Failure of Deferasirox, an Iron Chelator Agent, Combined with Antifungals in a Case of Severe Zygomycosis

Zygomycosis, an increasingly prevalent systemic fungal disease, mostly occurs in immunocompromised patients ([6][1], [8][2]). First-line therapeutic strategy includes surgery and lipid amphotericin B ([2][3], [8][2]). New iron chelators have recently been reported to be successful experimentally ([3

[1]  B. Spellberg,et al.  The iron chelator deferasirox protects mice from mucormycosis through iron starvation. , 2007, The Journal of clinical investigation.

[2]  B. Spellberg,et al.  Deferiprone iron chelation as a novel therapy for experimental mucormycosis. , 2006, The Journal of antimicrobial chemotherapy.

[3]  B. Spellberg,et al.  Deferasirox, an Iron-Chelating Agent, as Salvage Therapy for Rhinocerebral Mucormycosis , 2006, Antimicrobial Agents and Chemotherapy.

[4]  Brad Spellberg,et al.  Novel Perspectives on Mucormycosis: Pathophysiology, Presentation, and Management , 2005, Clinical Microbiology Reviews.

[5]  B. Spellberg,et al.  Combination Therapy with Amphotericin B Lipid Complex and Caspofungin Acetate of Disseminated Zygomycosis in Diabetic Ketoacidotic Mice , 2005, Antimicrobial Agents and Chemotherapy.

[6]  B. Spellberg,et al.  Rhizopus oryzae Adheres to, Is Phagocytosed by, and Damages Endothelial Cells In Vitro , 2005, Infection and Immunity.

[7]  O. Lortholary,et al.  Vascularites secondaires aux infections fongiques , 2004 .

[8]  F. Marty,et al.  Breakthrough zygomycosis after voriconazole treatment in recipients of hematopoietic stem-cell transplants. , 2004, The New England journal of medicine.

[9]  O. Lortholary,et al.  [Vasculitis secondary to fungal infections]. , 2004, Presse medicale.

[10]  J. Meis,et al.  In vitro susceptibilities of zygomycetes to conventional and new antifungals. , 2003, The Journal of antimicrobial chemotherapy.

[11]  Y. Schneider,et al.  Mucormycosis during deferoxamine therapy is a siderophore-mediated infection. In vitro and in vivo animal studies. , 1993, The Journal of clinical investigation.