Cytokines tumor necrosis factor and interleukin‐6 in experimental biliary obstruction in mice

The putative role of the cytokines interleukin‐6 and tumor necrosis factor in the pathophysiology of the complications and mortality after surgery in jaundiced patients was studied in a murine model. Cytokine serum levels were determined in mice with experimental biliary obstruction. As an indicator of the activation status of macrophages, cytokine release by mononuclear phagocytes obtained from such mice was assessed.

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