Bioinformatics in the post-genome era.

Recent years saw a dramatic increase in genomic and proteomic data in public archives. Now with the complete genome sequences of human and other species in hand, detailed analyses of the genome sequences will undoubtedly improve our understanding of biological systems and at the same time require sophisticated bioinformatic tools. Here we review what computational challenges are ahead and what are the new exciting developments in this exciting field.

[1]  Steven C. Lawlor,et al.  GenMAPP, a new tool for viewing and analyzing microarray data on biological pathways , 2002, Nature Genetics.

[2]  Michael Y. Galperin,et al.  The COG database: new developments in phylogenetic classification of proteins from complete genomes , 2001, Nucleic Acids Res..

[3]  Ian Korf,et al.  Integrating genomic homology into gene structure prediction , 2001, ISMB.

[4]  Stu Borman.  Divining protein architecture: Predicting structure from sequence has advanced impressively in the past few years , 2003 .

[5]  A. Packer.  Spreading the word , 2002, Nature Genetics.

[6]  Ron Shamir,et al.  CLICK and EXPANDER: a system for clustering and visualizing gene expression data , 2003, Bioinform..

[7]  International Human Genome Sequencing Consortium.  Initial sequencing and analysis of the human genome , 2001, Nature.

[8]  J. V. Moran,et al.  Initial sequencing and analysis of the human genome. , 2001, Nature.

[9]  E. Birney,et al.  Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs , 2002, Nature.

[10]  P. Khatri,et al.  Profiling gene expression using onto-express. , 2002, Genomics.

[11]  Robert D. Finn,et al.  The Pfam protein families database , 2004, Nucleic Acids Res..

[12]  Susumu Goto,et al.  The KEGG databases at GenomeNet , 2002, Nucleic Acids Res..

[13]  J. Blake,et al.  Creating the Gene Ontology Resource : Design and Implementation The Gene Ontology Consortium 2 , 2001 .

[14]  Tom H. Pringle,et al.  The human genome browser at UCSC. , 2002, Genome research.

[15]  F. Collins,et al.  A vision for the future of genomics research , 2003, Nature.