Dysfunctional neural regulation of lacrimal gland secretion and its role in the pathogenesis of dry eye syndromes.

[1]  K. Ammer,et al.  Radon therapy for the treatment of rheumatic diseases—review and meta-analysis of controlled clinical trials , 2005, Rheumatology International.

[2]  S. Pflugfelder,et al.  Inflammation in dry eye. , 2004, The ocular surface.

[3]  R. Auger,et al.  Regulated Cell Surface Pro-EGF Ectodomain Shedding Is a Zinc Metalloprotease-dependent Process* , 2003, Journal of Biological Chemistry.

[4]  M. Dana,et al.  Are women with Sjögren's syndrome androgen-deficient? , 2003, The Journal of rheumatology.

[5]  S. Hamm-Alvarez,et al.  Biochemical Changes Contributing to Functional Quiescence in Lacrimal Gland Acinar Cells after Chronic Ex Vivo Exposure to a Muscarinic Agonist , 2003, Scandinavian journal of immunology.

[6]  J. Putney,et al.  Capacitative calcium entry in the nervous system. , 2003, Cell calcium.

[7]  A. Mircheff Sjogrens syndrome as failed local immunohomeostasis: prospects for cell-based therapy. , 2003, The ocular surface.

[8]  K. Tsubota,et al.  Abnormal protein profiles in tears with dry eye syndrome. , 2003, American journal of ophthalmology.

[9]  J. Buring,et al.  Prevalence of dry eye syndrome among US women. , 2003, American journal of ophthalmology.

[10]  T. Kveder,et al.  Parasympathetic nervous system dysfunction in primary Sjögren’s syndrome , 2003, Annals of the rheumatic diseases.

[11]  G. Chiou,et al.  Induction of nitric oxide synthase and over-production of nitric oxide by interleukin-1beta in cultured lacrimal gland acinar cells. , 2003, Experimental eye research.

[12]  S. Pillemer,et al.  Sex steroid hormones in primary Sjögren's syndrome. , 2003, The Journal of rheumatology.

[13]  Y. Konttinen,et al.  Corneal innervation and morphology in primary Sjögren's syndrome. , 2003, Investigative ophthalmology & visual science.

[14]  S. Hamm-Alvarez,et al.  Cytoplasmic dynein participates in apically targeted stimulated secretory traffic in primary rabbit lacrimal acinar epithelial cells , 2003, Journal of Cell Science.

[15]  T. Tervo,et al.  In vivo confocal microscopy for evaluation of wound healing following corneal refractive surgery , 2003, Progress in Retinal and Eye Research.

[16]  Renée Solomon,et al.  The effect of hinge position on corneal sensation and dry eye after LASIK. , 2003, Ophthalmology.

[17]  D. Zoukhri,et al.  Signal transduction pathways used by EGF to stimulate protein secretion in rat lacrimal gland. , 2003, Investigative ophthalmology & visual science.

[18]  T. Witte,et al.  Antibodies against alpha-fodrin in Sjögren's syndrome. , 2003, Autoimmunity reviews.

[19]  T. Gray,et al.  Alcohol debridement of the corneal epithelium in PRK and LASEK: an electron microscopic study. , 2003, Investigative ophthalmology & visual science.

[20]  J. McLaren,et al.  Reinnervation in the cornea after LASIK. , 2002, Investigative ophthalmology & visual science.

[21]  G. Chiou,et al.  Nitric oxide and cyclic GMP-mediated protein secretion from cultured lacrimal gland acinar cells. , 2002, Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics.

[22]  C. Kublin,et al.  Role of proinflammatory cytokines in the impaired lacrimation associated with autoimmune xerophthalmia. , 2002, Investigative ophthalmology & visual science.

[23]  Donald C. Chang,et al.  Growth of purified lacrimal acinar cells in Matrigel raft cultures. , 2002, Experimental eye research.

[24]  S. Dissing,et al.  Nitric oxide-induced signalling in rat lacrimal acinar cells. , 2002, Acta physiologica Scandinavica.

[25]  R. Jonsson,et al.  Up-regulation of M3-Muscarinic Receptors in Labial Salivary Gland Acini in Primary Sjögren's Syndrome , 2002, Laboratory Investigation.

[26]  G. Matthews,et al.  Calcium dependence of exocytosis in lacrimal gland acinar cells. , 2002, American journal of physiology. Cell physiology.

[27]  G. Matthews,et al.  Differences in stimulus induced calcium increases in lacrimalgland acinar cells from normal and NZB/NZW F1 female mice , 2002, Current eye research.

[28]  K. Keyser,et al.  Neuronal nitric oxide synthase and the autonomic innervation of the mouse lacrimal gland. , 2001, Investigative ophthalmology & visual science.

[29]  C. A. Carraway,et al.  Production and localization of Muc4/sialomucin complex and its receptor tyrosine kinase ErbB2 in the rat lacrimal gland. , 2001, Investigative ophthalmology & visual science.

[30]  R. Ambrósio,et al.  Laser in situ keratomileusis-induced neurotrophic epitheliopathy. , 2001, American journal of ophthalmology.

[31]  S. Nakagawa,et al.  Presence of neuronal nitric oxide synthase in autonomic and sensory ganglion neurons innervating the lacrimal glands of the cat: an immunofluorescent and retrograde tracer double-labeling study , 2001, Journal of Chemical Neuroanatomy.

[32]  M. J. van den Bent,et al.  Involvement of the peripheral nervous system in primary Sjögren's syndrome. , 2001, Annals of the rheumatic diseases.

[33]  K. Tsubota,et al.  Dry eye after refractive surgery , 2001, Current opinion in ophthalmology.

[34]  M. C. Acosta,et al.  Sensations evoked by selective mechanical, chemical, and thermal stimulation of the conjunctiva and cornea. , 2001, Investigative ophthalmology & visual science.

[35]  P. Smith,et al.  Acetylcholine‐evoked calcium mobilization and ion channel activation in human labial gland acinar cells from patients with primary Sjögren's syndrome , 2001, Clinical and experimental immunology.

[36]  S. Wilson Laser in situ keratomileusis-induced (presumed) neurotrophic epitheliopathy. , 2001, Ophthalmology.

[37]  J. Putney,et al.  Role of the Phospholipase C-Inositol 1,4,5-Trisphosphate Pathway in Calcium Release-activated Calcium Current and Capacitative Calcium Entry* , 2001, The Journal of Biological Chemistry.

[38]  J. Hovanesian,et al.  Symptoms of dry eye and recurrent erosion syndrome after refractive surgery , 2001, Journal of cataract and refractive surgery.

[39]  C. Kublin,et al.  Impaired neurotransmitter release from lacrimal and salivary gland nerves of a murine model of Sjögren's syndrome. , 2001, Investigative ophthalmology & visual science.

[40]  A. Berra,et al.  Muscarinic acetylcholine receptor antibodies as a new marker of dry eye Sjögren syndrome. , 2001, Investigative ophthalmology & visual science.

[41]  A. Castillo,et al.  Decrease in Tear Secretion and Corneal Sensitivity After Laser In Situ Keratomileusis , 2001, Cornea.

[42]  D. Lam,et al.  Effect of laser in situ keratomileusis on tear stability. , 2000, Ophthalmology.

[43]  P. Brink,et al.  A model of fluid secretion by the acinar cells of the mouse lacrimal gland. , 2000, Advances in experimental medicine and biology.

[44]  J. Brayer,et al.  Evidence for antimuscarinic acetylcholine receptor antibody-mediated secretory dysfunction in nod mice. , 2000, Arthritis and rheumatism.

[45]  R. Fox,et al.  Update in Sjögren syndrome. , 2000, Current opinion in rheumatology.

[46]  J. B. Lee,et al.  Comparison of tear secretion and tear film instability after photorefractive keratectomy and laser in situ keratomileusis , 2000, Journal of cataract and refractive surgery.

[47]  W. Mathers,et al.  Why the eye becomes dry: a cornea and lacrimal gland feedback model. , 2000, The CLAO journal : official publication of the Contact Lens Association of Ophthalmologists, Inc.

[48]  M. Rischmueller,et al.  Inhibitory effects of muscarinic receptor autoantibodies on parasympathetic neurotransmission in Sjögren's syndrome. , 2000, Arthritis and rheumatism.

[49]  C. Aras,et al.  Decreased tear secretion after laser in situ keratomileusis for high myopia. , 2000, Journal of refractive surgery.

[50]  P. McDonnell,et al.  Corneal sensation after laser in situ keratomileusis. , 2000, Journal of cataract and refractive surgery.

[51]  W. Petroll,et al.  Effect of myopic LASIK on corneal sensitivity and morphology of subbasal nerves. , 2000, Investigative ophthalmology & visual science.

[52]  C. Sergheraert,et al.  Cholinergic-Induced Ca2+ Elevation in Rat Lacrimal Gland Acini Is Negatively Modulated by PKCδ and PKCε , 2000 .

[53]  L. Kovács,et al.  Impaired microvascular response to cholinergic stimuli in primary Sjögren's syndrome , 2000, Annals of the rheumatic diseases.

[54]  C. Okamoto,et al.  Stimulation with carbachol alters endomembrane distribution and plasma membrane expression of intracellular proteins in lacrimal acinar cells. , 1999, Experimental eye research.

[55]  G. van der Heijde,et al.  Parasympathetic failure does not contribute to ocular dryness in primary Sjögren's syndrome , 1999, Annals of the rheumatic diseases.

[56]  S. Wilson,et al.  Lacrimal gland HGF, KGF, and EGF mRNA levels increase after corneal epithelial wounding. , 1999, Investigative ophthalmology & visual science.

[57]  S. Pflugfelder,et al.  Altered cytokine balance in the tear fluid and conjunctiva of patients with Sjögren's syndrome keratoconjunctivitis sicca. , 1999, Current eye research.

[58]  John B. Bundrick,et al.  Autonomic failure and proximal skeletal myopathy in a patient with primary Sjögren syndrome. , 1999, Mayo Clinic proceedings.

[59]  A. Berra,et al.  Sjögren autoantibodies modify neonatal cardiac function via M1 muscarinic acetylcholine receptor activation. , 1999, International journal of cardiology.

[60]  J. Alió,et al.  Corneal sensitivity after photorefractive keratectomy and laser in situ keratomileusis for low myopia. , 1999, American journal of ophthalmology.

[61]  Jaipaul Singh,et al.  Evidence to suggest morphological and physiological alterations of lacrimal gland acini with ageing. , 1999, Experimental eye research.

[62]  W. Kim,et al.  Change in corneal sensitivityfollowing laser in situ keratomileusis , 1999 .

[63]  H. Jammes,et al.  EGF precursor mRNA and membrane-associated EGF precursor protein in rat exorbital lacrimal gland. , 1999, American journal of physiology. Cell physiology.

[64]  J. Christodoulou,et al.  Autonomic cardiovascular neuropathy in Sjögren's syndrome. A controlled study. , 1998, The Journal of rheumatology.

[65]  A. Berra,et al.  Human primary Sjögren's syndrome autoantibodies as mediators of nitric oxide release coupled to lacrimal gland muscarinic acetylcholine receptors. , 1998, Current eye research.

[66]  R. Beuerman,et al.  The pathology of dry eye: the interaction between the ocular surface and lacrimal glands. , 1998, Cornea.

[67]  D. Zoukhri,et al.  Ca2+ signaling by cholinergic and alpha1-adrenergic agonists is up-regulated in lacrimal and submandibular glands in a murine model of Sjögren's syndrome. , 1998, Clinical immunology and immunopathology.

[68]  D. Zoukhri,et al.  Lacrimal gland innervation is not altered with the onset and progression of disease in a murine model of Sjögren's syndrome. , 1998, Clinical immunology and immunopathology.

[69]  S. Hamm-Alvarez,et al.  Microtubules facilitate the stimulated secretion of beta-hexosaminidase in lacrimal acinar cells. , 1998, Journal of cell science.

[70]  Jaipaul Singh,et al.  Age-related changes in morphology and secretory responses of male rat lacrimal gland. , 1998, Journal of the autonomic nervous system.

[71]  B. Walcott The Lacrimal Gland and Its Veil of Tears. , 1998, News in physiological sciences : an international journal of physiology produced jointly by the International Union of Physiological Sciences and the American Physiological Society.

[72]  K. Barton,et al.  The effects of age, gender, and fluid dynamics on the concentration of tear film epidermal growth factor. , 1997, Cornea.

[73]  D. Zoukhri,et al.  Immunolocalization of Lacrimal Gland PKC Isoforms. Effect of Phorbol Esters and Cholinergic Agonists on Their Cellular Distribution , 1997, The Journal of Membrane Biology.

[74]  M. Meneray,et al.  Gs and Gq/11 couple vasoactive intestinal peptide and cholinergic stimulation to lacrimal secretion. , 1997, Investigative ophthalmology & visual science.

[75]  N. Hynes,et al.  ErbB‐2, the preferred heterodimerization partner of all ErbB receptors, is a mediator of lateral signaling , 1997, The EMBO journal.

[76]  C. Sergheraert,et al.  Identification of vasoactive intestinal peptide receptor subtypes in the lacrimal gland and their signal-transducing components. , 1997, Investigative ophthalmology & visual science.

[77]  A. Kanellopoulos,et al.  Comparison of corneal sensation following photorefractive keratectomy and laser in situ keratomileusis , 1997, Journal of cataract and refractive surgery.

[78]  S. Pflugfelder,et al.  Cholinergic stimulation of lactoferrin and epidermal growth factor secretion by the human lacrimal gland. , 1996, Cornea.

[79]  L. Hesse,et al.  Corneal reinnervation after photorefractive keratectomy and laser in situ keratomileusis: an in vivo study with a confocal videomicroscope. , 1996, German journal of ophthalmology.

[80]  K. Sharkey,et al.  Secretion and serotonin release in the isolated rat lacrimal gland: the effects of substance P and calcitonin gene-related peptide. , 1996, Journal of the autonomic nervous system.

[81]  M. Zimmerman,et al.  Tear Film Changes Associated with Normal Aging , 1996, Cornea.

[82]  M. Berridge,et al.  Capacitative calcium entry. , 1995, The Biochemical journal.

[83]  M. Lemp Report of the National Eye Institute/Industry workshop on Clinical Trials in Dry Eyes. , 1995, The CLAO journal : official publication of the Contact Lens Association of Ophthalmologists, Inc.

[84]  P. Robin,et al.  Effect of microtubule network disturbance by nocodazole and docetaxel (Taxotere) on protein secretion in rat extraorbital lacrimal and parotid glands. , 1995, European journal of cell biology.

[85]  S. Yamamoto,et al.  Histopathologic study of human lacrimal gland. Statistical analysis with special reference to aging. , 1995, Ophthalmology.

[86]  J. Gromada,et al.  Cyclic ADP‐ribose and inositol 1,4,5‐trisphosphate mobilizes Ca2+ from distinct intracellular pools in permeabilized lacrimal acinar cells , 1995, FEBS letters.

[87]  D. Zoukhri,et al.  Cholinergic activation of phospholipase D in lacrimal gland acini is independent of protein kinase C and calcium. , 1995, The American journal of physiology.

[88]  S. Muallem,et al.  Actin filament disassembly is a sufficient final trigger for exocytosis in nonexcitable cells , 1995, The Journal of cell biology.

[89]  D. Dartt Regulation of inositol phosphates, calcium and protein kinase C in the lacrimal gland , 1994, Progress in Retinal and Eye Research.

[90]  K. Sharkey,et al.  Innervation and mast cells of the rat exorbital lacrimal gland: the effects of age. , 1994, Journal of the autonomic nervous system.

[91]  F. Kiechle,et al.  Nitric oxide. Biochemistry, pathophysiology, and detection. , 1993, American journal of clinical pathology.

[92]  H. Jammes,et al.  M3 muscarinic acetylcholine receptor coupling to PLC in rat exorbital lacrimal acinar cells. , 1993, The American journal of physiology.

[93]  J. Putney,et al.  Sustained Ca2+ signaling in mouse lacrimal acinar cells due to photolysis of "caged" glycerophosphoryl-myo-inositol 4,5-bisphosphate. , 1992, The Journal of biological chemistry.

[94]  J. Garbus,et al.  Corneal sensitivity after photorefractive keratectomy. , 1992, American journal of ophthalmology.

[95]  P. Rose,et al.  Alpha 1-adrenergic and cholinergic agonists use separate signal transduction pathways in lacrimal gland. , 1992, The American journal of physiology.

[96]  A. Tarkkanen,et al.  Ocular disease leads to decreased concentrations of epidermal growth factor in the tear fluid. , 1991, Current eye research.

[97]  D. Sullivan,et al.  Endocrine, neural, and immune control of secretory component output by lacrimal gland acinar cells. , 1991, Journal of immunology.

[98]  L. Ronco,et al.  Lacrimal gland inositol trisphosphate isomer and inositol tetrakisphosphate production. , 1990, The American journal of physiology.

[99]  S. Yiu,et al.  Subcellular distribution of muscarinic acetylcholine receptors in rat exorbital lacrimal gland. , 1990, Investigative ophthalmology & visual science.

[100]  R. Irvine ‘Quanta’ Ca2+ release and the control of Ca2+ entry by inositol phosphates ‐ a possible mechanism , 1990, FEBS letters.

[101]  Martin Cl,et al.  Distribution of cholinergic and adrenergic nerve fibers in the lacrimal glands of dogs. , 1989 .

[102]  A. Mircheff Lacrimal fluid and electrolyte secretion: a review. , 1989, Current eye research.

[103]  D. Dartt Signal transduction and control of lacrimal gland protein secretion: a review. , 1989, Current eye research.

[104]  S. Patel,et al.  Relation Between Precorneal Tear Film Stability and Tear Production Rate in Normal Eyes , 1989, Optometry and vision science : official publication of the American Academy of Optometry.

[105]  K. Ólafsdóttir,et al.  T‐lymphocyte subsets in the human lacrimal gland , 1988, Acta ophthalmologica.

[106]  M. Welch,et al.  Sympathomimetic protein secretion by young and aged lacrimal gland. , 1986, Current eye research.

[107]  M. Welch,et al.  Lacrimal protein secretion: comparison of young and old rats. , 1985, Experimental eye research.

[108]  M. Millodot,et al.  THE INFLUENCE OF AGE ON THE FRAGILITY OF THE CORNEA , 1984, Acta ophthalmologica.

[109]  B. Damato,et al.  Senile atrophy of the human lacrimal gland: the contribution of chronic inflammatory disease. , 1984, The British journal of ophthalmology.

[110]  J. Putney,et al.  Receptor-mediated metabolism of the phosphoinositides and phosphatidic acid in rat lacrimal acinar cells. , 1984, The Biochemical journal.

[111]  H. Söling,et al.  Adrenocorticotropic hormone and alpha-melanocyte-stimulating hormone induce secretion and protein phosphorylation in the rat lacrimal gland by activation of a cAMP-dependent pathway. , 1982, European journal of biochemistry.

[112]  J. C. Kotulak,et al.  Age-related changes in the cornea. , 1980, Journal of the American Optometric Association.

[113]  M. Millodot The influence of age onthe sensitivity of the cornea,. , 1977, Investigative ophthalmology & visual science.

[114]  M. Hisada,et al.  Functional innervation of the lacrimal gland in the cat. Origin of secretomotor fibers in the lacrimal nerve. , 1966, Archives of ophthalmology.

[115]  S. Botelho,et al.  TEARS AND THE LACRIMAL GLAND. , 1964, Scientific American.

[116]  H. Uusitalo,et al.  The lacrimal glands of the rat and the guinea pig are innervated by nerve fibers containing immunoreactivities for substance P and vasoactive intestinal polypeptide , 2004, Histochemistry.

[117]  H. Huikuri,et al.  Comprehensive study of autonomic function in a population with primary Sjögren's syndrome. No evidence of autonomic involvement. , 2003, The Journal of rheumatology.

[118]  K. Yamamoto,et al.  Pathogenesis of Sjögren's syndrome. , 2003, Autoimmunity reviews.

[119]  R. Hodges,et al.  Regulatory pathways in lacrimal gland epithelium. , 2003, International review of cytology.

[120]  D. Zoukhri,et al.  Alpha 1-adrenergic and cholinergic agonists activate MAPK by separate mechanisms to inhibit secretion in lacrimal gland. , 2003, American journal of physiology. Cell physiology.

[121]  S. Hamm-Alvarez,et al.  Heterotrimeric GTP-binding proteins in the lacrimal acinar cell endomembrane system. , 2002, Experimental eye research.

[122]  R. Jonsson,et al.  Current concepts on diagnosis, autoantibodies and therapy in Sjögren's syndrome. , 2000, Scandinavian journal of rheumatology.

[123]  M. Meneray,et al.  Adrenergic stimulation of lacrimal protein secretion is mediated by G(q/11)alpha and G(s)alpha. , 2000, Current eye research.

[124]  J. Marshall,et al.  Loss and recovery of corneal sensitivity following photorefractive keratectomy for myopia. , 1999, Journal of refractive surgery.

[125]  E. Borda,et al.  Autoantibodies against lacrimal gland M3 muscarinic acetylcholine receptors in patients with primary Sjögren's syndrome. , 1998, Investigative ophthalmology & visual science.

[126]  A. Toker,et al.  Lacrimal gland PKC isoforms are differentially involved in agonist-induced protein secretion. , 1997, The American journal of physiology.

[127]  H. Sheardown,et al.  Tear EGF concentration following corneal epithelial wound creation. , 1996, Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics.

[128]  D. Warren Hormonal Influences on the Lacrimal Gland , 1994, International ophthalmology clinics.

[129]  J. Massagué,et al.  Membrane-anchored growth factors. , 1993, Annual review of biochemistry.

[130]  C. Pholpramool,et al.  Modification of stimulated lacrimal gland flow by sympathetic nerve impulses in rabbit. , 1976, The American journal of physiology.

[131]  B. Ehinger Distribution of adrenergic nerves in the eye and some related structures in the cat. , 1966, Acta physiologica Scandinavica.