Skin involvement in chronic myelomonocytic leukaemia as a predictor of transformation into acute myeloid leukaemia

We report on the case of a patient with myelodysplastic syndrome (MDS) who presented with leukaemia cutis preceding development of acute myeloid leukaemia. Leukaemic infiltration of the skin should be considered an early manifestation of leukaemic transformation and an indicator of poor prognosis in MDS.

[1]  H. Kerl,et al.  Specific cutaneous infiltrates in patients with myelogenous leukemia: a clinicopathologic study of 26 patients with assessment of diagnostic criteria. , 1999, Journal of the American Academy of Dermatology.

[2]  Y. Ozisik,et al.  Aleukemic leukemia cutis in a patient with acute lymphoblastic leukemia. , 1998, Journal of the American Academy of Dermatology.

[3]  M. Piris,et al.  Aleukemic "leukemia cutis" of monocytic lineage. , 1997, Journal of the American Academy of Dermatology.

[4]  A. Navarro,et al.  Aleukemic leukemia cutis preceding overt acute myeloid leukemia in myelodysplastic syndrome , 1997, American journal of hematology.

[5]  M. Ishii,et al.  Lymphocytic aleukemic leukemia cutis. , 1996, Journal of the American Academy of Dermatology.

[6]  L. Gibson,et al.  Aleukemic monocytic leukemia cutis. , 1996, Mayo Clinic proceedings.

[7]  D. R. Pulitzer,et al.  CUTANEOUS INVOLVEMENT IN CHRONIC MYELOMONOCYTIC LEUKEMIA , 1994, International journal of dermatology.

[8]  W. Su Clinical, histopathologic, and immunohistochemical correlations in leukemia cutis. , 1994, Seminars in dermatology.

[9]  R. Gay,et al.  Oncogenes, growth factors, and matrix in the pathogenesis of systemic sclerosis. , 1994, Clinics in dermatology.

[10]  B. Smoller,et al.  The spectrum of cutaneous disease in leukemias , 1993, Journal of cutaneous pathology.

[11]  B. Smoller,et al.  Leukemia cutis. Analysis of 50 biopsy-proven cases with an emphasis on occurrence in myelodysplastic syndromes. , 1993, American journal of clinical pathology.

[12]  K. V. Ratnam,et al.  Value of immunohistochemistry in the diagnosis of leukemia cutis: study of 54 cases using paraffin‐section markers , 1992, Journal of cutaneous pathology.

[13]  K. Danno,et al.  Aleukemic leukemia cutis. , 1990, Journal of the American Academy of Dermatology.

[14]  J. Hermans,et al.  Utility of the FAB classification for myelodysplastic syndromes: investigation of prognostic factors in 237 cases , 1987, British journal of haematology.

[15]  J. Armitage,et al.  Myelodysplastic syndromes. A clinical and pathologic analysis of 109 cases , 1985, Cancer.

[16]  D. Machin,et al.  Myelodysplastic syndromes: a scoring system with prognostic significance , 1985, British journal of haematology.

[17]  K. V. Ratnam,et al.  Leukemia cutis : Cutaneous lymphomas , 1994 .

[18]  D. Roseeuw,et al.  Aleukemic Leukemia cutis , 1986 .