Will systems biology offer new holistic paradigms to life sciences?

A biological system, like any complex system, blends stochastic and deterministic features, displaying properties of both. In a certain sense, this blend is exactly what we perceive as the “essence of complexity” given we tend to consider as non-complex both an ideal gas (fully stochastic and understandable at the statistical level in the thermodynamic limit of a huge number of particles) and a frictionless pendulum (fully deterministic relative to its motion). In this commentary we make the statement that systems biology will have a relevant impact on nowadays biology if (and only if) will be able to capture the essential character of this blend that in our opinion is the generation of globally ordered collective modes supported by locally stochastic atomisms.

[1]  For the biotechnology industry, the penny drops (at last): genes are not autonomous agents but function within networks! , 2007, BioEssays : news and reviews in molecular, cellular and developmental biology.

[2]  M. Tewari,et al.  The Limits of Reductionism in Medicine: Could Systems Biology Offer an Alternative? , 2006, PLoS medicine.

[3]  Masaru Tomita,et al.  Indeterminacy of Reverse Engineering of Gene Regulatory Networks: The Curse of Gene Elasticity , 2007, PloS one.

[4]  Dee W. Hock.  Birth of the Chaordic Age , 2000 .

[5]  Naama Brenner,et al.  Genome-wide transcriptional plasticity underlies cellular adaptation to novel challenge , 2007, Molecular systems biology.

[6]  京都大学基礎物理学研究所,et al.  A Different Universe , 2005 .

[7]  Joseph P. Zbilut,et al.  Invariant features of metabolic networks: a data analysis application on scaling properties of biochemical pathways , 2004 .

[8]  D. Murray,et al.  A genomewide oscillation in transcription gates DNA replication and cell cycle. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[9]  Neal S. Holter,et al.  Fundamental patterns underlying gene expression profiles: simplicity from complexity. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[10]  Osamu Takeuchi,et al.  Regulation of lipopolysaccharide-inducible genes by MyD88 and Toll/IL-1 domain containing adaptor inducing IFN-beta. , 2005, Biochemical and biophysical research communications.

[11]  A. Leggett.  A Different Universe: Reinventing Physics from the Bottom Down , 2005 .

[12]  G. Dorda,et al.  New Method for High-Accuracy Determination of the Fine-Structure Constant Based on Quantized Hall Resistance , 1980 .

[13]  Alfredo Colosimo,et al.  Gene expression waves , 2007, The FEBS journal.

[14]  Oxana V. Galzitskaya,et al.  Physics of protein folding , 2004 .

[15]  Barbara Drossel,et al.  Emergence of complexity in evolving niche-model food webs. , 2008, Journal of theoretical biology.

[16]  R Benigni,et al.  Quantitative modeling and biology: the multivariate approach. , 1994, The American journal of physiology.

[17]  A Keith Dunker,et al.  Intrinsic disorder and protein function. , 2002, Biochemistry.

[18]  Hiroaki Kitano,et al.  Biological robustness , 2008, Nature Reviews Genetics.