Prediction of recurrence of hepatocellular carcinoma after curative hepatectomy using preoperative Lens culinaris agglutinin‐reactive fraction of alpha‐fetoprotein

Aim:  Lens culinaris agglutinin A‐reactive fraction of α‐fetoprotein (AFP‐L3) status has been reported to be an independent prognostic factor in patients with hepatocellular carcinoma (HCC). In this study, we evaluated the clinical usefulness of measuring preoperative AFP‐L3 to predict the recurrence and prognosis of HCC after curative hepatectomy.

[1]  H. Yoshida,et al.  Prediction of recurrence of hepatocellular carcinoma after curative ablation using three tumor markers , 2006, Hepatology.

[2]  H. Miyake,et al.  Effect of a new adjuvant systemic interferon alpha, 5-fluorouracil and cisplatin on advanced hepatocellular carcinoma with macroscopic portal invasion. , 2008, Hepato-gastroenterology.

[3]  W. Lau,et al.  Lens Culinaris Agglutinin-Reactive Fraction of Alpha-Fetoprotein as a Marker of Prognosis and a Monitor of Recurrence of Hepatocellular Carcinoma After Curative Liver Resection , 2011, Annals of Surgical Oncology.

[4]  Y. Maehara,et al.  LIVING DONOR LIVER TRANSPLANTATION FOR HEPATOCELLULAR CARCINOMA: A SPECIAL REFERENCE TO A PREOPERATIVE DES-GAMMA-CARBOXY PROTHROMBIN VALUE. , 2004, Transplantation proceedings.

[5]  T. Ono,et al.  Fucosylation of serum α-fetoprotein in patients with primary hepatocellular carcinoma , 1985 .

[6]  J. Bręborowicz,et al.  Microheterogeneity of Alpha‐fetoprotein in Patient Serum as Demonstrated by Lectin Affino‐electrophoresis , 1981, Scandinavian journal of immunology.

[7]  M. Makuuchi,et al.  Accurate preoperative evaluation of liver mass lesions without fine‐needle biopsy , 1999, Hepatology.

[8]  K. Taketa Alpha-fetoprotein: reevaluation in hepatology. , 1990, Hepatology.

[9]  H. Imamura,et al.  AFP, AFP-L3, DCP, and GP73 as markers for monitoring treatment response and recurrence and as surrogate markers of clinicopathological variables of HCC , 2010, Journal of Gastroenterology.

[10]  Shou-Dong Lee,et al.  Des-γ-Carboxy (Abnormal) Prothrombin as a Serum Marker of Primary Hepatocellular Carcinoma , 1984 .

[11]  S. Strasberg,et al.  Nomenclature of hepatic anatomy and resections: a review of the Brisbane 2000 system. , 2005, Journal of hepato-biliary-pancreatic surgery.

[12]  T. Ishiko,et al.  Preoperative tumor marker doubling time is a useful predictor of recurrence and prognosis after hepatic resection of hepatocellular carcinoma , 2010, Journal of surgical oncology.

[13]  K. Sung,et al.  Lens culinaris Agglutinin-Reactive Alpha-Fetoprotein as a Prognostic Marker in Patients With Hepatocellular Carcinoma Undergoing Transcatheter Arterial Chemoembolization , 2002, Journal of clinical gastroenterology.

[14]  S. Satomura,et al.  Clinical utility of Lens culinaris agglutinin-reactive alpha-fetoprotein in small hepatocellular carcinoma: special reference to imaging diagnosis. , 1999, Journal of hepatology.

[15]  T. Kuzuya,et al.  Relationship between Lens culinaris agglutinin‐reactive α‐fetoprotein and pathologic features of hepatocellular carcinoma , 2005, Liver international : official journal of the International Association for the Study of the Liver.

[16]  Hideyuki Shimizu,et al.  Usefulness of measurement of lens culinaris agglutinin-reactive fraction of α-fetoprotein as a marker of prognosis and recurrence of small hepatocellular carcinoma , 1999, American Journal of Gastroenterology.

[17]  B. Furie,et al.  Des-gamma-carboxy (abnormal) prothrombin as a serum marker of primary hepatocellular carcinoma. , 1984, The New England journal of medicine.

[18]  T. Ono,et al.  Fucosylation of serum alpha-fetoprotein in patients with primary hepatocellular carcinoma. , 1985, Biochimica et biophysica acta.

[19]  H. Asakura,et al.  The fucosylation index of α‐fetoprotein as a possible prognostic indicator for patients with hepatocellular carcinoma , 1998 .

[20]  K. Taketa α‐fetoprotein: Reevaluation in hepatology , 1990 .

[21]  G. Dusheiko,et al.  Management of hepatocellular carcinoma. , 1992, Journal of hepatology.

[22]  Y. Hiasa,et al.  Fucosylated Fraction of Alpha-Fetoprotein as a Predictor of Prognosis in Patients with Hepatocellular Carcinoma After Curative Treatment , 2010, Digestive Diseases and Sciences.