  Synthesis of [11C-carbonyl]hydroxyureas by a rhodium-mediated carbonylation reaction using [11C]carbon monoxide , 2006 .

[63]  Kazutoshi Suzuki,et al.  Quality control of PET radiopharmaceuticals using HPLC with electrochemical detection. , 2006, Nuclear medicine and biology.

[64]  A. Windhorst,et al.  One‐pot synthesis of [11C]ureas via triphenylphosphinimines , 2006 .

[65]  U. Pleiss,et al.  Synthesis of a 11C-labelled taxane derivative by [1-11C]acetylation , 2006 .

[66]  D. Bars,et al.  Simple synthesis of [1-11C]acetate , 2006 .

[67]  S. Lim,et al.  Preparation of 3′-deoxy-3′-[18F]fluorothymidine ([18F]FLT) in ionic liquid, [bmim][OTf] , 2006 .

[68]  D. O'Hagan,et al.  Fluorine in medicinal chemistry: A review of anti-cancer agents , 2006 .

[69]  C. Halldin,et al.  Synthesis, radiosynthesis and in vivo preliminary evaluation of [11C]LBT-999, a selective radioligand for the visualisation of the dopamine transporter with PET. , 2006, Bioorganic & medicinal chemistry.

[70]  F. Wuest,et al.  11C–C bond formation by palladium‐mediated cross‐coupling of alkenylzirconocenes with [11C]methyl iodide , 2006 .

[71]  O. Prante,et al.  18F-glycosylation using Koenigs–Knorr conditions: a comparative study , 2006 .

[72]  A. Windhorst,et al.  Synthesis of N‐(3‐[18F]Fluoropropyl)‐2β‐carbomethoxy‐3β‐(4‐iodophenyl)nortropane ([18F]FP‐β‐CIT) , 2006 .

[73]  M. Schwaiger,et al.  Chemoselective hydrazone formation between HYNIC-functionalized peptides and (18)F-fluorinated aldehydes. , 2006, Nuclear medicine and biology.

[74]  A. Gee,et al.  Fluorinase mediated C-(18)F bond formation, an enzymatic tool for PET labelling. , 2006, Chemical communications.

[75]  Masaaki Suzuki,et al.  Rapid methylation on carbon frameworks useful for the synthesis of 11CH3-incorporated PET tracers: Pd(0)-mediated rapid coupling of methyl iodide with an alkenyltributylstannane leading to a 1-methylalkene. , 2006, Organic & biomolecular chemistry.

[76]  M. Lasne,et al.  Oxidation of aromatic lithium thiolates into sulfinate salts: an attractive entry to aryl sulfones labeled with carbon-11. , 2006, The Journal of organic chemistry.

[77]  J. Jhamandas,et al.  18F‐FESB: synthesis and automated radiofluorination of a novel 18F‐labeled pet tracer for β‐amyloid plaques , 2005 .

[78]  Sibylle Ziegler,et al.  PET/CT: challenge for nuclear cardiology. , 2005, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[79]  F. Dollé.  Fluorine-18-labelled fluoropyridines: advances in radiopharmaceutical design. , 2005, Current pharmaceutical design.

[80]  B. Långström,et al.  Photoinitiated free radical carbonylation enhanced by photosensitizers. , 2005, Organic letters.

[81]  B. Långström,et al.  Synthesis of Aliphatic [carbonyl‐11C]Esters Using [11C]Carbon Monoxide , 2005 .

[82]  O. Prante,et al.  Utility of 1,3,4,6-tetra-O-acetyl-2-deoxy-2-[18F]fluoro-glucopyranoside for no-carrier-added 18F-glycosylation of amino acids , 2005 .

[83]  T. Ruth,et al.  Arylfluoroborates and alkylfluorosilicates as potential PET imaging agents: high-yielding aqueous biomolecular 18F-labeling. , 2005, Journal of the American Chemical Society.

[84]  F. Füchtner,et al.  Module-assisted synthesis of the bifunctional labelling agent N-succinimidyl 4-[(18)F]fluorobenzoate ([(18)F]SFB). , 2005, Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine.

[85]  Jingli Wang,et al.  Positron Emission Tomography: applications in drug discovery and drug development. , 2005, Current topics in medicinal chemistry.

[86]  D. Lee,et al.  Preparation of 18F-human serum albumin: a simple and efficient protein labeling method with 18F using a hydrazone-formation method. , 2005, Bioconjugate chemistry.

[87]  Garth E. Terry,et al.  An improved synthesis of substituted [11C]toluenes via Suzuki coupling with [11C]methyl iodide , 2005 .

[88]  Christine Ryan,et al.  Synthesis, characterization, and first successful monkey imaging studies of metabotropic glutamate receptor subtype 5 (mGluR5) PET radiotracers , 2005, Synapse.

[89]  Bengt Långström,et al.  Palladium-mediated 11C-carbonylative cross coupling of alkyl / aryl iodides with organostannanes. An efficient synthesis of un-symmetrical alkyl - aryl [carbonyl-11C]ketones , 2005 .

[90]  A. Gee,et al.  Radiosynthesis of carbon‐11‐labelled GI181771, a new selective CCK‐A agonist , 2005 .

[91]  E. Nakamura,et al.  Ultra-rapid synthesis of 15O-labeled 2-deoxy-D-glucose for positron emission tomography (PET). , 2005, Angewandte Chemie.

[92]  C. Solbach,et al.  Efficient radiosynthesis of carbon-11 labelled uncharged Thioflavin T derivatives using [11C]methyl triflate for beta-amyloid imaging in Alzheimer's Disease with PET. , 2005, Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine.

[93]  Michael J Welch,et al.  Positron-emitting isotopes produced on biomedical cyclotrons. , 2005, Current medicinal chemistry.

[94]  Steen Jakobsen,et al.  Behaviour of [11C]R(−)‐ and [11C]S(+)‐rolipram in vitro and in vivo, and their use as PET radiotracers for the quantificative assay of PDE4 , 2005, Synapse.

[95]  R. Boisgard,et al.  1-[3-(2-[18F]fluoropyridin-3-yloxy)propyl]pyrrole-2,5-dione: design, synthesis, and radiosynthesis of a new [18F]fluoropyridine-based maleimide reagent for the labeling of peptides and proteins. , 2005, Bioconjugate chemistry.

[96]  Bengt Långström,et al.  Radical-mediated carboxylation of alkyl iodides with [11C]carbon monoxide in solvent mixtures. , 2005, The Journal of organic chemistry.

[97]  P. Metz,et al.  Synthesis of 18F-labelled cyclooxygenase-2 (COX-2) inhibitors via Stille reaction with 4-[18F]fluoroiodobenzene as radiotracers for positron emission tomography (PET). , 2005, Organic & biomolecular chemistry.

[98]  D. Wilbur,et al.  Radiohalogens for imaging and therapy. , 2005, Chemical Society reviews.

[99]  Egill Rostrup,et al.  The relationship between cerebral blood flow and volume in humans , 2005, NeuroImage.

[100]  F. Wüst,et al.  N‐Arylation of indoles with 4‐[18F]fluoroiodobenzene: synthesis of 18F‐labelled σ2 receptor ligands for positron emission tomography (PET) , 2005 .

[101]  Chunying Wu,et al.  Amyloid imaging: from benchtop to bedside. , 2005, Current topics in developmental biology.

[102]  Morand Piert,et al.  Hypoxia-specific tumor imaging with 18F-fluoroazomycin arabinoside. , 2005, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[103]  G. Hutchins,et al.  An Improved Synthesis of PET Dopamine D2 Receptors Radioligand [11C]Raclopride , 2004 .

[104]  T. Ruth,et al.  Studies of the mechanism of the in-loop synthesis of radiopharmaceuticals. , 2004, Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine.

[105]  D. Lee,et al.  Rapid synthesis of [18F]FDG without an evaporation step using an ionic liquid. , 2004, Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine.

[106]  H. Hoekstra,et al.  [18F]FLT-PET in oncology: current status and opportunities , 2004, European Journal of Nuclear Medicine and Molecular Imaging.

[107]  Ryoji Noyori,et al.  Synthesis of 11C-labelled N,N'-diphenylurea and ethyl phenylcarbamate by a rhodium-promoted carbonylation via [11C]isocyanatobenzene using phenyl azide and [11C]carbon monoxide. , 2004, Organic & biomolecular chemistry.

[108]  S. Luthra,et al.  18F-fluorothiols: a new approach to label peptides chemoselectively as potential tracers for positron emission tomography. , 2004, Bioconjugate chemistry.

[109]  Alan A. Wilson,et al.  A rapid one-step radiosynthesis of the β-amyloid imaging radiotracer N-methyl-[11C]2-(4′-methylaminophenyl)-6-hydroxybenzothiazole ([11C]-6-OH-BTA-1) , 2004 .

[110]  Agneta Nordberg,et al.  PET imaging of amyloid in Alzheimer's disease , 2004, The Lancet Neurology.

[111]  Valerie Treyer,et al.  Constant-infusion H(2)15O PET and acetazolamide challenge in the assessment of cerebral perfusion status. , 2004, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[112]  F. Wüst,et al.  No‐carrier added synthesis of 18F‐labelled nucleosides using Stille cross‐coupling reactions with 4‐[18F]fluoroiodobenzene , 2004 .

[113]  Karl Herholz,et al.  Positron emission tomography in clinical neurology. , 2004, Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging.

[114]  B. Långström,et al.  Photoinitiated carbonylation with [(11)C]carbon monoxide using amines and alkyl iodides. , 2004, The Journal of organic chemistry.

[115]  B. Långström,et al.  Organic Bases as Additives to Improve the Radiochemical Yields of [11C]Ketones Prepared by the Suzuki Coupling Reaction , 2004 .

[116]  H. Coenen,et al.  Comparison of pathways to the versatile synthon of no‐carrier‐added 1‐bromo‐4‐[18F]fluorobenzene , 2004 .

[117]  Martin Stahl,et al.  Fluorine in Medicinal Chemistry , 2004, Chembiochem : a European journal of chemical biology.

[118]  Horst Kessler,et al.  Two-step methodology for high-yield routine radiohalogenation of peptides: (18)F-labeled RGD and octreotide analogs. , 2004, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[119]  B. Tavitian,et al.  Design and synthesis of a new [18F]fluoropyridine-based haloacetamide reagent for the labeling of oligonucleotides: 2-bromo-N-[3-(2-[18F]fluoropyridin-3-yloxy)propyl]acetamide. , 2004, Bioconjugate chemistry.

[120]  Subhani M Okarvi,et al.  Peptide‐based radiopharmaceuticals: Future tools for diagnostic imaging of cancers and other diseases , 2004, Medicinal research reviews.

[121]  K. Ishiwata,et al.  Improved synthesis of [11C]SA4503, [11C]MPDX and [11C]TMSX by use of [11C]methyl triflate , 2004, Annals of nuclear medicine.

[122]  F. O’Sullivan,et al.  Hypoxia and Glucose Metabolism in Malignant Tumors , 2004, Clinical Cancer Research.

[123]  W. Klunk,et al.  Imaging brain amyloid in Alzheimer's disease with Pittsburgh Compound‐B , 2004, Annals of neurology.

[124]  H. Ravert,et al.  PET imaging of opioid receptors in pain: progress and new directions. , 2004, Current pharmaceutical design.

[125]  A. Gee,et al.  Utilisation of [11C]-labelled boron carbonyl complexes in palladium carbonylation reaction. , 2004, Chemical communications.

[126]  Bengt Långström,et al.  Synthesis of 11C-/13C-Ketones by Suzuki Coupling , 2004 .

[127]  B. Långström,et al.  A 11C-methyl stannane (5-[11C]methyl-1-aza-5-stannabicyclo[3.3.3]undecane) for use in palladium-mediated [11C]C-C bond forming reactions with organohalides , 2004 .

[128]  M. Schwaiger,et al.  Chemoselective pre-conjugate radiohalogenation of unprotected mono- and multimeric peptides via oxime formation , 2004 .

[129]  C. Halldin,et al.  A novel electrophilic synthesis and evaluation of medium specific radioactivity (1R,2S)-4-[18F]fluorometaraminol, a tracer for the assessment of cardiac sympathetic nerve integrity with PET. , 2004, Nuclear medicine and biology.

[130]  V. Pike,et al.  Synthesis of NCA [carbonyl‐11C]amides by direct reaction of in situ generated [11C]carboxymagnesium halides with amines under microwave‐enhanced conditions , 2003 .

[131]  A. Gee,et al.  The first enzymatic method for C–18F bond formation: the synthesis of 5′‐[18F]‐fluoro‐5′‐deoxyadenosine for imaging with PET , 2003 .

[132]  R. Boisgard,et al.  Fluorine‐18 labelling of oligonucleotides: Prosthetic labelling at the 5′‐end using the N‐(4‐[18F]fluorobenzyl)‐2‐bromoacetamide reagent , 2003 .

[133]  J. Barrio,et al.  Synthesis of a new heterobifunctional linker, N-[4-(aminooxy)butyl]maleimide, for facile access to a thiol-reactive 18F-labeling agent. , 2003, Bioconjugate chemistry.

[134]  M. Beller,et al.  Palladium‐Catalyzed Cyanation of Aryl Halides: Recent Developments and Perspectives , 2003 .

[135]  F. Dollé,et al.  2-, 3- and 4-[18F]Fluoropyridine by no-carrier-added nucleophilic aromatic substitution with K[18F]F-K222- a comparative study: 2-, 3- and 4-[18F] FLUOROPYRIDINE , 2003 .

[136]  M. Ibazizène,et al.  Debenzylation of tertiary amines using phosgene or triphosgene: an efficient and rapid procedure for the preparation of carbamoyl chlorides and unsymmetrical ureas. Application in carbon-11 chemistry. , 2003, The Journal of organic chemistry.

[137]  A. Studenov,et al.  Efficient in‐loop synthesis of high specific radioactivity [11C]carfentanil , 2003 .

[138]  J. Barrio,et al.  Safety-catch linker strategies for the production of radiopharmaceuticals labeled with positron-emitting isotopes. , 2003, Journal of the American Chemical Society.

[139]  D. O'Hagan,et al.  Isolation and characterisation of 5′‐fluorodeoxyadenosine synthase, a fluorination enzyme from Streptomyces cattleya , 2003, FEBS letters.

[140]  F. Wüst,et al.  Synthesis of 4‐[18F]fluoroiodobenzene and its application in sonogashira cross‐coupling reactions , 2003 .

[141]  B. Långström,et al.  Synthesis of 11C‐Labelled Amides by Palladium‐Mediated Carboxamination Using [11C]Carbon Monoxide, in situ Activated Amines and 1,2,2,6,6‐Pentamethylpiperidine , 2003 .

[142]  Dong Wook Kim,et al.  A new nucleophilic fluorine-18 labeling method for aliphatic mesylates: reaction in ionic liquids shows tolerance for water. , 2003, Nuclear medicine and biology.

[143]  B. Långström,et al.  Aryl triflates and [11C]/(13C)carbon monoxide in the synthesis of 11C-/13C-amides. , 2003, The Journal of organic chemistry.

[144]  Marianne Patt,et al.  [18F]Fluoroazomycinarabinofuranoside (18FAZA) and [18F]Fluoromisonidazole (18FMISO): a comparative study of their selective uptake in hypoxic cells and PET imaging in experimental rat tumors. , 2003, Nuclear medicine and biology.

[145]  B. Johannsen,et al.  A new approach for 11C–C bond formation: Synthesis of 17α-(3′-[11C]prop-1-yn-1-yl)-3-methoxy-3,17β-estradiol , 2003 .

[146]  B. Långström,et al.  Synthesis of 1-(2′-deoxy-2′-fluoro-β-D-arabinofuranosyl)-[Methyl-11C]thymine ([11C]FMAU) via a Stille cross-coupling reaction with [11C]methyl iodide , 2003 .

[147]  A. Gee.  Neuropharmacology and drug development. , 2003, British medical bulletin.

[148]  B. Långström,et al.  Synthesis of 11C-amides using [11C]carbon monoxide and in situ activated amines by palladium-mediated carboxaminations. , 2003, Organic & biomolecular chemistry.

[149]  Kengo Ito,et al.  Direct electrophilic radiofluorination of a cyclic RGD peptide for in vivo αvβ3 integrin related tumor imaging , 2003 .

[150]  A. Paans.  Compact cyclotrons for the production of tracers and radiopharmaceuticals , 2003 .

[151]  K. Hamacher,et al.  Efficient routine production of the 18F-labelled amino acid O-2-18F fluoroethyl-L-tyrosine. , 2002, Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine.

[152]  B. Christian,et al.  Brain imaging of 18F‐fallypride in normal volunteers: Blood analysis, distribution, test‐retest studies, and preliminary assessment of sensitivity to aging effects on dopamine D‐2/D‐3 receptors , 2002, Synapse.

[153]  M. Welch,et al.  Handbook of Radiopharmaceuticals: Radiochemistry and Applications , 2002 .

[154]  E. Hostetler,et al.  A remote-controlled high pressure reactor for radiotracer synthesis with [11C]carbon monoxide. , 2002, Nuclear medicine and biology.

[155]  B. Långström,et al.  Palladium-mediated synthesis of [carbonyl-11C]amides and hydrazides using [11C]carbon monoxide , 2002 .

[156]  S. Stone-Elander,et al.  Microwave applications in radiolabelling with short-lived positron-emitting radionuclides , 2002 .

[157]  de Mja Martien Voigt,et al.  Production of chemically pure gaseous [13N]NH3 pulses for PEP studies using a modified DeVarda reduction. , 2002 .

[158]  H. Coenen,et al.  Synthesis of 2-[18F]fluoro-L-tyrosine via regiospecific fluoro-de-stannylation. , 2002, Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine.

[159]  P. Elsinga.  Radiopharmaceutical chemistry for positron emission tomography. , 2002, Methods.

[160]  A. van Waarde,et al.  Positron emission tomography: the conceptual idea using a multidisciplinary approach. , 2002, Methods.

[161]  Raphaël Boisgard,et al.  Labelled oligonucleotides as radiopharmaceuticals: pitfalls, problems and perspectives. , 2002, Current pharmaceutical design.

[162]  M. Piel,et al.  Efficient synthesis of 2-bromo-1-[18F]fluoroethane and its application in the automated preparation of 18F-fluoroethylated compounds. , 2002, Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine.

[163]  Bengt Långström,et al.  [11C]Carbon Monoxide in Selenium-Mediated Synthesis of 11C-Carbamoyl Compounds , 2002 .

[164]  N. Tamaki,et al.  A simplified and improved synthesis of [11C]phosgene with iron and iron (III) oxide. , 2002, Nuclear medicine and biology.

[165]  K. Ishiwata,et al.  A combined loop-SPE method for the automated preparation of [11C]doxepin , 2002 .

[166]  J. Hamilton,et al.  Biochemistry: Biosynthesis of an organofluorine molecule , 2002, Nature.

[167]  H. VanBrocklin,et al.  Photoconjugation of 3-azido-5-nitrobenzyl-[18F]fluoride to an oligonucleotide aptamer , 2002 .

[168]  S. Buchwald,et al.  Practical Palladium Catalysts for C-N and C-O Bond Formation , 2002 .

[169]  C. Crouzel,et al.  Chemistry of β +-Emitting Compounds Based on Fluorine-18 , 2002 .

[170]  P. Marsden,et al.  Rapid solid phase synthesis and biodistribution of 18F-labelled linear peptides , 2002, European Journal of Nuclear Medicine and Molecular Imaging.

[171]  A. Gee,et al.  Synthesis of [4-11C]amino acids via ring-opening of aziridine-2-carboxylates , 2001 .

[172]  J van den Hoff,et al.  [1-(11)C]Acetate as a quantitative perfusion tracer in myocardial PET. , 2001, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[173]  S. Cherry,et al.  Combining anatomy and function: the path to true image fusion , 2001, European Radiology.

[174]  A. Bogni,et al.  A simple loop method for the automated preparation of (11C)raclopride from (11C)methyl triflate. , 2001, Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine.

[175]  O. Solin,et al.  Automated synthesis and purification of [18F]bromofluoromethane at high specific radioactivity. , 2001, Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine.

[176]  Denis Guilloteau,et al.  Carbon-11 labelling of MADAM in two different positions: a highly selective PET radioligand for the serotonin transporter , 2001 .

[177]  Okarvi Sm,et al.  Recent progress in fluorine-18 labelled peptide radiopharmaceuticals , 2001 .

[178]  T. Jones,et al.  In vivo pharmacokinetics and pharmacodynamics in drug development using positron-emission tomography. , 2001, Drug discovery today.

[179]  C. Koch,et al.  [18F]-EF5, a marker for PET detection of hypoxia: synthesis of precursor and a new fluorination procedure. , 2001, Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine.

[180]  L. Barré,et al.  Total synthesis and radiolabelling of an efficient rt-PA inhibitor: [11C] (Z,Z)-BABCH. A first route to [11C] labelled amidines , 2001 .

[181]  N. Kitteringham,et al.  Metabolism of fluorine-containing drugs. , 2001, Annual review of pharmacology and toxicology.

[182]  Yasuyoshi Watanabe,et al.  Synthesis of a 11C-labelled prostaglandin F2α analogue using an improved method for stille reactions with [11C]methyl iodide , 2000 .

[183]  Yasuyoshi Watanabe,et al.  Rapid Methylation for the Synthesis of a 11C-Labeled Tolylisocarbacyclin Imaging the IP2 Receptor in a Living Human Brain , 2000 .

[184]  Paul Kinahan,et al.  A combined PET/CT scanner for clinical oncology. , 2000, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[185]  M E Phelps,et al.  Positron emission tomography provides molecular imaging of biological processes. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[186]  M. O'Doherty,et al.  Solid phase synthesis of [18F]labelled peptides for positron emission tomography. , 2000, Bioorganic & medicinal chemistry letters.

[187]  B Beuthien-Baumann,et al.  Preparation of fluorine-18 labelled sugars and derivatives and their application as tracer for positron-emission-tomography. , 2000, Carbohydrate research.

[188]  V. Pike,et al.  Rapid mild syntheses of [11C]benzophenones by Pd(0)‐catalysed 11C‐carbonylative coupling of iodoarenes with phenyltributylstannane in DME‐water , 2000 .

[189]  Alan A. Wilson,et al.  Radiotracer synthesis from [(11)C]-iodomethane: a remarkably simple captive solvent method. , 2000, Nuclear medicine and biology.

[190]  J. Steinbach,et al.  No‐carrier‐added 11C‐labelling of benzenoid compounds in ring positions by condensation of nitro‐[11C]methane with pyrylium salts , 2000 .

[191]  J. Rouden,et al.  Synthesis of analogues of (-)-cytisine for in vivo studies of nicotinic receptors using positron emission tomography. , 2000, Organic letters.

[192]  C. Amatore,et al.  Anionic Pd(0) and Pd(II) intermediates in palladium-catalyzed Heck and cross-coupling reactions. , 2000, Accounts of chemical research.

[193]  M. Laruelle.  Imaging Synaptic Neurotransmission with in Vivo Binding Competition Techniques: A Critical Review , 2000, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[194]  A. Shields,et al.  Radiosynthesis of 3'-deoxy-3'-[(18)F]fluorothymidine: [(18)F]FLT for imaging of cellular proliferation in vivo. , 2000, Nuclear medicine and biology.

[195]  J. Liow,et al.  A system for continuous production and infusion of [15O]H2O for PET activation studies. , 2000, Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine.

[196]  John R. Jones,et al.  Microwave-enhanced radiochemistry , 2000 .

[197]  C. Aubert,et al.  Reductive amination of carboxylic acids and [11C]magnesium halide carboxylates , 2000 .

[198]  V. Pike,et al.  Palladium(II)-mediated 11C-carbonylative coupling of diaryliodonium salts with organostannanes—a new, mild and rapid synthesis of aryl [11C]ketones , 2000 .

[199]  M. Berridge,et al.  Synthesis of [18F]fluoromethyl iodide, a synthetic precursor for fluoromethylation of radiopharmaceuticals. , 2000, Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine.

[200]  B. Långström,et al.  Biologically Active 11C-Labeled Amides Using Palladium-Mediated Reactions with Aryl Halides and [11C]Carbon Monoxide , 1999 .

[201]  Christer Halldin,et al.  Precursor synthesis and radiolabelling of the dopamine D2 receptor ligand (11C)raclopride from (11C)methyl triflate , 1999 .

[202]  C. Crouzel,et al.  2‐[18F]fluoropyridines by no‐carrier‐added nucleophilic aromatic substitution with [18F]FK‐K222—a comparative study , 1999 .

[203]  R. Krasikova,et al.  Improved []ammonia yield from the proton irradiation of water using methane gas , 1999 .

[204]  D. Hwang,et al.  An improved one-pot procedure for the preparation of [11C-carbonyl]-WAY100635. , 1999, Nuclear medicine and biology.

[205]  Butanol is Superior to Water for Performing Positron Emission Tomography Activation Studies , 1999, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[206]  J. Steinbach,et al.  Synthesis of triphenylarsonium [11C]methylide, a new 11C‐precursor. Application in the preparation of [2‐11C]indole , 1999 .

[207]  Kazutoshi Suzuki,et al.  Development of an automated system for the quick production of 13N-labeled compounds with high specific activity using anhydrous [13N]NH3 , 1999 .

[208]  Kazutoshi Suzuki,et al.  Production of [13N]NH3 with ultra-high specific activity , 1999 .

[209]  S. Minoshima,et al.  In vivo mapping of cerebral acetylcholinesterase activity in aging and Alzheimer’s disease , 1999, Neurology.

[210]  V. Pike,et al.  Facile synthesis of substituted diaryliodonium tosylates by treatment of aryltributylstannanes with Koser’s reagent , 1999 .

[211]  A. Luxen,et al.  Solid phase extraction : An alternative to the use of rotary evaporators for solvent removal in the rapid formulation of PET radiopharmaceuticals , 1999 .

[212]  Michael J. Welch,et al.  Positron emission tomographic assessment of ”metabolic flare” to predict response of metastatic breast cancer to antiestrogen therapy , 1999, European Journal of Nuclear Medicine.

[213]  Otto Muzik,et al.  Imaging proliferation in vivo with [F-18]FLT and positron emission tomography , 1998, Nature Medicine.

[214]  J. Hartwig.  Carbon−Heteroatom Bond-Forming Reductive Eliminations of Amines, Ethers, and Sulfides , 1998 .

[215]  M. Bergström,et al.  Synthesis and In Vitro Evaluation of [carbonyl-11C]Estramustine and [carbonyl-11C]Estramustine Phosphate , 1998, Steroids.

[216]  V. Pike,et al.  The synthesis of [18F]fluoroarenes from the reaction of cyclotron-produced [18F]fluoride ion with diaryliodonium salts , 1998 .

[217]  B. Långstrom,et al.  F-18-labelling of oligonucleotides using succinimido 4-[F-18]fluorobenzoate , 1998 .

[218]  O. Solin,et al.  Fluorine-18-labeled fluorine gas for synthesis of tracer molecules. , 1997, Nuclear medicine and biology.

[219]  Single-step synthesis of [18F]haloperidol from the chloro-precursor and its applications in PET imaging of a cat's brain. , 1997, Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine.

[220]  V. Pike,et al.  A simple technique for the automated production of no-carrier-added [1-11C]acetate , 1997 .

[221]  M. Nader,et al.  Conversion of No-carrier-added [11C]carbon dioxide to [11C]carbon monoxide on molybdenum for the synthesis of 11C-labelled aromatic ketones , 1997 .

[222]  E. Nakamura,et al.  Conversion of Alkyl Halides into Alcohols Using a Near Stoichiometric Amount of Molecular Oxygen: An Efficient Route to 18O- and 17O-Labeled Alcohols , 1997 .

[223]  C. Crouzel,et al.  [11C]copper(I) cyanide: a new radioactive precursor for 11C-cyanation and functionalization of haloarenes , 1997 .

[224]  K. Hamacher,et al.  [13N]Cisplatin: a fast and efficient on-line synthesis using a solid state support , 1997 .

[225]  A. Wolf,et al.  Working Against Time: Rapid Radiotracer Synthesis and Imaging the Human Brain , 1997 .

[226]  P. Larsen,et al.  Synthesis of [11C]iodomethane by iodination of [11C]methane , 1997 .

[227]  C. Crouzel,et al.  Synthesis of [11C]RPR-72840A and its evaluation as a radioligand for the serotonin reuptake site in positron emission tomography. , 1997, Bioorganic & medicinal chemistry.

[228]  B. Långström,et al.  [11C]Carbon monoxide in the palladium-mediated synthesis of11C-labelled ketones , 1997 .

[229]  C. Aubert,et al.  Rapid synthesis of aliphatic amides by reaction of carboxylic acids, Grignard reagent and amines: application to the preparation of [11C]amides , 1997 .

[230]  V. Pike,et al.  Synthesis of functionalised unsymmetrical diaryliodonium salts , 1997 .

[231]  K. Krohn,et al.  Production of [11C]CH3I by single pass reaction of [11C]CH4 with I2. , 1997, Nuclear medicine and biology.

[232]  Victor W. Pike,et al.  Remotely-controlled production of the 5-HT1A receptor radioligand, [carbonyl-11C]WAY-100635, via 11C-carboxylation of an immobilized Grignard reagent , 1996 .

[233]  K. Markides,et al.  Synthesis of 11C-Labeled Guanidines in Supercritical Ammonia , 1996 .

[234]  Production, automatic delivery and bolus injection of [15O]water for positron emission tomography studies. , 1996, Nuclear medicine and biology.

[235]  K. Hamacher,et al.  A comparative study of N.C.A. fluorine-18 labeling of proteins via acylation and photochemical conjugation. , 1996, Nuclear medicine and biology.

[236]  R. Gur,et al.  Mood effects on limbic blood flow correlate with emotional self-rating: A PET study with oxygen-15 labeled water , 1995, Psychiatry Research: Neuroimaging.

[237]  Norio Miyaura,et al.  Palladium-Catalyzed Cross-Coupling Reactions of Organoboron Compounds , 1995 .

[238]  S. Ametamey,et al.  Comparison of two synthetic methods to obtain [18F] N-(2-aminoethyl)-5-fluoropyridine-2-carboxamide, a potential MAO-B imaging tracer for PET , 1995 .

[239]  Wilhelm Hamkens,et al.  Remote controlled one-step production of 18F labeled butyrophenone neuroleptics exemplified by the synthesis of n.c.a. [18F] N-methylspiperone , 1995 .

[240]  Y. Miyake,et al.  HIGH YIELD SYNTHESIS OF HIGH PURITY 18F-LABELLED AROMATIC COMPOUNDS BY ARYL-F-FOR-X HALOGEN EXCHANGE REACTIONS , 1995 .

[241]  M. K. Das,et al.  Fluorinated benzamide neuroleptics--III. Development of (S)-N-[(1-allyl-2-pyrrolidinyl)methyl]-5-(3-[18F]fluoropropyl)-2, 3-dimethoxybenzamide as an improved dopamine D-2 receptor tracer. , 1995, Nuclear medicine and biology.

[242]  An automated [15Q]H2O production and injection system for PET imaging. , 1995, Nuclear medicine and biology.

[243]  V. Pike,et al.  Reactions of cyclotron-produced [18F]fluoride with diaryliodonium salts—a novel single-step route to no-carrier-added [18]fluoroarenes , 1995 .

[244]  M. Bergström,et al.  Synthesis of 11C-labelled benzamide compounds as potential tracers for poly(ADP-ribose) synthetase. , 1994, Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine.

[245]  D. Hwang,et al.  NCA F-18 fluoroarylketones: Useful bifunctional radiopharmaceutical intermediates , 1994 .

[246]  M E Raichle,et al.  Visualizing the mind. , 1994, Scientific American.

[247]  B. Långström,et al.  Transition metal-mediated reactions using [11C]cyanide in synthesis of 11C-labelled aromatic compounds , 1994 .

[248]  M. Berridge,et al.  In-target production of [13N]ammonia: target design, products, and operating parameters. , 1993, Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine.

[249]  M J Welch,et al.  Automated production of oxygen-15 labeled butanol for PET measurement of regional cerebral blood flow. , 1993, Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine.

[250]  K. Hamacher,et al.  Optimization studies concerning the direct nucleophilic fluorination of butyrophenone neuroleptics , 1993 .

[251]  D. Nutt,et al.  Radioligands for PET studies of central benzodiazepine receptors and PK (peripheral benzodiazepine) binding sites--current status. , 1993, Nuclear medicine and biology.

[252]  D. Jewett,et al.  A simple synthesis of [11C]methyl triflate. , 1992, International journal of radiation applications and instrumentation. Part A, Applied radiation and isotopes.

[253]  S S Gambhir,et al.  Quantification of Regional Myocardial Blood Flow Using 13N‐Ammonia and Reoriented Dynamic Positron Emission Tomographic Imaging , 1992, Circulation.

[254]  N Satyamurthy,et al.  Regioselective radiofluorodestannylation with [18F]F2 and [18F]CH3COOF: a high yield synthesis of 6-[18F]Fluoro-L-dopa. , 1992, International journal of radiation applications and instrumentation. Part A, Applied radiation and isotopes.

[255]  C. Shea,et al.  Radiochemical and chemical quality-assurance methods for [13N]-ammonia made from a small volume H2(16)O target. , 1991, International journal of radiation applications and instrumentation. Part A, Applied radiation and isotopes.

[256]  B. Långström,et al.  [11C]Methylenetriphenylphosphorane, a new 11C‐precursor, used in a one‐pot wittig synthesis of [β‐11C]styrene , 1990 .

[257]  G. Hutchins,et al.  Neuronal mapping of the heart with 6-[18F]fluorometaraminol. , 1990, Journal of medicinal chemistry.

[258]  M. Berridge,et al.  Low-carrier production of [15O]oxygen, water and carbon monoxide , 1990 .

[259]  M. Sajjad,et al.  Novel solid-state support for rapid synthesis of radiopharmaceuticals labelled with [11C]-cyanide , 1990 .

[260]  M. Welch,et al.  Comparison of bromo- and iodoalkyl triflates for 18F-radiolabeling of amines. , 1990, International journal of radiation applications and instrumentation. Part A, Applied radiation and isotopes.

[261]  O. Inoue,et al.  Production of 3-N-[11C]methylspiperone with high specific activity and high radiochemical purity for PET studies: suppression of its radiolysis. , 1990, International journal of radiation applications and instrumentation. Part A, Applied radiation and isotopes.

[262]  J. Barrio,et al.  N-[18F]fluoro-N-alkylsulfonamides: novel reagents for mild and regioselective radiofluorination. , 1990, International journal of radiation applications and instrumentation. Part A, Applied radiation and isotopes.

[263]  M. Kilbourn,et al.  Direct simultaneous production of [15O]water and [13N]ammonia or [18F]fluoride ion by 26 MeV proton irradiation of a double chamber water target. , 1990, International journal of radiation applications and instrumentation. Part A, Applied radiation and isotopes.

[264]  C. Mathis,et al.  A radiosynthesis of fluorine-18 fluoromisonidazole. , 1989, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[265]  F. Oberdorfer,et al.  Preparation of 18F‐labelled N‐fluoropyridinium triflate , 1988 .

[266]  F. Oberdorfer,et al.  Preparation of a new 18F-labelled precursor: 1-[18F]fluoro-2-pyridone , 1988 .

[267]  M J Welch,et al.  Positron Emission Tomographic Measurement of Cerebral Blood Flow and Permeability—Surface Area Product of Water Using [15O]Water and [11C]Butanol , 1987, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[268]  R. Iwata,et al.  Optimization of carbon 11 hydrogen cyanide production and no carrier added 1 carbon 11 amino acid synthesis , 1987 .

[269]  G. Antoni,et al.  Synthesis of L- and D-[methyl-11C]methionine. , 1987, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[270]  M. Welch,et al.  A rapid and efficient method for the fluoroalkylation of amines and amides. Development of a method suitable for incorporation of the short-lived positron emitting radionuclide fluorine-18 , 1987 .

[271]  G. Antoni,et al.  Synthesis of racemic [3‐11C]‐labelled alanine, 2‐aminobutyric acid, norvaline, norleucine, leucine and phenylalanine and preparation of L‐[3‐11C]alanine and L‐[3‐11C]phenylalanine , 1987 .

[272]  C. Crouzel,et al.  A new synthesis of carbon-11 labelled phosgene , 1987 .

[273]  R. Iwata,et al.  Optimization of [11C]HCN production and no-carrier-added [1-11C]amino acid synthesis. , 1987, International journal of radiation applications and instrumentation. Part A, Applied radiation and isotopes.

[274]  C. Crouzel,et al.  Current methodology for oxygen-15 production for clinical use. , 1987, International journal of radiation applications and instrumentation. Part A, Applied radiation and isotopes.

[275]  K. Hamacher,et al.  Efficient stereospecific synthesis of no-carrier-added 2-[18F]-fluoro-2-deoxy-D-glucose using aminopolyether supported nucleophilic substitution. , 1986, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[276]  G. Antoni,et al.  The synthesis of 1-11C-labelled ethyl, propyl, butyl and isobutyl iodides and examples of alkylation reactions , 1986 .

[277]  B E Sobel,et al.  Positron emission tomography of the heart. , 1992, Progress in cardiovascular diseases.

[278]  A. Alavi,et al.  Cerebral Blood Flow with the Continuous Infusion of Oxygen-15-Labeled Water , 1985, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[279]  J. Fowler,et al.  Synthesis of 15O-labeled butanol via organoborane chemistry. , 1985, The International journal of applied radiation and isotopes.

[280]  C. D. Arnett,et al.  Syntheses and Specific Activity Determinations of No-Carrier-Added Fluorine-18-Labeled Neuroleptic Drugs , 1985 .

[281]  Kazutoshi Suzuki,et al.  Automatic production of 13NH3 and L-[13N]glutamate ready for intravenous injection , 1984 .

[282]  C. Dence,et al.  Carrier-added and no-carrier-added syntheses of [18F]spiroperidol and [18F]haloperidol. , 1984, The International journal of applied radiation and isotopes.

[283]  Iwao Kanno,et al.  Measurement of Cerebral Blood Flow Using Bolus Inhalation of C15O2 and Positron Emission Tomography: Description of the Method and its Comparison with the C15O2 Continuous Inhalation Method , 1984, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[284]  D. Jewett,et al.  Simple synthesis of F-18-labeled 2-fluoro-2-deoxy-D-glucose: concise communication. , 1984, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[285]  J. Barrio,et al.  Synthesis and myocardial kinetics of N-13 and C-11 labeled branched-chain L-amino acids. , 1983, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[286]  S. T. Purrington,et al.  1-Fluoro-2-pyridone: a useful fluorinating reagent , 1983 .

[287]  D. Kuhl,et al.  N‐13 Ammonia as an Indicator of Myocardial Blood Flow , 1981, Circulation.

[288]  Arthur J. L. Cooper,et al.  The use of immobilized glutamate dehydrogenase to synthesize 13N-labeled L-amino acids. , 1981, Analytical biochemistry.

[289]  J. S. Laughlin,et al.  Imaging of the human heart after administration of L-(N-13)glutamate. , 1980, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[290]  Gopal B. Saha,et al.  Fundamentals of Nuclear Pharmacy , 1979, Springer New York.

[291]  D. Kuhl,et al.  Positron emission tomography of the heart , 1979 .

[292]  E. Davies.  Reconstruction tomography in diagnostic radiology and nuclear medicine , 1978 .

[293]  J. S. Laughlin,et al.  Enzymatic Synthesis and Organ Distribution Studies with 13N-Labeled L-Glutamine and L-Glutamic Acid1 , 1975 .

[294]  W. Vaalburg,et al.  An improved method for the cyclotron production of 13N-labelled ammonia. , 1975, The International journal of applied radiation and isotopes.

[295]  J. Schwartz,et al.  Hydrozirconation. II. Oxidative homologation of olefins via carbon monoxide insertion into the carbon-zirconium bond , 1975 .

[296]  P. Buckingham,et al.  Short-lived radioactive gases for clinical use , 1975 .